Article
Immunology
Mingfei Liu, Shirong Li, Ningning Cao, Qingguo Wang, Yuhao Liu, Qianqian Xu, Lin Zhang, Chenghong Sun, Xuefeng Xiao, Jingchun Yao
Summary: This study investigates the relationship between intestinal flora, metabolism, and immunity, and reveals the significant changes in intestinal flora and reduced immune cell abundance in RA mice. The findings provide new therapeutic strategies for RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Yixin Zou, Haifei Yu, Li Zhang, Zheng Ruan
Summary: Vegetable powder supplementation has a positive effect on the intestinal immune homeostasis and microbial community of mice, increasing immunoglobulin concentration and cytokine content. Additionally, it alters the composition of intestinal flora and their metabolites.
Article
Biotechnology & Applied Microbiology
Qilong Chen, Lin Xu, Tinglun Wu, Jian Li, Li Hua
Summary: This study investigated the effect of abnormal intestinal flora on the risk of colorectal cancer and the impact of heparin on bacterial biofilm formation. The results showed significant differences in the number and type of intestinal flora strains between colorectal cancer patients and healthy subjects. The experimental group had higher levels of D-lactic acid and endotoxin, and the amount of biofilm formation increased significantly with higher heparin concentrations. Overall, there is a close relationship between abnormal intestinal flora and the occurrence of colorectal cancer, and heparin may have a positive effect on regulating intestinal flora in colorectal cancer patients, providing valuable insights for the treatment of colorectal cancer.
Article
Medicine, General & Internal
Changhao Dong, Guangxiang Wang, Rui Xian, Chao Li, Shaoxin Wang, Lihong Cui
Summary: Several recent studies have investigated the relationship between atherosclerosis and gut microbial imbalance, specifically small intestinal bacterial overgrowth (SIBO). This study aimed to explore the association between SIBO and subclinical atheromatous plaques. The results showed that SIBO was significantly associated with an increased frequency of plaques in various arterial territories.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Yangyan Yin, Yuying Liao, Jun Li, Zhe Pei, Leping Wang, Yan Shi, Hongyan Peng, Yizhou Tan, Changting Li, Huili Bai, Chunxia Ma, Yu Gong, Tianchao Wei, Hao Peng
Summary: This study found that Lactobacillus plantarum GX17 can be used as a feed additive to improve the growth performance and intestinal barrier function of yellow-feather chickens. It has more positive effects compared to commercial complex probiotics and can benefit the Chinese poultry industry.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Ruibiao Fu, Zhongpeng Li, Rui Zhou, Chaoyang Li, Shuai Shao, Jin Li
Summary: This study found that dysregulation of intestinal flora can lead to decreased diversity of flora, an increase in SERT expression, a decrease in 5-HT levels, resulting in changes in intestinal movement and damage to the mucosal protective barrier, ultimately leading to constipation. Proper regulation of intestinal flora balance, increasing diversity of flora, and reducing opportunistic pathogens can help improve constipation.
Review
Immunology
Alessandra Gurtner, Ignacio Gonzalez-Perez, Isabelle C. Arnold
Summary: Eosinophils, traditionally seen as end-stage effector cells, are now recognized for their highly plastic nature and involvement in various homeostatic processes, particularly in maintaining intestinal barrier function and protecting against bacterial pathogens. Their ability to regulate local immune responses and respond to microbial stimuli underscores their pivotal role in maintaining tissue homeostasis at the intestinal interface.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Yiming Wang, Jiayi Li, Yuanhong Xie, Hongxing Zhang, Junhua Jin, Lixia Xiong, Hui Liu
Summary: The probiotic-fermented herbal blend (PF) treatment was found to prevent death, improve growth performance, regulate intestinal flora, and enhance immune ability in Salmonella pullorum-infected chicks.
