Article
Behavioral Sciences
Kenya Watanabe, Osamu Nakagawasai, Syu-ichi Kanno, Satoru Mitazaki, Hiroshi Onogi, Kohei Takahashi, Kei-ichiro Watanabe, Koichi Tan-No, Masaaki Ishikawa, Lalit K. Srivastava, Remi Quirion, Takeshi Tadano
Summary: Genetic studies have implicated the neuregulin-1 gene as a potential susceptibility gene for schizophrenia. It is involved in regulating receptor expression and function in various brain regions. This study found that neonatal ventral hippocampal lesioned rats showed decreased levels of NRG-1 and p-erbB4 in the prefrontal cortex, and microinjection of NRG-1 improved behavioral deficits in these rats.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Nan Su, Weiqi Zhang, Nicole Eter, Peter Heiduschka, Mingyue Zhang
Summary: Schizophrenia is associated with abnormalities in visual processes, and abnormal Nrg1 expression has been observed in clinical studies. This study investigated the effects of Nrg1 overexpression on visual function in transgenic mice. The results showed that Nrg1 overexpression changed visual function, suggesting its potential as a biomarker for psychiatric disorders and a tool for diagnosis in psychiatry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Atefeh Moradkhani, Abduladheem Turki Jalil, Marwan Mahmood Saleh, Elmira Vanaki, Hossein Daghagh, Behrouz Daghighazar, Zahra Akbarpour, Hossein Ghahramani Almanghadim
Summary: This study investigated the allelic and genotypic correlation of the mononucleotide rs35753505 polymorphism of Neuregulin 1 (NRG1) gene with psychopathology and intelligence. The results showed a significant correlation between this polymorphism and Positive and Negative Syndrome Scale (PANSS) test results, and a significant decrease in overall intelligence in patients with schizophrenia compared to the control group.
Article
Psychiatry
Yangsik Kim, Young Woo Noh, Kyungdeok Kim, Eunjoon Kim
Summary: The lack of IRSp53 results in decreased PPI, and the hyperactive ACC-MDT pathway suppresses PPI.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Yangsik Kim, Esther Yang, Hyun Kim
Summary: The study found that deletion of IRSp53 in mice leads to a decrease in prepulse inhibition (PPI), indicating that dysfunction of various modulatory neurons may result in PPI impairment. This suggests that PPI could be broadly affected by changes in various types of modulatory neurons.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Cell Biology
Bruno Vincent, Subhamita Maitra
Summary: Alzheimer's disease and schizophrenia have common fronto-temporal anomalies that may result in coexisting symptoms. β-amyloid precursor protein and neuregulin 1, two neuronal proteins, have been considered in explaining the relationship between these two disorders. However, the mechanisms behind the development of co-morbid symptoms are still unclear.
AGEING RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Hisayoshi Kubota, Kazuo Kunisawa, Moe Niijima, Mami Hirakawa, Yuko Mori, Masaya Hasegawa, Suwako Fujigaki, Hidetsugu Fujigaki, Yasuko Yamamoto, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri
Summary: Phencyclidine (PCP) causes mental symptoms similar to schizophrenia by inhibiting the glutamatergic system. Deficiency of kynurenine 3-monooxygenase (KMO) may be associated with exacerbation of PCP-induced symptoms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Clinical Neurology
Rose Chesworth, Rossana Rosa-Porto, Sofia Yao, Tim Karl
Summary: The study found that overexpression of Nrg1 type III modulates schizophrenia-relevant behaviors, which may help explain the increased sensitivity to the psychoactive effects of METH in patients with schizophrenia.
