Article
Biochemistry & Molecular Biology
Anne K. Kronborg Hansen, Magdalena Dubik, Joanna Marczynska, Bhavya Ojha, Estanislao Nistal-Villan, Gloria Gonzalez Aseguinolaza, Dina S. Arengoth, Trevor Owens, Reza Khorooshi
Summary: This study investigated the potential therapeutic effect of activating the RIG-I signaling pathway to promote the production of IFN beta within the central nervous system (CNS) and its impact on multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). The results demonstrate that intrathecal administration of AAV-CM resulted in sustained IFN beta expression within the CNS and suppressed the development of EAE. These findings suggest that targeting the downstream signaling pathway of RIG-I represents a promising therapeutic strategy for inflammatory CNS diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
George Kassiotis
Summary: Our immune system faces challenges in distinguishing retroviruses integrated into the host. This review explores the limits of the immune response to retroviruses and their impact on host health and disease. Despite expectations, endogenous retroelements can still provoke immune responses leading to autoimmune disease.
ANNUAL REVIEW OF IMMUNOLOGY
(2023)
Review
Immunology
Karima Landelouci, Shruti Sinha, Genevieve Pepin
Summary: Fanconi Anemia (FA) is a genome instability syndrome caused by mutations in repair genes, leading to congenital abnormalities, premature aging, and bone marrow failure. There is a close relationship between genome instability, inflammation, and the production of type-I Interferon. Understanding the molecular mechanisms of type-I Interferon activation in FA may lead to the discovery of therapeutic targets for the associated inflammation and premature aging.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Zhiqiang Hu, Dan Wu, Jiansen Lu, Yufen Zhang, Shao-Meng Yu, Yingchao Xie, Hongyu Li, Jianwu Yang, De-Hua Lai, Ke Zeng, Huaji Jiang, Zhao-Rong Lun, Xiao Yu
Summary: In this study, the researchers found that inflammasome signaling is activated by pathogen-associated molecular patterns (PAMPs) of T. gondii, leading to a protective immune response against T. gondii invasion by suppressing the production of type I interferon (IFN-I). The study also revealed that inflammasome-coupled IL-1 beta signaling triggers the expression of negative regulator SOCS1, which binds to IRF3 to inhibit IFN-I production. This research provides new insights into the mechanisms of host immunity against toxoplasmosis and highlights the importance of the cross talk between innate immune signaling in infectious disease prevention.
Review
Immunology
Xiaoxin Ji, Wei Meng, Zichuan Liu, Xin Mu
Summary: This article summarizes the roles of long noncoding RNAs (lncRNAs) in modulating the RNA-activated IFN-I signaling pathway. By analyzing the event order during the signaling, the regulatory mechanisms of lncRNAs in this pathway are revealed.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Shanti S. D'Souza, Yuanyue Zhang, Jacob T. Bailey, Ivan T. H. Fung, Marcy L. Kuentzel, Sridar Chittur, Qi Yang
Summary: Research has shown that physiological lung aging leads to increased interferon signaling and elevated chemokine concentrations, which exacerbate monocyte infiltration into the lung parenchyma, including a novel subset dependent on type-1 interferon signaling. Treatment with anti-IFNAR1 neutralizing antibodies can rapidly eradicate this subset of monocytes, reduce airway chemokine concentrations, and suppress the accumulation of monocytes in the aged lung parenchyma.
Article
Multidisciplinary Sciences
Alexandra M. Moore, Lei Zhou, Jing Cui, Luyi Li, Nanping Wu, Alice Yu, Soumya Poddar, Keke Liang, Evan R. Abt, Stephanie Kim, Razmik Ghukasyan, Nooneh Khachatourian, Kristina Pagano, Irmina Elliott, Amanda M. Dann, Rana Riahi, Thuc Le, David W. Dawson, Caius G. Radu, Timothy R. Donahue
Summary: Emerging evidence suggests that intratumoral interferon signaling can trigger targetable vulnerabilities in PDAC by reducing NAD levels through up-regulating NAD-consuming enzymes. This sensitizes PDAC cells to NAMPT inhibition, leading to decreased cell proliferation and invasion in vitro, as well as suppression of tumor growth and metastases in vivo.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Microbiology
Huimin Liu, Chen Li, Wenfeng He, Jing Chen, Guoqing Yang, Lu Chen, Hongtao Chang
Summary: This study demonstrates the importance of free ISG15 in inhibiting PRV growth and promoting IFN-alpha-mediated antiviral activity. The interaction between ISG15 and STAT2 plays a key role in this process.
