The importance of interactions with helix 5 in determining the efficacy of β-adrenoceptor ligands
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The importance of interactions with helix 5 in determining the efficacy of β-adrenoceptor ligands
Authors
Keywords
-
Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 41, Issue 1, Pages 159-165
Publisher
Portland Press Ltd.
Online
2013-01-29
DOI
10.1042/bst20120228
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Biased Signaling Pathways in 2-Adrenergic Receptor Characterized by 19F-NMR
- (2012) J. J. Liu et al. SCIENCE
- Crystal Structures of a Stabilized β1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol
- (2012) Tony Warne et al. STRUCTURE
- Engineering an Ultra-Thermostable β1-Adrenoceptor
- (2011) Jennifer L. Miller et al. JOURNAL OF MOLECULAR BIOLOGY
- Quantifying Ligand Bias at Seven-Transmembrane Receptors
- (2011) S. Rajagopal et al. MOLECULAR PHARMACOLOGY
- Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation
- (2011) Guillaume Lebon et al. NATURE
- The structural basis for agonist and partial agonist action on a β1-adrenergic receptor
- (2011) Tony Warne et al. NATURE
- Structure of a nanobody-stabilized active state of the β2 adrenoceptor
- (2011) Søren G. F. Rasmussen et al. NATURE
- Structure and function of an irreversible agonist-β2 adrenoceptor complex
- (2011) Daniel M. Rosenbaum et al. NATURE
- Crystal structure of the β2 adrenergic receptor–Gs protein complex
- (2011) Søren G. F. Rasmussen et al. NATURE
- The pharmacological effects of the thermostabilising (m23) mutations and intra and extracellular (β36) deletions essential for crystallisation of the turkey β-adrenoceptor
- (2011) Jillian G. Baker et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Two distinct conformations of helix 6 observed in antagonist-bound structures of a 1-adrenergic receptor
- (2011) R. Moukhametzianov et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of an Agonist-Bound Human A2A Adenosine Receptor
- (2011) F. Xu et al. SCIENCE
- Distinct Phosphorylation Sites on the 2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of -Arrestin
- (2011) K. N. Nobles et al. Science Signaling
- Conserved Binding Mode of Human β2Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography
- (2010) Daniel Wacker et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Teaching old receptors new tricks: biasing seven-transmembrane receptors
- (2010) Sudarshan Rajagopal et al. NATURE REVIEWS DRUG DISCOVERY
- Engineering G protein-coupled receptors to facilitate their structure determination
- (2009) Christopher G Tate et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Analysis of full and partial agonists binding to β2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes
- (2009) Vsevolod Katritch et al. JOURNAL OF MOLECULAR RECOGNITION
- Transferability of thermostabilizing mutations between β-adrenergic receptors
- (2009) Maria J. Serrano-Vega et al. MOLECULAR MEMBRANE BIOLOGY
- The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex
- (2009) X. J. Yao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Development and crystallization of a minimal thermostabilised G protein-coupled receptor
- (2009) Tony Warne et al. PROTEIN EXPRESSION AND PURIFICATION
- Structure of a β1-adrenergic G-protein-coupled receptor
- (2008) Tony Warne et al. NATURE
- Stabilization of the Human β2-Adrenergic Receptor TM4–TM3–TM5 Helix Interface by Mutagenesis of Glu1223.41, A Critical Residue in GPCR Structure
- (2007) Christopher B. Roth et al. JOURNAL OF MOLECULAR BIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started