Article
Chemistry, Analytical
Wei Pan, Xianhe Huang, Qiao Chen
Summary: This study theoretically analyzes the impact of different sizes of dot ring and dot double-ring electrodes on the mass sensitivity distribution of the quartz crystal microbalance (QCM), and proposes a dot triple-ring electrode to enhance uniformity. The research provides a new direction for improving the uniformization of QCM mass sensitivity distribution.
ANALYTICAL CHEMISTRY
(2021)
Article
Optics
Mirit Hen, Leroy Dokhanian, Etai Grunwald, Matan Slook, Moshe Katzman, Maayan Priel, Olga Girshevitz, Avi Zadok
Summary: In this work, the analysis of elastic properties of thin layers deposited on surface acoustic wave-photonic devices is proposed and demonstrated. By measuring the changes in the group velocity of surface acoustic waves after deposition of thin layers, estimates for Young's modulus of these layers can be obtained.
Article
Chemistry, Analytical
Di Jiang, Xiaona Zhao, Yi-Nan Liu, Hai-Bo Chen, Wen-Li Lv, Chen Qian, Xian-Wei Liu
Summary: The study introduces a label-free optical imaging technology that can detect molecule binding kinetics by tracking charge-sensitive variations in the oscillation amplitude with sub-nanometer precision, allowing for the measurement of small molecules and metal ions binding to the surface as well as protein-protein binding kinetics. This capability offers a promising platform for screening small-molecule drugs, probing conformational changes in proteins, and detecting environmental pollutants.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Philipp Ortner, Maren Umlandt, Nino Lomadze, Svetlana Santer, Marek Bekir
Summary: The quartz crystal microbalance with dissipation (QCM-D) has been widely used for investigating the external stimuli responsiveness at solid-liquid interfaces. However, in light responsive adsorption investigation, the quartz crystal itself reacts to optical stimulation, which poses challenges in data interpretation. This article introduces a simple guideline for correcting the measurement artifacts and minimizing the impact of light induced detuning (LID).
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Minoru Yoshimoto, Shigeru Kurosawa, Mutsuo Tanaka
Summary: The study found that under different temperatures and oscillation frequencies, the nanoscale dynamics of soft materials can be described linearly by the relationship between resonant length or molecular weight and the logarithm of QCM angular frequency, and converged to a single point independently of temperature within a certain temperature range.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Biochemistry & Molecular Biology
Gergely Stankovits, Agnes Abraham, Eva Kiss, Zoltan Varga, Anil Misra, Andras Szilagyi, Benjamin Gyarmati
Summary: The type and concentration of charged groups in polymers play a crucial role in mucoadhesive interactions. This study investigated the correlation between chemical structure and mucin-polymer interactions by designing cationic poly(amino acid)s with different charge densities. The results showed that the interactions between mucin and polyaspartamides with at least 50% cationic groups displayed a non-linear change, causing increased light scattering. The analysis further revealed that fully cationic polyaspartamide is not necessarily superior, and the maximum adsorbed mass of polymers on mucin occurred at medium cationic group contents. This highlights the importance of cationic polyaspartamides as mucoadhesive excipients due to their multiple functionalities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Jugal Suthar, Alberto Alvarez-Fernandez, Esther Osarfo-Mensah, Stefano Angioletti-Uberti, Gareth R. Williams, Stefan Guldin
Summary: Extracellular vesicles (EVs) are released from various cell types and contain biomolecular content for health and disease identification. However, the heterogeneity of EVs and complexity of biofluids pose challenges to current analytical approaches. This study explores nanostructuring the sensor electrode surface to enhance detection capabilities and achieves significant improvement.
NANOSCALE HORIZONS
(2023)
Article
Polymer Science
Nisha Hollingsworth, Ronald G. Larson
Summary: This study investigates the swelling/deswelling and hysteresis behavior of weakly ionizable polyanion poly(acrylic acid) (PAA) brushes and bilayers containing PAA and poly(ethylene imine) (PEI) using a quartz crystal microbalance with dissipation (QCM-D) system. The results demonstrate that the brush height is influenced by grafting density, chain length, ion charge distribution, and pH value, leading to hysteresis phenomena under different conditions. The findings highlight the complex thermodynamics and kinetics of polyelectrolyte films, even at the monolayer and bilayer level.
Article
Chemistry, Applied
Tian Liu, Yu Zhang, Xiaomin Lu, Peipei Wang, Xinyu Zhang, Jing Tian, Qingcheng Wang, Junlong Song, Yongcan Jin, Huining Xiao
Summary: CBM4 binds preferentially to both CNF and CNC, with different driving forces: hydrogen bonds for CNF resulting in favorable enthalpy but compensated by unfavorable entropy change, while favorable entropy for CNC but compensated by unfavorable enthalpic change due to water rearrangement.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Analytical
Vasiliy S. Chernyshev, Mikhail Skliar
Summary: This article introduces a method for quantifying extracellular vesicles (EVs) using a quartz crystal microbalance (QCM) as a biosensor. This method has the advantages of high sensitivity, small sample volume, and low cost, and is of great importance for research in cell-to-cell signaling, disease modeling, and drug development.