Article
Oncology
Saranya Chidambaranathan Reghupaty, Sadia Kanwal, Rachel G. Mendoza, Eva Davis, Haiwen Li, Zhao Lai, Mikhail G. Dozmorov, Milton Omar Faison, Rafat Ali Siddiqui, Devanand Sarkar
Summary: Hepatocellular carcinoma (HCC) is a common primary liver cancer influenced by chronic liver inflammation and race/ethnicity. Analysis of RNA-sequencing data revealed the activation of an inflammatory pathway in HCC tumors of African-American/Black patients. Ginger extract (GE), known for its anti-inflammatory properties, showed potential efficacy in inhibiting HCC cell growth, particularly in cells from African-American/Black patients. These findings suggest that a holistic diet containing ginger may benefit African-American/Black HCC patients.
Article
Microbiology
Nele Zoellner, Noemi Coesfeld, Frederik Henry De Vos, Jennifer Denter, Haifeng C. Xu, Elena Zimmer, Birgit Knebel, Hadi Al-Hasani, Sofie Mossner, Philipp A. Lang, Doreen M. Floss, Juergen Scheller
Summary: Researchers found that synthetic type I interferon signaling mainly originates from IFNAR2, rather than IFNAR1, by reformatting the structure of IFNAR1 and IFNAR2.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Johannes Schwerk, Lucas Kemper, Kendra A. Bussey, Stefan Lienenklaus, Siegfried Weiss, Luka Cicin-Sain, Andrea Kroeger, Ulrich Kalinke, Christopher M. Collins, Samuel H. Speck, Martin Messerle, Dagmar Wirth, Melanie M. Brinkmann, Hansjoerg Hauser, Mario Koester
Summary: This study investigated the regulation of murine gammaherpesvirus 68 (MHV-68) latency by type I interferon (IFN). The results showed that IFN can control the latency of MHV-68 to a certain extent, but cannot fully prevent viral dissemination during latency. Moreover, impaired IFN signaling in latently infected cells increased the risk of virus reactivation.
Article
Immunology
Beibei Wu, Arunachalam Ramaiah, Gustavo Garcia, Spyridon Hasiakos, Vaithilingaraja Arumugaswami, Sonal Srikanth
Summary: This study revealed the different effects of ORAI1 and STIM1 on SARS-CoV-2 infection. Knockout of STIM1 resulted in enhanced resistance to viral infection, while ORAI1 deletion increased susceptibility. ORAI1-mediated Ca2+ signaling played an important role in regulating baseline IFN-I levels, determining host resistance to SARS-CoV-2 infection.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Microbiology
Hongyu Li, Shuai Yang, Ke Zeng, Jiayin Guo, Jian Wu, Huaji Jiang, Yingchao Xie, Zhiqiang Hu, Jiansen Lu, Jianwu Yang, Xin-zhuan Su, Jun Cui, Xiao Yu
Summary: Malaria remains a serious disease affecting millions of people worldwide. In this study, a host gene called Src homology 2-containing inositol phosphatase 1 (SHIP1) is discovered to regulate IFN-I signaling, which significantly affects the parasitemia and resistance of Plasmodium-infected mice. The study highlights the potential of targeting SHIP1 for immunotherapies in malaria and reveals the crosstalk between IFN-I signaling and autophagy in preventing related infectious diseases.
Article
Oncology
Razmik Ghukasyan, Keke Liang, Kevin Chau, Luyi Li, Charlotte Chan, Evan R. Abt, Thuc Le, Joon Y. Park, Nanping Wu, Alykhan Premji, Robert Damoiseaux, Tony Luu, Amanda Labora, Khalid Rashid, Jason M. Link, Caius G. Radu, Timothy R. Donahue
Summary: The purpose of this study is to identify combination therapies that can enhance the efficacy of STING agonists for the treatment of pancreatic ductal adenocarcinoma. The researchers found that MEK inhibitors showed the greatest synergy with a specific STING agonist, leading to enhanced tumor cell death. They also discovered that MEK signaling inhibits the NFxB-dependent mechanism of STING-induced cell death.
