Article
Surgery
Shao-bin Chen, Di-tian Liu, Yu-ping Chen
Summary: This study aimed to evaluate the impact of adjuvant chemotherapy on patients with surgically resected esophageal squamous cell carcinoma (ESCC). The results showed that postoperative adjuvant chemotherapy can improve the overall survival (OS) and disease-free survival (DFS) of ESCC patients after radical resection, but its efficacy may be limited to certain subgroups of patients.
FRONTIERS IN SURGERY
(2023)
Article
Oncology
Weiming Han, Xiao Chang, Wencheng Zhang, Jingsong Yang, Shufei Yu, Wei Deng, Wenjie Ni, Zongmei Zhou, Dongfu Chen, Qinfu Feng, Jun Liang, Zhouguang Hui, Lvhua Wang, Shugeng Gao, Yu Lin, Xiaohui Chen, Junqiang Chen, Zefen Xiao
Summary: For patients with esophageal squamous cell carcinoma (ESCC), postoperative radiotherapy (PORT) can improve local-regional recurrence-free survival (LRFS). However, concerns about treatment-related toxicity limit its application. This study analyzed 3591 ESCC patients and found that increasing the adjuvant radiation dose (aRTD) improved LRFS until it exceeded 50 Gy, after which it remained steady. Treatment-related mortality also increased after aRTD exceeded 50 Gy. The findings suggest that there is an optimal aRTD that can enhance LRFS without increasing toxicity. This study highlights the potential of PORT to improve survival outcomes in ESCC patients treated with upfront surgery, and suggests that further research is needed to determine the appropriate aRTD.
Article
Oncology
Linlin Xiao, Yvonne M. Mowery, Brian G. Czito, Yajing Wu, Guangbin Gao, Chang Zhai, Jianing Wang, Jun Wang
Summary: Brain metastases are rare in patients with esophageal squamous cell carcinoma (ESCC). Diagnosis-specific graded prognostic assessment (DS-GPA) score may be a useful prognostic tool for ESCC patients with brain metastases. Receipt of locoregional treatment, including brain surgery and radiotherapy, was associated with improved survival outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Xin Wang, Nuo Yu, Guowei Cheng, Tao Zhang, Jianyang Wang, Lei Deng, Jiao Li, Xiaotian Zhao, Yang Xu, Peng Yang, Na Bai, Yin Li, Nan Bi
Summary: In this study, ctDNA was identified as a robust biomarker for early detection of disease progression and prognosis stratification after RT/CRT in ESCC. Detectable ctDNA at week 4 of RT/CRT might indicate higher local recurrence risks, implying the potential clinical utility of ctDNA tests in guiding post-RT/CRT treatments for locoregional control in ESCC.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Dongxian Jiang, Haixing Wang, Minying Deng, Qi Song, Yufeng Liu, Rui Peng, Lei Xu, Jieakesu Su, Chen Xu, Yingyong Hou
Summary: The number of diagnosed esophageal basaloid squamous cell carcinoma (EBSCC) has been increasing recently, but available data on EBSCC are limited. A retrospective analysis of 165 EBSCC and 515 conventional esophageal squamous cell carcinoma (ESCC) showed that EBSCC had similar prognosis to ESCC in pIA-B stage, pIIA-B stage, pIIIA-B stage, and pIVA-B stage. Pure EBSCC did not have poorer survival compared to mixed EBSCC with concomitant ESCC or other components.
Article
Oncology
Keting Li, Wentao Hao, Xianben Liu, Yin Li, Haibo Sun, Shilei Liu, Wenqun Xing, Yan Zheng
Summary: This study compared the efficacy of adjuvant chemotherapy and postoperative observation in patients with esophageal squamous cell carcinoma (ESCC) after neoadjuvant chemotherapy. The results showed that adjuvant chemotherapy did not improve overall survival (OS) in these patients, but it may benefit certain groups of patients.
Article
Oncology
Hai-Bo Sun, Sen Yan, Xian-Ben Liu, Wen-Qun Xing, Pei-Nan Chen, Shi-Lei Liu, Peng Li, Ya-Xing Ma, Toni Lerut, Ahmed Daoud, Duo Jiang, Hai-Bo Sun
Summary: The study demonstrates that neoadjuvant chemotherapy (NAC) plus surgery prolongs overall survival (OS) and disease-free survival (DFS) and significantly decreases the rate of recurrence in patients with clinical stage II and III esophageal squamous cell carcinoma (ESCC) compared with surgery plus adjuvant chemotherapy (AC).
