Article
Endocrinology & Metabolism
Margaret A. Mohr, Lourdes A. Esparza, Paige Steffen, Paul E. Micevych, Alexander S. Kauffman
Summary: Kisspeptin neurons in the AVPV play a crucial role in the regulation of reproductive hormones, with estrogen and progesterone receptors being coexpressed in these neurons. The targeted reintroduction of progesterone receptors into AVPV kisspeptin neurons restores proper LH surges in females lacking PGR, highlighting the importance of progesterone signaling in the positive feedback induction of LH surges and ovulation.
Article
Neurosciences
Naoko Inoue, Safiullah Hazim, Hitomi Tsuchida, Yuri Dohi, Ren Ishigaki, Ai Takahashi, Yuki Otsuka, Koki Yamada, Yoshihisa Uenoyama, Hiroko Tsukamura
Summary: Ovulation in female rodents is triggered by ATP-purinergic signaling, which activates kisspeptin neurons in the AVPV. The administration of an ATP receptor antagonist blocks the LH surge and reduces ovulation rate. ATP also increases intracellular Ca2+ levels in kisspeptin neurons, indicating its role in mediating ovulation.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Margaret A. Mohr, Lourdes A. Esparza, Paige Steffen, Paul E. Micevych, Alexander S. Kauffman
Summary: Kisspeptin plays a crucial role in regulating reproduction by activating gonadotropin-releasing hormone neurons. Progesterone's action in AVPV kisspeptin neurons is essential for the proper induction of E-2-induced LH surges.
Review
Cell Biology
Xuehan Li, Chunyu Liang, Yi Yan
Summary: The Kiss1/GPR54 system plays a crucial role in regulating energy balance and metabolic homeostasis by controlling energy intake and expenditure balance, affecting insulin secretion, and influencing skeletal muscle function.
Review
Neurosciences
Alexander S. Kauffman
Summary: Sex steroid feedback is a fundamental principle in reproductive neuroendocrinology, which regulates the neural circuits governing the reproductive neuroendocrine axis through the feedback loops. In females, the rise of estradiol during the menstrual cycle switches the effect on GnRH secretion from negative to positive, resulting in ovulation. However, the underlying mechanisms and the interaction between the circadian clock and endocrine signals are still poorly understood.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Eulalia A. Coutinho, Lourdes A. Esparza, Alexandra D. Hudson, Nathanael Rizo, Paige Steffen, Alexander S. Kauffman
Summary: Classic pharmacological studies have shown the importance of endogenous dynorphin-KOR signaling in reproductive neuroendocrine regulation. However, the necessity of KOR signaling in kisspeptin neurons for LH secretion has not been directly tested until now. This study knocked out KOR selectively from kisspeptin neurons and found no significant effect on puberty, LH pulse parameters, LH surges, FSH levels, estrous cycles, or fertility. These findings suggest that besides KNDy neurons, other mechanisms may regulate GnRH and LH pulses, necessitating the expansion of current models.
Article
Endocrinology & Metabolism
Xian-Hua Lin, Geffen Lass, Ling-Si Kong, Hui Wang, Xiao-Feng Li, He-Feng Huang, Kevin T. O'Byrne
Summary: The study showed that optogenetic stimulation of ARC kisspeptin neurons can increase LH secretion in mice and generate surge-like effects under different hormonal conditions.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Md. Mahiuddin Zahangir, Md. Shahjahan, Hironori Ando
Summary: Kisspeptin plays an important role in reproductive regulation in animals. In grass puffer, kisspeptin has different effects depending on the reproductive stage, and it mainly acts by regulating the expression of genes in the hypothalamic-pituitary-gonadal axis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
D. Franssen, A. Barroso, F. Ruiz-Pino, M. J. Vazquez, D. Garcia-Galiano, J. M. Castellano, R. Onieva, M. Ruiz-Cruz, M. Poutanen, F. Gaytan, C. Dieguez, L. Pinilla, M. Lopez, J. Roa, M. Tena-Sempere
Summary: Reproduction is closely linked to energy and metabolic status, with AMPK signaling in GnRH neurons playing a crucial role in metabolic control of the female reproductive axis, particularly during puberty and negative energy balance.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Endocrinology & Metabolism
Veronica Sobrino, Maria Soledad Avendano, Cecilia Perdices-Lopez, Manuel Jimenez-Puyer, Manuel Tena-Sempere
Summary: In late 2003, the identification of the reproductive roles of kisspeptins and Gpr54 led to a surge in research interest and established fundamental concepts in physiological roles of kisspeptins. This early knowledge set the stage for more recent in-depth studies on neuronal networks involving Kiss1 neurons and their regulation mechanisms.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Review
Cell Biology
Virginia Delli, Mauro S. B. Silva, Vincent Prevot, Konstantina Chachlaki
Summary: Kisspeptin and nitric oxide play opposing roles in regulating GnRH secretion, with kisspeptin promoting release and NO inhibiting secretion, creating a dynamic interplay that is fine-tuned by the gonadal steroid environment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Robert L. Goodman, Allan E. Herbison, Michael N. Lehman, Victor M. Navarro
Summary: This article discusses the neural mechanisms underlying the episodic and surge secretion of GnRH, with a focus on the core components. Recent studies have revealed that the arcuate nucleus kisspeptin neurons, also known as KNDy cells, and their projections to GnRH dendrons serve as the GnRH pulse generator in mice and rats. Similar roles have been observed in sheep and goats, but the evidence is weaker in monkeys and humans. In spontaneous ovulators, the core endocrine signal for GnRH/luteinising hormone surge is an increase in estradiol secretion, with species variations in the neural trigger.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Article
Physiology
Yaping Ma, Olubusayo Awe, Sally Radovick, Xiaofeng Yang, Sara Divall, Andrew Wolfe, Sheng Wu
Summary: The kisspeptin receptor plays an important role in the regulation of reproductive function. Deleting the kisspeptin receptor gene in pituitary gonadotropes led to lower follicle-stimulating hormone (FSH) levels in male mice without affecting testis function. Female mice with the deleted gene had normal reproductive function.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Endocrinology & Metabolism
Anne Duittoz, Xavier Cayla, Renaud Fleurot, Jonas Lehnert, Anmar Khadra
Summary: Kisspeptin (Kp), acting through the GPR54 receptor, controls reproduction by influencing GnRH neuronal activity, with potential complex mechanisms involved. Mutual regulation between GnRH and Kp neurons has been suggested, with Kp-dependent volume transmission playing a crucial role in this process. Mathematical modeling highlights the synergy between GnRH-R and GPR54 in defining GnRH neuronal activity and release.
JOURNAL OF NEUROENDOCRINOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Gustavo Guerino Macedo, Emiliana de Oliveira Santana Batista, Gustavo Martins Gomes dos Santos, Michael J. D'Occhio, Pietro Sampaio Baruselli
Summary: The study showed that priming with estradiol benzoate (EB) for 12 hours increased both the peak and duration of LH release in response to kisspeptin (KISS1) in cows. Incorporating EB priming and KISS1 could improve estrus synchronization efficiency, with potential practical applications in assisted breeding in beef and dairy cattle.