Article
Computer Science, Software Engineering
Xiaosong Zhu, Youyuan Wang
Summary: In this paper, a new fully automatic pure hexahedron mesh generation technique is presented for an arbitrary 2D/3D geometric domain. Additionally, a polyhedral smoothed finite element method is proposed for efficient numerical simulation. Several demonstration examples are provided to verify the accuracy of the proposed methods.
COMPUTER-AIDED DESIGN
(2022)
Article
Biotechnology & Applied Microbiology
Kalin D. Gibbons, Vahid Malbouby, Oliver Alvarez, Clare K. Fitzpatrick
Summary: Osteoarthritis of the knee is a common condition that affects the elderly population and has a significant impact on both finances and quality of life. Computational tools, specifically deep learning, offer a promising solution for studying knee biomechanics without the need for invasive procedures or expensive cadaveric studies. In this study, a fully automated pipeline was developed to generate finite element simulations from magnetic resonance knee images. The pipeline utilized a convolutional neural network for image segmentation and a meshing algorithm to create simulation-ready meshes. The results showed that the pipeline was able to produce high-quality meshes in a short amount of time, enabling large-scale studies of the knee. Comparison between manual and automated reconstructions demonstrated comparable results, indicating the feasibility of this approach for population-sized finite element studies. This framework, combined with further advancements in deep learning, offers a valuable tool for investigating the natural knee and its biomechanics on a population level.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Eric Heisler, Aadesh Deshmukh, Sandip Mazumder, Ponnuswamy Sadayappan, Hari Sundar
Summary: FINCH, a domain specific language and code generation framework, is showcased for solving PDE problems including the advection diffusion equation and the phonon Boltzmann transport equation. It explores both finite volume and finite element methods. The recent developments in solving nonlinear equations using automatic and symbolic differentiation are also discussed, along with demonstration of the capability for the Bratu equation.
JOURNAL OF COMPUTATIONAL SCIENCE
(2023)
Article
Engineering, Marine
Luka Grubisic, Domagoj Lacmanovic, Marin Palaversa, Pero Prebeg, Josip Tambaca
Summary: We present an algorithm for the fully automatic generation of a class-compliant mesh for ship structural analysis. The algorithm consists of automatic geometry refinement and a preconditioned Delaunay frontal quad dominant mesh generator. The main contribution of the paper is the automatic geometry refinement algorithm and the virtual stiffener procedure. The algorithm is implemented in Python using the open-source Gmsh system and the Open CASCADE kernel.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2022)
Article
Engineering, Multidisciplinary
Mohamad Mohmadsalehi, Soheil Soghrati
Summary: In this manuscript, an algorithm called conforming to interface structured adaptive mesh refinement (CISAMR) is expanded for modeling complex 2D crack growth problems involving contact/friction and multiple cracks interaction. The algorithm transforms a structured mesh into a conforming mesh without iterations, allowing minimal changes to the underlying mesh structure during the crack geometry evolution. The algorithm achieves accurate approximation of the energy release rate and predicts new crack path by adaptively refining and updating the mesh structure near the crack tip. The high-quality mesh construction enables the use of an explicit dynamic solver to simulate the nonlinear response caused by contact forces along crack faces. The algorithm's accuracy and ability are verified through benchmark fracture problems and more complex problems involving interactions between multiple growing cracks and embedded heterogeneities in the domain.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2022)
Article
Engineering, Multidisciplinary
Teseo Schneider, Daniele Panozzo, Xianlian Zhou
Summary: The paper introduces a new posteriori method to generate high order curved meshes using a poly-spline isogeometric method, ensuring continuity and smoothness between elements. Fitting algorithms adjust control points for final mesh interpolation or approximation, outperforming an elastic analogy based approach in terms of computational performance and overall mesh quality. The method can be extended for higher order IGA basis construction and smooth refinement important for high order physics simulations.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2021)
Article
Engineering, Mechanical
Hossein Saberi, Hamid Saberi, Tinh Quoc Bui, Yousef Heider, Minh Ngoc Nguyen
Summary: In finite element analysis, adaptive mesh refinement (AMR) is commonly used to improve numerical solution accuracy in specific regions without refining the entire mesh. This study introduces a novel AMR technique for determining when and how to adjust element size during phase field fracture analysis, reducing computational cost without compromising accuracy. The technique involves approximating distance between field nodes in an existing mesh and performing remeshing as the crack propagates. Numerical examples demonstrate that this approach significantly reduces computational cost and maintains accuracy without prior knowledge of the crack propagation path. The technique also offers advantages in terms of convergence, ease of implementation, and applicability to irregular meshes.
