Telomere biology: Cancer firewall or aging clock?

How does the body know how old it is? Introducing the epigenetic clock hypothesis

(2013) J. J. Mitteldorf   BIOCHEMISTRY-MOSCOW

Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

(2012) Bruno Bernardes de Jesus et al.   EMBO Molecular Medicine

Ectopic Expression of Telomerase Safely Increases Health Span and Life Span

(2012) Andrew R. Mendelsohn et al.   REJUVENATION RESEARCH

The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence

(2011) Bruno Bernardes de Jesus et al.   AGING CELL

Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination

(2011) Nuno M. V. Gomes et al.   AGING CELL

Telomerase activity in the bats Hipposideros armiger and Rousettus leschenaultia

(2011) Lei Wang et al.   BIOCHEMISTRY-MOSCOW

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Shortened Telomere Length Is Associated with Increased Risk of Cancer: A Meta-Analysis

(2011) Hongxia Ma et al.   PLoS One

Change and Aging Senescence as an Adaptation

(2011) André C. R. Martins   PLoS One

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations

(2009) S. Schoeftner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Telomere dynamics rather than age predict life expectancy in the wild

(2009) P. Bize et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Telomere Length and Mortality: A Study of Leukocytes in Elderly Danish Twins

(2008) M. Kimura et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice

(2008) Antonia Tomás-Loba et al.   CELL

Actions of human telomerase beyond telomeres

(2008) Yusheng Cong et al.   CELL RESEARCH