Developing imidazole analogues as potential inhibitor forLeishmania donovanitrypanothione reductase: virtual screening, molecular docking, dynamics and ADMET approach

Dibenzosuberyl substituted polyamines and analogs of clomipramine as effective inhibitors of trypanothione reductase; molecular docking, and assessment of trypanocidal activities

(2015) Mary C. O’Sullivan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Arsenic Exposure and Outcomes of Antimonial Treatment in Visceral Leishmaniasis Patients in Bihar, India: A Retrospective Cohort Study

(2015) Meghan R. Perry et al.   PLoS Neglected Tropical Diseases

Molecular Mechanisms of In vitro Betulin-Induced Apoptosis of Leishmania donovani

(2014) Prakash Saudagar et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Investigational drugs for visceral leishmaniasis

(2014) Shyam Sundar et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Treatment options for second-stage gambiense human African trypanosomiasis

(2014) Gilles Eperon et al.   Expert Review of Anti-Infective Therapy

Nitroimidazo-oxazole compound DNDI-VL-2098: an orally effective preclinical drug candidate for the treatment of visceral leishmaniasis

(2014) Suman Gupta et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Best of Both Worlds: Combining Pharma Data and State of the Art Modeling Technology To Improve in Silico pKa Prediction

(2014) Robert Fraczkiewicz et al.   Journal of Chemical Information and Modeling

Randomized Trial of Posaconazole and Benznidazole for Chronic Chagas' Disease

(2014) Israel Molina et al.   NEW ENGLAND JOURNAL OF MEDICINE

In vitro Susceptibility of Leishmania donovani to Miltefosine in Indian Visceral Leishmaniasis

(2013) Vijay Kumar Prajapati et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Increasing Failure of Miltefosine in the Treatment of Kala-azar in Nepal and the Potential Role of Parasite Drug Resistance, Reinfection, or Noncompliance

(2013) Suman Rijal et al.   CLINICAL INFECTIOUS DISEASES

Molecular mechanism underlying antileishmanial effect of oxabicyclo[3.3.1]nonanones: Inhibition of key redox enzymes of the pathogen

(2013) Prakash Saudagar et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Evaluation of a diospyrin derivative as antileishmanial agent and potential modulator of ornithine decarboxylase of Leishmania donovani

(2013) Sudipta Hazra et al.   EXPERIMENTAL PARASITOLOGY

Structure prediction of gBP21 protein ofL. donovaniand its molecular interaction

(2013) Ganesh Chandra Sahoo et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Docking and in silico ADMET studies of noraristeromycin, curcumin and its derivatives with Plasmodium falciparum SAH hydrolase: A molecular drug target against malaria

(2013) Dev Bukhsh Singh et al.   Interdisciplinary Sciences-Computational Life Sciences

In vitro Antileishmanial Drug Susceptibility of Clinical Isolates from Patients with Indian Visceral Leishmaniasis—Status of Newly Introduced Drugs

(2012) Vijay Kumar Prajapati et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Assessing the Essentiality of Leishmania donovani Nitroreductase and Its Role in Nitro Drug Activation

(2012) S. Wyllie et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Management of trypanosomiasis and leishmaniasis

(2012) M. P. Barrett et al.   BRITISH MEDICAL BULLETIN

Efficacy of Miltefosine in the Treatment of Visceral Leishmaniasis in India After a Decade of Use

(2012) S. Sundar et al.   CLINICAL INFECTIOUS DISEASES

Mechanistic insights into the dual inhibition strategy for checking Leishmaniasis

(2012) Abhinav Grover et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Leishmaniasis Worldwide and Global Estimates of Its Incidence

(2012) Jorge Alvar et al.   PLoS One

The Anti-Trypanosome Drug Fexinidazole Shows Potential for Treating Visceral Leishmaniasis

(2012) S. Wyllie et al.   Science Translational Medicine

Molecular Docking and in Vitro Antileishmanial Evaluation of Chromene-2-thione Analogues

(2012) Rajiv Kumar Verma et al.   ACS Medicinal Chemistry Letters

Targeted killing of Leishmania donovani in vivo and in vitro with amphotericin B attached to functionalized carbon nanotubes

(2011) V. K. Prajapati et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Evaluation of plumbagin and its derivative as potential modulators of redox thiol metabolism of Leishmania parasite

(2011) Neha Sharma et al.   PARASITOLOGY RESEARCH

Visceral Leishmaniasis and Arsenic: An Ancient Poison Contributing to Antimonial Treatment Failure in the Indian Subcontinent?

(2011) Meghan R. Perry et al.   PLoS Neglected Tropical Diseases

Molecular docking studies of selected tricyclic and quinone derivatives on trypanothione reductase ofLeishmania infantum

(2010) Santhosh Kannan Venkatesan et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Ligand docking and binding site analysis with PyMOL and Autodock/Vina

(2010) Daniel Seeliger et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Efficient Drug Lead Discovery and Optimization

(2009) William L. Jorgensen   ACCOUNTS OF CHEMICAL RESEARCH

Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis

(2009) John L. Richardson et al.   ChemMedChem

The poorest of the poor: a poverty appraisal of households affected by visceral leishmaniasis in Bihar, India

(2009) M. Boelaert et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors

(2008) Betty C. Galarreta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Benchmarking the Reliability of QikProp. Correlation between Experimental and Predicted Values

(2007) Leukothea Ioakimidis et al.   Quantitative structure-activity relationships & combinatorial science