THEORETICAL AND APPLIED FRACTURE MECHANICS
(2023)
Article
Mathematics, Applied
Jothi Mani Thondiraj, Akhshaya Paranikumar, Devesh Tiwari, Daniel Paquet, Pritam Chakraborty
Summary: This study develops a diffused interface CPFEM framework, which reduces computational cost by using biased mesh and provides accurate results using non-conformal elements in the mesh size transiting regions. The accuracy of the framework is confirmed through comparisons with sharp and stepped interface results.
FINITE ELEMENTS IN ANALYSIS AND DESIGN
(2024)
Article
Cardiac & Cardiovascular Systems
Siavash Zamirpour, Yue Xuan, Zhongjie Wang, Axel Gomez, Joseph Leach, Dimitrios Mitsouras, David A. Saloner, Julius M. Guccione, Liang Ge, Elaine E. Tseng
Summary: This study evaluated the association between aortic area/height and peak aneurysm wall stresses, valve morphology, and 3-year all-cause mortality. The results showed that the aortic area/height ratio was more predictive of high circumferential stresses in bicuspid valve aneurysms, while peak longitudinal stress independently predicted all-cause mortality.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Review
Chemistry, Physical
Abdulnaser M. Alshoaibi, Yahya Ali Fageehi
Summary: This paper introduces a robust algorithm for generating high-quality triangular meshes to model complex two-dimensional crack growth problems. The algorithm incorporates adaptive refinement and mesh structure updates near the crack tip to accurately predict crack growth path based on stress intensity factors. Experimental and numerical results demonstrate the effectiveness of the algorithm in accurately predicting crack growth and facilitating reliable stress analysis.
Article
Computer Science, Interdisciplinary Applications
Kejie Fu, Jianjun Chen, Jie Li, Kaixin Yu, Jiangda He, Min Tang, Yao Zheng
Summary: This paper presents an automatic unstructured mesh generation approach for discretizing complex electronic packaging systems for finite element analysis. Various novel schemes are developed to automate the entire mesh generation pipeline and resolve common issues, such as geometrical defects, small necessary features, and predefined simulation properties on models.
ENGINEERING WITH COMPUTERS
(2023)
Article
Computer Science, Software Engineering
Teseo Schneider, Yixin Hu, Xifeng Gao, Jeremie Dumas, Denis Zorin, Daniele Panozzo
Summary: The Finite Element Method (FEM) is commonly used to solve discrete Partial Differential Equations (PDEs) in engineering and graphics applications. This study introduces a set of benchmark problems and compares the performance of different element types for solving common elliptic PDEs using tetrahedral and hexahedral meshes. The results suggest that for certain problem sets and available mesh generation algorithms, quadratic tetrahedral elements perform well and can outperform hexahedral elements in structural analysis, thermal analysis, and low Reynolds number flows.
ACM TRANSACTIONS ON GRAPHICS
(2022)
Article
Computer Science, Interdisciplinary Applications
Zheyan Zhang, Peter K. Jimack, He Wang
Summary: This paper introduces a new algorithm for generating high quality tetrahedral meshes using artificial neural networks, focusing on solving linear elasticity equations and quantifying the relative accuracy of different meshes by comparing the energy associated with FE solutions on these meshes.
ADVANCES IN ENGINEERING SOFTWARE
(2021)
Article
Physics, Multidisciplinary
Chun-Feng Zhang, Wei Wang, Si-Guang An, Nan-Ying Shentu
Summary: A novel two-dimensional finite element mesh generation algorithm is proposed in this paper, which includes image boundary extraction, node location identification, and force-based mesh smoothing, to improve the efficiency and accuracy of electromagnetic field calculation. Test results demonstrate that the algorithm can produce high-quality meshes with fewer iterations.
Article
Materials Science, Multidisciplinary
M. Shafayet Zamil, Duane P. Harland, Brian K. Fisher, Michael G. Davis, James R. Schwartz, Anja Geitmann
Summary: Research has shown that hair fiber growth is influenced by a variety of biological, biochemical, and biomechanical factors, with biomechanical factors playing a largely unknown role. A multiscale mechanical modeling approach revealed that biomechanical features such as follicle geometry and keratinization-mediated hardening are likely crucial in hair fiber protrusion. Fine tuning biomechanical parameters is proposed as a key strategy to ensure smooth hair growth.
