Article
Cell Biology
Maryna Koskela, T. Petteri Piepponen, Maria Lindahl, Brandon K. Harvey, Jaan-Olle Andressoo, Vootele Voikar, Mikko Airavaara
Summary: The study explored the impact of GDNF and BDNF on alcohol-seeking behavior in group-housed female mice. While an increase in endogenous Gdnf mRNA level was found to affect behavioral responses to alcohol consumption, overexpression of AVV-GDNF in the nucleus accumbens suppressed alcohol-seeking behavior.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Nutrition & Dietetics
Julia de Ternay, Agathe Larrieu, Laura Sauvestre, Solene Montegue, Monique Guenin, Christophe Icard, Benjamin Rolland
Summary: Improving physical activity in patients with alcohol use disorder is essential for improving drinking outcomes and quality of life. Patients with insufficient baseline physical activity show markers of severity and should receive physical exercise interventions as part of a multimodal treatment program.
Article
Medicine, General & Internal
Mateusz Curylo, Marlena Rynkiewicz-Andryskiewicz, Przemyslaw Andryskiewicz, Marcin Mikos, Dariusz Lusina, Jan W. Raczkowski, Monika Pajewska, Olga Partyka, Katarzyna Sygit, Marian Sygit, Elzbieta Cipora, Mateusz Kaczmarski, Roman Zaluska, Tomasz Banas, Lukasz Strzepek, Edyta Krzych-Falta, Ewa Bandurska, Weronika Ciecko, Michal Zabojszcz, Barbara Maciuszek-Bartkowska, Artur Kotwas, Anna Knyszynska, Dariusz A. Kosior, Michal Marczak, Aleksandra Czerw, Remigiusz Kozlowski
Summary: Alcohol consumption is associated with over 200 diseases and injuries, and is classified as a risk factor for neoplasms and infectious diseases. Our study aimed to examine health patterns and stress levels among patients undergoing alcohol addiction treatment. The results showed that perceived stress was negatively correlated with sense of coherence and health behaviors, while age was positively correlated with positive mental attitude, proper eating habits, and health behaviors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Gene Y. Im, Jessica L. Mellinger, Adam Winters, Elizabeth S. Aby, Zurabi Lominadze, John Rice, Michael R. Lucey, Juan P. Arab, Aparna Goel, Loretta L. Jophlin, Courtney B. Sherman, Richard Parker, Po-Hung Chen, Deepika Devuni, Sandeep Sidhu, Winston Dunn, Gyongyi Szabo, Ashwani K. Singal, Vijay H. Shah
Summary: The survey of hepatology and gastroenterology providers showed high rates of alcohol screening and referrals for behavioral therapy, but low rates of prescribing AUD pharmacotherapy due to knowledge gaps from insufficient education. Further studies are needed to improve provider alignment with best practices for treating patients with AUD and ALD.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Carla Occhipinti, Raffaele La Russa, Naomi Iacoponi, Julia Lazzari, Andrea Costantino, Nicola Di Fazio, Fabio Del Duca, Aniello Maiese, Vittorio Fineschi
Summary: This article provides an overview of the role of miRNAs in substance addiction, evaluating their regulatory role in neuroadaptation and synaptic plasticity. It also explores the potential diagnostic role of miRNAs in various stages of drug and substance addiction, and discusses future prospects for miRNAs as potential novel therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
M. Adrienne McGinn, Brendan J. Tunstall, Joel E. Schlosburg, Adriana Gregory-Flores, Olivier George, Giordano de Guglielmo, Barbara J. Mason, Hazel J. Hunt, George F. Koob, Leandro F. Vendruscolo
Summary: The study demonstrated the potential of GR modulators in reducing alcohol consumption, with different effects observed in different circumstances. These findings provide insights for the development of treatments for AUD.
