Article
Biotechnology & Applied Microbiology
Miyeon Jeon, Gaeun Kim, Wooseung Lee, Seungki Baek, Han Na Jung, Hyung-Jun Im
Summary: The novel dual-layered nanomaterial LAL, with the addition of a liposomal layer and PEG functionalization, shows improved in vivo stability and tumor-targeting ability. Cu-64-LAL demonstrates good blood circulation and tumor targeting capabilities in PET imaging.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Medicine, Research & Experimental
Junjie Ren, Jing Zhou, Han Liu, Xiaodan Jiao, Yang Cao, Zhigang Xu, Yuejun Kang, Peng Xue
Summary: The study introduces a new therapeutic strategy of inducing redox dyshomeostasis by inhibiting glutaminolysis and accumulating ROS, which triggers immunogenic cell death to suppress tumor cell proliferation. Utilizing custom-made nanoparticles with ultrasound-activated therapy can effectively disrupt redox homeostasis within tumor cells.
Review
Pharmacology & Pharmacy
Afsana Sheikh, Nabil A. Alhakamy, Shadab Md, Prashant Kesharwani
Summary: This article introduces the research progress of liposomes as drug delivery systems for cancer treatment, focusing on the modification of liposome surface to be recognized and uptaken by cancer cells, and the mechanism of targeting, accumulation, and drug release at specific sites mediated by integrin recognition.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Kai Wang, Fusheng Shang, Dagui Chen, Tieliu Cao, Xiaowei Wang, Jianpeng Jiao, Shengli He, Xiaofei Liang
Summary: The study proposed a transferrin-modified proteolipid-mediated gene delivery strategy for targeted liver cancer treatment, which exhibited premium targeting efficacy and high transfection efficiency in vitro and in vivo.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Zhou Ye, Benjamin D. Gastfriend, Benjamin J. Umlauf, David M. Lynn, Eric Shusta
Summary: A receptor-mediated antibody-targeted liposomal system was developed and evaluated for targeted delivery of therapeutics into the brain. The system showed increased brain accumulation by targeting the brain vasculature through the blood-brain barrier. These findings indicate the potential of this system for transporting therapeutic molecules into the central nervous system.
PHARMACEUTICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Gloria Yi Wei Tseu, Khairul Azfar Kamaruzaman
Summary: Breast cancer incidence and mortality rates have significantly increased, especially among female patients, in the past decade. Current therapies have negative impacts on patients and gene therapy using non-viral vectors such as liposomes is being considered as a safer alternative. Cationic liposomes appear to be more suitable for gene delivery and therapy for breast cancer treatment due to their practical approach and ability to absorb negatively charged nucleic acids and cell membranes.
Article
Chemistry, Physical
Minxian Li, Mei Jiang, Mengting Chen, Lilusi Ma, Xiaocui Fang, Yanlian Yang, Chen Wang
Summary: Cell membrane-engineered nano-delivery systems have shown potential in improving drug bioavailability and reversing drug resistance in cancer therapy. In this study, a nano-liposome called cLCE was developed, which consists of a hybrid of cisplatin-resistant A549 cancer cell membrane and phospholipids, for co-delivery of cisplatin and EZH2-targeting peptide EIP103. The formulated nano-liposome demonstrated efficient inhibition of cancer cell invasion and metastasis, as well as reversal of cisplatin resistance both in vitro and in vivo.
Article
Nanoscience & Nanotechnology
Yue Yu, Zhenfeng Wang, Sichen Wu, Chunmeng Zhu, Xianshe Meng, Chao Li, Sheng Cheng, Wei Tao, Feng Wang
Summary: In this study, DNA was successfully decorated onto lipid nanoparticles using MnO2 nanosheets as nanoglues, without the need for complex and expensive DNA modification. The method demonstrated potential clinical applications in tumor cells.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Veronica Almeida-Marrero, Fleur Bethlehem, Sara Longo, M. Candelaria Bertolino, Tomas Torres, Jurriaan Huskens, Andres de la Escosura
Summary: Modifying surfaces with multiple ligands allows for the study of multivalency, which has been successfully demonstrated in the efficient binding of a photosensitizer-nanocarrier system to siglec10. This approach represents a potential method for targeting siglec-expressing cells with photosensitizing nanocarriers.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Van Du Nguyen, Hyun-Ki Min, Ho Yong Kim, Jiwon Han, You Hee Choi, Chang-Sei Kim, Jong-Oh Park, Eunpyo Choi
Summary: The study developed dual-targeting Mϕ-based microrobots that were regulated by chemotaxis and an external magnetic field, allowing for precise spatiotemporal controlled drug release at tumor sites in response to NIR laser irradiation. These microrobots effectively infiltrated tumors and induced tumor cell death with the assistance of a magnetic field, further enhanced by NIR laser irradiation. The application of the magnetic field and NIR laser could markedly inhibit tumor growth with a subtherapeutic dose of DOX and a single injection of the microrobots in vivo experiments.