Article
Chemistry, Analytical
Subramanian Suriyanarayanan, Sudip Mandal, Kothandaraman Ramanujam, Ian A. Nicholls
Summary: Proteinaceous and tunable nanostructures of zein were developed as receptors using a molecular imprinting technique. Sacrificial templates were used to control the nanostructural patterns. Highly oriented, predetermined, and uniformly grown hyperporous and nanowires motifs of zein were obtained. These zein nanostructures showed high sensitivity towards biotin or its derivatives, making them suitable for detecting relevant analytes.
Article
Chemistry, Analytical
Dongzhi Zhang, Zhanjia Kang, Xiaohua Liu, Jingyu Guo, Yan Yang
Summary: This paper presents a QCM ammonia gas sensor based on PSS-doped ZIF-8-derived porous carbon and polyaniline decorated nanocomposite (PSS/ZIF-C/PANI). The sensor exhibits high sensitivity, excellent linearity, and strong response/recovery capability towards ammonia. Impedance analysis confirms the electrical parameters and quality factor of the QCM, and suggests a potential ammonia adsorption mechanism related to the synergistic effect of the composite nanomaterials.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Engineering, Multidisciplinary
Andrzej Biadasz, Michal Kotkowiak, Damian Lukawski, Jakub Jadwi zak, Karol Rytel, Kamil K. Edzierski
Summary: In this study, a comprehensive gas transmission system was developed by combining elements from two commonly used systems, which allowed for automatic humidity changes and reliable gas flows in closed measurement chambers. The system demonstrated excellent stability and high precision, making it suitable for thorough investigation of humidity sensor properties.
Article
Engineering, Environmental
Nagy L. Torad, Jeonghun Kim, Minjun Kim, Hyunsoo Lim, Jongbeom Na, Saad M. Alshehri, Tansir Ahamad, Yusuke Yamauchi, Miharu Eguchi, Bing Ding, Xiaogang Zhang
Summary: This study demonstrates the preparation of various nanoporous carbons by carbothermal treatment of ZIF crystals under different gas atmospheres, and investigates their sensitivity and selectivity towards volatile aromatic compounds. The growth of hairy graphitic-like CNTs on the surface of CNT-rich NPCs acts as highly selective sensing antennae for the discrimination of toxic aromatic hydrocarbons. Despite increased selectivity, the sacrifice of surface area in CNT-rich NPCs derived from certain ZIFs limits their potential applications in gas sensing.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Reika Tsuji, Soichi Ogata, Shinichi Mochizuki
Summary: Proteins and nucleic acids derived from bioresources have shown potential as a new medical modality. In this study, conjugates of bovine serum albumin (BSA) and hyaluronic acid (HA) were prepared to deliver proteins to cancer cells. The conjugates, with a highly condensed structure and crosslinking through BSA, induced a larger decrease in frequency change and showed high fluorescence intensity in CT26 cells. These conjugates and nanoparticles with densely packed HA structures could serve as an effective platform for delivering proteins to cancer tissues.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Analytical
Nicole E. Weckman, Cassey McRae, Paul Ko Ferrigno, Ashwin A. Seshia
Article
Engineering, Electrical & Electronic
Nicole E. Weckman, Ashwin A. Seshia
SENSORS AND ACTUATORS A-PHYSICAL
(2017)
Article
Chemistry, Multidisciplinary
Nicole E. Weckman, Niklas Ermann, Richard Gutierrez, Kaikai Chen, James Graham, Ran Tivony, Andrew Heron, Ulrich F. Keyser
Article
Physics, Multidisciplinary
Stuart F. Knowles, Nicole E. Weckman, Vincent J. Y. Lim, Douwe J. Bonthuis, Ulrich F. Keyser, Alice L. Thorneywork
Summary: The study demonstrates that the adsorption of short, neutral polymers on the surface of solid-state nanopores can change the characteristics of ionic current noise, with the change depending strongly on polymer length and salt concentration. The agreement between experimental data and simulations provides insight into the shape of the adsorption potential and underlying processes, paving the way for in situ characterization of functionalized nanopores using noise spectral analysis.
PHYSICAL REVIEW LETTERS
(2021)
Article
Multidisciplinary Sciences
Helena de Puig, Rose A. Lee, Devora Najjar, Xiao Tan, Luis R. Soekensen, Nicolaas M. Angenent-Mari, Nina M. Donghia, Nicole E. Weckman, Audrey Ory, Carlos F. Ng, Peter Q. Nguyen, Angelo S. Mao, Thomas C. Ferrante, Geoffrey Lansberry, Hani Sallum, James Niemi, James J. Collins
Summary: The miSHERLOCK is a low-cost CRISPR-based POC diagnostic platform that can rapidly detect SARS-CoV-2 and its variants with high sensitivity in just 1 hour. This modular system can be quickly adapted to different viruses and variants, and is complemented by a smartphone application for output interpretation and result reporting.
Proceedings Paper
Engineering, Electrical & Electronic
Nicole E. Weckman, Niklas Ermann, Richard Gutierrez, Kaikai Chen, James Graham, Andrew Heron, Ulrich F. Keyser
Proceedings Paper
Engineering, Electrical & Electronic
N. Weckman, A. Seshia
Article
Engineering, Electrical & Electronic
Arthur T. Zielinski, Nicole E. Weckman, Roderic L. Jones, Markus Kalberer, Ashwin A. Seshia
IEEE SENSORS LETTERS
(2017)
Proceedings Paper
Engineering, Multidisciplinary
Nicole Weckman, Ashwin Seshia
Proceedings Paper
Engineering, Multidisciplinary
Nicole Weckman, Ashwin Seshia