Article
Multidisciplinary Sciences
Mari Honda, Ayaka Tsuboi, Satomi Minato-Inokawa, Mika Takeuchi, Miki Kurata, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
Summary: Limited expandability of subcutaneous adipose tissue may be a characteristic of first-degree relatives of type 2 diabetes. This study found an association between family history of type 2 diabetes (FHD) and reduced subcutaneous fat mass in young Japanese women, suggesting impaired adipose tissue expandability.
SCIENTIFIC REPORTS
(2022)
Review
Endocrinology & Metabolism
Ting Zhang, Jun Li, Xi Li, Yanjun Liu
Summary: Intermuscular adipose tissue (IMAT) is a unique adipose depot located between muscle fibers or muscle groups. It is strongly associated with insulin resistance and muscular dysfunction in metabolic diseases such as obesity and type 2 diabetes. Understanding the cellular origins, properties, and regulatory mechanisms of IMAT is crucial for developing therapeutic strategies and drugs targeting IMAT-related metabolic diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Colm Mcelwain, Samprikta Manna, Andrea Musumeci, Isaac Sylvester, Chloe Rouchon, Anne Marie O'Callaghan, Mustafa Abdalla Bakhit Ebad, Fergus Mccarthy, Cathal Mccarthy
Summary: This study finds that GDM-obese pregnancies are characterized by inadequate VAT remodeling and dysfunctional molecular signaling, which contribute to insulin resistance and hinder metabolic health.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Alastair G. Kerr, Zuoneng Wang, Na Wang, Kelvin H. M. Kwok, Jutta Jalkanen, Alison Ludzki, Simon Lecoutre, Dominique Langin, Martin O. Bergo, Ingrid Dahlman, Carsten Mim, Peter Arner, Hui Gao
Summary: The study identifies ADIPINT, a human adipocyte-specific lncRNA, as a regulator of lipid metabolism in white adipocytes. ADIPINT interacts with pyruvate carboxylase and affects its abundance and enzymatic activity, which in turn influences adipocyte lipid synthesis and breakdown. ADIPINT expression is increased in obesity and is associated with adipose insulin resistance and pyruvate carboxylase activity.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Irving L. M. H. Aye, Fredrick J. Rosario, Anita Kramer, Oddrun Kristiansen, Trond M. Michelsen, Theresa L. Powell, Thomas Jansson
Summary: Obesity in pregnancy is associated with adipose tissue inflammation, endoplasmic reticulum stress, insulin resistance, increased adiponectin ubiquitination, and decreased total abundance of adiponectin.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Robert Hauffe, Michaela Rath, Wilson Agyapong, Wenke Jonas, Heike Vogel, Tim J. Schulz, Maria Schwarz, Anna P. Kipp, Matthias Bluher, Andre Kleinridders
Summary: The intake of high-fat diets leads to obesity, oxidative stress, inflammation, and insulin resistance. The trace element selenium can protect against the development of diet-induced insulin resistance. However, selenium might not be able to attenuate insulin resistance in the presence of obesity.
Article
Medicine, Research & Experimental
Jennifer M. Petrosino, Jacob Z. Longenecker, Srinivasagan Ramkumar, Xianyao Xu, Lisa E. Dorn, Anna Bratasz, Lianbo Yu, Santosh Maurya, Vladimir Tolstikov, Valerie Bussberg, Paul M. L. Janssen, Muthu Periasamy, Michael A. Kiebish, Gregg Duester, Johannes von Lintig, Ouliana Ziouzenkova, Federica Accornero
Summary: The research demonstrates that the size and function of paracardial fat (pCF) in elderly individuals and individuals with obesity are controlled by alcohol dehydrogenase 1 (ADH1), and the ADH1/retinaldehyde pathway regulates adipocyte remodeling in pCF depot via promoting mitochondrial fusion and biogenesis.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Agriculture, Dairy & Animal Science
Miguel Chirivi, C. Javier Rendon, Madison N. Myers, Crystal M. Prom, Sambit Roy, Aritro Sen, Adam L. Lock, G. Andres Contreras
Summary: The exposure to endotoxin can enhance lipolysis and reduce insulin sensitivity in adipose tissue, leading to decreased sensitivity of adipocytes to the antilipolytic action of insulin.