Review
Pharmacology & Pharmacy
Yongguang Gao, Xinhua Liu, Na Chen, Xiaochun Yang, Fang Tang
Summary: Gene therapy has shown significant advantages in the treatment of major diseases. Nucleic acid drugs, especially when modified with liposome nanoparticles, have the potential to overcome the limitations of nucleic acid such as poor stability and targeting, and improve their clinical application.
Article
Chemistry, Multidisciplinary
Yitong Chen, Yue Zhang, Beilei Wang, Qin Fan, Qianyu Yang, Jialu Xu, Huaxing Dai, Fang Xu, Chao Wang
Summary: An implantable blood clot loaded with LPH-vaccine and LPHsiRNA is used to recruit and activate dendritic cells, improving the efficacy of tumor vaccines and reducing immunosuppressive signals. This strategy has shown promising results in mouse models and has the potential for personalized therapy.
Review
Pharmacology & Pharmacy
Laxmikant Gautam, Priya Shrivastava, Bhavana Yadav, Anamika Jain, Rajeev Sharma, Sonal Vyas, S. P. Vyas
Summary: This review discusses the recent developments and clinical potential of multicompartment systems called vesosomes, as well as their preparation methods, surface modifications, and potential for site-specific drug delivery. The focus is on the possibility of vesosome accumulation mediated by the reticuloendothelial system (RES) and their application in tumor targeting, which are areas for further exploration.
DRUG DISCOVERY TODAY
(2022)
Article
Pharmacology & Pharmacy
Shuo Wang, Shuaishuai Yang, Xiaoxue Lai, Yanzhi Song, Ling Hu, Cong Li, Tao Shi, Xinrong Liu, Yihui Deng, Guoliang Chen
Summary: The study investigated the impact of particle size on neutrophil-mediated drug delivery, with findings showing that small DP-SALs efficiently released the drug, resulting in excellent anti-rheumatoid arthritis effects at the inflammatory site.
Article
Medicine, Research & Experimental
Anna Kotowska-Zimmer, Lukasz Przybyl, Marianna Pewinska, Joanna Suszynska-Zajczyk, Dorota Wronka, Maciej Figiel, Marta Olejniczak
Summary: This study demonstrates that vector-based RNAi triggers can effectively reduce mutant huntingtin levels in an animal model of Huntington's disease (HD) without affecting endogenous mouse huntingtin. The use of artificial miRNA (amiRNA) treatment not only improves motor performance and organ weight but also shows good safety and tolerability. These findings suggest that CAG-targeting strategy and amiRNA could be a valuable contribution to current therapeutic approaches for HD.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Green & Sustainable Science & Technology
Kamyar Shirvanimoghaddam, Bozena Czech, Ram Yadav, Cemile Gokce, Laura Fusco, Lucia Gemma Delogu, Acelya Yilmazer, Graham Brodie, Amani Al-Othman, Adil K. Al-Tamimi, Jarret Grout, Minoo Naebe
Summary: Coronavirus disease (COVID-19) is a rapidly spreading pandemic that poses a severe threat to global public health. Human-to-human transmission of the virus is well established, primarily through aerosols and droplets. This review highlights the environmental challenges and risks associated with the surge in facemask production during the pandemic. It also discusses the potential of nanomaterial-based antiviral and self-cleaning facemasks as a sustainable solution.
