Constitutive and induced functions of the p53 gene

The effects of p53 on whole organism longevity are mediated by autophagy

(2014) Nektarios Tavernarakis et al.   Autophagy

A dual role of p53 in the control of autophagy

(2014) Ezgi Tasdemir et al.   Autophagy

MdmX regulates transformation and chromosomal stability in p53-deficient cells

(2011) Zdenka Matijasevic et al.   CELL CYCLE

Mutant p53 protein localized in the cytoplasm inhibits autophagy

(2011) Eugenia Morselli et al.   CELL CYCLE

Metformin slows down aging and extends life span of female SHR mice

(2011) Vladimir N. Anisimov et al.   CELL CYCLE

Wrap53, a novel regulator of p53

(2011) Marianne Farnebo   CELL CYCLE

TOR-driven aging: Speeding car without brakes

(2011) Mikhail V Blagosklonny   CELL CYCLE

Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo

(2011) Vladimir N. Anisimov et al.   CELL CYCLE

Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans)

(2011) Mikhail V Blagosklonny   CELL CYCLE

TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death

(2010) Kageaki Kuribayashi et al.   CANCER BIOLOGY & THERAPY

Aging: ROS or TOR

(2010) Mikhail V Blagosklonny   CELL CYCLE

Polypyrimidine tract binding protein regulates IRES-mediated translation of p53 isoforms

(2010) Richa Grover et al.   CELL CYCLE

Stimulation of autophagy by the p53 target gene Sestrin2

(2010) Maria Chiara Maiuri et al.   CELL CYCLE

The interaction of p53 with 3'-terminal mismatched DNA

(2010) Mary Bakhanashvili et al.   CELL CYCLE

Defective autophagy control by the p53 rheostat in cancer

(2010) Lorenzo Galluzzi et al.   CELL CYCLE

Regulation of autophagy in mammals and its interplay with apoptosis

(2010) Gian Maria Fimia et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Autophagy regulation by p53

(2010) Maria Chiara Maiuri et al.   CURRENT OPINION IN CELL BIOLOGY

Autophagy in cellular growth control

(2010) Richard C. Wang et al.   FEBS LETTERS

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice

(2010) Yasushi Hirota et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

(2010) J. H. Lee et al.   SCIENCE

Therapeutic targeting of p53 by small molecules

(2010) Galina Selivanova   SEMINARS IN CANCER BIOLOGY

Life with or without AIF

(2010) Emilie Hangen et al.   TRENDS IN BIOCHEMICAL SCIENCES

p53 and stem cells: new developments and new concerns

(2010) Tongbiao Zhao et al.   TRENDS IN CELL BIOLOGY

TP53INP2 is the new guest at the table of self-eating

(2009) Jonathan Nowak et al.   Autophagy

Functions of p53 in metabolism and invasion:

(2009) Karen H. Vousden   BIOCHEMICAL SOCIETY TRANSACTIONS

Mechanism of Inactivation of Human Ribonucleotide Reductase with p53R2 by Gemcitabine 5′-Diphosphate

(2009) Jun Wang et al.   BIOCHEMISTRY

Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis

(2009) Maria A. Lebedeva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The do's and don'ts of p53 isoforms

(2009) Reiner U. Jänicke et al.   BIOLOGICAL CHEMISTRY

Signaling to p53: Ribosomal Proteins Find Their Way

(2009) Yanping Zhang et al.   CANCER CELL

High expression of Pirh2, an E3 ligase for p27, is associated with low expression of p27 and poor prognosis in head and neck cancers

(2009) Mai Shimada et al.   CANCER SCIENCE

The cell death machinery governed by the p53 tumor suppressor in response to DNA damage

(2009) Kiyotsugu Yoshida et al.   CANCER SCIENCE

Telomeres and telomerase in cancer

(2009) S. E. Artandi et al.   CARCINOGENESIS

A PP2A Regulatory Subunit Regulates C. elegans Insulin/IGF-1 Signaling by Modulating AKT-1 Phosphorylation

(2009) Srivatsan Padmanabhan et al.   CELL

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

Modulation of intracellular ROS levels by TIGAR controls autophagy

(2009) Karim Bensaad et al.   EMBO JOURNAL

The regulation of the endosomal compartment byp53the tumor suppressor gene

(2009) Xin Yu et al.   FEBS Journal

Wrap53, a Natural p53 Antisense Transcript Required for p53 Induction upon DNA Damage

(2009) Salah Mahmoudi et al.   MOLECULAR CELL

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

(2009) Rosa M. Marión et al.   NATURE

Suppression of induced pluripotent stem cell generation by the p53–p21 pathway

(2009) Hyenjong Hong et al.   NATURE

Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

(2009) Jochen Utikal et al.   NATURE

BH3-only proteins in apoptosis and beyond: an overview

(2009) E Lomonosova et al.   ONCOGENE

p53 and little brother p53/47: linking IRES activities with protein functions

(2009) R Grover et al.   ONCOGENE

Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans

(2009) H.-J. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRIMming p53 for ubiquitination: Table 1.

