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Biochemistry & Molecular Biology
Qing-Xin Ji, Fei-Yan Zeng, Jian Zhou, Wen-Bin Wu, Xu-Jie Wang, Zhen Zhang, Guo-Yan Zhang, Jie Tong, Di-Yang Sun, Jia-Bao Zhang, Wen-Xiang Cao, Fu-Ming Shen, Jin-Jian Lu, Dong-Jie Li, Pei Wang
Summary: This study explores the potential role of ferroptosis in smooth muscle cell (SMC) phenotypic switch and neointimal formation. It found that ferroptotic stress is triggered in dedifferentiated SMCs and arterial neointimal tissue. Inhibition of ferroptosis delays SMC phenotype switch and arterial remodeling, while ferroptosis stress directly triggers SMC dedifferentiation.
CELL DEATH AND DIFFERENTIATION
(2023)
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Environmental Sciences
Jing Wu, Jiayan Li, Yanwei Liu, Xinxin Liao, Dongyi Wu, Yunqin Chen, Zengenni Liang, Zhihang Yuan, Rongfang Li, Jine Yi, Lixin Wen
Summary: The study demonstrates that TA can effectively alleviate the appearance of congestion and redness of the ovary caused by ZEA, increase the number of healthy growing follicles, decrease estrogen content, MDA and ROS levels in the ovaries, reduce ovarian cell apoptosis, modulate the protein expression levels of multiple apoptosis-related proteins, and increase Bcl-2 expression.
ENVIRONMENTAL POLLUTION
(2021)
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Biochemistry & Molecular Biology
Yonglu Li, Xin Yu, Lingchi Deng, Su Zhou, Yaxuan Wang, Xiaodong Zheng, Qiang Chu
Summary: This study revealed that intervention with Tetrastigma hemsleyanum leaves flavone could inhibit tumor growth, and neochlorogenic acid exhibited stronger anti-proliferation ability. Molecular docking analysis suggested that neochlorogenic acid could interact with mitochondrial calcium uniporter, leading to mitochondrial calcium imbalance and ultimately achieving cancer therapy.
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Biochemistry & Molecular Biology
Wojciech Trybus, Ewa Trybus, Teodora Krol
Summary: This study evaluated the effects of combining emodin with vinblastine on cervical cancer cells. The combination increased oxidative stress, mitotic catastrophe, and apoptosis, potentially offering a promising approach for anticancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
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Anatomy & Morphology
Amir Raoofi, Melody Omraninava, Roghayeh Javan, Davood Maghsodi, Auob Rustamzadeh, Davood Nasiry, Alireza Ghaemi
Summary: Chronic scrotal hyperthermia (SHT) can lead to serious male reproductive system disorders, mainly due to oxidative stress. Epigallocatechin gallate (EGCG) as a potent antioxidant can alleviate cellular and tissue damage caused by SHT. EGCG improves sperm parameters, testosterone levels, and reduces cellular apoptosis and oxidative stress.
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Biochemistry & Molecular Biology
Sarah Kassis, Melanie Grondin, Diana A. Averill-Bates
Summary: Short-term heat shock at 42 degrees Celsius (<60 min) increased autophagy, while long-term heat shock (1-3 h) at 42 degrees Celsius led to apoptosis. Thermotolerant cells were resistant to apoptosis at 42 degrees Celsius. Autophagy inhibitors sensitized cells to apoptosis triggered by heat shock at 42 degrees Celsius.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
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Biochemistry & Molecular Biology
Jing Li, Junhua Li, Yuji Pu, Sai Li, Wenxia Gao, Bin He
Summary: This study introduced a novel nanocomplex PAF for enhanced cancer treatment through photodynamic therapy, demonstrating potent anticancer effects. The PAF showed excellent biocompatibility and enhanced photodynamic and near-infrared absorption capabilities under acidic conditions. The findings suggest that PDT-enhanced ferroptosis in PAF could be a promising strategy for nanotherapeutics due to its high potency, tumor selectivity, and excellent biocompatibility.
Review
Biochemistry & Molecular Biology
Tapan Behl, Rashita Makkar, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Gokhan Zengin, Simona Bungau, Felicia Liana Andronie-Cioara, Mihai Alexandru Munteanu, Mihaela Cristina Brisc, Diana Uivarosan, Ciprian Brisc
Summary: The human body is complex and comprises various living cells and extracellular material forming tissues, organs, and organ systems. While most human cells turnover regularly, postmitotic nerve cells have the exceptional ability to regenerate and sustain throughout an individual's life to safeguard the central nervous system's functioning. Neurodegenerative diseases, such as Parkinson's and Alzheimer's disease, result from factors like oxidative stress, cell death, and neuroinflammation, causing neuronal degradation and impacting the quality of life for millions worldwide.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Kwannapas Saengsin, Rekwan Sittiwangkul, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Cardiovascular disease is the leading cause of death globally. Molecular hydrogen, which can be administered through various methods, has shown antioxidant, anti-inflammatory, and anti-apoptotic effects, providing protection for the heart.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
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Plant Sciences
Mohammad Shah Jahan, Md Mahadi Hasan, Fahad S. Alotaibi, Nadiyah M. Alabdallah, Basmah M. Alharbi, Khaled M. A. Ramadan, Eslam S. A. Bendary, Dikhnah Alshehri, Dilfuza Jabborova, Doha A. Al-Balawi, Eldessoky S. Dessoky, Mohamed F. M. Ibrahim, Shirong Guo
Summary: Polyamine putrescine (Put) contributes to increased heat tolerance in tomato seedlings by regulating chlorophyll metabolism, oxidative stress, antioxidant defense, and the expression of heat-shock-related genes.