JOURNAL OF PSYCHOPHARMACOLOGY
(2021)
Article
Psychiatry
Shabeesh Balan, Tetsuo Ohnishi, Akiko Watanabe, Hisako Ohba, Yoshimi Iwayama, Manabu Toyoshima, Tomonori Hara, Yasuko Hisano, Yuki Miyasaka, Tomoko Toyota, Chie Shimamoto-Mitsuyama, Motoko Maekawa, Shusuke Numata, Tetsuro Ohmori, Tomomi Shimogori, Yoshiaki Kikkawa, Takeshi Hayashi, Takeo Yoshikawa
Summary: The study reanalyzed previously identified quantitative trait loci for prepulse inhibition (PPI) and identified a PPI-regulating Cdh23 variant, as well as a possible contribution of CDH23 to schizophrenia susceptibility.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Behavioral Sciences
K. T. Sun, Jimmy W. Y. Lam, William C. S. Tai, Benson W. M. Lau, Benjamin K. Yee
Summary: The study found that in mouse experiments, trials showing a stronger prepulse response also exhibited a larger startle response to the subsequent pulse stimulus, indicating weaker PPI. Within-subjects and between-subjects analyses revealed contrasting relationships between the direct motor response to the prepulse and the inhibition of subsequent startle reaction induced by the same prepulse.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Psychiatry
Qing Tian, Ning-Bo Yang, Yu Fan, Fang Dong, Qi-Jing Bo, Fu-Chun Zhou, Ji-Cong Zhang, Liang Li, Guang-Zhong Yin, Chuan-Yue Wang, Ming Fan
Summary: This study developed a machine learning pipeline based on neurocognitive and electrophysiological features to distinguish schizophrenia patients from healthy individuals. The results showed that the combination of neurocognitive and electrophysiological features achieved good classification performance, with the extreme gradient boosting algorithm performing the best.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Qijing Bo, Zhen Mao, Qing Tian, Ningbo Yang, Xianbin Li, Fang Dong, Fuchun Zhou, Liang Li, Chuanyue Wang
Summary: The study revealed that PSSPPI may serve as a promising objective approach to identify CHR individuals, who demonstrated lower PPI levels compared to healthy controls.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Neurosciences
Isis Gil-Miravet, Alejandro Fuertes-Saiz, Ana Benito, Isabel Almodovar, Enrique Ochoa, Gonzalo Haro
Summary: This study evaluated the PPI and phenotype of patients with CRD and psychiatric disorders, finding differences in PPI between groups but overall indicating PPI as a non-specific endophenotype in certain mental disorders.
Review
Behavioral Sciences
Andrey T. Proshin
Summary: This article presents a comparative analysis of the characteristics of cholinergic and dopaminergic mechanisms associated with gating decline in healthy individuals and patients with schizophrenia, and discusses the differences in gating mechanisms between the two cohorts.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Biology
Helgi B. Schioeth, Laura Donzelli, Nicklas Arvidsson, Michael J. Williams, Thiago C. Moulin
Summary: Prepulse inhibition (PPI) is a behavior where a smaller stimulus presented before a larger stimulus results in a weaker response. This behavior has been observed in various animals and is used to study anxiety and schizophrenia. Our study found that adult fruit flies also exhibit PPI, which has not been previously reported. We also showed that PPI in flies can be affected by a drug that targets the NMDA receptor.
Article
Psychology, Clinical
E. Fonseca-Pedrero, M. Debbane, J. Ortuno-Sierra, R. C. K. Chan, D. C. Cicero, L. C. Zhang, C. Brenner, E. Barkus, R. J. Linscott, T. Kwapil, N. Barrantes-Vidal, A. Cohen, A. Raine, M. T. Compton, E. B. Tone, J. Suhr, J. Muniz, A. Fumero, S. Giakoumaki, I. Tsaousis, A. Preti, M. Chmielewski, J. Laloyaux, A. Mechri, M. A. Lahmar, V. Wuthrich, F. Laroi, J. C. Badcock, A. Jablensky
PSYCHOLOGICAL MEDICINE
(2018)
Article
Psychiatry
Alex Hatzimanolis, Dimitrios Avramopoulos, Dan E. Arking, Anna Moes, Pallav Bhatnagar, Todd Lencz, Anil K. Malhotra, Stella G. Giakoumaki, Panos Roussos, Nikolaos Smyrnis, Panos Bitsios, Nicholas C. Stefanis
SCHIZOPHRENIA BULLETIN
(2018)
Article
Psychiatry
Boris B. Quednow, Kenechi Ejebe, Michael Wagner, Stella G. Giakoumaki, Panos Bitsios, Veena Kumari, Panos Roussos
SCHIZOPHRENIA RESEARCH
(2018)
Article
Psychiatry
D. Mimarakis, T. Roumeliotaki, P. Roussos, S. G. Giakoumaki, P. Bitsios
EUROPEAN PSYCHIATRY
(2018)
Article
Genetics & Heredity
Jeanne E. Savage, Philip R. Jansen, Sven Stringer, Kyoko Watanabe, Julien Bryois, Christiaan A. de Leeuw, Mats Nagel, Swapnil Awasthi, Peter B. Barr, Jonathan R. I. Coleman, Katrina L. Grasby, Anke R. Hammerschlag, Jakob A. Kaminski, Robert Karlsson, Eva Krapohl, Max Lam, Marianne Nygaard, Chandra A. Reynolds, Joey W. Trampush, Hannah Young, Delilah Zabaneh, Sara Hagg, Narelle K. Hansell, Ida K. Karlsson, Sten Linnarsson, Grant W. Montgomery, Ana B. Munoz-Manchado, Erin B. Quinlan, Gunter Schumann, Nathan G. Skene, Bradley T. Webb, Tonya White, Dan E. Arking, Dimitrios Avramopoulos, Robert M. Bilder, Panos Bitsios, Katherine E. Burdick, Tyrone D. Cannon, Ornit Chiba-Falek, Andrea Christoforou, Elizabeth T. Cirulli, Eliza Congdon, Aiden Corvin, Gail Davies, Ian J. Deary, Pamela DeRosse, Dwight Dickinson, Srdjan Djurovic, Gary Donohoe, Emily Drabant Conley, Johan G. Eriksson, Thomas Espeseth, Nelson A. Freimer, Stella Giakoumaki, Ina Giegling, Michael Gill, David C. Glahn, Ahmad R. Hariri, Alex Hatzimanolis, Matthew C. Keller, Emma Knowles, Deborah Koltai, Bettina Konte, Jari Lahti, Stephanie Le Hellard, Todd Lencz, David C. Liewald, Edythe London, Astri J. Lundervold, Anil K. Malhotra, Ingrid Melle, Derek Morris, Anna C. Need, William Ollier, Aarno Palotie, Antony Payton, Neil Pendleton, Russell A. Poldrack, Katri Raikkonen, Ivar Reinvang, Panos Roussos, Dan Rujescu, Fred W. Sabb, Matthew A. Scult, Olav B. Smeland, Nikolaos Smyrnis, John M. Starr, Vidar M. Steen, Nikos C. Stefanis, Richard E. Straub, Kjetil Sundet, Henning Tiemeier, Aristotle N. Voineskos, Daniel R. Weinberger, Elisabeth Widen, Jin Yu, Goncalo Abecasis, Ole A. Andreassen, Gerome Breen, Lene Christiansen, Birgit Debrabant, Danielle M. Dick, Andreas Heinz, Jens Hjerling-Leffler, M. Arfan Ikram, Kenneth S. Kendler, Nicholas G. Martin, Sarah E. Medland, Nancy L. Pedersen, Robert Plomin, Tinca J. C. Polderman, Stephan Ripke, Sophie van der Sluis, Patrick F. Sullivan, Scott I. Vrieze, Margaret J. Wright, Danielle Posthuma
Article
Psychiatry
Eduardo Fonseca-Pedrero, Javier Ortuno-Sierra, Beatriz Lucas-Molina, Martin Debbane, Raymond C. K. Chan, David C. Cicero, Lisa C. Zhang, Colleen Brenner, Emma Barkus, Richard J. Linscott, Thomas Kwapil, Neus Barrantes-Vidal, Alex Cohen, Adrian Raine, Michael T. Compton, Erin B. Tone, Julie Suhr, Julio Bobes, Axit Fumero, Stella Giakoumaki, Ioannis Tsaousis, Antonio Preti, Michael Chmielewski, Julien Laloyaux, Anwar Mechri, Mohamed Aymen Lahmar, Viviana Wuthrich, Frank Laroi, Johanna C. Badcock, Assen Jablensky, David Barron, Viren Swami, Ulrich S. Tran, Martin Voracek
SCHIZOPHRENIA RESEARCH
(2018)
Article
Psychiatry
Chrysoula Zouraraki, Leda Karagiannopoulou, Penny Karamaouna, Eleftherios G. Pallis, Stella G. Giakoumaki
PSYCHIATRY RESEARCH
(2019)
Article
Psychiatry
Stella G. Giakoumaki, Leda Karagiannopoulou, Penny Karamaouna, Chrysoula Zouraraki, Panos Bitsios
COGNITIVE NEUROPSYCHIATRY
(2020)
Article
Cell Biology
Vasiliki Stavroulaki, Stella G. Giakoumaki, Kyriaki Sidiropoulou
Summary: The debate over whether training on working memory tasks can improve memory function and other cognitive abilities remains controversial, with contradictory findings from prior studies. The lack of systematic approaches and methodological shortcomings further complicate the issue.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Review