CLINICAL CANCER RESEARCH
(2023)
Article
Immunology
Taylor T. Chrisikos, Yifan Zhou, Laura M. Kahn, Bhakti Patel, Nina L. Denne, Athena Brooks, Li Shen, Jing Wang, Stephanie S. Watowich
Summary: This study reveals the crucial role of the cytokine-responsive transcriptional regulator STAT3 in restraining cDC1 function. Through the analysis of RNA sequencing datasets, we elucidate the inflammatory and anti-inflammatory pathways in cDC1s induced by poly(I:C) stimulation. Additionally, we discover that IL-10-activated STAT3 inhibits the transcriptional response of IFN-I and demonstrate the essential role of IFN-I receptor in cDC1 maturation.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Cell & Tissue Engineering
Marine Charrier, Judith Lorant, Rafael Contreras-Lopez, Gautier Tejedor, Christophe Blanquart, Blandine Lieubeau, Cindy Schleder, Isabelle Leroux, Sophie Deshayes, Jean-Francois Fonteneau, Candice Babarit, Antoine Hamel, Armelle Magot, Yann Pereon, Sabrina Viau, Bruno Delorme, Patricia Luz-Crawford, Guillaume Lamirault, Farida Djouad, Karl Rouger
Summary: The study demonstrates that hMuStem cells possess an immunosuppressive phenotype and can inhibit T-cell proliferation and cytotoxic response while promoting the generation of regulatory T cells through both direct contact and secretion of soluble factors. The secretion profile of hMuStem cells is shown to be superior to that of BM-MSCs. These findings reinforce the candidacy of hMuStem cells as therapeutic agents for MDs.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Oncology
Michele Carbone, Harvey Pass, Guntulu Ak, H. Richard Alexander, Paul Baas, Francine Baumann, Andrew M. Blakely, Raphael Bueno, Aleksandra Bzura, Giuseppe Cardillo, Jane E. Churpek, Irma Dianzani, Assunta De Rienzo, Mitsuru Emi, Salih Emri, Emanuela Felley-Bosco, Dean A. Fennell, Raja M. Flores, Federica Grosso, Nicholas K. Hayward, Mary Hesdorffer, Chuong D. Hoang, Peter A. Johansson, Hedy L. Kindler, Muaiad Kittaneh, Thomas Krausz, Aaron Mansfield, Muzaffer Metintas, Michael Minaai, Luciano Mutti, Maartje Nielsen, Kenneth O'Byrne, Isabelle Opitz, Sandra Pastorino, Francesca Pentimalli, Marc de Perrot, Antonia Pritchard, Robert Taylor Ripley, Bruce Robinson, Valerie Rusch, Emanuela Taioli, Yasutaka Takinishi, Mika Tanji, Anne S. Tsao, A. Murat Tuncer, Sebastian Walpole, Andrea Wolf, Haining Yang, Yoshie Yoshikawa, Alicia Zolondick, David S. Schrump, Raffit Hassan
Summary: The most common malignancies that develop in carriers of BAP1 germline mutations include mesothelioma, melanoma, renal cell carcinoma, and other tumor types. The features of malignancies can vary among individuals, and a multidisciplinary approach is required for diagnosis and treatment. Detecting BAP1 germline mutations has significant medical, social, and economic impact.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Microbiology
Beat Frey, Gilda Varliero, Weihong Qi, Beat Stierli, Lorenz Walthert, Ivano Brunner
Summary: Soil microorganisms, such as Bacteria and Archaea, have important roles in soil nutrient cycling and can influence plant growth and health. This study investigated the distribution of soil metagenomes in Swiss forests to understand the effects of tree species and soil depth on genetic potential and microbial carbon and nitrogen cycling. Results showed a higher abundance of Archaea in deep soil, while Bacteria abundance remained constant with soil depth. Genes related to carbohydrate-active enzymes and nitrogen cycling were overrepresented in deep soil, suggesting the presence of low oxygen conditions. Overall, this study provides new insights into soil microorganisms and their genetic potential, highlighting the importance of soil properties and depth.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Jakub Kubacki, Weihong Qi, Cornel Fraefel
Summary: The intestinal virus community affects health and disease. A study found that Runting and Stunting Syndrome (RSS) in broiler chickens is associated with enteric viruses. Through sequencing analysis, numerous virus genomes related to RSS were identified, and these viruses were also found in healthy animals. This study expands the knowledge of enteric virus diversity in healthy and RSS-affected broiler flocks, and raises questions about the association of certain viruses with the disease.
Article
Biotechnology & Applied Microbiology
Zhenhui Zhong, Suhua Feng, Ben N. Mansfeld, Yunqing Ke, Weihong Qi, Yi-Wen Lim, Wilhelm Gruissem, Rebecca S. Bart, Steven E. Jacobsen
PLANT BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Emanuela Felley-Bosco, Weihong Qi, Didier Jean, Clement Meiller, Hubert Rehrauer
Summary: This study reveals the association between RNA editing and the epithelial-mesenchymal transition (EMT) phenotype in pleural mesothelioma (PM). Analysis of RNA editing expression changes in PM samples showed increased editing in introns and decreased editing in 3' UTR in samples with EMT phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Environmental
Joel Ruthi, Basil M. Rast, Weihong Qi, Carla Perez-Mon, Lucrezia Pardi-Comensoli, Ivano Brunner, Beat Frey
Summary: In this study, the impacts of different plastics on the genetic potential of the soil microbiome in alpine soils were investigated using shotgun metagenomics. The results showed that biodegradable plastics, such as Ecovio and BI-OPL, had a greater impact on the soil microbiome compared to polyethylene, with fungi, alpha-, and 8-Proteobacteria dominating on the biodegradable films.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Licun Wu, Kosuke Yoshihara, Hana Yun, Saraf Karim, Nastaran Shokri, Fatemeh Zaeimi, H. S. Jeffrey Man, Amin Zia, Emanuela Felley-Bosco, Marc de Perrot
Summary: Malignant mesothelioma (MESO) has different subtypes and epithelial-mesenchymal transition (EMT) phenotypes. A panel of MESO EMT genes were found to be correlated with hypermethylation of epigenetic genes and loss of CDKN2A/B expression. The MESO EMT genes were associated with activation of TGF-beta, hedgehog, and IL-2-STAT5 signaling, and suppression of IFN-alpha and IFN-gamma response. Immune checkpoints were upregulated, while certain immune receptors were downregulated with the expression of MESO EMT genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lea Frachon, Luca Arrigo, Quint Rusman, Lucy Poveda, Weihong Qi, Giovanni Scopece, Florian P. Schiestl
Summary: Based on genomic analysis, we identified genetic variations associated with the ecological variation in Brassica incana. These genetic variations are potentially involved in the adaptation of B. incana to local pollinator functional categories and pollinator community composition. Our study highlights the importance of considering multiple environmental factors to understand the adaptive landscape of plant populations.