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Biochemistry & Molecular Biology
Ioannis Tsialtas, Achilleas Georgantopoulos, Maria E. Karipidou, Foteini D. Kalousi, Aikaterini G. Karra, Demetrios D. Leonidas, Anna-Maria G. Psarra
Summary: Estrogens play a crucial role in regulating both reproductive and non-reproductive system physiology, with a particular impact on the nervous system. The presence of mitochondrial estrogen receptor beta (mtER beta) has been shown to directly participate in neuronal physiology maintenance. Overexpression of mtER beta in N2A cells enhances resistance to apoptotic stimuli, suggesting its potential as a therapeutic target for degenerative diseases associated with mitochondrial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
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Biochemistry & Molecular Biology
Wojciech Trybus, Teodora Krol, Ewa Trybus
Summary: This study evaluated the impact of rhein, an anthraquinone compound found in Chinese medicine, on the lysosomal compartment and its indirect influence on cell apoptosis. The results showed that high concentrations of rhein caused oxidative stress and changes in lysosomal membrane permeability, leading to cell apoptosis. In addition, the use of an autophagy inhibitor, chloroquine, enhanced the cytotoxicity of rhein.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
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Agriculture, Dairy & Animal Science
Tori E. Rudolph, Crystal M. Roach, Lance H. Baumgard, Jason W. Ross, Aileen F. Keating, Josh T. Selsby
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JOURNAL OF ANIMAL SCIENCE
(2022)
Review
Agriculture, Dairy & Animal Science
A. S. Marquez-Acevedo, W. R. Hood, R. J. Collier, A. L. Skibiel
Summary: Heat stress negatively affects milk production and increases disease risk in dairy cows. It alters metabolic adaptations, such as nutrient mobilization and partitioning, compromising the energy demands of lactation. Mitochondrial density and bioenergetic capacity at the cellular level play a role in meeting the changing energy requirements in response to heat stress.
JOURNAL OF DAIRY SCIENCE
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Physiology
John O. Osborne, Ian B. Stewart, David N. Borg, Kenneth W. Beagley, Robert L. Buhmann, Geoffrey M. Minett
Summary: Short-term heat acclimation training may increase knee extensor strength without changes in central fatigue or intestinal damage. However, this type of training is insufficient to improve 20 km self-paced cycling performance in the heat compared to workload-matched training in a temperate environment.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
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Biochemistry & Molecular Biology
Ahmed Bettaieb, Diana A. Averill-Bates
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
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Biochemical Research Methods
Melanie Grondin, Melanie Chow-Shi-Yee, Francois Ouellet, Diana A. Averill-Bates
BIOTECHNOLOGY JOURNAL
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Biochemical Research Methods
Melanie Grondin, Melanie Chow-Shi-Yee, Francois Ouellet, Diana A. Averill-Bates
BIOTECHNOLOGY JOURNAL
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Biochemistry & Molecular Biology
Maureen Redza-Dutordoir, Sarah Kassis, Hou Ve, Melanie Grondin, Diana A. Averill-Bates
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2016)
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Maureen Redza-Dutordoir, Diana A. Averill-Bates
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(2016)
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Biotechnology & Applied Microbiology
Melanie Chow-shi-yee, Melanie Grondin, Diana A. Averill-Bates, Francois Ouellet
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Audrey Glory, Diana A. Averill-Bates
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Melanie Chow-Shi-Yee, Jennie G. Briard, Melanie Grondin, Diana A. Averill-Bates, Robert N. Ben, Francois Ouellet
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Andre Tanel, Pragathi Pallepati, Ahmed Bettaieb, Patrick Morin, Diana A. Averill-Bates
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(2014)
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Marceline Tchouague, Melanie Grondin, Audrey Glory, Diana Averill-Bates
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Melanie Chow-shi-yee, Melanie Grondin, Francois Ouellet, Diana A. Averill-Bates
CELL STRESS & CHAPERONES
(2020)
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Biochemistry & Molecular Biology
Sarah Kassis, Melanie Grondin, Diana A. Averill-Bates
Summary: Short-term heat shock at 42 degrees Celsius (<60 min) increased autophagy, while long-term heat shock (1-3 h) at 42 degrees Celsius led to apoptosis. Thermotolerant cells were resistant to apoptosis at 42 degrees Celsius. Autophagy inhibitors sensitized cells to apoptosis triggered by heat shock at 42 degrees Celsius.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
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Biochemistry & Molecular Biology
Maureen Redza-Dutordoir, Diana A. Averill-Bates
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)