Article
Multidisciplinary Sciences
Abhilasha Srivastava, Harshita Sharma, Shibasish Chowdhury, Rajdeep Chowdhury, Sudeshna Mukherjee
Summary: Hepatocellular carcinoma (HCC) often develops under inflammatory conditions with various cytokines present. Transforming growth factor-beta (TGF-beta) is a major cytokine in the tumor environment and is involved in promoting epithelial to mesenchymal transition (EMT) in tumor cells. However, the cellular events and molecular regulation of TGF-beta-induced EMT are still unclear. In this study, HCC cells were treated with TGF-beta and it was found that EMT induced by TGF-beta is associated with cytostasis and altered cellular metabolism. TGF-beta down-regulates cell cycle-associated transcripts and metabolic genes through epigenetic silencing, and this process is mediated by TGF-beta downstream signaling mediator-SMAD and chromatin repressive complex member-EZH2.
Article
Medicine, Research & Experimental
Junju Zou, Xiaotao Zhou, Yuerong Ma, Rong Yu
Summary: The genesis and development of renal fibrosis involve various pathways related to inflammation, cytokines, oxidative stress, and metabolic abnormalities. Losartan, as a medication, can reduce renal fibrosis by regulating the TGF-beta/Smad and metabolic pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Heng Shi, Jinbo Xie, Keyi Wang, Weiyi Li, Lei Yin, Guangchun Wang, Zonglin Wu, Jinliang Ni, Weipu Mao, Changcheng Guo, Bo Peng
Summary: This study identified LINC01451 as a functional lncRNA with significantly higher expression in BLCa tissues compared to normal tissues. LINC01451 was found to directly interact with LIN28A and LIN28B, promoting proliferation, invasion, and metastasis of BLCa. Mechanistically, LINC01451 was shown to facilitate epithelial-mesenchymal transition through activating the TGF-beta/Smad signaling pathway, leading to the progression of BLCa.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Tianxiao Sun, Haihua Li, Yan Zhang, Guixin Xiong, Yuerun Liang, Fang Lu, Rong Zheng, Qi Zou, Jiejie Hao
Summary: In this study, it was found that DGM could inhibit TGF-beta 1-induced EMT in A549 cells and bleomycin-induced pulmonary fibrosis in rats. Furthermore, DGM treatment improved lung function, reduced lung inflammation and fibrosis, and decreased collagen deposition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pathology
Hailang Zhou, Junwei Zou, Changjiang Shao, Aijun Zhou, Jiufeng Yu, Song Chen, Chunfang Xu
Summary: The study showed that P4HA3 promotes human colon cancer growth and metastasis by affecting the TGF-beta/Smad signaling pathway. P4HA3 knockdown significantly decreased migration, proliferation, and invasion abilities of colon cancer cells, while overexpression had the opposite effect. Additionally, P4HA3 can serve as a potential new target for early diagnosis, treatment, and prognosis assessment of colon cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
Hsin-Yi Chen, Shu-Jou Chan, Xinxin Liu, An-Chi Wei, Ru-In Jian, Kuan-Wei Huang, Yaw-Dong Lang, Jou-Ho Shih, Chun-Chieh Liao, Chiu-Lin Luan, Yu-Tung Kao, Shang-Yin Chiang, Pei-Wen Hsiao, Yuh-Shan Jou, Yunching Chen, Ruey-Hwa Chen
Summary: This study identifies the lncRNA Smyca as an oncogene that promotes poor prognosis in multiple cancer types. Smyca enhances tumor metabolic reprogramming, migration, invasion, cancer stemness, metastasis, and chemoresistance by potentiating TGF-beta/Smad signaling and c-Myc-mediated transcription. Targeting Smyca prevents metastasis and overcomes chemoresistance.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Oncology
Fan Feng, Zongqing Zhao, Xuechang Cai, Xueyuan Heng, Ximeng Ma
Summary: This study identifies CKS2 as a critical contributor to the development of gliomas, suggesting that it may serve as a novel therapeutic target for inhibiting the spread and infiltration of glioma.
