Review
Cell Biology
Bahareh Kashani, Zahra Zandi, Atieh Pourbagheri-Sigaroodi, Davood Bashash, Seyed H. Ghaffari
Summary: The TLR family is crucial for pattern recognition in innate immunity, with TLR4 playing a significant role in inflammatory diseases and cancer. Aberrant expression of TLR4 in tumors is closely associated with tumorigenesis, progression, and drug resistance. TLR4 inhibitors show promise in cancer therapy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Chemistry, Medicinal
Yongsheng Zhang, Xinjie Liang, Xuefei Bao, Wei Xiao, Guoliang Chen
Summary: This review discusses TLR4 inhibitors that can bind directly to TLR4 or the TLR4/MD2 complex, as well as compounds that can downregulate the expression of TLR4. The involvement of specific residues in the binding of antagonistic ligands to the TLR4/MD2 complex provides useful information for structure-based TLR4 inhibitor design.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Integrative & Complementary Medicine
Wenbin Dai, Longhai Long, Xiaoqiang Wang, Sen Li, Houping Xu
Summary: This review surveyed the in vivo effects of phytochemicals targeting TLR4 in different models of IBD and highlighted the significance of TLR4 as a therapeutic target for IBD.
Review
Medicine, Research & Experimental
Jinrui Wei, Yan Zhang, Haopeng Li, Fuquan Wang, Shanglong Yao
Summary: This review focuses on the role and mechanism of TLR4 in various diseases, aiming to provide new research directions and therapeutic targets for clinical intervention.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Kiran Shabir, Seley Gharanei, Sophie Orton, Vanlata Patel, Parbata Chauhan, Emmanouil Karteris, Harpal S. Randeva, James E. Brown, Ioannis Kyrou
Summary: Adipose tissue functions as an endocrine organ by secreting various adipokines that regulate metabolism and other physiological processes. The altered secretion of adipokines has been associated with obesity and cardio-metabolic diseases. Asprosin, a recently discovered adipokine, is elevated in cardio-metabolic diseases and has pro-inflammatory effects, at least in part through the TLR4 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Ankush Kumar Jha, Shobhit Gairola, Sourav Kundu, Pakpi Doye, Abu Mohammad Syed, Chetan Ram, Upadhyayula Suryanarayana Murty, V. G. M. Naidu, Bidya Dhar Sahu
Summary: This review emphasizes the role of TLR4 signaling pathway in AKI and highlights potential compounds of natural and synthetic origin that can avert renal TLR4 signaling and offer protection against AKI in preclinical models. Targeting TLR4 and its downstream effectors could serve as an effective therapeutic intervention to prevent renal inflammation and subsequent kidney damage.
Article
Clinical Neurology
Xingjie Ping, Zhi Chai, Weiping Wang, Cungen Ma, Fletcher F. A. White, Xiaoming Jin
Summary: Blocking RAGE and TLR4 signaling pathways significantly increased seizure threshold, reduced spontaneous seizure events, increased neuronal and inhibitory interneuron densities in the lesioned cortex, and decreased astrocyte and microglia densities in the treatment groups, suggesting a potential strategy for preventing posttraumatic epilepsy.
Review
Nutrition & Dietetics
Karen S. Coutinho-Wolino, Patricia P. Almeida, Denise Mafra, Milena B. Stockler-Pinto
Summary: Chronic inflammation is linked to the development and progression of various non-communicable diseases, and Toll-like receptor 4 (TLR4) plays a crucial role in chronic inflammation. Bioactive compounds have the potential to modulate the TLR4 pathway and alleviate inflammation.
NUTRITION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Yingying Chen, Dongyue Li, Liying Sun, Kai Qi, Lijun Shi
Summary: This study aimed to evaluate the effect and mechanism of toll-like receptor 4 (TLR4) inhibitor TLR4-IN-C34 on gut microbiota in mice with ulcerative colitis (UC). The results showed that TLR4-IN-C34 partially improved dysbiosis of intestinal flora, inflammatory infiltration, oxidative stress, and intestinal barrier function in UC mice.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Oncology
Caixu Pan, Qinchuan Wu, Shuai Wang, Zhibin Mei, Lele Zhang, Xingxing Gao, Junjie Qian, Zhentian Xu, Ke Zhang, Rong Su, Danjing Guo, Lin Zhou, Shusen Zheng
Summary: This study revealed that tumor-infiltrating regulatory T cells (Ti-Tregs) significantly expressed the glucocorticoid-induced tumor necrosis factor receptor (GITR), which was associated with poor prognosis in HCC patients. DTA-1 treatment reduced Treg infiltration but failed to activate CD8(+) T cells and elicit antitumor efficacy. Furthermore, DTA-1 treatment enforced alternative M2 polarization of macrophages, and macrophage depletion enhanced DTA-1-mediated antitumor efficacy in HCC.