JOURNAL OF DAIRY SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Xuelian Zhang, Bin Zhang, Chenyang Zhang, Guibo Sun, Xiaobo Sun
Summary: The increasing prevalence of obesity worldwide has led to limited options for effective and safe anti-obesity drugs. Notoginsenosides, derived from traditional Chinese medicine Panax notoginseng, show potential in treating obesity by reducing lipid synthesis and improving insulin sensitivity. Further research is still needed to fully understand the effects and mechanisms of notoginsenosides in combating obesity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Jessica Latorre, Jordi Mayneris-Perxachs, Nuria Oliveras-Canellas, Francisco Ortega, Ferran Comas, Jose Manuel Fernandez-Real, Jose Maria Moreno-Navarrete
Summary: This study investigated the role of CDO1 gene expression in adipose tissue and found that higher CDO1 expression was associated with improved metabolic profiles, decreased fasting triglycerides and blood HbA1c levels, as well as gene expression markers of adipocyte function and inflammation in both visceral and subcutaneous adipose tissue.
Article
Biochemistry & Molecular Biology
Adam Prabata, Koji Ikeda, Elda Putri Rahardini, Ken-Ichi Hirata, Noriaki Emoto
Summary: The study demonstrates that GPNMB negatively regulates macrophage inflammatory capacities and ameliorates WAT inflammation in obesity, making it a promising therapeutic target for metabolic disorders associated with obesity.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Daniel Castellano-Castillo, Bruno Ramos-Molina, Wilfredo Oliva-Olivera, Luis Ocana-Wilhelmi, Maria Isabel Queipo-Ortuno, Fernando Cardona
Summary: This study aimed to analyze the changes in H3K4me3 histone mark in human adipose tissue under obesity and insulin resistance conditions. The results showed that H3K4me3 enrichment in gene promoters was closely related to higher mRNA levels, and differentially enriched H3K4me3 could regulate genes in adipose tissue, affecting its function during obesity and insulin resistance.
Article
Nutrition & Dietetics
Xin Shu, Jiaqi Wu, Tao Zhang, Xiaoyu Ma, Zuoqin Du, Jin Xu, Jingcan You, Liqun Wang, Ni Chen, Mao Luo, Jianbo Wu
Summary: The study suggests that PCSK9 expression in adipose tissue may mediate statin-induced adipocyte insulin resistance. PCSK9 deficiency could protect against statin-induced impairments in insulin signaling.
Article
Biochemistry & Molecular Biology
Klaudia Berk, Karolina Konstantynowicz-Nowicka, Tomasz Charytoniuk, Ewa Harasim-Symbor, Adrian Chabowski
Summary: Available data suggests that cannabidiol (CBD) can improve symptoms of insulin resistance by modulating sphingolipid concentrations. CBD reduces ceramide content in adipose tissues, enhancing insulin sensitivity. Therefore, CBD may be considered as a potential therapeutic strategy for treating insulin resistance and metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ignacio Colon-Mesa, Neira Sainz, Patricia Corrales, Maria Collantes, Philipp Kaldis, Jose Alfredo Martinez, Gema Medina-Gomez, Maria Jesus Moreno-Aliaga, Xavier Escote
Summary: The aim of this study was to investigate the effect of p27 deletion on the activity of brown adipose tissue and the susceptibility to develop obesity and glucose homeostasis disturbances in mice. The results showed that p27 knockout mice were more prone to obesity and insulin resistance. The study suggested that p27 may play a role in brown adipose tissue activation and the development of obesity and insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
G. V. Sharonov, M. N. Balatskaya, V. A. Tkachuk
BIOCHEMISTRY-MOSCOW
(2016)
Review
Biochemistry & Molecular Biology
