Article
Immunology
Chunchen Wu, Luzhi Zeng, Wenfu Yi, Yuanjiu Miao, Yihan Liu, Qiming Wang, Shi Liu, Guoping Peng, Zhenhua Zheng, Jianbo Xia
Summary: This study demonstrates that echovirus infection can induce autophagy, which promotes viral replication and VP1 expression in host cells. The mechanism involves the regulation of the mTOR/ULK1 signaling pathway, providing insight into the potential role of autophagy in echovirus infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Darshini Kuruppu, Deepak Bhere, Christian T. Farrar, Khalid Shah, Anna-Liisa Brownell, Umar Mahmood Umar Mahmood, Kenneth K. Tanabe
Summary: This study investigates the therapeutic efficacy of oncolytic Herpes simplex virus 1 (HSV1) on different stages of breast cancer leptomeningeal metastases growth. The results show that targeting the lag and intermediate phases of the disease can inhibit tumor growth, delay symptoms onset, and extend survival.
CANCER GENE THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Zhi Zhu, A. J. Robert McGray, Weijian Jiang, Binfeng Lu, Pawel Kalinski, Zong Sheng Guo
Summary: Oncolytic viruses (OVs) are a new class of multi-modal immunotherapies for cancer, with the key to their effectiveness being the immune response they elicit. However, the clinical effectiveness of OV as a monotherapy is limited, leading researchers to explore combinations with other anti-cancer agents. The signaling pathways in cancer and immune cells offer promising targets for rational cancer therapy design. Small molecule modulators of these pathways have shown potential in enhancing anti-tumor immunity.
Review
Virology
Bangxing Hong, Upasana Sahu, Matthew P. Mullarkey, Balveen Kaur
Summary: Oncolytic herpes simplex virus (oHSV) shows promise as a treatment for solid tumors, but there are still barriers that limit its efficacy. This review focuses on the essential viral genes that allow for virus replication and spread, with the aim of enhancing oHSV infection and replication among tumor cells.
Article
Chemistry, Medicinal
Yanrong Zhou, Qianpeng Wang, Qi Ying, Xiaomei Zhang, Ting Ye, Kan Chen, Gongchu Li
Summary: This study compares the efficacy of oncolytic vaccinia viruses carrying different marine lectins in breast cancer cells and finds that oncoVV-AVL shows the highest anti-tumor effect. Further studies show that apoptosis and replication can enhance the cytotoxicity of oncoVV-lectins, but the mechanisms differ in different cell types.
Article
Multidisciplinary Sciences
Marie-Eve Wedge, Victoria A. Jennings, Mathieu J. F. Crupi, Joanna Poutou, Taylor Jamieson, Adrian Pelin, Giuseppe Pugliese, Christiano Tanese de Souza, Julia Petryk, Brian J. Laight, Meaghan Boileau, Zaid Taha, Nouf Alluqmani, Hayley E. McKay, Larissa Pikor, Sarwat Tahsin Khan, Taha Azad, Reza Rezaei, Bradley Austin, Xiaohong He, David Mansfield, Elaine Rose, Emily E. F. Brown, Natalie Crawford, Almohanad Alkayyal, Abera Surendran, Ragunath Singaravelu, Dominic G. Roy, Gemma Migneco, Benjamin McSweeney, Mary Lynn Cottee, Egon J. Jacobus, Brian A. Keller, Takafumi N. Yamaguchi, Paul C. Boutros, Michele Geoffrion, Katey J. Rayner, Avijit Chatterjee, Rebecca C. Auer, Jean-Simon Diallo, Derrick Gibbings, Benjamin R. tenOever, Alan Melcher, John C. Bell, Carolina S. Ilkow
Summary: This study identifies an artificial microRNA (amiR-4) that enhances the anticancer potency of oncolytic viruses and promotes bystander killing of uninfected cancer cells through the intercellular transfer of extracellular vesicles. These findings suggest that oncolytic viruses can serve as replicating vehicles for amiRNA therapeutics, potentially in combination with other treatment modalities.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Wencai Qiu, Xiuyan Ding, Shitao Li, Yongming He, Liqian Zhu
Summary: The study demonstrates that BoHV-1 has oncolytic effects against human lung adenocarcinoma in vivo. BoHV-1 infection reduced HDAC protein levels in A549 cells and showed synergy with the HDAC inhibitor TSA. In the mouse xenograft model, BoHV-1 effectively infected tumors and suppressed tumor growth, potentially through interaction with HDACs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Sarah Dellac, Hamutal Ben-Dov, Ayala Raanan, Hanna Saleem, Rachel Zamostiano, Rinat Semyatich, Sara Lavi, Isaac P. Witz, Eran Bacharach, Marcelo Ehrlich
