Why eukaryotic cells use introns to enhance gene expression: Splicing reduces transcription-associated mutagenesis by inhibiting topoisomerase I cutting activity

Intronic delay is essential for oscillatory expression in the segmentation clock

(2011) Y. Takashima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The leader intron of AtMHX can elicit, in the absence of splicing, low-level intron-mediated enhancement that depends on the internal intron sequence

(2010) Tsofit Akua et al.   BMC PLANT BIOLOGY

Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis

(2010) A. El Hage et al.   GENES & DEVELOPMENT

Testing the IMEter on rice introns and other aspects of intron-mediated enhancement of gene expression

(2010) Laura Morello et al.   JOURNAL OF EXPERIMENTAL BOTANY

Evaluation of Models of the Mechanisms Underlying Intron Loss and Gain in Aspergillus Fungi

(2010) Lei-Ying Zhang et al.   JOURNAL OF MOLECULAR EVOLUTION

Distinct Patterns of Expression and Evolution of Intronless and Intron-Containing Mammalian Genes

(2010) Svetlana A. Shabalina et al.   MOLECULAR BIOLOGY AND EVOLUTION

A Pause to Splice

(2010) Pia K. Andersen et al.   MOLECULAR CELL

Splicing-Dependent RNA Polymerase Pausing in Yeast

(2010) Ross D. Alexander et al.   MOLECULAR CELL

Global Analysis of Nascent RNA Reveals Transcriptional Pausing in Terminal Exons

(2010) Fernando Carrillo Oesterreich et al.   MOLECULAR CELL

A Novel Role for Minimal Introns: Routing mRNAs to the Cytosol

(2010) Jiang Zhu et al.   PLoS One

A Complete Set of Nascent Transcription Rates for Yeast Genes

(2010) Vicent Pelechano et al.   PLoS One

Role for topoisomerase 1 in transcription-associated mutagenesis in yeast

(2010) M. J. Lippert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Topoisomerase 1 provokes the formation of short deletions in repeated sequences upon high transcription in Saccharomyces cerevisiae

(2010) T. Takahashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The spliceosomal proteome: At the heart of the largest cellular ribonucleoprotein machine

(2010) Saba Valadkhan et al.   PROTEOMICS

Traffic patrol in the transcription of ribosomal RNA

(2010) Stefan Klumpp et al.   RNA Biology

Evolution of Yeast Noncoding RNAs Reveals an Alternative Mechanism for Widespread Intron Loss

(2010) Q. M. Mitrovich et al.   SCIENCE

In plants, expression breadth and expression level distinctly and non-linearly correlate with gene structure

(2009) Hangxing Yang   Biology Direct

Rates of in situ transcription and splicing in large human genes

(2009) Jarnail Singh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conserved principles of mammalian transcriptional regulation revealed by RNA half-life

(2009) Caroline C. Friedel et al.   NUCLEIC ACIDS RESEARCH

Splicing in the eukaryotic ancestor: form, function and dysfunction

(2009) Scott William Roy et al.   TRENDS IN ECOLOGY & EVOLUTION

The SR protein family

(2009) Peter J Shepard et al.   GENOME BIOLOGY

Evidence against the energetic cost hypothesis for the short introns in highly expressed genes

(2008) Yi-Fei Huang et al.   BMC EVOLUTIONARY BIOLOGY

Database for mRNA Half-Life of 19 977 Genes Obtained by DNA Microarray Analysis of Pluripotent and Differentiating Mouse Embryonic Stem Cells

(2008) L. V. Sharova et al.   DNA RESEARCH

Spatial mapping of splicing factor complexes involved in exon and intron definition

(2008) Jonathan D. Ellis et al.   JOURNAL OF CELL BIOLOGY

Extremely Intron-Rich Genes in the Alveolate Ancestors Inferred with a Flexible Maximum-Likelihood Approach

(2008) M. Csuros et al.   MOLECULAR BIOLOGY AND EVOLUTION

Deletion of Many Yeast Introns Reveals a Minority of Genes that Require Splicing for Function

(2008) Julie Parenteau et al.   MOLECULAR BIOLOGY OF THE CELL

A Single SR-like Protein, Npl3, Promotes Pre-mRNA Splicing in Budding Yeast

(2008) Tracy L. Kress et al.   MOLECULAR CELL

Genome instability: a mechanistic view of its causes and consequences

(2008) Andrés Aguilera et al.   NATURE REVIEWS GENETICS

The functional response of upstream DNA to dynamic supercoiling in vivo

(2008) Fedor Kouzine et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Promoter-Proximal Introns in Arabidopsis thaliana Are Enriched in Dispersed Signals that Elevate Gene Expression

(2008) A. B. Rose et al.   PLANT CELL

EST Analysis of Ostreococcus lucimarinus, the Most Compact Eukaryotic Genome, Shows an Excess of Introns in Highly Expressed Genes

(2008) William Lanier et al.   PLoS One

Rapidly regulated genes are intron poor

(2008) Daniel C. Jeffares et al.   TRENDS IN GENETICS

Co-evolution of the branch site and SR proteins in eukaryotes

(2008) Mireya Plass et al.   TRENDS IN GENETICS