Review
Nutrition & Dietetics
David Nutt, Alexandra Hayes, Leon Fonville, Rayyan Zafar, Emily O. C. Palmer, Louise Paterson, Anne Lingford-Hughes
Summary: Alcohol affects the brain in various harmful ways, including damage during intoxication, withdrawal effects, and peripheral factors like poor diet and vitamin deficiencies. Prenatal alcohol exposure can also have lasting impacts on brain development.
Article
Veterinary Sciences
Diego D. Miceli, Jorge D. Garcia, Gustavo A. Pompili, Juan P. Rey Amunategui, Sergio Ferraris, Omar P. Pignataro, Mirtha Guitelman
Summary: The safety and efficacy of cabergoline in controlling hypersomatotropism and diabetes mellitus in cats were evaluated in this study. The results showed that cabergoline could reduce and normalize serum IGF-1 concentration. Cabergoline improved diabetes control and achieved remission in some cases.
JOURNAL OF FELINE MEDICINE AND SURGERY
(2022)
Article
Cell Biology
Chenchen Pan, Frank Winkler
Summary: This article reviews recent advances in understanding the interactions between cancer and the nervous system, and how this knowledge can be applied to improve cancer therapies. It highlights the importance of cancer neuroscience research and provides a roadmap for future studies.
NATURE CELL BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Catalina Fuenzalida, Maria Soledad Dufeu, Jaime Poniachik, Juan Pablo Roblero, Lucia Valenzuela-Perez, Caroll Jenny Beltran
Summary: ALD is a leading cause of morbidity among adults with alcohol use disorder globally. Its clinical course ranges from steatosis to severe forms of liver damage. The complex pathogenesis involves various factors such as environmental, genetic, immune response, and gut microbiota alterations.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Frederic Castinetti, Frederique Albarel, Vincent Amodru, Thomas Cuny, Henry Dufour, Thomas Graillon, Isabelle Morange, Thierry Brue
Summary: Cabergoline is the first-line treatment for prolactinoma, with classical side-effects like low blood pressure and nausea. Other side-effects, such as cardiac valvular fibrosis, pleural and pericardial fibrosis, as well as addictive/compulsive behaviors, and risks related to decreased tumor volume, should also be monitored and managed. Despite the rarity of these side -effects, they should not undermine the role of cabergoline in treating prolactinoma.
ANNALES D ENDOCRINOLOGIE
(2021)
Article
Ophthalmology
Abhigna Akurathi, Erin A. Boese, Randy H. Kardon, Johannes Ledolter, Markus H. Kuehn, Matthew M. Harper
Summary: This study aimed to investigate the expression of glial-derived neurotrophic factor (GDNF) and its receptors, GFR alpha 1 and GFR alpha 2, ciliary neurotrophic factor (CNTF), and its receptor CNTFR alpha, in both normal and glaucomatous human tissue. The results showed that the expression of GFR alpha 2 was significantly decreased in glaucomatous eyes, while the expression of GFR alpha 1 was decreased in the peripapillary region. The findings suggest that the decreased expression of GDNF receptors in glaucomatous tissue may limit the potential for neuroprotective therapy using GDNF supplementation.
CURRENT EYE RESEARCH
(2022)
Review
Psychology, Clinical
Mariangela Antonelli, Liana Fattore, Luisa Sestito, Daniela Di Giuda, Marco Diana, Giovanni Addolorato
Summary: Repetitive TMS has shown promising results in patients with alcohol, tobacco, and cocaine use disorder, indicating a potential role in the treatment of SUD.
ADDICTIVE BEHAVIORS
(2021)
Review
Cell Biology
Guihong Liu, Tao Chen, Zhenyu Ding, Yang Wang, Yuquan Wei, Xiawei Wei
Summary: The FGF-FGFR signaling pathway and the VEGF-VEGFR signaling pathway play important roles in the treatment of tumors, and inhibitors targeting these two pathways can optimize therapeutic effects and expand the antitumor range. In addition, biomarkers should be developed in the future to predict efficacy, and combination with immune checkpoint inhibitors is a promising direction.