Article
Chemistry, Multidisciplinary
Thomas Loret, Luis Augusto Visani de Luna, Alexander Fordham, Atta Arshad, Katharine Barr, Neus Lozano, Kostas Kostarelos, Cyrill Bussy
Summary: Graphene has attracted significant attention in the material community due to its unique physicochemical properties. Graphene oxide (GO), as an oxidized derivative, shows promising potential as a drug delivery system. This study investigates the lung tolerability of two different dimensions of GO and finds that nanometric GO is more suitable for pulmonary drug delivery, as it induces milder immune and tissue responses and is cleared more easily from the respiratory tract.
Review
Cardiac & Cardiovascular Systems
Cemile Gokce, Cansu Gurcan, Lucia Gemma Delogu, Acelya Yilmazer
Summary: Cardiovascular diseases have a significant impact on human health, and regenerative strategies are the most promising approaches. This review provides an overview of biomaterial-based tissue engineering approaches for cardiac repair and regeneration, with a specific focus on the potential of 2D materials.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Chemistry, Physical
Ahmet Karatay, Digdem Erdener, Cansu Gurcan, Elif Akhuseyin Yildiz, Acelya Yilmazer, Bahadir Boyacioglu, Huseyin Unver, Mustafa Yildiz, Ayhan Elmali
Summary: Recent advances in nanotechnology have allowed for the development of graphene quantum dots (GQDs) for functional imaging and cancer therapy. The study introduced polyethyleneimine functionalized nitrogen-doped graphene quantum dots (PEI N-doped GQDs) and silver nanoparticles/nitrogen-doped graphene quantum dots (AgNPs/PEI N-doped GQDs) nanocomposites, showing that the sensing ability of AgNPs/PEI N-doped GQDs nanocomposite is better than that of PEI N-doped GQDs.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Correction
Nanoscience & Nanotechnology
Thomas Kisby, Acelya Yilmazer, Kostas Kostarelos
NATURE NANOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Paul S. Sharp, Maria Stylianou, Luis M. Arellano, Juliana C. Neves, Alfredo M. Gravagnuolo, Abbie Dodd, Katharine Barr, Neus Lozano, Thomas Kisby, Kostas Kostarelos
Summary: Graphene-based 2D nanomaterials have unique physicochemical characteristics that can be used in various biomedical applications, such as drug delivery and treatment. This study investigates the distribution of thin graphene oxide (GO) nanosheets in GBM mouse models and designs a novel nano-chemotherapeutic approach using GO sheets as platforms for drug complexation. The results demonstrate enhanced cytotoxic effects of the GO-BTZ complex in vivo.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Giuseppe Di Mauro, Roberta Amoriello, Neus Lozano, Alberto Carnasciali, Daniele Guasti, Maurizio Becucci, Giada Cellot, Kostas Kostarelos, Clara Ballerini, Laura Ballerini
Summary: In neuroinflammation, astrocytes respond to pro-inflammatory cytokines (CKs) through Ca2+ signaling and play important roles in disease progression. Graphene oxide (GO) nanoparticles offer a promising approach to target astrocytes and regulate their reactivity. This study investigates the effects of CKs on astrocytic Ca2+ signaling and demonstrates the potential of GO to reverse the dysregulated cellular changes in astrocytes. The findings suggest that GO-based therapeutics may be effective in treating immune-mediated neuroinflammatory diseases.
Article
Nanoscience & Nanotechnology
Guotao Peng, Hanna M. Sinkko, Harri Alenius, Neus Lozano, Kostas Kostarelos, Lars Brautigam, Bengt Fadeel
Summary: The presence of graphene oxide in the diet alters the composition of the gut microbiome in adult zebrafish, with differences seen between wild-type and ahr2-deficient animals. Furthermore, oral exposure to graphene oxide in combination with butyrate induces AhR-dependent expression of cyp1a and homing of lck(+) cells to the gut in germ-free zebrafish. Single-cell RNA sequencing studies reveal the presence of innate lymphoid cell (ILC)-like cells in germ-free zebrafish, and a "corona" of microbial butyrate triggered by graphene oxide leads to the induction of ILC2-like cells with regulatory properties.