Summary: STAT1 is a critical mediator of IFN signaling and antiviral responses, with its expression correlating with >700 genes in melanoma patient samples. Oncolytic virus EHDV-TAU targets melanomas with low STAT1 expression and reverses this deficiency using epigenetic modifiers, while inducing immune-stimulatory responses.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Wei-Che Yen, Qiao-Zhu Li, Li-Hsien Wu, Wei-Ya Lee, Wen-Wei Chang, Peng-Ju Chien, Che-Hsin Lee
Summary: EpCAM plays a crucial role in tumor metastasis and progression by regulating epithelial-mesenchymal transition and inducing stem cell-like phenotype. Salmonella-based treatments show potential in inhibiting tumor metastasis through downregulation of EpCAM and inhibition of the AKT/mTOR signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Microbiology
Chasity E. Trammell, Gabriela Ramirez, Irma Sanchez-Vargas, Laura A. St Clair, Oshani C. Ratnayake, Shirley Luckhart, Rushika Perera, Alan G. Goodman
Summary: This study demonstrates that targeting insulin signaling through the repurposing of small molecule drugs can effectively reduce viral replication and transmission of Zika virus. Activation of RNAi and JAK/STAT antiviral pathways by insulin signaling leads to a significant reduction in virus levels in mosquitoes. The findings suggest a potential field delivery approach to reduce virus transmission from mosquitoes to humans.
Article
Biotechnology & Applied Microbiology
Timo Oosenbrug, Diana J. M. van den Wollenberg, Eline W. Duits, Rob C. Hoeben, Maaike E. Ressing
Summary: Oncolytic viruses selectively infect and kill tumor cells while triggering immune responses that boost anticancer immunity. Successful oncolytic virotherapy relies on tightly controlled levels of IFN-I, which requires understanding when and how tumor cells induce IFN-I in response to specific viruses.
HUMAN GENE THERAPY
(2021)
Article
Microbiology
Shuang Jiao, Changyao Li, Hongyang Liu, Mengdi Xue, Qiongqiong Zhou, Longfeng Zhang, Xiaohong Liu, Chunying Feng, Guangqiang Ye, Jia Liu, Jiangnan Li, Li Huang, Tao Xiong, Zhaoxia Zhang, Changjiang Weng
Summary: Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly contagious pathogen that causes significant economic losses to the swine industry worldwide. The nonstructural protein 4 (Nsp4) of PRRSV is shown to inhibit the activation of the nuclear transcription factor kappa B (NF-kappa B) signaling pathway by cleaving the inhibitor kappa B kinase beta (IKK beta). The cleavage of IKK beta by PRRSV Nsp4 is dependent on its 3C-like serine protease activity.
VETERINARY MICROBIOLOGY
(2023)
Review
Cell Biology
Zhengfu He, Peter J. Houghton, Terence M. Williams, Changxian Shen
Summary: Accurate and complete DNA replication and separation are crucial for genetic information inheritance and organism maintenance. Errors in DNA duplication are the main source of genetic instability and understanding DNA duplication regulation is essential for elucidating mechanisms and finding treatment strategies for human genetic disorders, especially cancer. The mechanistic target of rapamycin (mTOR) plays a central role in cell growth and proliferation by monitoring cell physiology, and its dysregulation is associated with various human diseases, including cancer and diabetes. Emerging evidence suggests that mTOR signaling is key in regulating DNA replication, including origin licensing, replication fork progression, and stabilization.
Article
Biochemistry & Molecular Biology
Yanrong Zhou, Qianpeng Wang, Qi Ying, Xiaomei Zhang, Kan Chen, Ting Ye, Gongchu Li
Summary: This study evaluated the cytotoxic effects of oncolytic vaccinia viruses (oncoVV) carrying different lectins on hepatocellular carcinoma (HCC). Results showed that oncoVV-AVL exhibited the highest cytotoxicity, while oncoVV-APL showed no effect. Further research revealed that AVL may promote oncoVV replication through multiple pathways in a cell-dependent manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Dandan Qiao, Qian He, Xiaowei Cheng, Yongxiu Yao, Venugopal Nair, Hongxia Shao, Aijian Qin, Kun Qian
Summary: This study investigated the role of the Wnt/beta-catenin signaling pathway during avian leukosis virus subgroup J (ALV-J) infection. The results showed that activation of this pathway increased viral replication, while inhibition significantly reduced virus titer and gene expression.
