Iron-induced Local Complement Component 3 (C3) Up-regulation via Non-canonical Transforming Growth Factor (TGF)-β Signaling in the Retinal Pigment Epithelium

Smoke Exposure Causes Endoplasmic Reticulum Stress and Lipid Accumulation in Retinal Pigment Epithelium through Oxidative Stress and Complement Activation

(2014) Kannan Kunchithapautham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells

(2014) Danielle Kamato et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration

(2013) Johanna M Seddon et al.   NATURE GENETICS

Seven new loci associated with age-related macular degeneration

(2013) Lars G Fritsche et al.   NATURE GENETICS

The Oral Iron Chelator Deferiprone Protects Against Retinal Degeneration Induced through Diverse Mechanisms

(2013) Majda Hadziahmetovic et al.   Translational Vision Science & Technology

Ferroxidase Hephaestin's Cell-Autonomous Role in the Retinal Pigment Epithelium

(2012) Natalie Wolkow et al.   AMERICAN JOURNAL OF PATHOLOGY

Smad3 linker phosphorylation attenuates Smad3 transcriptional activity and TGF-β1/Smad3-induced epithelial–mesenchymal transition in renal epithelial cells

(2012) Eunjin Bae et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phospho-specific Smad3 signaling

(2012) Elizabeth Tarasewicz et al.   CELL CYCLE

Systemic administration of the iron chelator deferiprone protects against light-induced photoreceptor degeneration in the mouse retina

(2012) Delu Song et al.   FREE RADICAL BIOLOGY AND MEDICINE

How does the macula protect itself from oxidative stress?

(2012) James T. Handa   MOLECULAR ASPECTS OF MEDICINE

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TGF-Beta Induced Erk Phosphorylation of Smad Linker Region Regulates Smad Signaling

(2012) Chris Hough et al.   PLoS One

ERK1/2 activation is a therapeutic target in age-related macular degeneration

(2012) S. Dridi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aceruloplasminemia

(2011) Natalie Wolkow   ARCHIVES OF OPHTHALMOLOGY

Complement Factor H–ligand interactions: Self-association, multivalency and dissociation constants

(2011) Stephen J. Perkins et al.   IMMUNOBIOLOGY

Iron MediatesN-Methyl-d-aspartate Receptor-dependent Stimulation of Calcium-induced Pathways and Hippocampal Synaptic Plasticity

(2011) Pablo Muñoz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sublytic Membrane-Attack-Complex (MAC) Activation Alters Regulated Rather than Constitutive Vascular Endothelial Growth Factor (VEGF) Secretion in Retinal Pigment Epithelium Monolayers

(2011) Kannan Kunchithapautham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron overload triggers redox-sensitive signals in human IMR-32 neuroblastoma cells

(2010) Gabriela A. Salvador et al.   NEUROTOXICOLOGY

Transforming Growth Factor-β-inducible Phosphorylation of Smad3

(2009) Guannan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative Stress Renders Retinal Pigment Epithelial Cells Susceptible to Complement-mediated Injury

(2009) Joshua M. Thurman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin Ligase Nedd4L Targets Activated Smad2/3 to Limit TGF-β Signaling

(2009) Sheng Gao et al.   MOLECULAR CELL

Up-regulation of complement factor B in retinal pigment epithelial cells is accompanied by complement activation in the aged retina

(2008) Mei Chen et al.   EXPERIMENTAL EYE RESEARCH