Growth or longevity: the TOR’s decision on lifespan regulation

If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice

(2016) Vladimir N. Anisimov et al.   Aging-US

Rapamycin increases oxidative stress response gene expression in adult stem cells

(2016) Amber E. Kofman et al.   Aging-US

Autophagy is required for extension of yeast chronological life span by rapamycin

(2014) Ashley L. Alvers et al.   Autophagy

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Impaired Insulin/IGF1 Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS Signal

(2012) Kim Zarse et al.   Cell Metabolism

Metabolic Regulation, Mitochondria and the Life-Prolonging Effect of Rapamycin: A Mini-Review

(2012) Yong Pan et al.   GERONTOLOGY

MAF1: a new target of mTORC1

(2011) Annemieke A. Michels   BIOCHEMICAL SOCIETY TRANSACTIONS

A longer and healthier life with TOR down-regulation: genetics and drugs: Figure 1

(2011) Ivana Bjedov et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Biogerontology: from here to where? The Lord Cohen Medal Lecture-2011

(2011) Suresh I. S. Rattan   BIOGERONTOLOGY

Sch9 partially mediates TORC1 signaling to control ribosomal RNA synthesis

(2011) Yuehua Wei et al.   CELL CYCLE

Regulation of Yeast Chronological Life Span by TORC1 via Adaptive Mitochondrial ROS Signaling

(2011) Yong Pan et al.   Cell Metabolism

On the Programmed/Non-Programmed Nature of Ageing within the Life History

(2011) Thomas B.L. Kirkwood et al.   CURRENT BIOLOGY

Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L

(2011) Alexandre Huber et al.   EMBO JOURNAL

Mitochondria, reactive oxygen species, and chronological aging: A message from yeast

(2011) Yong Pan   EXPERIMENTAL GERONTOLOGY

Rapamycin passes the torch: a new generation of mTOR inhibitors

(2011) Don Benjamin et al.   NATURE REVIEWS DRUG DISCOVERY

Hyperactive S6K1 Mediates Oxidative Stress and Endothelial Dysfunction in Aging: Inhibition by Resveratrol

(2011) Angana G. Rajapakse et al.   PLoS One

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

(2010) Laura R. Pearce et al.   BIOCHEMICAL JOURNAL

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity

(2010) Seung-Jae Lee et al.   CURRENT BIOLOGY

Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

(2010) V. P. Houde et al.   DIABETES

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

Stb3 Plays a Role in the Glucose-Induced Transition from Quiescence to Growth in Saccharomyces cerevisiae

(2010) D. Liko et al.   GENETICS

mTORC1 Directly Phosphorylates and Regulates Human MAF1

(2010) A. A. Michels et al.   MOLECULAR AND CELLULAR BIOLOGY

Can autophagy promote longevity?

(2010) Frank Madeo et al.   NATURE CELL BIOLOGY

Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

(2010) Brian Onken et al.   PLoS One

mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1

(2010) T. Kantidakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

(2010) Wen Yang et al.   PLOS BIOLOGY

Manipulation of Behavioral Decline in Caenorhabditis elegans with the Rag GTPase raga-1

(2010) Matthew A. Schreiber et al.   PLoS Genetics

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

(2009) Brian M. Zid et al.   CELL

Mechanisms of regulation of RNA polymerase III-dependent transcription by TORC1

(2009) Yuehua Wei et al.   EMBO JOURNAL

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tor Directly Controls the Atg1 Kinase Complex To Regulate Autophagy

(2009) Y. Kamada et al.   MOLECULAR AND CELLULAR BIOLOGY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

An Atg1/Atg13 Complex with Multiple Roles in TOR-mediated Autophagy Regulation

(2009) Yu-Yun Chang et al.   MOLECULAR BIOLOGY OF THE CELL

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

The Vam6 GEF Controls TORC1 by Activating the EGO Complex

(2009) Matteo Binda et al.   MOLECULAR CELL

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

HIF-1 Modulates Dietary Restriction-Mediated Lifespan Extension via IRE-1 in Caenorhabditis elegans

(2009) Di Chen et al.   PLoS Genetics

Increased molecular damage and heterogeneity as the basis of aging

(2008) Suresh I.S. Rattan   BIOLOGICAL CHEMISTRY

Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

(2008) Kristan K. Steffen et al.   CELL

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Caffeine extends yeast lifespan by targeting TORC1

(2008) Valeria Wanke et al.   MOLECULAR MICROBIOLOGY

Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans

(2008) Sakiko Honjoh et al.   NATURE

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE