Synthesis of post-translationally modified proteins

Current Chemical Biology Approaches to Interrogate Protein Methyltransferases

(2012) Minkui Luo   ACS Chemical Biology

Triple Bioorthogonal Ligation Strategy for Simultaneous Labeling of Multiple Enzymatic Activities

(2012) Lianne I. Willems et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conversion of Cysteine into Dehydroalanine Enables Access to Synthetic Histones Bearing Diverse Post-Translational Modifications

(2012) Justin M. Chalker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of Homogeneous Antifreeze Glycopeptides and Glycoproteins

(2012) Brendan L. Wilkinson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Alzheimer’s Disease Related Tau Protein as a New Target for Chemical Protein Engineering

(2012) Malgorzata Broncel et al.   CHEMISTRY-A EUROPEAN JOURNAL

Interrogation of MDM2 Phosphorylation in p53 Activation Using Native Chemical Ligation: The Functional Role of Ser17 Phosphorylation in MDM2 Reexamined

(2012) Changyou Zhan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis

(2012) Mary Katherine Tarrant et al.   Nature Chemical Biology

From Mechanism to Mouse: A Tale of Two Bioorthogonal Reactions

(2011) Ellen M. Sletten et al.   ACCOUNTS OF CHEMICAL RESEARCH

Introducing Bioorthogonal Functionalities into Proteins in Living Cells

(2011) Ziyang Hao et al.   ACCOUNTS OF CHEMICAL RESEARCH

A “Tag-and-Modify” Approach to Site-Selective Protein Modification

(2011) Justin M. Chalker et al.   ACCOUNTS OF CHEMICAL RESEARCH

Emerging Technologies for Making Glycan-Defined Glycoproteins

(2011) Lai-Xi Wang et al.   ACS Chemical Biology

A Multifunctional Protease Inhibitor To Regulate Endolysosomal Function

(2011) Sander I. van Kasteren et al.   ACS Chemical Biology

Generation of a Mono-ubiquitinated PCNA Mimic by Click Chemistry

(2011) Silvia Eger et al.   CHEMBIOCHEM

Exploring Protein Lipidation with Chemical Biology

(2011) Howard C. Hang et al.   CHEMICAL REVIEWS

Enzymes in the Synthesis of Glycoconjugates

(2011) Ryan M. Schmaltz et al.   CHEMICAL REVIEWS

Current Chemical Biology Tools for Studying Protein Phosphorylation and Dephosphorylation

(2011) Candy H. S. Lu et al.   CHEMISTRY-A EUROPEAN JOURNAL

A dual role of H4K16 acetylation in the establishment of yeast silent chromatin

(2011) Mariano Oppikofer et al.   EMBO JOURNAL

Expanding the Genetic Code of an Animal

(2011) Sebastian Greiss et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein Glycoengineering Enabled by the Versatile Synthesis of Aminooxy Glycans and the Genetically Encoded Aldehyde Tag

(2011) Jason E. Hudak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemoenzymatic Synthesis and Fcγ Receptor Binding of Homogeneous Glycoforms of Antibody Fc Domain. Presence of a Bisecting Sugar Moiety Enhances the Affinity of Fc to FcγIIIa Receptor

(2011) Guozhang Zou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antifreeze glycoprotein agents: structural requirements for activity

(2011) Patricio A Carvajal-Rondanelli et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

RF1 knockout allows ribosomal incorporation of unnatural amino acids at multiple sites

(2011) David B F Johnson et al.   Nature Chemical Biology

Expanding the Genetic Code of Escherichia coli with Phosphoserine

(2011) H.-S. Park et al.   SCIENCE

Precise Manipulation of Chromosomes in Vivo Enables Genome-Wide Codon Replacement

(2011) Farren J. Isaacs et al.   SCIENCE

The Amazing Transglycosylation Activity of Endo-β-N-Acetylglucosaminidases

(2011) Lai-Xi Wang   TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY

In Vivo Double and Triple Labeling of Proteins Using Synthetic Amino Acids

(2010) Sandra Lepthien et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Synthesis of Ubiquitin, Ubiquitin-Based Probes, and Diubiquitin

(2010) Farid El Oualid et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Toward fully synthetic, homogeneous glycoproteins: Advances in chemical ligation

(2010) Yu Yuan et al.   BIOPOLYMERS

Generation of Site-Specific and Enzymatically Stable Conjugates of Recombinant Proteins with Ubiquitin-Like Modifiers by the CuI-Catalyzed Azide-Alkyne Cycloaddition

