Review
Cell Biology
Linchong Sun, Huafeng Zhang, Ping Gao
Summary: Metabolic rewiring and epigenetic remodeling, which are closely linked in cancer development, play important roles in tumor progression and immune escape. Metabolites can affect the function of chromatin-modifying enzymes, influencing processes such as tumor progression and immunosurveillance.
Article
Oncology
Diego M. Avella Patino, Vijay Radhakrishnan, Kanve N. Suvilesh, Yariswamy Manjunath, Guangfu Li, Eric T. Kimchi, Kevin F. Staveley-O'Carroll, Wesley C. Warren, Jussuf T. Kaifi, Jonathan B. Mitchem
Summary: This review article summarizes the role of epigenetic regulation in immune response in a wide range of cancers, including the epigenetic changes in immune cells such as T cells, macrophages, and natural killer cells.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xuemeng Xu, Qiu Peng, Xianjie Jiang, Shiming Tan, Yiqing Yang, Wenjuan Yang, Yaqian Han, Yuyu Chen, Linda Oyang, Jinguan Lin, Longzheng Xia, Mingjing Peng, Nayiyuan Wu, Yanyan Tang, Jinyun Li, Qianjin Liao, Yujuan Zhou
Summary: Cancer: Epigenetic changes alter tumor metabolism by modifying gene expression. Metabolic reprogramming and epigenetic modifications are key features of cancer cells. Understanding the mechanisms behind these modifications is crucial for understanding tumor pathogenesis. The latest research has shown that changes in glucose, lipid, and amino acid metabolism, as well as epigenetic modifications such as DNA methylation and histone lactylation, play significant roles in tumor growth and progression, opening up potential therapeutic strategies for cancer treatment.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Aleksandra Lopez Krol, Hannah P. Nehring, Felix F. Krause, Anne Wempe, Hartmann Raifer, Andrea Nist, Thorsten Stiewe, Wilhelm Bertrams, Bernd Schmeck, Maik Luu, Hanna Leister, Ho-Ryun Chung, Uta-Maria Bauer, Till Adhikary, Alexander Visekruna
Summary: This study indicates that lactate can induce changes in the gene expression program of Th17 cells by modulating their metabolism and epigenetic status, resulting in a shift in their function.
Review
Immunology
Liangjie Xu, Cuicui Zhou, Yi Liang, Tinpan Fan, Fen Zhang, Xinxin Chen, Wei Yuan
Summary: This article reviews the interaction between epigenetic modifications and the functions of myeloid-derived suppressor cells (MDSCs), and briefly introduces how the accumulation and function of MDSCs caused by epigenetic modifications impact disease development, providing a promising therapeutic strategy for related disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhiming Li, Xinzong Zhang, Shiming Xie, Xingping Liu, Caifeng Fei, Xunbin Huang, Yunge Tang, Li-quan Zhou
Summary: This study reveals the important role of Nuclear receptor binding SET domain protein 2 (Nsd2) in spermatogenesis. The loss of Nsd2 leads to apoptosis and abnormal development of spermatogenic cells, as well as dysregulation of genes and histone modifications. Furthermore, Nsd2 deficiency results in the retention of histones and increased protamine proteins in spermatozoa. These findings uncover the involvement of Nsd2 in chromatin remodeling during spermatogenesis and provide insights into the molecular mechanisms of epigenetic abnormalities affecting male reproductive health.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Lirui Wang, Chunlei Zhang, Yuping Hong, Xinhong Li, Tangan Li, Ang Gao, Shaojun Pan, Bin Liu, Han Jin, Daxiang Cui
Summary: The study developed a method of combinatorial delivery of epigenetic modulatory drugs through self-assembly, effectively regulating DNA methylation and histone deacetylation, ultimately inhibiting tumor cell proliferation and promoting cell apoptosis.
Review
Genetics & Heredity
Tahereh Hojjatipour, Amirhosein Maali, Mehdi Azad
Summary: Natural killer (NK) cells are critical in fighting against early-stage cancers. NK cell development is tightly regulated by genetic and epigenetic factors. Cancer cells use epigenetic modifications to suppress NK cell activity, but these modifications are reversible and can be used to activate NK cells against cancers.
Review
Plant Sciences
Jun-Li Wang, Dong-Wei Di, Pan Luo, Li Zhang, Xiao-Feng Li, Guang-Qin Guo, Lei Wu
Summary: This review focuses on the molecular mechanisms through which epigenetic modifications regulate auxin biosynthesis, demonstrating that complex signaling pathways affect gene expression and subsequently protein production.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Qiong Wu, Anders E. Berglund, Arnold B. Etame
Summary: Glioblastoma is highly resistant to standard therapies and the durability of response to the best chemotherapy agent, Temozolomide, is often short-lived due to tumor resistance. The need for therapies that can provide synergy to chemoradiation is urgent, as adaptive resistance evolution in GBM is facilitated through treatment-induced epigenetic modifications. Understanding and targeting these epigenetic modifications associated with GBM resistance is a top priority.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Environmental Sciences
Arijit Chakraborty, Soma Ghosh, Bratisha Biswas, Sreemanta Pramanik, Jerome Nriagu, Subhamoy Bhowmick
Summary: Arsenic exposure can cause harmful epigenetic alterations, leading to various health complications. This review summarizes the mechanisms underlying arsenic-induced epigenetic changes and proposes therapeutic strategies to alleviate the global burden of arsenic poisoning.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Biochemistry & Molecular Biology
Jesus Porcuna, Jorge Minguez-Martinez, Mercedes Ricote
Summary: PPARs are ligand-modulated nuclear receptors involved in nutrient sensing, metabolism, and lipid-related processes. Dysregulation of PPAR-dependent transcriptional programs is linked to various diseases, and therapeutic exploitation of PPAR epigenetic modulation may provide new insights for treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Foteinos-Ioannis Dimitrakopoulos, Anastasia Kottorou, Aspasia Tzezou
Summary: Breast cancer, the most common cancer in women, poses a challenge in therapeutic management for hormone receptor-positive patients due to resistance mechanisms. Molecular mechanisms involved in endocrine resistance include changes in hormone receptor signaling, activation of parallel pathways, cell cycle regulator modifications, transcription factor activation, and stem cell activity changes. Epigenetic changes, such as DNA methylation, histone modifications, and ncRNAs alterations, play a pivotal role not only in breast cancer progression but also in resistance to endocrine therapy.