NATURE NANOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Thomas Loret, Luis Augusto Visani de Luna, Matteo Andrea Lucherelli, Alexander Fordham, Neus Lozano, Alberto Bianco, Kostas Kostarelos, Cyrill Bussy
Summary: The study investigates the biological response, distribution, and bio-persistence of four different graphene-based materials (GBMs) in mouse lungs. The size, carbon to oxygen ratio, and thickness of the GBMs do not induce a strong pulmonary immune response. Neutrophils internalize and degrade small GBMs faster than macrophages, revealing their crucial role in the elimination of these materials. Large GBMs, on the other hand, have hindered degradation and long-term persistence in macrophages, leading to more damages. These findings are important for the design of safer GBMs for biomedical applications.
Article
Chemistry, Physical
Acelya Yilmazer, Keshav Narayan Alagarsamy, Cemile Gokce, Gokce Yagmur Summak, Alireza Rafieerad, Fatma Bayrakdar, Berfin Ilayda Ozturk, Suleyman Aktuna, Lucia Gemma Delogu, Mehmet Altay Unal, Sanjiv Dhingra
Summary: MXene QDs (MQDs) have potential as nanotherapeutics against viral infections, including COVID-19. In this study, Ti3C2 MQDs are synthesized and their efficacy in mitigating SARS-CoV-2 infection is investigated. Results show that MQDs can effectively inhibit virus particles' multiplication at low doses, and global proteomics analysis reveals the mechanisms by which MQDs interfere with the viral life cycle. These findings suggest that MQDs could be used to develop future immunoengineering-based nanotherapeutic strategies against SARS-CoV-2 and other viral infections.
Article
Chemistry, Physical
Laura Fusco, Arianna Gazzi, Christopher E. Shuck, Marco Orecchioni, Eiman Ahmed, Linda Giro, Barbara Zavan, Acelya Yilmazer, Klaus Ley, Davide Bedognetti, Yury Gogotsi, Lucia Gemma Delogu
Summary: Although vanadium-based metallodrugs are explored for their anti-inflammatory activity, they often have side effects. Transition metal carbides (MXenes) have been studied as potential biomedical platforms. In this study, vanadium carbide MXene (V4C3) is synthesized and evaluated for its biocompatibility and immunomodulatory effects. The findings show that V4C3 can inhibit T cell-dendritic cell interactions and downregulate antigen presentation-associated genes in primary human immune cells, suggesting its potential as a negative modulator of immune response in inflammatory and autoimmune diseases.
Article
Chemistry, Multidisciplinary
Lorenza Tortella, Irene Santini, Neus Lozano, Kostas Kostarelos, Giada Cellot, Laura Ballerini
Summary: Small graphene oxide nanosheets can reversibly downregulate excitatory synapses in the central nervous system and have potential applications as therapeutic tools for neuro-disorders. This study demonstrates that the delivery of s-GO can improve neuronal survival during oxygen-glucose deprivation and protect neuronal integrity under exogenous glutamate application.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Helene Cazier, Carole Malgorn, Dominique Georgin, Nathalie Fresneau, Fabrice Beau, Kostas Kostarelos, Cyrill Bussy, Stephane Campidelli, Mathieu Pinault, Martine Mayne-L'Hermite, Frederic Taran, Christophe Junot, Francois Fenaille, Antoine Sallustrau, Benoit Colsch
Summary: Research on graphene based nanomaterials has expanded in recent years due to their unique properties and potential socio-economic impact. This study proposes a novel approach combining radioimaging and mass spectrometry imaging for detecting Graphene Oxide (GO) labeled with carbon-14 in mice. The results demonstrate the advantages of this correlative imaging technique for the pre-clinical development of graphene-based biomedical applications.
Article
Chemistry, Multidisciplinary
Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Neus Lozano, Kostas Kostarelos, Giada Cellot, Laura Ballerini
Summary: Graphene oxide nanosheets have the potential to alter neurobiological processes and regulate glutamatergic synapses, making them a promising candidate for future neurotherapeutic developments. In a rat model of post-traumatic stress disorder (PTSD), it was found that a single injection of graphene oxide to the lateral amygdala could induce behavior remission and reduce dendritic spine densities associated with PTSD. Mechanistically, graphene oxide was found to affect the probability of release, thus modulating synaptic plasticity in the amygdala.
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