Article
Oncology
Xiangjie Qiu, Guojun Wu, Lili Wang, Yurong Tan, Zhi Song
Summary: The study revealed that probiotics like Lactobacillus can effectively inhibit lipopolysaccharide-induced depression-like behaviors and improve symptoms of depression by regulating the balance of intestinal flora. Lactobacillus can also inhibit dysbiosis induced by metabolites and exert its antidepressant effect by inhibiting TLR4 signaling.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Danieli F. Buccini, Beatriz C. Roriz, Julia M. Rodrigues, Octavio L. Franco
Summary: Antimicrobial peptides are important molecules in the organism's defense system. They can modulate the immune system and recognize molecules present in pathogens. Overstimulation of TLR4 can lead to uncontrolled inflammatory responses, which can be counteracted by antimicrobial peptides.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Piumi B. Wickramasinghe, Shuwen Qian, Lyndsey E. Langley, Chen Liu, Lin Jia
Summary: Accumulating evidence suggests that alcohol overconsumption is associated with insulin resistance, and this study investigated the role of hepatocyte toll-like receptor 4 (TLR4) in alcohol-induced insulin resistance. The findings indicate that hepatocyte TLR4 is both required and sufficient for the development of insulin resistance caused by alcohol overconsumption.
Review
Biochemistry & Molecular Biology
Natticha Sumneang, Pongpan Tanajak, Thura Tun Oo
Summary: Doxorubicin (Dox) is commonly used chemotherapeutic drug, but its cardiotoxicity reduces its therapeutic efficacy. Dox-induced cardiac inflammation is considered as one of the underlying mechanisms involved in Dox-induced cardiotoxicity. Understanding the role of the Toll-like receptor 4 (TLR4) signaling pathway in Dox-induced cardiac inflammation might be beneficial for developing potential therapeutic strategies.
Article
Chemistry, Multidisciplinary
Tianqing Zhang, Bryan Wei
Summary: A rational design scheme for building synthetic nucleic acid allosteric nanodevices was presented, inspired by allosteric regulation of natural molecules. The scheme includes developing DNA switches with triplex-forming oligos as allosteric modulators, implementing designated allosteric transitions, and applying toehold-mediated strand displacement for synthetic nucleic acid computing.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Microbiology
Changhee Cho, Seungpyo Hong, Hyeon Gi Moon, Yu-Sin Jang, Dongsup Kim, Sang Yup Lee
Article
Biochemistry & Molecular Biology
Eun Ju Shin, Ji Su Lee, Seungpyo Hong, Tae-Gyu Lim, Sanguine Byun
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Multidisciplinary Sciences
Mi Young Lim, Seungpyo Hong, Bo-Min Kim, Yongju Ahn, Hyun-Jin Kim, Young-Do Nam
SCIENTIFIC REPORTS
(2020)
Article
Biotechnology & Applied Microbiology
Seungpyo Hong, Inonge Noni Siziya, Myung-Ji Seo, Cheon-Seok Park, Dong-Ho Seo
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2020)
Article
Cell Biology
Da-Hye Lee, So-Hyun Park, Jiyun Ahn, Seung Pyo Hong, Eunyoung Lee, Young-Jin Jang, Tae-Youl Ha, Yang Hoon Huh, Seung-Yeon Ha, Tae-Il Jeon, Chang Hwa Jung
Summary: The study revealed that inhibition of Mir214-3p expression alleviated fatty liver disease by increasing autophagic activity through upregulation of Ulk1. Mir214-3p is a potential therapeutic target for nonalcoholic fatty liver disease.