CELL PROLIFERATION
(2021)
Article
Endocrinology & Metabolism
Rosa Pirchio, Renata S. Auriemma, Domenico Solari, Mauro Arnesi, Claudia Pivonello, Mariarosaria Negri, Cristina de Angelis, Luigi M. Cavallo, Paolo Cappabianca, Annamaria Colao, Rosario Pivonello
Summary: Pituitary surgery may improve lipid metabolism, while high-dose cabergoline may have beneficial effects on both insulin secretion and peripheral sensitivity, leading to overall metabolic improvement.
FRONTIERS IN ENDOCRINOLOGY
(2021)
News Item
Medicine, Research & Experimental
Mathieu Favier, Carole Carcenac, Marc Savasta, Sebastien Carnicella
M S-MEDECINE SCIENCES
(2017)
Editorial Material
Neurosciences
Kurt M. Fraser, Patricia H. Janak
NATURE NEUROSCIENCE
(2018)
Article
Neurosciences
Benjamin T. Saunders, Jocelyn M. Richard, Elyssa B. Margolis, Patricia H. Janak
NATURE NEUROSCIENCE
(2018)
Article
Biology
Jocelyn M. Richard, Nakura Stout, Deanna Acs, Patricia H. Janak
Article
Multidisciplinary Sciences
Arnauld Belmer, Omkar L. Patkar, Vanessa Lanoue, Selena E. Bartlett
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
David Ottenheimer, Jocelyn M. Richard, Patricia H. Janak
NATURE COMMUNICATIONS
(2018)
Article
Behavioral Sciences
Robin Magnard, Yvan Vachez, Carole Carcenac, Sabrina Boulet, Jean-Luc Houeto, Marc Savasta, David Belin, Sebastien Carnicella
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2018)
Article
Neurosciences
David J. Ottenheimer, Karen Wang, Alexandria Haimbaugh, Patricia H. Janak, Jocelyn M. Richard
EUROPEAN JOURNAL OF NEUROSCIENCE
(2019)
Article
Biology
Youna Vandaele, Nagaraj R. Mahajan, David J. Ottenheimer, Jocelyn M. Richard, Shreesh P. Mysore, Patricia H. Janak
Article
Neurosciences
David J. Ottenheimer, Bilal A. Bari, Elissa Sutlief, Kurt M. Fraser, Tabitha H. Kim, Jocelyn M. Richard, Jeremiah Y. Cohen, Patricia H. Janak
NATURE NEUROSCIENCE
(2020)
Biographical-Item
Neurosciences
Patricia H. Janak
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Arnauld Belmer, Ronan Depoortere, Kate Beecher, Adrian Newman-Tancredi, Selena E. Bartlett
Summary: This study demonstrates that stimulating the 5-HT1A receptor can reduce ethanol binge-drinking behavior and withdrawal-induced anxiety. Using a combination of pharmacological and chemogenetic approaches, the researchers identified the involvement of 5-HT1A autoreceptors and 5-HT neuronal function in regulating ethanol intake. They also discovered a serotonergic microcircuit originating from the MRN and projecting to the DG that specifically affects and modulates long-term ethanol consumption.
MOLECULAR PSYCHIATRY
(2022)
Editorial Material
Nutrition & Dietetics
Kerri M. Gillespie, Eva Kemps, Melanie J. White, Selena E. Bartlett
Summary: This narrative review addresses the debate on the role of added and free sugars in human health and discusses various health conditions associated with sugar. The findings suggest that excessive added sugar consumption negatively affects human health and wellbeing, and the type and source of carbohydrates greatly influence their impact on health. Further research is needed to understand the complex relationship between sugar and health in diverse populations.
Article
Multidisciplinary Sciences
David J. Ottenheimer, Karen Wang, Xiao Tong, Kurt M. Fraser, Jocelyn M. Richard, Patricia H. Janak
Article
Neurosciences
Kurt M. Fraser, Patricia H. Janak
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)