Journal
JOURNAL OF NANOBIOTECHNOLOGY
Volume 19, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12951-021-00777-9
Keywords
Liposome; Transferrin; Acetylcholinesterase; Liver cancer; Gene therapy
Funding
- National Natural Science Foundation of China [81773173, 81572973]
- Joint Research of Medicine and Industry of Shanghai Jiao Tong University [YG2017MS55]
- Shanghai Municipal Administrator for Traditional Chinese Medical [ZYBZ-2017066]
- Open Project of Key Laboratory of Systems Biomedicine (Ministry of Education) [KLSB2017KF-03]
- Shanghai Municipal Health Commission [201940407]
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The study proposed a transferrin-modified proteolipid-mediated gene delivery strategy for targeted liver cancer treatment, which exhibited premium targeting efficacy and high transfection efficiency in vitro and in vivo.
Background: Effective methods to deliver therapeutic genes to solid tumors and improve their bioavailability are the main challenges of current medical research on gene therapy. The development of efficient non-viral gene vector with tumor-targeting has very important application value in the field of cancer therapy. Proteolipid integrated with tumor-targeting potential of functional protein and excellent gene delivery performance has shown potential for targeted gene therapy. Results: Herein, we prepared transferrin-modified liposomes (Tf-PL) for the targeted delivery of acetylcholinesterase (AChE) therapeutic gene to liver cancer. We found that the derived Tf-PL/AChE liposomes exhibited much higher transfection efficiency than the commercial product Lipo 2000 and shown premium targeting efficacy to liver cancer SMMC-7721 cells in vitro. In vivo, the Tf-PL/AChE could effectively target liver cancer, and significantly inhibit the growth of liver cancer xenografts grafted in nude mice by subcutaneous administration. Conclusions: This study proposed a transferrin-modified proteolipid-mediated gene delivery strategy for targeted liver cancer treatment, which has a promising potential for precise personalized cancer therapy.
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