Understanding and manipulating antibiotic production in actinomycetes

Cloning and Analysis of the Planosporicin Lantibiotic Biosynthetic Gene Cluster of Planomonospora alba

(2013) E. J. Sherwood et al.   JOURNAL OF BACTERIOLOGY

Molecular Regulation of Antibiotic Biosynthesis in Streptomyces

(2013) G. Liu et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Phage P1-Derived Artificial Chromosomes Facilitate Heterologous Expression of the FK506 Gene Cluster

(2013) Adam C. Jones et al.   PLoS One

The antibiotic planosporicin coordinates its own production in the actinomycete Planomonospora alba

(2013) E. J. Sherwood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic Biotechnology to Study and Engineer Ribosomal Bottromycin Biosynthesis

(2012) Liujie Huo et al.   CHEMISTRY & BIOLOGY

Thoughts and facts about antibiotics: Where we are now and where we are heading

(2012) János Bérdy   JOURNAL OF ANTIBIOTICS

Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)

(2012) C. Barreiro et al.   JOURNAL OF BACTERIOLOGY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

Biosynthesis of the tunicamycin antibiotics proceeds via unique exo-glycal intermediates

(2012) Filip J. Wyszynski et al.   Nature Chemistry

Structure and Biosynthesis of the Antibiotic Bottromycin D

(2012) Yanpeng Hou et al.   ORGANIC LETTERS

Posttranslational β-methylation and macrolactamidination in the biosynthesis of the bottromycin complex of ribosomal peptide antibiotics

(2012) Juan Pablo Gomez-Escribano et al.   Chemical Science

Identification and characterisation of the gene cluster for the anti-MRSA antibiotic bottromycin: expanding the biosynthetic diversity of ribosomal peptides

(2012) William J. K. Crone et al.   Chemical Science

Efficacy of the New Lantibiotic NAI-107 in Experimental Infections Induced by Multidrug-Resistant Gram-Positive Pathogens

(2011) Daniela Jabés et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Feed-Forward Regulation of Microbisporicin Biosynthesis in Microbispora corallina

(2011) L. Foulston et al.   JOURNAL OF BACTERIOLOGY

Biosynthesis and Regulation of Grisemycin, a New Member of the Linaridin Family of Ribosomally Synthesized Peptides Produced by Streptomyces griseus IFO 13350

(2011) J. Claesen et al.   JOURNAL OF BACTERIOLOGY

The regulation of the secondary metabolism of Streptomyces: new links and experimental advances

(2011) Gilles P. van Wezel et al.   NATURAL PRODUCT REPORTS

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

(2011) L. Laureti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2)

(2010) M. Gottelt et al.   MICROBIOLOGY-SGM

Genome mining and genetic analysis of cypemycin biosynthesis reveal an unusual class of posttranslationally modified peptides

(2010) J. Claesen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbisporicin gene cluster reveals unusual features of lantibiotic biosynthesis in actinomycetes

(2010) L. C. Foulston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissecting tunicamycin biosynthesis by genome mining: cloning and heterologous expression of a minimal gene cluster

(2010) Filip J. Wyszynski et al.   Chemical Science

Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters

(2010) Juan Pablo Gomez-Escribano et al.   Microbial Biotechnology

Structure Revision of the Lantibiotic 97518

(2009) Sonia I. Maffioli et al.   JOURNAL OF NATURAL PRODUCTS

Determining the Structure and Mode of Action of Microbisporicin, a Potent Lantibiotic Active Against Multiresistant Pathogens

(2008) Franca Castiglione et al.   CHEMISTRY & BIOLOGY

Renaissance in antibacterial discovery from actinomycetes

(2008) R BALTZ   CURRENT OPINION IN PHARMACOLOGY