MOLECULAR BIOLOGY AND EVOLUTION
(2023)
Article
Multidisciplinary Sciences
Licun Wu, Mikihiro Kohno, Junichi Murakami, Amin Zia, Jonathan Allen, Hana Yun, Meilin Chan, Cristina Baciu, Mingyao Liu, Veronique Serre-Beinier, Michele De Palma, Emanuela Felley-Bosco, Jonathan Yeung, Trevor J. Pugh, Marc de Perrot
Summary: Defining the origin of tumor-associated macrophages (TAM) is crucial for developing targeted therapies for mesothelioma. Two distinct macrophage populations, small peritoneal/pleural macrophages (SPM) and large peritoneal/pleural macrophages (LPM), were identified in mice. SPM, which mainly consisted of M2-like TAM, rapidly increased in the tumor microenvironment and contributed to tumor development. On the other hand, LPM activated the IFN-gamma response and played a crucial role in the immune response, as confirmed by their depletion leading to loss of antitumoral memory immunity. The gene signature of SPM was observed in the pleural effusion and tumor of untreated mesothelioma patients, suggesting potential therapeutic targets.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Oncology
Alexander Laure, Angelica Rigutto, Michaela B. Kirschner, Lennart Opitz, Linda Grob, Isabelle Opitz, Emanuela Felley-Bosco, Stefanie Hiltbrunner, Alessandra Curioni-Fontecedro
Summary: Patient-derived cell lines show closer resemblance to MPM tumors in terms of genome and transcriptome compared to commercial cell lines. This finding has significant implications for using cell line models to study predictive biomarkers and interpret preclinical results that cannot be translated in clinical practice.
Article
Oncology
Paul Stockhammer, Hannah Baumeister, Till Ploenes, Francesco Bonella, Dirk Theegarten, Balazs Dome, Christine Pirker, Walter Berger, Luca Hegedues, Marcell Baranyi, Martin Schuler, Sophie Deshayes, Servet Bolukbas, Clemens Aigner, Christophe Blanquart, Balazs Hegedues
Summary: This study is the first to demonstrate KL-6 as a potential novel liquid-based diagnostic and prognostic biomarker in pleural mesothelioma, which may help improve patients' survival rates.
Article
Biology
Weihong Qi, Yi-Wen Lim, Andrea Patrignani, Pascal Schlapfer, Anna Bratus-Neuenschwander, Simon Gruter, Christelle Chanez, Nathalie Rodde, Elisa Prat, Sonia Vautrin, Margaux-Alison Fustier, Diogo Pratas, Ralph Schlapbach, Wilhelm Gruissem
Summary: This study demonstrates the use of high-fidelity sequencing reads and a specific assembler to achieve a high-resolution assembly of the cassava genome. The resulting assembly is the most accurate, continuous, complete, and haplotype-resolved cassava genome assembly to date. The study also identifies novel gene loci and explores the differential expression of transcripts. Additionally, the researchers use the assembly to build a cassava pan-genome, highlighting its importance for further research and breeding.
Review
Oncology
Laurent Mathiot, Guillaume Herbreteau, Simeon Robin, Charlotte Fenat, Jaafar Bennouna, Christophe Blanquart, Marc Denis, Elvire Pons-Tostivint
Summary: The occurrence of HRAS mutations in NSCLC patients is low, and there is limited research data on the clinical characteristics and treatment response of these patients. This study identified four NSCLC patients with HRAS p.Gln61Leu mutation using Next-Generation Sequencing and reviewed relevant literature. The results showed that most cases had pleural or pericardial effusion at diagnosis, and some patients died during first-line therapy. Further research is needed to clarify the prognosis and treatment response of HRAS-mutant NSCLC patients.
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