(2009) Elizabeth Tai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trim24 targets endogenous p53 for degradation

(2009) Kendra Allton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate

(2009) Shanta Dhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

p53 as a therapeutic target

(2009) O.D. Staples et al.   SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND

TOR complex 2: a signaling pathway of its own

(2009) Nadine Cybulski et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of the aging process by autophagy

(2009) Antero Salminen et al.   TRENDS IN MOLECULAR MEDICINE

Interactions between extracellular matrix and growth factors in wound healing

(2009) Gregory S. Schultz et al.   WOUND REPAIR AND REGENERATION

p53 Regulation of the IGF-1/AKT/mTOR Pathways and the Endosomal Compartment

(2009) Z. Feng   Cold Spring Harbor Perspectives in Biology

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

The mitochondrial p53 pathway

(2008) Angelina V. Vaseva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis

(2008) Veronique Nogueira et al.   CANCER CELL

p53-Dependent and p53-Independent Activation of Autophagy by ARF

(2008) W. M. Abida et al.   CANCER RESEARCH

Tumor Protein 53-Induced Nuclear Protein 1 Is a Major Mediator of p53 Antioxidant Function

(2008) C. E. Cano et al.   CANCER RESEARCH

SnapShot: p53 Posttranslational Modifications

(2008) Jan-Philipp Kruse et al.   CELL

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

AMPK and PPARδ Agonists Are Exercise Mimetics

(2008) Vihang A. Narkar et al.   CELL

Autophagy in aging, disease and death: the true identity of a cell death impostor

(2008) B Levine et al.   CELL DEATH AND DIFFERENTIATION

Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice

(2008) A Lespagnol et al.   CELL DEATH AND DIFFERENTIATION

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

(2008) E M Michalak et al.   CELL DEATH AND DIFFERENTIATION

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Roles of p53, Myc and HIF-1 in Regulating Glycolysis — the Seventh Hallmark of Cancer

(2008) S. J. Yeung et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2–DAXX–HAUSP complex

(2008) Min Sup Song et al.   EMBO JOURNAL

Signaling from endosomes: Location makes a difference

(2008) Lukasz Sadowski et al.   EXPERIMENTAL CELL RESEARCH

ROS and p53: A versatile partnership

(2008) Bin Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

How is AMPK activity regulated in skeletal muscles during exercise?

(2008) Sebastian Beck Jorgensen   Frontiers in Bioscience-Landmark

The regulation of AMP-activated protein kinase by upstream kinases

(2008) D Carling et al.   INTERNATIONAL JOURNAL OF OBESITY

A Novel Antioxidant Function for the Tumor-Suppressor Gene p53 in the Retinal Ganglion Cell

(2008) J. C. O'Connor et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Histone Arg Modifications and p53 Regulate the Expression ofOKL38, a Mediator of Apoptosis

(2008) Hongjie Yao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2

(2008) J. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

The TP53INP2 Protein Is Required for Autophagy in Mammalian Cells

(2008) Jonathan Nowak et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY

Discovery of novel tumor suppressor p53 response elements using information theory

(2008) Ilya G. Lyakhov et al.   NUCLEIC ACIDS RESEARCH

The role of FoxO in the regulation of metabolism

(2008) D N Gross et al.   ONCOGENE

The PTEN–PI3K pathway: of feedbacks and cross-talks

(2008) A Carracedo et al.   ONCOGENE

How to Live Long and Prosper: Autophagy, Mitochondria, and Aging

(2008) Wei-Lien Yen et al.   PHYSIOLOGY

A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

(2008) Jamie L. Barger et al.   PLoS One

Homeostatic functions of the p53 tumor suppressor: Regulation of energy metabolism and antioxidant defense

(2008) Ivan A. Olovnikov et al.   SEMINARS IN CANCER BIOLOGY

Exosome Function: From Tumor Immunology to Pathogen Biology

(2008) Jeffrey S. Schorey et al.   TRAFFIC

Aberrant Insulin Receptor Signaling and Amino Acid Homeostasis as a Major Cause of Oxidative Stress in Aging

(2007) Wulf Dröge et al.   ANTIOXIDANTS & REDOX SIGNALING