PNAS-4, an Early DNA Damage Response Gene, Induces S Phase Arrest and Apoptosis by Activating Checkpoint Kinases in Lung Cancer Cells

A Novel Topoisomerase Inhibitor, Daurinol, Suppresses Growth of HCT116 Cells with Low Hematological Toxicity Compared to Etoposide

(2015) Kyungsu Kang et al.   NEOPLASIA

The nuclear γ-H2AX apoptotic ring: implications for cancers and autoimmune diseases

(2014) Stéphanie Solier et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

hPNAS-4 inhibits proliferation through S phase arrest and apoptosis: underlying action mechanism in ovarian cancer cells

(2013) Lei Li et al.   APOPTOSIS

Decoding the Ubiquitin-Mediated Pathway of Arthropod Disease Vectors

(2013) Anthony Choy et al.   PLoS One

CHK1 cleavage in programmed cell death is intricately regulated by both caspase and non-caspase family proteases

(2012) Naoyuki Okita et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Induction of autophagy and senescence by knockdown of ROC1 E3 ubiquitin ligase to suppress the growth of liver cancer cells

(2012) D Yang et al.   CELL DEATH AND DIFFERENTIATION

DeSUMOylating isopeptidase: a second class of SUMO protease

(2012) Eun Ju Shin et al.   EMBO REPORTS

Combination of Caspy2 and IP-10 Gene Therapy Significantly Improves Therapeutic Efficacy Against Murine Malignant Neoplasm Growth and Metastasis

(2012) Na Zhang et al.   HUMAN GENE THERAPY

Expression of hPNAS-4 Radiosensitizes Lewis Lung Cancer

(2012) Hui Zeng et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression

(2012) S. S. Foster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The apoptotic ring: A novel entity with phosphorylated histones H2AX and H2B, and activated DNA damage response kinases

(2011) Stéphanie Solier et al.   CELL CYCLE

The RNA surveillance protein SMG1 activates p53 in response to DNA double-strand breaks but not exogenously oxidized mRNA

(2011) Jennifer S. Gewandter et al.   CELL CYCLE

Dbf4 Is Direct Downstream Target of Ataxia Telangiectasia Mutated (ATM) and Ataxia Telangiectasia and Rad3-related (ATR) Protein to Regulate Intra-S-phase Checkpoint

(2011) Alan Yueh-Luen Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PNAS4 knockout does not induce obviously neurocytes apoptosis and abnormal development in mice brain

(2011) Peiling Cai et al.   MOLECULAR BIOLOGY REPORTS

PNAS-4 expression and its relationship to p53 in colorectal cancer

(2011) Bin Zhou et al.   MOLECULAR BIOLOGY REPORTS

Intrinsic regenerative potential of murine cochlear supporting cells

(2011) Saku T. Sinkkonen et al.   Scientific Reports

Eukaryotic Chromosome DNA Replication: Where, When, and How?

(2010) Hisao Masai et al.   Annual Review of Biochemistry

Targeting Apoptotic Signaling Pathways in Human Lung Cancer

(2010) S.W. Han et al.   CURRENT CANCER DRUG TARGETS

Induction of Cell Death through Alteration of Oxidants and Antioxidants in Lung Epithelial Cells Exposed to High Energy Protons

(2010) Sudhakar Baluchamy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PNAS-4, a novel pro-apoptotic gene, can potentiate antineoplastic effects of cisplatin

(2009) Zhu Yuan et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Improved therapeutic efficacy against murine carcinoma by combining honokiol with gene therapy of PNAS-4, a novel pro-apoptotic gene

(2009) Zhu Yuan et al.   CANCER SCIENCE

A novel pro-apoptosis gene PNAS4 that induces apoptosis in A549 human lung adenocarcinoma cells and inhibits tumor growth in mice

(2008) Fei Yan et al.   BIOCHIMIE

Genetic transfer of PNAS-4 induces apoptosis and enhances sensitivity to gemcitabine in lung cancer

(2008) Shengyan Hou et al.   CELL BIOLOGY INTERNATIONAL

Cleavage-mediated Activation of Chk1 during Apoptosis

(2008) Kenkyo Matsuura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATR: an essential regulator of genome integrity

(2008) Karlene A. Cimprich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress

(2008) S C Gehen et al.   ONCOGENE

A chemical method for fast and sensitive detection of DNA synthesis in vivo

(2008) A. Salic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA