Innate immunesenescence: underlying mechanisms and clinical relevance

Mononuclear Phagocyte-Derived IL-10 Suppresses the Innate IL-12/IFN-  Axis in Lung-Challenged Aged Mice

(2014) B.-C. Chiu et al.   JOURNAL OF IMMUNOLOGY

The impact of ageing on natural killer cell function and potential consequences for health in older adults

(2013) Jon Hazeldine et al.   AGEING RESEARCH REVIEWS

Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence

(2013) E. Sapey et al.   BLOOD

Reduced Neutrophil Chemotaxis and Infiltration Contributes to Delayed Resolution of Cutaneous Wound Infection with Advanced Age

(2013) A. L. Brubaker et al.   JOURNAL OF IMMUNOLOGY

Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function

(2012) Anna C. Hearps et al.   AGING CELL

Reduced release and binding of perforin at the immunological synapse underlies the age-related decline in natural killer cell cytotoxicity

(2012) Jon Hazeldine et al.   AGING CELL

The three human monocyte subsets: implications for health and disease

(2012) Kok Loon Wong et al.   IMMUNOLOGIC RESEARCH

Human NK Cells Induce Neutrophil Apoptosis via an NKp46- and Fas-Dependent Mechanism

(2012) F. B. Thoren et al.   JOURNAL OF IMMUNOLOGY

Granule exocytosis mediates immune surveillance of senescent cells

(2012) A Sagiv et al.   ONCOGENE

Innate Immune Dysfunctions in Aged Mice Facilitate the Systemic Dissemination of Methicillin-Resistant S. aureus

(2012) Ching Wen Tseng et al.   PLoS One

Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans

(2012) Rafael Solana et al.   SEMINARS IN IMMUNOLOGY

Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly

(2011) Feng Qian et al.   AGING CELL

Age-related changes in natural killer cell receptors from childhood through old age

(2011) Aline Almeida-Oliveira et al.   HUMAN IMMUNOLOGY

Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice

(2011) Jincun Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Human NK Cells Proliferate and Die In Vivo More Rapidly than T Cells in Healthy Young and Elderly Adults

(2011) C. T. Lutz et al.   JOURNAL OF IMMUNOLOGY

Advanced Age Impairs Macrophage Polarization

(2011) Shegufta Mahbub et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Natural killer cell function is altered during the primary response of aged mice to influenza infection

(2011) Eleni Beli et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria

(2011) Yuki Kinjo et al.   NATURE IMMUNOLOGY

Aging reduces the functionality of anti-pneumococcal antibodies and the killing of Streptococcus pneumoniae by neutrophil phagocytosis

(2011) Birgit Simell et al.   VACCINE

Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity

(2010) Aishwarya Sridharan et al.   AGE

Human NK cells display major phenotypic and functional changes over the life span

(2010) Magali Le Garff-Tavernier et al.   AGING CELL

Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults

(2010) Sebastian Seidler et al.   BMC IMMUNOLOGY

Variation of human natural killer cell phenotypes with age: Identification of a unique KLRG1-negative subset

(2010) Richard P.G. Hayhoe et al.   HUMAN IMMUNOLOGY

Impaired Functions of Peripheral Blood Monocyte Subpopulations in Aged Humans

(2010) Joseph Nyugen et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking

(2010) Min Fang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Age-Associated Decrease in TLR Function in Primary Human Dendritic Cells Predicts Influenza Vaccine Response

(2010) Alexander Panda et al.   JOURNAL OF IMMUNOLOGY

An Integrated View of Humoral Innate Immunity: Pentraxins as a Paradigm

(2009) Barbara Bottazzi et al.   Annual Review of Immunology

Aging is associated with a numerical and functional decline in plasmacytoid dendritic cells, whereas myeloid dendritic cells are relatively unaltered in human peripheral blood

(2009) Yu Jing et al.   HUMAN IMMUNOLOGY

Decreased TNF-α synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+T cells during aging

(2009) Elaine Agius et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Impaired Dendritic Cell Function in Aging Leads to Defective Antitumor Immunity

(2008) A. Grolleau-Julius et al.   CANCER RESEARCH

Age-Related Changes in Eosinophil Function in Human Subjects

(2008) Sameer K. Mathur et al.   CHEST

Innate immunity and aging

(2008) Christian R. Gomez et al.   EXPERIMENTAL GERONTOLOGY

An age-associated increase in pulmonary inflammation after burn injury is abrogated by CXCR2 inhibition

(2008) V. Nomellini et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophils of Centenarians Show Function Levels Similar to Those of Young Adults

(2008) Patricia Alonso-Fernández et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark