Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 42, Issue -, Pages 1327-+Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20140177
Keywords
autophagosome; autophagy; Atg12-5-16; LC3 conjugation; phosphatidylinositol 3-phosphate; WIPI2
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Funding
- Cancer Research UK
- Biotechnology and Biological Sciences Research Council
- BBSRC [BBS/E/B/000C0413] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/B/000C0413] Funding Source: researchfish
- Cancer Research UK [15153] Funding Source: researchfish
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The double-membraned autophagosome organelle is an integral part of autophagy, a process that recycles cellular components by non-selectively engulfing and delivering them to lysosomes where they are digested. Release of metabolites from this process is involved in cellular energy homoeostasis under basal conditions and during nutrient starvation. Selective engulfment of protein aggregates and dysfunctional organelles by autophagosomes also prevents disruption of cellular metabolism. Autophagosome formation in animals is crucially dependent on the unique conjugation of a group of ubiquitin-like proteins in the microtubule-associated proteins 1A/1B light chain 3 (LC3) family to the headgroup of phosphatidylethanolamine (PE) lipids. LC3 lipidation requires a cascade of ubiquitin-like ligase and conjugation enzymes. The present review describes recent progress and discovery of the direct interaction between the PtdIns3P effector WIPI2b and autophagy-related protein 16-like 1 (Atg16L1), a component of the LC3-conjugation complex. This interaction makes the link between endoplasmic reticulum (ER)-localized production of PtdIns3P, triggered by the autophagy regulatory network, and recruitment of the LC3-conjugation complex crucial for autophagosome formation.
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