In vivo implant forces acting on a vertebral body replacement during upper body flexion

Knowledge about in vivo spinal loads is required for the identification of risk factors for low back pain and for realistic preclinical testing of spinal implants. Therefore, the aim of the present study was to measure the in vivo forces on a vertebral body replacement (VBR) during trunk flexion and to analyze in detail the typical relationship between trunk inclination and spinal load. Telemeterized VBRs were implanted in five patients. In vivo loads were measured 135 times during flexion while standing or sitting. The trunk inclination was simultaneously recorded. To reveal elementary differences between flexion while standing and sitting, the force increases at the maximal inclination, as compared to the upright position, were also determined. Approximately 90% of all standing trials showed a characteristic inclination-load relationship, with an initial increase of the resultant force followed by a plateau or even a decrease of the force at an inclination of approximately 33 degrees. Further flexion to the average maximal inclination angle of 53 degrees only marginally affected the implant loads (similar to 450 N). Maximal forces were measured during the return to the initial standing position (similar to 565 N). Flexion during standing led to a greater force increase (similar to 330 N) than during sitting (similar to 200 N) when compared to the respective upright positions. The force plateau at greater inclination angles might be explained by abdominal load support, complex stabilization of active and passive spinal structures or intricate load sharing within the implant complex. The data presented here aid in understanding the loads acting on an instrumented lumbar spine. (C) 2015 Elsevier Ltd. All rights reserved.