Article
Geriatrics & Gerontology
Mi Young Lim, Seungpyo Hong, Jung-Ha Kim, Young-Do Nam
Summary: Frailty is associated with altered energy metabolism and dysregulated immunity, which are related to gut microbiome dysbiosis. Measures of frailty were found to have associations with specific microbial taxa and metabolic functions. A potential indicator of an increased risk of frailty or a target for improving health in frail older adults.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Nutrition & Dietetics
Da Hyun Kim, Joong-Hyuck Auh, Jeongyeon Oh, Seungpyo Hong, Sungbin Choi, Eun Ju Shin, Soon Ok Woo, Tae-Gyu Lim, Sanguine Byun
Article
Food Science & Technology
Ye-Jin Kim, Inonge Noni Siziya, Seungpyo Hong, Gil-Yong Lee, Myung-Ji Seo, Young-Rok Kim, Sang-Ho Yoo, Cheon-Seok Park, Dong-Ho Seo
Summary: Amylosucrase was used to synthesize biosurfactants, with DgAS and BtAS both effectively synthesizing surfactants from different substrates, with DgAS showing more effective transglycosylation reactions.
FOOD SCIENCE AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hyeryon Lee, Kyung-Hwa Baek, Trong-Nhat Phan, I. Seul Park, Sangchul Lee, Jiho Kim, Joo Hwan No
Summary: This study identified a potential drug target for visceral leishmaniasis and identified small molecule inhibitors with anti-leishmanial activity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Microbiology
Mi Young Lim, Seungpyo Hong, So-Jung Bang, Won-Hyong Chung, Ji-Hee Shin, Jung-Ha Kim, Young-Do Nam
Summary: This study characterized the gut microbiome of 890 healthy Koreans and found that the gut microbiome composition differed from other countries, and was associated with age, dietary patterns, and other factors. The data obtained in this study provides valuable insights into the gut microbiome composition in healthy Korean population and its association with host health conditions.
Article
Nutrition & Dietetics
Ji-Hee Shin, Yong Ju Ahn, Won-Hyong Chung, Mi Young Lim, Seungpyo Hong, Joong-Hark Kim, Mi Houn Park, Young-Do Nam
Summary: This study investigated the effects of Saengshik intake on changes in gut microbiota, finding a significant decrease in gut microbiota diversity and changes in major microbial taxa composition after Saengshik consumption. The gut microbial response was related to individual habitual dietary intake and enterotype at baseline.
FRONTIERS IN NUTRITION
(2021)
Article
Pharmacology & Pharmacy
Seongin Jo, Snigdha Samarpita, Ji Su Lee, Yong Joon Lee, Joe Eun Son, Minju Jeong, Jae Hwan Kim, Seungpyo Hong, Seung-Ah Yoo, Wan-Uk Kim, Mahaboobkhan Rasool, Sanguine Byun
Summary: Fibroblast-like synoviocytes (FLS) play a pivotal role in the pathogenesis of rheumatoid arthritis (RA), and targeting FLS has been suggested as an attractive therapeutic strategy. This study found that the compound 8-Shogaol in ginger can inhibit the development of RA by targeting TAK1 and its signaling pathways, thus reversing the pathological changes in the inflamed synovium.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Microbiology
Jong-Hyun Jung, Seungpyo Hong, Eun Jung Jeon, Min-Kyu Kim, Dong-Ho Seo, Eui-Jeon Woo, James F. Holden, Cheon-Seok Park
Summary: This study investigated the catalytic properties and mode of action of a 4-alpha-glucanotransferase (4-alpha-GTase) from a hyperthermophile. Unlike other similar enzymes, the 4-alpha-GTase in this hyperthermophile produced maltotriose as a product and preferred maltose and maltotriose over glucose as the acceptor molecule. The study also revealed the critical role of two aromatic amino acids in the binding of maltotriose.
FRONTIERS IN MICROBIOLOGY
(2022)
Letter
Oncology
Mi Young Lim, Seungpyo Hong, Kum Hui Hwang, Eun Jin Lim, Ji-Youn Han, Young-Do Nam
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Hyo-Jin Kim, Jangho Lee, Min-Yu Chung, Seungpyo Hong, Jae Ho Park, Seung-Hyun Lee, Sahng Wook Park, Hyo-Kyoung Choi, Jin-Taek Hwang
PHARMACOLOGICAL RESEARCH
(2020)