ERAD ubiquitin ligases

The role of MRH domain-containing lectins in ERAD

(2010) N. Hosokawa et al.   GLYCOBIOLOGY

Modularity of the Hrd1 ERAD complex underlies its diverse client range

(2010) Kazue Kanehara et al.   JOURNAL OF CELL BIOLOGY

Stringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LSsubstrates

(2010) Riccardo Bernasconi et al.   JOURNAL OF CELL BIOLOGY

Loss of HRD1-Mediated Protein Degradation Causes Amyloid Precursor Protein Accumulation and Amyloid-  Generation

(2010) M. Kaneko et al.   JOURNAL OF NEUROSCIENCE

RNF-121 Is an Endoplasmic Reticulum-Membrane E3 Ubiquitin Ligase Involved in the Regulation of β-Integrin

(2010) Amir Darom et al.   MOLECULAR BIOLOGY OF THE CELL

Huntingtin Interacts with the Cue Domain of gp78 and Inhibits gp78 Binding to Ubiquitin and p97/VCP

(2010) Hui Yang et al.   PLoS One

Targeting of gp78 for ubiquitin-mediated proteasomal degradation by Hrd1: Cross-talk between E3s in the endoplasmic reticulum

(2009) Ayelet Shmueli et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein transport across the peroxisomal membrane

(2009) Wolfgang Girzalsky et al.   BIOLOGICAL CHEMISTRY

Glycoprotein folding, quality control and ER-associated degradation

(2009) Gerardo Z Lederkremer   CURRENT OPINION IN STRUCTURAL BIOLOGY

Sec61p is part of the endoplasmic reticulum-associated degradation machinery

(2009) Antje Schäfer et al.   EMBO JOURNAL

An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid β-protein

(2009) Tomoji Maeda et al.   FEBS Journal

The Ubiquitin Ligase RNF5 Regulates Antiviral Responses by Mediating Degradation of the Adaptor Protein MITA

(2009) Bo Zhong et al.   IMMUNITY

Differential regulation of CFTRΔF508 degradation by ubiquitin ligases gp78 and Hrd1

(2009) Petek Ballar et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Usa1p Is Required for Optimal Function and Regulation of the Hrd1p Endoplasmic Reticulum-associated Degradation Ubiquitin Ligase

(2009) Sarah M. Carroll et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human OS-9, a Lectin Required for Glycoprotein Endoplasmic Reticulum-associated Degradation, Recognizes Mannose-trimmedN-Glycans

(2009) Nobuko Hosokawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER

(2009) Helen R. Stagg et al.   JOURNAL OF CELL BIOLOGY

Htm1 protein generates the N-glycan signal for glycoprotein degradation in the endoplasmic reticulum

(2009) Simone Clerc et al.   JOURNAL OF CELL BIOLOGY

The mammalian UPR boosts glycoprotein ERAD by suppressing the proteolytic downregulation of ER mannosidase I

(2009) D. J. Termine et al.   JOURNAL OF CELL SCIENCE

The E3 Ubiquitin Ligase TEB4 Mediates Degradation of Type 2 Iodothyronine Deiodinase

(2009) A. M. Zavacki et al.   MOLECULAR AND CELLULAR BIOLOGY

Intrinsic Conformational Determinants Signal Protein Misfolding to the Hrd1/Htm1 Endoplasmic Reticulum–associated Degradation System

(2009) Wei Xie et al.   MOLECULAR BIOLOGY OF THE CELL

The E3 Ubiquitin Ligases Hrd1 and gp78 Bind to and Promote Cholera Toxin Retro-Translocation

(2009) Kaleena M. Bernardi et al.   MOLECULAR BIOLOGY OF THE CELL

EDEM1 Recognition and Delivery of Misfolded Proteins to the SEL1L-Containing ERAD Complex

(2009) James H. Cormier et al.   MOLECULAR CELL

Usa1 Functions as a Scaffold of the HRD-Ubiquitin Ligase

(2009) Sabine C. Horn et al.   MOLECULAR CELL

Misfolded Membrane Proteins Are Specifically Recognized by the Transmembrane Domain of the Hrd1p Ubiquitin Ligase

(2009) Brian K. Sato et al.   MOLECULAR CELL

The ubiquitylation machinery of the endoplasmic reticulum

(2009) Christian Hirsch et al.   NATURE

Usa1 Protein Facilitates Substrate Ubiquitylation through Two Separate Domains

(2009) Ikjin Kim et al.   PLoS One

N-glycan structures: recognition and processing in the ER

(2009) Markus Aebi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ubiquitin ligase Kf-1 is involved in the endoplasmic reticulum-associated degradation pathway

(2008) Yoshiaki Maruyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48p

(2008) Veit Goder et al.   FEBS LETTERS

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1

(2008) H. Nishitoh et al.   GENES & DEVELOPMENT

A Dual Task for the Xbp1-responsive OS-9 Variants in the Mammalian Endoplasmic Reticulum

(2008) Riccardo Bernasconi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sec61p Is Required for ERAD-L

(2008) Martin Willer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gp78 Cooperates with RMA1 in Endoplasmic Reticulum-associated Degradation of CFTRΔF508

(2008) Daisuke Morito et al.   MOLECULAR BIOLOGY OF THE CELL

Defining the Glycan Destruction Signal for Endoplasmic Reticulum-Associated Degradation

(2008) Erin M. Quan et al.   MOLECULAR CELL

OS-9 and GRP94 deliver mutant α1-antitrypsin to the Hrd1–SEL1L ubiquitin ligase complex for ERAD

(2008) John C. Christianson et al.   NATURE CELL BIOLOGY

SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins

(2008) B. Mueller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Derlin-1 Facilitates the Retro-Translocation of Cholera Toxin

(2007) Kaleena M. Bernardi et al.   MOLECULAR BIOLOGY OF THE CELL