Article
Chemistry, Multidisciplinary
Phong K. Quach, Jesse H. Hsu, Ivan Keresztes, Brett P. Fors, Tristan H. Lambert
Summary: The ring-opening metathesis polymerization of cyclopropenes using hydrazonium initiators was investigated. The initiators, formed by condensing 2,3-diazabicyclo[2.2.2]octane and an aldehyde, polymerize cyclopropene monomers through a sequence of [3+2] cycloaddition and cycloreversion reactions. The study showed that the monomer to initiator ratio had a positive correlation with the degree of polymerization.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Polymer Science
Yujin Cha, JiHyeon Hwang, Luis Ramos, Huina Lin, Tianyu Zhu, Chuanbing Tang
Summary: The synthesis of cyclic cobaltocenium and its application in the synthesis of high-performance copolymers have been reported.
Article
Polymer Science
Sebla Onbulak, Marc A. Hillmyer
Summary: The synthesis of sequence-controlled poly(ethylene-co-styrene) copolymers is challenging due to limitations in catalytic olefin polymerizations. An alternative method using ROMP of cyclic olefins followed by hydrogenation can generate ethylene copolymers with regioregularity. Investigating the ROMP of low-strain cyclododecenes provided useful information for mechanistic aspects of polymerization.
Article
Chemistry, Multidisciplinary
Dmitry S. Belov, Logesh Mathivathanan, Melanie J. Beazley, William Blake Martin, Konstantin V. Bukhryakov
Summary: The study explores the capability of an iron-based catalyst in performing ring-opening metathesis polymerization of olefins, demonstrating that the use of in situ prepared heteroleptic iron catalysts significantly enhances polymerization rate and selectivity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Applied
Nina Guy, Olivia Giani, Sebastien Blanquer, Julien Pinaud, Jean-Jacques Robin
Summary: Photopolymerization is gaining interest in both industrial and academic fields due to its high reaction kinetics, low emissions of organic solvents, and reduced shrinking stress. This method has mainly been developed for radical polymerization of vinyl monomers and to a lesser extent for ring-opening polymerization (ROP). With the emergence of new initiating systems, the photopolymerization of various cyclic monomers has expanded beyond epoxides, which were the first monomers polymerized by cationic ring-opening polymerization (CROP).
PROGRESS IN ORGANIC COATINGS
(2021)
Article
Polymer Science
Mohammad Yasir, Andreas F. M. Kilbinger
Summary: Norbornene and cyclohexene show different polymerization behaviors using Grubbs' catalysts due to their varying ring strain energy levels; a sequence-selective cascade polymerization of a monomer containing both rings resulted in polymers with moderate molecular weight dispersities and good control over molecular weight.
Article
Chemistry, Multidisciplinary
Zhen Yu, Meng Wang, Xu-Man Chen, Shuai Huang, Hong Yang
Summary: The novel macrobicyclic olefin system shows good selectivity and high stereoselectivity in ROMP, with sacrificial cleavage of the silyloxide bridge providing clean-structured, non-auxiliaried polymers.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Polymer Science
Honggang Mei, Bingjie Zhao, Huaming Wang, Sixun Zheng
Summary: The preparation of crosslinked PDCPD nanoparticles via ROMP-induced self-assembly approach was reported in this communication. The morphology of the obtained nanoparticles varied from spherical, cylindrical to planar depending on the molecular weights of Macro-CTAs, the concentrations of DCPD and the natures of solvents. The ROMPISA method provides a new and efficient approach to prepare crosslinked polymer nanoparticles.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Federica Sbordone, Juliet Veskova, Bailey Richardson, Phuong Thi Do, Aaron Micallef, Hendrik Frisch
Summary: Biopolymers, such as proteins and nucleic acids, are essential for life, while synthetic polymers have greatly impacted our everyday lives. By combining the functionality of biopolymers with the versatility of synthetic polymers, it is possible to create materials with tailored properties for various applications. However, traditional radical polymerization typically yields non-functional all-carbon backbones, limiting the incorporation of natural polymers into synthetic polymers. In this study, we developed a solid-phase peptide synthesis approach to generate synthetic peptide conjugates that can be readily copolymerized with synthetic comonomers, allowing for the incorporation of defined peptide sequences into the main chain of synthetic polymers. This strategy is compatible with all 20 standard amino acids and uses commonly available chemicals, making it suitable for widespread application.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Federica Sbordone, Juliet Veskova, Bailey Richardson, Phuong Thi Do, Aaron Micallef, Hendrik Frisch
Summary: Biopolymers, such as proteins and nucleic acids, are crucial to life, while synthetic polymers have greatly impacted our daily lives due to their accessibility. By combining the functionality of biopolymers with the durability of synthetic polymers, it is possible to create materials that can be customized for various applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Polymer Science
Narumi Miyasako, Shin-ichi Matsuoka, Masato Suzuki
Summary: New ester-functionalized bicyclic aliphatic polymers were successfully synthesized through ring-opening metathesis polymerization (ROMP) of various norbornene lactones and their analogues, followed by hydrogenation. The comparison and discussion of polymerizability and thermal properties between different monomers before and after hydrogenation were conducted. The obtained polymers showed excellent thermal stability and processing deformation suitable for transparent resin materials.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Review
Polymer Science
Jiaxi Xu, Nikos Hadjichristidis
Summary: The incorporation of heteroatom-containing weak bonds along polymer backbones has become a popular tool to accelerate degradation. Many methods have been reported for the synthesis of degradable heteroatom-containing polymers based on step-growth polymerization and chain-growth ring-opening polymerization. Ring-opening metathesis polymerization has emerged as an approach for the synthesis of various types of degradable polymers. This review covers the synthesis of different heteroatom-containing degradable polymers via ring-opening metathesis polymerization and their degradation mechanisms under different conditions.
PROGRESS IN POLYMER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Taeyang An, Hanseul Ryu, Tae-Lim Choi
Summary: This study presents a versatile approach to improve the alternation and degradability of 2,3-dihydrofuran (DHF) copolymers by carefully controlling the reactivity of both the Ru initiators and the monomers. The DHF copolymers showed outstanding A, B-alternation and could be broken down to a single repeat unit level under acidic conditions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Environmental
Kerui Chen, Wenjian Han, Xin Hu, Yihuan Liu, Yujing Hu, Shuangfei Zhao, Ning Zhu, Zheng Fang, Kai Guo
Summary: A microreactor-based enzymatic and metal-catalytic cascade reaction platform was developed for the synthesis of bottlebrush polymers. By using a continuous flow chemo-enzymatic strategy, well-defined bottlebrush polymers with fast kinetics and narrow molecular weight distribution were successfully prepared.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Ervin Kovacs, Bence Balterer, Nguyen Anh Duc, Gyorgyi Szarka, Michael C. Owen, Attila Domjan, Bela Ivan
Summary: A large number of organic solvents contaminate the environment on a daily basis worldwide. This study demonstrates that benzotrifluoride can be used as a suitable solvent for olefin metathesis reactions, providing high yields and similar or even higher reaction rates compared to dichloromethane.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Suna Sun, Francesca Frontini, Weihong Qi, Ananya Hariharan, Manuel Ronner, Martin Wipplinger, Christophe Blanquart, Hubert Rehrauer, Jean-Francois Fonteneau, Emanuela Felley-Bosco
Summary: Early events in mesothelioma development involve increased levels of editing in double-stranded RNA (dsRNA). Expression of endogenous retroviruses (ERV) contributes to dsRNA formation and type-I interferon signaling. These findings may have implications for early diagnosis and treatment strategies.
Article
Multidisciplinary Sciences
Pierre Tournier, Jerome Guicheux, Arnaud Pare, Aymeric Maltezeanu, Thibaut Blondy, Joelle Veziers, Caroline Vignes, Manon Andre, Julie Lesoeur, Ana Barbeito, Raphael Bardonnet, Christophe Blanquart, Pierre Corre, Valerie Geoffroy, Pierre Weiss, Alexis Gaudin
Summary: Partially demineralized allogenic bone paste is a novel bone graft with superior bone regeneration and osteogenic potential, making it a promising alternative to allogeneic bone grafts for bone regeneration in oral and maxillofacial clinical contexts.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Antonia Marazioti, Anthi C. Krontira, Sabine J. Behrend, Georgia A. Giotopoulou, Giannoula Ntaliarda, Christophe Blanquart, Hasan Bayram, Marianthi Iliopoulou, Malamati Vreka, Lilith Trassl, Mario A. A. Pepe, Caroline M. Hackl, Laura Klotz, Stefanie A. Weiss, Ina Koch, Michael Lindner, Rudolph A. Hatz, Juergen Behr, Darcy E. Wagner, Helen Papadaki, Sophia G. Antimisiaris, Didier Jean, Sophie Deshayes, Marc Gregoire, Ozgecan Kayalar, Deniz Mortazavi, Sukru Dilege, Serhan Tanju, Suat Erus, Omer Yavuz, Pinar Bulutay, Pinar Firat, Ioannis Psallidas, Magda Spella, Ioanna Giopanou, Ioannis Lilis, Anne-Sophie Lamort, Georgios T. Stathopoulos
Summary: A portion of human MPM cases have mutations in KRAS, and mouse models suggest that KRAS mutations can lead to MPM, especially when combined with TP53 deletion. These findings indicate that KRAS alterations may play an important and underestimated role in certain MPM patients.
EMBO MOLECULAR MEDICINE
(2022)
Article
Cell & Tissue Engineering
Marine Charrier, Judith Lorant, Rafael Contreras-Lopez, Gautier Tejedor, Christophe Blanquart, Blandine Lieubeau, Cindy Schleder, Isabelle Leroux, Sophie Deshayes, Jean-Francois Fonteneau, Candice Babarit, Antoine Hamel, Armelle Magot, Yann Pereon, Sabrina Viau, Bruno Delorme, Patricia Luz-Crawford, Guillaume Lamirault, Farida Djouad, Karl Rouger
Summary: The study demonstrates that hMuStem cells possess an immunosuppressive phenotype and can inhibit T-cell proliferation and cytotoxic response while promoting the generation of regulatory T cells through both direct contact and secretion of soluble factors. The secretion profile of hMuStem cells is shown to be superior to that of BM-MSCs. These findings reinforce the candidacy of hMuStem cells as therapeutic agents for MDs.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Engineering, Biomedical
Sarah Iaquinta, Shahram Khazaie, Elena Ishow, Christophe Blanquart, Sylvain Freour, Frederic Jacquemin
Summary: In this paper, the influence of nanoparticles' mechanical and geometrical properties on their cellular uptake was numerically investigated. The results revealed that the aspect ratio of the particle had the greatest impact on the wrapping of the particle by the cell membrane, with adhesion contributing twice as much as membrane tension.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2022)
Review
Pharmacology & Pharmacy
Daniel L. Pouliquen, Alice Boissard, Cecile Henry, Olivier Coqueret, Catherine Guette
Summary: Curcuminoids have the potential to fight against invasive cancers by targeting multiple molecular targets, modulating signaling pathways, and enhancing the host's immune response. This review explores the role of curcuminoids in inhibiting the epithelial-to-mesenchymal transition (EMT) in cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daniel L. Pouliquen, Marine Malloci, Alice Boissard, Cecile Henry, Catherine Guette
Summary: Curcumin's effects on tumor microenvironment and cancer cell invasiveness were investigated in a rat model of peritoneal mesothelioma. The study found that curcumin can modulate protein abundance and affect proteins related to tumor microenvironment regulation and activated T cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Sabine Paternot, Eric Raspe, Clement Meiller, Maxime Tarabichi, Jean-Baptiste Assie, Frederick Libert, Myriam Remmelink, Xavier Bisteau, Patrick Pauwels, Yuna Blum, Nolwenn Le Stang, Severine Tabone-Eglinger, Francoise Galateau-Salle, Christophe Blanquart, Jan P. Van Meerbeeck, Thierry Berghmans, Didier Jean, Pierre P. Roger
Summary: This study evaluated the impact of CDK4/6 inhibition by palbociclib in malignant pleural mesothelioma (MPM) and found that MPM is uniquely sensitive to CDK4/6 inhibitors. Palbociclib can durably inhibit cell proliferation, even after drug washout, and induce a senescence-associated secretory phenotype. The study supports the evaluation of CDK4/6 inhibitors as monotherapy or combination therapy for MPM treatment.