Article
Environmental Sciences
Xiao Yun, Jie Zhou, Jiting Wang, Qi Li, Yanji Wang, Wenjing Zhang, Zhicheng Fan
Summary: This study investigated the acute and chronic toxicity of florfenicol (FF) to zebrafish. It found that concentrations of FF exceeding 20 mg/L can cause oxidative damage to fish liver and gill tissues, leading to impaired antioxidant capacity. Severe oxidative stress can activate inflammation and disrupt the immune system. Additionally, exposure to a concentration of 5 mg/L can significantly reduce the diversity and evenness of gut microbiota.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Immunology
Yan-Chun Ji, Qian Sun, Chun-Yan Fu, Xiang She, Xiao-Chen Liu, Yu He, Qing Ai, Lu-Quan Li, Zheng-Li Wang
Summary: The study found that in a mouse model of necrotizing enterocolitis (NEC), exogenous AI-2 partially reversed flora disorder and reduced inflammation levels.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Veterinary Sciences
Yingying Li, Dan Jia, Jiahui Wang, Hehai Li, Xijuan Yin, Junlong Liu, Jinming Wang, Guiquan Guan, Jianxun Luo, Hong Yin, Sa Xiao, Youquan Li
Summary: The study investigated the effects of three probiotic strains on the overall growth performance, immune function, and gut microbiota of mice, showing that these probiotics enhanced growth performance, regulated intestinal mucosa morphology, and influenced the content of immune-related cytokines. In addition, probiotic administration altered the gut microbiota composition in mice, reducing the relative abundance of opportunistic pathogens.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Immunology
Zhen Xiong, Xiaoxiao Zhu, Jingjing Geng, Yuwei Xu, Runyuan Wu, Cunzhen Li, Dongdong Fan, Xiwen Qin, Ying Du, Yong Tian, Zusen Fan
Summary: This study surveyed the acceptance and concerns regarding mRNA vaccines among participants from the United States and China, revealing differences in attitudes between the two countries. The study suggests strengthening public awareness and education to enhance people's knowledge and acceptance of mRNA vaccines.
Review
Biochemistry & Molecular Biology
Xiangdong Yan, Liuhui Bai, Ping Qi, Jin Lv, Xiaojing Song, Lei Zhang
Summary: The intestinal flora plays a crucial role in the occurrence and development of liver cancer, as well as the effectiveness and side effects of conventional antitumor therapy. Immunotherapy has emerged as a promising treatment for advanced liver cancer without surgical options, utilizing immune checkpoint inhibitors, regulators, tumor vaccines, and cellular immunotherapies. The success of immunotherapy varies due to the heterogeneity of liver tumors, and the modulation of intestinal flora can influence its efficacy and side effects. Therefore, manipulating the intestinal flora through probiotics, prebiotics, antibiotics, and fecal transplantation may serve as a valuable adjunct to immunotherapy for liver cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Xuexia Jin, Mengyuan Su, Yunxiang Liang, Yingjun Li
Summary: In this study, it was found that feeding crucian carp with feed containing CGA can enhance their growth performance and immunity, regulate intestinal microbial activity, improve antioxidant capacity, and reduce triglyceride content. CGA also promotes the expression of lipid metabolism-related genes in the liver and enhances the relative abundance of beneficial intestinal bacteria. These findings highlight the significance of developing and using CGA as a natural and non-toxic feed additive.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Plant Sciences
Qingqing Chen, Rongrong Ren, Qingqing Zhang, Jingjing Wu, Yufeng Zhang, Mingsong Xue, Dengke Yin, Ye Yang
Summary: This study aimed to explore the dynamic regulation of Coptis chinensis Franch polysaccharides on intestinal microenvironment from the perspective of intestinal mucosal immunity and intestinal flora. The results showed that CCP had effective, dynamic, and dose-dependent regulations on intestinal microenvironment, impacting both intestinal flora and immune responses. These findings contribute to understanding the pharmacological mechanisms of Coptis chinensis Franch.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)