☆ 4.4 Article

Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO2(mpETSC)] and [Pt(mpETSC)Cl]

BIOINORGANIC CHEMISTRY AND APPLICATIONS (2010)

Journal

BIOINORGANIC CHEMISTRY AND APPLICATIONS

Volume 2010, Issue -, Pages -

Publisher

HINDAWI LTD

DOI: 10.1155/2010/149149

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Categories

Biochemistry & Molecular Biology Chemistry, Inorganic & Nuclear Chemistry, Organic

Funding

NSERC (Canada)
Minsitry of Higher Education, Egypt

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Abstract

Copyright c 2010 Shadia A. Elsayed et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. New complexes of dioxovanadium(V), zinc(II), ruthenium(II), palladium(II), and platinum(II) with 6-methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone (HmpETSC) have been synthesized. The composition of these complexes is discussed on the basis of elemental analyses, IR, Raman, NMR (H-1, C-13, and P-31), and electronic spectral data. The X-ray crystal structures of [VO2(mpETSC)] and [Pt(mpETSC)Cl] are also reported. The HmpETSC and its [Zn(HmpETSC)Cl-2] and [Pd(mpETSC)Cl] complexes exhibit antineoplastic activity against colon cancer human cell lines (HCT 116).

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