M. N. Balatskaya, A. V. Balatskii, G. V. Sharonov, V. A. Tkachuk
JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY
(2016)
Article
Multidisciplinary Sciences
Giorgia Maroni, Vsevolod A. Tkachuk, Alexander Egorov, Marco J. Morelli, Raffaele Luongo, Elena Levantini, Francesco Blasi, Maria Cristina Magli, Dmitry Penkov
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Maria N. Balatskaya, Georgy V. Sharonov, Alexandra I. Baglay, Yury P. Rubtsov, Vsevolod A. Tkachuk
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2019)
Review
Biochemistry & Molecular Biology
Anna E. Pravednikova, Sergey Y. Shevchenko, Victor V. Kerchev, Manana R. Skhirtladze, Svetlana N. Larina, Zaur M. Kachaev, Alexander D. Egorov, Yulii V. Shidlovskii
MOLECULAR MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Maria N. Balatskaya, Alexandra Baglay, Alexander Balatskiy
Summary: This study provided evidence supporting the presence of T-cadherin on platelets. The glycosylphosphatidylinositol anchor in the platelet T-cadherin form was confirmed. Furthermore, the study characterized T-cadherin with post-translational modifications as a new GPI-anchored protein on human platelets.
Review
Virology
Alexander Malogolovkin, Nizami Gasanov, Alexander Egorov, Marianna Weener, Roman Ivanov, Alexander Karabelsky
Summary: Recent breakthroughs in cancer immunotherapy have transformed oncology and provided new hope for a cure. The combination of oncolytic viruses with immune checkpoint inhibitors shows promise, but finding the most effective combinations remains complex. This review highlights the efficacy, safety, and future perspectives of virotherapy based on clinical trial data.
Article
Biochemistry & Molecular Biology
Alexander Balatskiy, Ilia Ozhimalov, Maria Balatskaya, Alexandra Savina, Julia Filatova, Natalia Kalinina, Vladimir Popov, Vsevolod Tkachuk
Summary: It was found that immature VSMCs expressing CD146 and neuron-glial antigen 2 are present in atherosclerosis-prone regions, but they are not directly involved in the formation of atherosclerotic lesions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Alexander Balatskiy, Marina Teterina, Alexandra Pisaryuk, Irina Balabanenko, Alexey Kadrev, Anastasia Tishuk, Maria Balatskaya, Larisa Samokhodskaya, Sergey Boytsov, Natalia Kalinina, Vsevolod Tkachuk
Summary: The study found an inverse correlation between carotid artery IMT and HMW levels in male subjects. The G allele of rs12444338 SNP in the T-cadherin gene was associated with lower levels of circulating T-cadherin and thinner IMT, suggesting a potential atheroprotective genotype.
Review
Biotechnology & Applied Microbiology
Alexander Malogolovkin, Alexander D. Egorov, Alexander Karabelsky, Roman A. Ivanov, Vladislav V. Verkhusha
Summary: Optogenetics, a technique that enables precise control of gene and cell activity using light, offers new possibilities for cancer treatment. By activating immune response, inhibiting tumor growth, and modulating cell signaling using specific wavelengths of light, optogenetics has the potential to revolutionize cancer therapy.
BIOTECHNOLOGY ADVANCES
(2022)
Article
Biochemical Research Methods
Maria N. Balatskaya, Alexandra I. Baglay, Yury P. Rubtsov, George V. Sharonov
METHODS AND PROTOCOLS
(2020)
Meeting Abstract
Biophysics
M. N. Balatskaya, G. Sharonov, A. Baglay, V. A. Tkachuk
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
(2018)
Article
Medicine, Research & Experimental
Fatima R. Chotchaeva, Alexander V. Balatskiy, Larisa M. Samokhodskaya, Vsevolod A. Tkachuk, Viktor A. Sadovnichiy
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2016)
Meeting Abstract
Biochemistry & Molecular Biology
M. Balatskaya, G. Sharonov, A. Baglay, A. Balatskiy, V. Tkachuk