Article
Cell Biology
Dae-Hee Lee, Daeho Kim, Sung Tae Kim, Soyeon Jeong, Jung Lim Kim, Sang Mi Shim, Ah Jung Heo, Xinxin Song, Zong Sheng Guo, David L. Bartlett, Sang Cheul Oh, Junho Lee, Yoshiro Saito, Bo Yeon Kim, Yong Tae Kwon, Yong J. Lee
Article
Biotechnology & Applied Microbiology
Stacy J. Kowalsky, Zuqiang Liu, Mathilde Feist, Sara E. Berkey, Congrong Ma, Roshni Ravindranathan, Enyong Dai, Edward J. Roy, Zong Sheng Guo, David L. Bartlett
Review
Oncology
Zong Sheng Guo, Binfeng Lu, Zongbi Guo, Esther Giehl, Mathilde Feist, Enyong Dai, Weilin Liu, Walter J. Storkus, Yukai He, Zuqiang Liu, David L. Bartlett
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2019)
Article
Oncology
Bingtao Tang, Zong Sheng Guo, David L. Bartlett, David Z. Yan, Claire P. Schane, Diana L. Thomas, Jia Liu, Grant McFadden, Joanna L. Shisler, Edward J. Roy
CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Yan Ge, Haiyan Wang, Jinghua Ren, Weilin Liu, Lingjuan Chen, Hongqi Chen, Junjie Ye, Enyong Dai, Congrong Ma, Songguang Ju, Zong Sheng Guo, Zuqiang Liu, David L. Bartlett
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Oncology
Fan Sun, Zong Sheng Guo, Alyssa D. Gregory, Steven D. Shapiro, Gutian Xiao, Zhaoxia Qu
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Biotechnology & Applied Microbiology
Mathilde Feist, Zhi Zhu, Enyong Dai, Congrong Ma, Zuqiang Liu, Esther Giehl, Roshni Ravindranathan, Stacy J. Kowalsky, Natasa Obermajer, Udai S. Kammula, Andrew J. H. Lee, Michael T. Lotze, Zong Sheng Guo, David L. Bartlett
Summary: The use of oncolytic virus (OV) can stimulate tumor-specific TIL, which show significant therapeutic effects in experiments after expansion, providing a potential option for adoptive cell therapy (ACT) for solid tumors.
CANCER GENE THERAPY
(2021)
Article
Oncology
Weilin Liu, Enyong Dai, Zuqiang Liu, Congrong Ma, Zong Sheng Guo, David L. Bartlett
MOLECULAR THERAPY-ONCOLYTICS
(2020)
Review
Biochemistry & Molecular Biology
Zong Sheng Guo, Michael T. Lotze, Zhi Zhu, Walter J. Storkus, Xiao-Tong Song
Editorial Material
Oncology
Zong-Sheng Guo
ANNALS OF TRANSLATIONAL MEDICINE
(2020)
Editorial Material
Biochemistry & Molecular Biology
Zong-Sheng Guo
Review
Biochemistry & Molecular Biology
Enyong Dai, Zhi Zhu, Shudipto Wahed, Zhaoxia Qu, Walter J. Storkus, Zong Sheng Guo
Summary: Epigenetic mechanisms play important roles in cancer initiation and immune cell function, with the potential to impact tumor microenvironment and therapeutic efficacy by modulating immune cell populations and promoting transcriptional and metabolic reprogramming. By regulating immune-associated genes and immune checkpoint molecules, epigenetic modulating agents can enhance tumor immunogenicity and facilitate anti-tumor immune responses.
Article
Biochemistry & Molecular Biology
Weilin Liu, Hongqi Chen, Zhi Zhu, Zuqiang Liu, Congrong Ma, Yong J. Lee, David L. Bartlett, Zong-Sheng Guo
Summary: The study found that the combination of the ferroptosis activator Erastin with the oncolytic vaccinia virus could effectively inhibit tumor growth, prolong host survival, and enhance antitumoral immunity in hepatocellular carcinoma and colon cancer models.
Meeting Abstract
Oncology
Bingtao Tang, Zong Sheng Guo, David L. Bartlett, David Yan, Claire P. Schane, Jia Liu, Grant McFadden, Joanna L. Shisler, Edward J. Roy
Meeting Abstract
Biotechnology & Applied Microbiology
Mathilde Feist, Zuqiang Liu, Esther Giehl, Congrong Ma, Udai Kammula, Zong Sheng Guo, David L. Bartlett