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Nutrition & Dietetics
Miao-Fen Chen, Ching-Chuan Hsieh, Ping-Tsung Chen, Ming-Shian Lu
Summary: Malnutrition is associated with poor prognosis in esophageal-SCC patients, and nutritional status evaluated by PGSGA may be useful to guide treatment decisions in clinical practice. Nutritional supplementation is suggested to improve prognosis, and it might be related to augmented anticancer immune response.
Article
Medicine, Research & Experimental
Lei Feng, Kaikai Zhao, Liangchao Sun, Xiaoyang Yin, Junpeng Zhang, Conghe Liu, Baosheng Li
Summary: This study revealed a connection between high expression of SLC7A11 and nuclear expression of NRF2 in patients with ESCC, which was associated with worse survival rates and poorer treatment outcomes. SLC7A11-mediated ferroptosis inhibition induced NRF2-associated radioresistance.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Lye-Yeng Wong, Douglas Z. Z. Liou, Lucas K. K. Vitzthum, Leah M. M. Backhus, Natalie S. S. Lui, Daniel Chang, Joseph B. B. Shrager, Mark F. F. Berry
Summary: This study evaluated the impact of the length of time between chemoradiation and esophagectomy on perioperative outcomes and long-term survival in patients with squamous cell carcinoma of the esophagus. The results showed that delaying surgery for more than 180 days after starting chemoradiation is associated with worse perioperative outcomes but does not significantly affect long-term survival.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Yaru Guo, Mingna Xu, Yufei Lou, Yan Yuan, Yuling Wu, Longzhen Zhang, Yong Xin, Fengjuan Zhou
Summary: A comparison was made between neoadjuvant chemoradiation (NCRT) and neoadjuvant chemotherapy (NCT) in terms of survival and complications for esophageal squamous cell carcinoma (ESCC) patients. The meta-analysis results showed that NCRT had a higher pathological complete remission rate, complete tumor resection rate, and 1-year, 3-year, and 5-year survival rates compared to NCT. There was no significant difference in postoperative complications between the two neoadjuvant treatments.
Article
Oncology
Mingqiang Liang, Jiazhou Xiao, Maohui Chen, Bin Zheng, Chun Chen
Summary: This study analyzed data from 705 ESCC patients who underwent minimally invasive surgery and found that the greatest improvement in conditional survival for patients who survived a period after surgery was observed at 2 years post-surgery. The study also suggests that patients with anastomotic leak and higher T and N stages should be closely monitored at different time points, and conditional survival should be used as a powerful prognostic tool for ESCC patients.
Review
Oncology
Yicong Chen, Ruixuan Yu, Yongmei Liu
Summary: Immune checkpoint inhibitors (ICIs) have improved the survival of advanced esophageal squamous cell carcinoma (ESCC) patients. However, the efficacy of combining radiotherapy with immunotherapy for ESCC treatment is still controversial. This review aims to discuss the efficacy and safety of combining radiotherapy and immunotherapy for treating ESCC, as well as the optimal radiotherapy dose and target volume, with a summary of clinical trials in ESCC.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Jinjun Shi, Chenchun Fu, Xiangyu Su, Shicheng Feng, Sheng Wang
Summary: The study shows that ultrasound-stimulated microbubbles have potential in improving drug delivery efficiency and treating esophageal squamous cell carcinoma, significantly affecting cell survival, proliferation, migration, invasion, and apoptosis. In addition, USMBs therapy further enhances the inhibitory effect of radiotherapy on ESCC cells by inhibiting angiogenesis.
Article
Oncology
Qiu-Yun Luo, Tian Di, Miao-Zhen Qiu, Zeng-Fei Xia, Yong Du, Run-Duan Lin, Li-Qiong Yang, Yu-Ting Sun, Da-Jun Yang, Jian Sun, Lin Zhang
Summary: High expression of AKAP8L is associated with poor prognosis of ESCC and can be considered an independent risk factor for ESCC.
CANCER CELL INTERNATIONAL
(2022)