Review
Plant Sciences
Kajal Samantara, Aalok Shiv, Lorenna Lopes de Sousa, Karansher Singh Sandhu, Parichita Priyadarshini, Sourav Ranjan Mohapatra
Summary: Epigenetics is an important mechanism that can help plants cope with various stressors by altering gene expression without involving changes in DNA sequences. It provides diversity to aid plants in responding to the impacts of climate change.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Review
Plant Sciences
Muthusamy Ramakrishnan, Mingbing Zhou, Stanislaus Antony Ceasar, Doulathunnisa Jaffar Ali, Theivanayagam Maharajan, Kunnummal Kurungara Vinod, Anket Sharma, Zishan Ahmad, Qiang Wei
Summary: Somatic embryogenesis is a complex process regulated by genetic and epigenetic factors, including DNA and histone modifications, as well as miRNA regulation. These regulations influence the transition of somatic cells and the development of embryos, with the potential for somatic cell regeneration.
PLANT CELL REPORTS
(2023)
Editorial Material
Oncology
Zong Sheng Guo
Article
Multidisciplinary Sciences
Zuqiang Liu, Yan Ge, Haiyan Wang, Congrong Ma, Mathilde Feist, Songguang Ju, Z. Sheng Guo, David L. Bartlett
NATURE COMMUNICATIONS
(2018)
Review
Oncology
Zong Sheng Guo, Binfeng Lu, Zongbi Guo, Esther Giehl, Mathilde Feist, Enyong Dai, Weilin Liu, Walter J. Storkus, Yukai He, Zuqiang Liu, David L. Bartlett
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2019)
Article
Oncology
Bingtao Tang, Zong Sheng Guo, David L. Bartlett, David Z. Yan, Claire P. Schane, Diana L. Thomas, Jia Liu, Grant McFadden, Joanna L. Shisler, Edward J. Roy
CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Yan Ge, Haiyan Wang, Jinghua Ren, Weilin Liu, Lingjuan Chen, Hongqi Chen, Junjie Ye, Enyong Dai, Congrong Ma, Songguang Ju, Zong Sheng Guo, Zuqiang Liu, David L. Bartlett
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Oncology
Fan Sun, Zong Sheng Guo, Alyssa D. Gregory, Steven D. Shapiro, Gutian Xiao, Zhaoxia Qu
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Biotechnology & Applied Microbiology
Mathilde Feist, Zhi Zhu, Enyong Dai, Congrong Ma, Zuqiang Liu, Esther Giehl, Roshni Ravindranathan, Stacy J. Kowalsky, Natasa Obermajer, Udai S. Kammula, Andrew J. H. Lee, Michael T. Lotze, Zong Sheng Guo, David L. Bartlett
Summary: The use of oncolytic virus (OV) can stimulate tumor-specific TIL, which show significant therapeutic effects in experiments after expansion, providing a potential option for adoptive cell therapy (ACT) for solid tumors.
CANCER GENE THERAPY
(2021)
Article
Oncology
Weilin Liu, Enyong Dai, Zuqiang Liu, Congrong Ma, Zong Sheng Guo, David L. Bartlett
MOLECULAR THERAPY-ONCOLYTICS
(2020)
Review
Biochemistry & Molecular Biology
Zong Sheng Guo, Michael T. Lotze, Zhi Zhu, Walter J. Storkus, Xiao-Tong Song
Editorial Material
Oncology
Zong-Sheng Guo
ANNALS OF TRANSLATIONAL MEDICINE
(2020)
Editorial Material
Biochemistry & Molecular Biology
Zong-Sheng Guo
Article
Biochemistry & Molecular Biology
Weilin Liu, Hongqi Chen, Zhi Zhu, Zuqiang Liu, Congrong Ma, Yong J. Lee, David L. Bartlett, Zong-Sheng Guo
Summary: The study found that the combination of the ferroptosis activator Erastin with the oncolytic vaccinia virus could effectively inhibit tumor growth, prolong host survival, and enhance antitumoral immunity in hepatocellular carcinoma and colon cancer models.
Meeting Abstract
Oncology
Bingtao Tang, Zong Sheng Guo, David L. Bartlett, David Yan, Claire P. Schane, Jia Liu, Grant McFadden, Joanna L. Shisler, Edward J. Roy
Meeting Abstract
Biotechnology & Applied Microbiology
Mathilde Feist, Zuqiang Liu, Esther Giehl, Congrong Ma, Udai Kammula, Zong Sheng Guo, David L. Bartlett