(2010) Nadine D. Weikart et al.   CHEMBIOCHEM

A method to site-specifically introduce methyllysine into proteins in E. coli

(2010) Hui-wang Ai et al.   CHEMICAL COMMUNICATIONS

Bioorthogonal chemistry: recent progress and future directions

(2010) Reyna K. V. Lim et al.   CHEMICAL COMMUNICATIONS

Genetically Directing ɛ-N, N-Dimethyl-l-Lysine in Recombinant Histones

(2010) Duy P. Nguyen et al.   CHEMISTRY & BIOLOGY

Synthesis of Defined Ubiquitin Dimers

(2010) Silvia Eger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-Specific Introduction of an Acetyl-Lysine Mimic into Peptides and Proteins by Cysteine Alkylation

(2010) Rong Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diffusion of Gold from the Inner Core to the Surface of Ag2S Nanocrystals

(2010) Jun Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expanding the Genetic Code of Yeast for Incorporation of Diverse Unnatural Amino Acids via a Pyrrolysyl-tRNA Synthetase/tRNA Pair

(2010) Susan M. Hancock et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of proteins with defined posttranslational modifications using the genetic noncanonical amino acid incorporation approach

(2010) Wenshe R. Liu et al.   Molecular BioSystems

Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome

(2010) Heinz Neumann et al.   NATURE

Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase

(2010) Satpal Virdee et al.   Nature Chemical Biology

Codon reassignment in the Escherichia coli genetic code

(2010) T. Mukai et al.   NUCLEIC ACIDS RESEARCH

Genetic Incorporation of Unnatural Amino Acids into Proteins in Mycobacterium tuberculosis

(2010) Feng Wang et al.   PLoS One

Chemoselective Staudinger-Phosphite Reaction of Azides for the Phosphorylation of Proteins

(2009) Remigiusz Serwa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Chemical Biology of Protein Phosphorylation

(2009) Mary Katherine Tarrant et al.   Annual Review of Biochemistry

Nonnatural Amino Acids for Site-Specific Protein Conjugation

(2009) Albert J. de Graaf et al.   BIOCONJUGATE CHEMISTRY

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

The α,α-Difluorinated Phosphonate L-pSer-Analogue: An Accessible Chemical Tool for Studying Kinase- Dependent Signal Transduction

(2009) Kaushik Panigrahi et al.   CHEMISTRY & BIOLOGY

Chemical Modification of Proteins at Cysteine: Opportunities in Chemistry and Biology

(2009) Justin M. Chalker et al.   Chemistry-An Asian Journal

Genetically EncodingNϵ-Methyl-l-lysine in Recombinant Histones

(2009) Duy P. Nguyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-Specific Incorporation of the Mucin-TypeN-Acetylgalactosamine-α-O-threonine into Protein inEscherichia coli

(2009) Ran Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemoselective Ligation and Modification Strategies for Peptides and Proteins

(2008) Christian P. R. Hackenberger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

From Disulfide- to Thioether-Linked Glycoproteins

(2008) Gonçalo J. L. Bernardes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Analysis of SerotoninN-Acetyltransferase Regulation in Vitro and in Live Cells Using Protein Semisynthesis†

(2008) Lawrence M. Szewczuk et al.   BIOCHEMISTRY

Glycoengineering of Human IgG1-Fc through Combined Yeast Expression andin VitroChemoenzymatic Glycosylation†§

(2008) Yadong Wei et al.   BIOCHEMISTRY

Glycoprotein Synthesis: An Update

(2008) David P. Gamblin et al.   CHEMICAL REVIEWS

Terminal sugars of Fc glycans influence antibody effector functions of IgGs

(2008) T Shantha Raju   CURRENT OPINION IN IMMUNOLOGY

Chemical approaches to mapping the function of post-translational modifications

(2008) David P. Gamblin et al.   FEBS Journal

Facile Conversion of Cysteine and Alkyl Cysteines to Dehydroalanine on Protein Surfaces: Versatile and Switchable Access to Functionalized Proteins

(2008) Gonçalo J. L. Bernardes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical site-selective prenylation of proteins

(2008) David P. Gamblin et al.   Molecular BioSystems

Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation

(2008) Robert K. McGinty et al.   NATURE

Genetically encoding Nε-acetyllysine in recombinant proteins

(2008) Heinz Neumann et al.   Nature Chemical Biology

Is there a code embedded in proteins that is based on post-translational modifications?

(2008) Robert J. Sims et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Azatryptophans endow proteins with intrinsic blue fluorescence

(2008) S. Lepthien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA