Article
Engineering, Biomedical
Chuanchuan Lin, Ye He, Qian Feng, Kun Xu, Zhe Chen, Bailong Tao, Xuemin Li, Zengzilu Xia, Hong Jiang, Kaiyong Cai
Summary: Researchers investigated the influence of stress relaxation rate of alginate hydrogels on the behavior of MSCs in a 3D environment. They found that the stress relaxation rate regulated the gene expression and cell proliferation of MSCs, leading to either self-renewal or quiescence of the stem cells. This study provides important insights for designing MSC-encapsulated biomaterials based on the physical factor of stress relaxation rate.
Article
Multidisciplinary Sciences
Jingjing Shang, Zhentang Yu, Chengwei Xiong, Junjie Zhang, Jinhong Gong, Changlin Yu, Yong Huang, Xindie Zhou
Summary: Osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) plays a crucial role in bone defect regeneration. Resistin, an adipose tissue-specific secretory factor, has diverse functions including metabolism, inflammation, cancer, and bone remodeling. However, the effects and mechanisms of resistin on BMSCs' osteogenic differentiation are still unclear.
Article
Oncology
Changhwan Yoon, Jun Lu, Brendan C. Yi, Kevin K. Chang, M. Celeste Simon, Sandra Ryeom, Sam S. Yoon
Summary: The Akt1/2-Nanog pathway plays a critical role in the maintenance of sarcoma CSCs and spheroid-forming cells, and targeting this pathway may be a promising therapeutic strategy for sarcoma treatment.
Article
Biochemistry & Molecular Biology
Maheshkumar Kannan, Sridharan Jayamohan, Rajesh Kannan Moorthy, Siva Chander Chabattula, Mathan Ganeshan, Antony Joseph Velanganni Arockiam
Summary: Hepatocellular carcinoma (HCC) is the third leading malignancy worldwide, causing high mortality in adults and children. This study explored the expression and function of the miR-221/AEG-1 axis in HCC. The silencing of the miR-221/AEG-1 axis induced apoptosis and G2/M phase arrest, inhibited cellular proliferation and angiogenesis in HCC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Shuang Chen, Kang Li, Xinqi Zhong, Ganping Wang, Xiaocheng Wang, Maosheng Cheng, Jie Chen, Zhi Chen, Jianwen Chen, Caihua Zhang, Gan Xiong, Xiuyun Xu, Demeng Chen, Heping Li, Liang Peng
Summary: Our study demonstrates that Sox9-expressing cells promote lung tissue regeneration, with their ablation leading to severe radiation damage phenotypes. Through analysis of an online scRNA-Seq dataset, we found that the PI3K/AKT pathway is enriched in Sox9-expressing cells during lung epithelium regeneration.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Pathology
Mohsen Karami Fath, Menooa Ebrahimi, Ehsan Nourbakhsh, Ahmad Zia Hazara, Ali Mirzaei, Saba Shafieyari, Azadeh Salehi, Mahsa Hoseinzadeh, Zahra Payandeh, Ghasem Barati
Summary: Cancer stem cells (CSCs) play a crucial role in tumor formation and resistance to therapy. Understanding the PI3K/Akt/mTOR signaling pathway in CSCs can provide insights into targeted therapy for drug-resistant tumors. While this pathway is well-known in tumor bulk, its functions in CSCs have not been fully explored.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Review
Biochemistry & Molecular Biology
Maricedes Acosta-Martinez, Maria Zulema Cabail
Summary: Obesity is a global epidemic and a major risk factor for cardiovascular disease, stroke, and mortality. Meta-inflammation, characterized by immune cell accumulation, dysregulation of adipokine synthesis, and increased production of proinflammatory factors, is believed to contribute to obesity's negative health consequences. The crosstalk between macrophages and adipocytes and the impairment of the PI3K/Akt signaling pathway play crucial roles in the development of meta-inflammation and insulin resistance associated with obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Martina S. Savova, Liliya Mihaylova, Daniel Tews, Martin Wabitsch, Milen I. Georgiev
Summary: Obesity is a growing disorder that damages patients' quality of life and increases healthcare costs. Developing safe and innovative prevention strategies and treatments for obesity is crucial. The pathophysiology of obesity is complex and involves multiple signaling pathways, including the PI3K/AKT pathway, which plays a critical role in metabolic homeostasis. Natural compounds have been shown to target the PI3K/AKT signaling pathway and have potential for managing obesity. This paper evaluates the druggability of PI3K as a target and suggests perspectives on using natural compounds to modulate the PI3K/AKT pathway for obesity management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Zongkui Wang, Peng Jiang, Fengjuan Liu, Xi Du, Li Ma, Shengliang Ye, Haijun Cao, Pan Sun, Na Su, Fangzhao Lin, Rong Zhang, Changqing Li
Summary: This study reveals that GDF11 negatively regulates neurogenesis by activating the ALK5-dependent PI3K-Akt signaling pathway in neural stem cells, inhibiting cell proliferation and migration while promoting differentiation and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Peipei Xu, Xiongshi Lin, Xing Dong, Ying Liu, Zhichong Wang, Shuangyong Wang
Summary: This study discovered that trigeminal nerve-derived substance P (SP) can promote corneal epithelial homeostasis and wound healing closure, as well as enhance the proliferation and stemness of limbal stem cells (LSCs). Through in vivo and in vitro experiments and RNA sequencing analysis, the positive effects of SP on LSCs and its underlying mechanism were revealed. The findings showed that SP regulated LSCs functions by modulating the PI3K-AKT pathway, which may provide new insights into the regulation of LSCs' fate and stem cell therapy.
Article
Multidisciplinary Sciences
Xiao Fu, Yanhong Zhang, Rui Zhang
Summary: In the advanced stage of cancer, the mechanism of bone cancer pain (BCP) is complex and unclear. This study used a mouse model to investigate the mechanism of BCP and found that blocking the Akt protein can relieve pain. Additionally, there is a close relationship between inflammatory factors and the PI3K-WNK1 signal pathway, and inhibition of Akt can reduce inflammatory cytokine levels and alleviate BCP.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Xiongjun He, Jiahui Liu, Xiaoran Wang, Tengfei Liu, Liu Yang, Chaoyang Li, Chenjie Wang, Ying Liu, Xuan Sang, Zhichong Wang, Xiaohe Lu
Summary: This study demonstrates that the embryonic stem cell microenvironment can partially reverse the malignancy of glioblastoma multiforme by inhibiting the PI3K signaling pathway. This may have important clinical implications for cell therapy in the treatment of glioma, providing hope for finding new treatment options.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Oncology
Bo Zhang, Yao Zhang, Xizi Jiang, Hongbo Su, Qiongzi Wang, Muli Wudu, Jun Jiang, Hongjiu Ren, Yitong Xu, Zongang Liu, Xueshan Qiu
Summary: JMJD8 functions as an oncogenic regulator in non-small-cell lung cancer (NSCLC), promoting carcinogenic activity by stabilizing EGFR and activating the downstream PI3K/AKT signaling pathway. High expression of JMJD8 is associated with the malignancy and staging of NSCLC patients.
Article
Pharmacology & Pharmacy
Huifen Zhou, Yu He, Jiaqi Zhu, Xiaojie Lin, Juan Chen, Chongyu Shao, Haitong Wan, Jiehong Yang
Summary: The study found that Guhong injection (GHI) can treat ischemic stroke by targeting the PI3K/AKT signaling pathway, leading to antiapoptotic effects and repair of cerebral microvessels and mitochondria.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hong-Yan Zhao, Yuan-Yuan Zhang, Tong Xing, Shu-Qian Tang, Qi Wen, Zhong-Shi Lyu, Meng Lv, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Yuan Kong, Xiao-Jun Huang
Summary: The study revealed the critical role of macrophages in regulating megakaryocyte production, with M1 and M2 macrophages exhibiting opposing effects in a manner dependent on the PI3K-AKT pathway. This sheds light on the pathogenesis of thrombocytopenia and presents a potential therapeutic strategy for promoting megakaryopoiesis.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)