MOLECULAR ONCOLOGY
(2022)
Article
Oncology
Daniel L. Pouliquen, Giacomo Ortone, Letizia Rumiano, Alice Boissard, Cecile Henry, Stephanie Blandin, Catherine Guette, Chiara Riganti, Joanna Kopecka
Summary: Cross-species investigations of cancer invasiveness have identified new biomarkers for improving tumor diagnosis and prognosis. This study analyzed rat tumors and human cell lines to identify common features associated with mitochondrial proteome rewiring. The differential expression of mitochondrial proteins, particularly ACADL, was found to be associated with invasiveness in mesothelioma.
Review
Pharmacology & Pharmacy
Daniel L. Pouliquen, Koraljka Gall Troselj, Ruby John Anto
Summary: The number of published studies on curcuminoids in cancer research, including its lead molecule curcumin and synthetic analogs, has been increasing substantially during the past two decades. Insights on the diversity of inhibitory effects they have produced on a multitude of pathways involved in carcinogenesis and tumor progression have been provided. This review will also cover the use of curcuminoids as chemosensitizing molecules that can be combined with several anticancer drugs to reverse the phenomenon of multidrug resistance.
Article
Oncology
Paul Stockhammer, Hannah Baumeister, Till Ploenes, Francesco Bonella, Dirk Theegarten, Balazs Dome, Christine Pirker, Walter Berger, Luca Hegedues, Marcell Baranyi, Martin Schuler, Sophie Deshayes, Servet Bolukbas, Clemens Aigner, Christophe Blanquart, Balazs Hegedues
Summary: This study is the first to demonstrate KL-6 as a potential novel liquid-based diagnostic and prognostic biomarker in pleural mesothelioma, which may help improve patients' survival rates.
Editorial Material
Pharmacology & Pharmacy
Daniel L. Pouliquen, Koraljka Gall Troselj, Ruby John Anto, Rakesh Naidu
FRONTIERS IN PHARMACOLOGY
(2023)
Editorial Material
Oncology
Daniel L. Pouliquen, Cristina Nunez Gonzalez
Review
Oncology
Laurent Mathiot, Guillaume Herbreteau, Simeon Robin, Charlotte Fenat, Jaafar Bennouna, Christophe Blanquart, Marc Denis, Elvire Pons-Tostivint
Summary: The occurrence of HRAS mutations in NSCLC patients is low, and there is limited research data on the clinical characteristics and treatment response of these patients. This study identified four NSCLC patients with HRAS p.Gln61Leu mutation using Next-Generation Sequencing and reviewed relevant literature. The results showed that most cases had pleural or pericardial effusion at diagnosis, and some patients died during first-line therapy. Further research is needed to clarify the prognosis and treatment response of HRAS-mutant NSCLC patients.
Article
Chemistry, Multidisciplinary
Thibaut Blondy, Julien Poly, Camille Linot, Joanna Boucard, Emilie Allard-Vannier, Steven Nedellec, Phillipe Hulin, Celine Henoumont, Lionel Larbanoix, Robert N. Muller, Sophie Laurent, Elena Ishow, Christophe Blanquart
Summary: The surface chemistry of nanoparticles has a significant impact on their cellular uptake, and the residual groups of chain transfer agents (CTAs) introduced in the main chain can modulate the cell uptake of nanoparticles. This study demonstrates that the cellular internalization of functionalized nanoparticles can be controlled by the compaction of the PEG comb-like shell incorporating CTAs with a long alkyl chain, without changing the overall surface potential.