Psychiatry
Chrysoula Zouraraki, Penny Karamaouna, Stella G. Giakoumaki
Summary: This systematic review aimed to clarify the relationship between schizotypal traits and facial emotion recognition deficits. The findings indicate that individuals with high schizotypal traits and patients with Schizotypal Personality Disorder (SPD) perform poorly in facial emotion recognition tasks. Different dimensions of schizotypy are associated with specific patterns of deficits in emotion recognition. These findings suggest that emotion recognition deficits may serve as trait markers for schizophrenia spectrum disorders and should be targeted in early-intervention programs.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Article
Psychology, Multidisciplinary
Chrysoula Zouraraki, Andriani Kyriklaki, Elias Economou, Stella G. Giakoumaki
Summary: The present study examined the potential moderating effects of early traumatic experiences on the association between schizotypal traits and visual perceptual processing. The findings revealed that different aspects of schizotypal traits were differently associated with visual illusions depending on the levels of early traumatic experiences.
SCANDINAVIAN JOURNAL OF PSYCHOLOGY
(2023)
Article
Psychology, Multidisciplinary
Vasiliki Stavroulaki, Kyriaki Sidiropoulou, Panos Bitsios, Stella G. Giakoumaki
Summary: This study investigated the far transfer effects of Executive Working Memory (EWM) on cognitive flexibility. The findings showed that participants who received EWM training demonstrated better cognitive flexibility, which is consistent with other studies on working memory training. These findings have promising implications for early intervention programs for individuals with cognitive impairments.
CURRENT PSYCHOLOGY
(2023)
Review
Neurosciences
Chrysoula Zouraraki, Penny Karamaouna, Stella G. Giakoumaki
Summary: Ample research findings suggest altered brain functioning in the schizophrenia spectrum. However, functional neuroimaging findings remain unclear for individuals with high schizotypal traits and diagnosed with schizotypal personality disorder (SPD). This systematic review aimed to identify neural abnormalities in task-related and resting-state conditions across these groups. The review found functional alterations in striatal, frontal, and temporal regions in individuals with high schizotypal traits, and default mode network abnormalities in SPD patients. Further research is needed to understand the neural correlates and compensatory mechanisms in these conditions.
Article
Clinical Neurology
Penny Karamaouna, Chrysoula Zouraraki, Elias Economou, Konstantinos Kafetsios, Panos Bitsios, Stella G. Giakoumaki
Summary: This study examines the cold and hot executive function processes in individuals with different schizotypal traits. The results indicate that there is no categorical association between the dimensions of schizotypy and cold or hot executive function processes, and impoverished emotional intelligence is a core feature of schizotypy.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2023)
Article
Psychology, Multidisciplinary
Stella G. Giakoumaki, Penny Karamaouna, Leda Karagiannopoulou, Chrysoula Zouraraki
Summary: The critical link between schizotypy and schizophrenia is the impoverished cognitive functioning. Different schizotypal dimensions are associated with different patterns of self-perceived cognitive lapses, with negative schizotypy being characterized by generalized cognitive failures and disorganized schizotypy showing specific cognitive slips related to fronto-parietal network functioning. Psychological well-being is negatively associated with negative schizotypy but positively associated with cognitive-perceptual schizotypy.
SCANDINAVIAN JOURNAL OF PSYCHOLOGY
(2021)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)