Article
Cell Biology
Xinyuan Liu, Jian Xu, Bingbing Shen, Jichuan Xu, Jianxin Jiang
Summary: Pancreatic cancer (PC) is the fourth leading cause of cancer-related death worldwide, with a survival rate below 5%. Abnormal proliferation and distant metastasis are major challenges for the diagnosis and treatment of PC, making it crucial for researchers to understand the molecular mechanisms underlying PC proliferation and metastasis. This study found that USP33, a member of the deubiquitinating enzyme family, is upregulated in PC samples and cells, and its high expression is associated with poor prognosis. Functional experiments showed that USP33 overexpression promotes PC cell proliferation, migration, and invasion, while inhibition of USP33 has the opposite effect. The study also identified TGFBR2 as a potential binding protein of USP33 and revealed a positive feedback loop between USP33 and the TGF-beta signaling pathway.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Wenyu Chen, Ye Zhang, Zhixian Fang, Weibo Qi, Yufen Xu
Summary: This study investigated the regulatory function and underlying mechanism of TRIM66 in non-small cell lung cancer (NSCLC). The results showed that TRIM66 and MMP9 were highly expressed in NSCLC cells and tissues, and the high level of TRIM66 was correlated with metastasis. Silencing TRIM66 inhibited proliferation, migration, and invasion of NSCLC cells, while forced expression of TRIM66 had the opposite effect. TRIM66 regulated the expression of MMP9 and modulated the TGF-beta/SMAD pathway, thereby facilitating the malignant progression of NSCLC.
Review
Oncology
Tong-tong Li, Yong-wei Lai, Xu Han, Xin Niu, Peng-xia Zhang
Summary: This article comprehensively summarizes the regulatory role and molecular mechanisms of bone morphogenetic protein 2 (BMP2) in tumorigenesis and development. Research has found that BMP2 plays important roles in cancer cell differentiation, proliferation, survival, and apoptosis, and may serve as an effective therapeutic target for cancer and a new marker for assessing treatment efficacy.
INVESTIGATIONAL NEW DRUGS
(2022)
Article
Respiratory System
Cailing Gan, Qianyu Zhang, Hongyao Liu, Guan Wang, Liqun Wang, Yali Li, Zui Tan, Wenya Yin, Yuqin Yao, Yongmei Xie, Liang Ouyang, Luoting Yu, Tinghong Ye
Summary: Nifuroxazide (NIF) shows potential as a treatment option for idiopathic pulmonary fibrosis (IPF) by inhibiting and reversing the development of pulmonary fibrosis. The findings of this study are important for exploring pharmaceutical treatments for pulmonary fibrosis.
RESPIRATORY RESEARCH
(2022)
Article
Cell Biology
Chenglai Dong, Kaiqin Wu, Shaorui Gu, Wenli Wang, Shiliang Xie, Yongxin Zhou
Summary: The study revealed the critical role of PTBP3 in LUAD, with its high expression associated with poor prognosis. PTBP3 mediates TGF-beta-induced EMT and metastasis by activating the Smad pathway for transcription. This research provides a new potential therapeutic target for the treatment of LUAD.
Review
Cell Biology
Ji-Ung Jung, Ankita B. Jaykumar, Melanie H. Cobb
Summary: In this review, the role of WNK1 in tumor malignancy, metastasis, angiogenesis, and mesenchymal transition is discussed, providing evidence for its unique association with a subset of invasive cancers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Yuxuan Li, Pan Wang, Dongmei Ye, Xue Bai, Xuemei Zeng, Qiang Zhao, Zhiwei Zhang
Summary: This study investigated the expression of IGHG1 in gastric cancer and its effects on the proliferation, migration, invasion, and EMT of gastric cancer SGC7901 cells. High expression of IGHG1 was found in gastric cancer tissues, promoting cell proliferation, migration, and invasion. Low expression of IGHG1 reduced EMT-related protein expression and induced EMT in SGC7901 cells through the TGF-beta/SMAD3 signaling pathway.
Review
Medicine, General & Internal
Masao Saitoh
Summary: Epithelial-mesenchymal transition (EMT) plays a crucial role in cancer progression, associated with invasion, metastasis, generation of tumor stem cells, and resistance to therapy. Transforming growth factor (TGF)-beta acts as a key mediator in the EMT process, initiating and maintaining EMT through signaling pathways and transcription factors.