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
(2021)
Article
Biophysics
Tejas Canchi, Sourav S. Patnaik, Hong N. Nguyen, E. Y. K. Ng, Sriram Narayanan, Satish C. Muluk, Victor De Oliveira, Ender A. Finol
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2020)
Article
Thermodynamics
Carlos A. Acosta, David Yanes, Amar Bhalla, Ruyan Guo, Ender A. Finol, Jimmy Frank
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2020)
Article
Materials Science, Multidisciplinary
N. R. Pillalamarri, S. S. Patnaik, S. Piskin, P. Gueldner, E. A. Finol
Summary: The regional mechanical characterization studies of porcine pulmonary arteries reveal significant dissimilarities in mechanical properties across different regions, which can be informative for future studies involving high fidelity finite element models.
EXPERIMENTAL MECHANICS
(2021)
Article
Biophysics
Mohammadali Sharzehee, Yasamin Seddighi, Eugene A. Sprague, Ender A. Finol, Hai-Chao Han
Summary: This study compared the hemodynamic effects of myocardial bridging (MB) and coronary stenosis, showing that the difference between MB and stenosis increased with severity and flowrate. Experimental results revealed that MB had a higher maximum and lower mean pressure drop compared to stenosis in all scenarios.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2021)
Article
Biophysics
Mirunalini Thirugnanasambandam, Tejas Canchi, Senol Piskin, Christof Karmonik, Ethan Kung, Prahlad G. Menon, Stephane Avril, Ender A. Finol
Summary: The biomechanical characterization of abdominal aortic aneurysms (AAAs) is crucial for assessing rupture risk, but its clinical translation is limited by tool complexity. A new approach using a deformable AAA silicone phantom in a controlled laboratory environment was proposed for analyzing AAA flow and sac volume changes. This study optimized impedance elements, quantitatively characterized attributes of a compliant AAA phantom, and demonstrated the use of MRI for flow visualization and quantification of AAA geometry changes.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2021)
Article
Medicine, General & Internal
Jennifer L. Anderson, Elizabeth E. Niedert, Sourav S. Patnaik, Renxiang Tang, Riley L. Holloway, Vangelina Osteguin, Ender A. Finol, Craig J. Goergen
Summary: Pentagalloyl glucose may reduce arterial calcium accumulation and potentially have limited therapeutic effects on abdominal aortic aneurysms.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biophysics
Alifer Bordones-Crom, Sourav S. Patnaik, Prahlad G. Menon, Srinivas Murali, Ender Finol
Summary: The study analyzed RV models of PH patients using cardiac magnetic resonance imaging, showing significant differences in RV shape, suggesting these geometry measures could be used as indicators of RV endocardial wall morphology changes in PH patients. Some global parameters also showed significant changes in the PH group at the one-year follow-up.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2021)
Article
Engineering, Biomedical
Nicolas Amigo, Alvaro Valencia, Wei Wu, Sourav Patnaik, Ender Finol
Summary: Morphological characterization and fluid dynamics simulations were used to classify ruptured and unruptured cerebral aneurysms in 71 patients, with size ratio, diastolic wall shear stress, and systolic wall shear stress showing the best predictive performance. Machine learning algorithms were employed, with logistic regression achieving the highest accuracy and random forest exhibiting the highest area under curve value, surpassing the performance of individual parameters like size ratio. The random forest model is proposed as a tool to improve rupture status prediction of cerebral aneurysms.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Frances Arnold, Nicolas Muzzio, Sourav S. Patnaik, Ender A. Finol, Gabriela Romero
Summary: Currently, nonsurgical therapy for abdominal aortic aneurysm (AAA) growth is not available, and AAA is considered an irreversible destructive disease. However, research suggests that pentagalloyl glucose (PGG) or its encapsulated form may help stabilize the aortic extracellular matrix, potentially offering a novel therapeutic option for preventing and reducing AAA progression.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biophysics
Balaji Rengarajan, Sourav S. Patnaik, Ender A. Finol
Summary: In this study, the use of geometric indices to predict patient-specific AAA wall stress through a novel neural network modeling approach was investigated. The results demonstrated that the NN models outperformed other algorithms in accurately predicting wall stress, showcasing potential for improved performance metrics with larger group sizes.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2021)
Article
Engineering, Biomedical
Narasimha R. Pillalamarri, Senol Piskin, Sourav S. Patnaik, Srinivas Murali, Ender A. Finol
Summary: Pulmonary hypertension is a progressive disease that requires multiple tests for diagnosis, with right heart catheterization being the gold standard. Hemodynamic indices show significant changes as the disease progresses. The study aims to identify computational biomarkers as non-invasive alternatives for diagnosing PH.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Alycia G. Berman, Daniel J. Romary, Katherine E. Kerr, Natalyn E. Gorazd, Morgan M. Wigand, Sourav S. Patnaik, Ender A. Finol, Abigail D. Cox, Craig J. Goergen
Summary: The study investigates the influence of elastase concentration and BAPN on the growth rate and severity of aneurysms in a mouse model, revealing their significant impact on aneurysm formation and expansion. Results highlight the potential of elastase concentration and BAPN to modulate aneurysm growth rate and severity.
SCIENTIFIC REPORTS
(2022)
Proceedings Paper
Computer Science, Interdisciplinary Applications
Anish Salvi, Ender Finol, Prahlad G. Menon
Summary: The study focuses on automating the classification of AAA rupture risk using neural networks, showcasing the accuracy achieved with latent embeddings and U-Net training on CTA images. By training and classifying different types of U-Nets, mixed class 3D ResNets were found to have 90% accuracy in rupture risk stratification.
MEDICAL IMAGING 2022: BIOMEDICAL APPLICATIONS IN MOLECULAR, STRUCTURAL, AND FUNCTIONAL IMAGING
(2022)
Proceedings Paper
Engineering, Biomedical
Anish Salvi, Ender Finol, Prahlad G. Menon
Summary: This study investigated the feasibility of automatic segmentation of AAA using patient-specific CTA images and a 3D U-Net CNN model. The research focused on determining optimal probability thresholds for model outputs and improving segmentation accuracy through transfer learning. The final trained models consistently produced visually accurate automatic segmentations with increasing training sample sizes.
2021 43RD ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE & BIOLOGY SOCIETY (EMBC)
(2021)
Meeting Abstract
Hematology
Elizabeth E. Niedert, Jennifer L. Anderson, Renxiang Tang, Riley L. Holloway, Sourav S. Patnaik, Ender A. Finol, Craig J. Goergen
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)
Article
Biophysics
Nathan D. Camarillo, Rafael Jimenez-Silva, Frances T. Sheehan
Summary: This article discusses the statistical dependence between multiple measurements from the same participant and provides recommendations for using these measurements when they are not independent.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
J. Huet, A. -S. Boureau, A. Sarcher, C. Cornu, A. Nordez
Summary: Standard compression in freehand 3D ultrasound induces a bias in volume calculations, but minimal compression and gel pad methods have similar results. With a trained examiner and precautions, the bias can be minimized and become acceptable in clinical applications.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
C. Lariviere, A. H. Eskandari, H. Mecheri, F. Ghezelbash, D. Gagnon, A. Shirazi-Adl
Summary: Recent developments in musculoskeletal modeling have focused on model customization. Personalization of the spine profile may affect estimates of spinal loading and stability. This study investigates the biomechanical consequences of changes in the spinal profile and finds that personalizing the spine profile has medium to large effects on trunk muscle forces and negligible to small effects on spinal loading and stability.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Luke T. Mattar, Arash B. Mahboobin, Adam J. Popchak, William J. Anderst, Volker Musahl, James J. Irrgang, Richard E. Debski
Summary: Exercise therapy fails in about 25.0% of cases for individuals with rotator cuff tears, and one reason for this failure may be the inability to strengthen and balance the muscle forces that keep the humeral head in the correct position. This study developed computational musculoskeletal models to compare the net muscle force before and after exercise therapy between successfully and unsuccessfully treated patients. The study found that unsuccessfully treated patients had less inferiorly oriented net muscle forces, which may increase the risk of impingement.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Natsuki Sado, Takeshi Edagawa, Toshihide Fujimori, Shogo Hashimoto, Yoshikazu Okamoto, Takahito Nakajima
Summary: The existing methods for predicting hip and lumbosacral joint centres in Japanese adults are biased and differ between sexes. We propose new regression equations that consider soft-tissue thickness, sex differences, and a height-directional measure, and validate them using leave-one-out cross-validation.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Peimin Yu, Xuanzhen Cen, Qichang Mei, Alan Wang, Yaodong Gu, Justin Fernandez
Summary: This study aimed to explore the intra-foot biomechanical differences among individuals with chronic ankle instability (CAI), copers, and healthy individuals during dynamic tasks. The study found that copers and CAI individuals had smaller dorsiflexion angles and copers presented a more eversion position compared to healthy participants. Copers also had greater dorsiflexion angles in the metatarsophalangeal joint and more inversion moments in the subtalar joint during certain tasks. These findings can help in designing interventions to restore ankle joint functions in CAI individuals.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Jon Skovgaard Jensen, Anders Holsgaard-Larsen, Anders Stengaard Sorensen, Per Aagaard, Jens Bojsen-Moller
Summary: This study investigates the biomechanical effects of robot-assisted body weight unloading (BWU) on gait patterns in healthy young adults. The results show that dynamic robot-assisted BWU enables reduced kinetic requirements without distorting biomechanically normal gait patterns during overground walking.
JOURNAL OF BIOMECHANICS
(2024)