Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice

Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia

(2018) Alexis A. Thompson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Non-Invasive Multiphoton Imaging of Islets Transplanted Into the Pinna of the NOD Mouse Ear Reveals the Immediate Effect of Anti-CD3 Treatment in Autoimmune Diabetes

(2018) Robert A. Benson et al.   Frontiers in Immunology

Gene Therapy in a Patient with Sickle Cell Disease

(2017) Jean-Antoine Ribeil et al.   NEW ENGLAND JOURNAL OF MEDICINE

AAV5–Factor VIII Gene Transfer in Severe Hemophilia A

(2017) Savita Rangarajan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of type 1 diabetes development and B-cell activation in nonobese diabetic mice by early life exposure to a diabetogenic environment

(2017) Alessandra De Riva et al.   PLoS One

Risk of tuberculosis in patients treated with TNF-α antagonists: a systematic review and meta-analysis of randomised controlled trials

(2017) Zheng Zhang et al.   BMJ Open

Overcoming the Host Immune Response to Adeno-Associated Virus Gene Delivery Vectors: The Race Between Clearance, Tolerance, Neutralization, and Escape

(2017) Federico Mingozzi et al.   Annual Review of Virology

AAV-mediated pancreatic overexpression of Igf1 counteracts progression to autoimmune diabetes in mice

(2017) Cristina Mallol et al.   Molecular Metabolism

Correction of Murine Diabetic Hyperglycaemia With A Single Systemic Administration of An AAV2/8 Vector Containing A Novel Codon Optimized Human Insulin Gene

(2016) Gan Shu Uin et al.   CURRENT GENE THERAPY

Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset

(2016) Frederico R.C. Costa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Promoter optimisation of lentiviral vectors for efficient insulin gene expression in canine mesenchymal stromal cells: potential surrogate beta cells

(2016) Pratigya Gautam et al.   JOURNAL OF GENE MEDICINE

Decreased chronic cellular and antibody-mediated injury in the kidney following simultaneous liver-kidney transplantation

(2016) Timucin Taner et al.   KIDNEY INTERNATIONAL

Synergistic Efficacy from Gene Therapy with Coreceptor Blockade and a β2-Agonist in Murine Pompe Disease

(2015) Sang-oh Han et al.   HUMAN GENE THERAPY

Long-term glycemic control with hepatic insulin gene therapy in streptozotocin-diabetic mice

(2015) Peter M. Thulé et al.   JOURNAL OF GENE MEDICINE

Insulin B chain 9–23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3 + T regs

(2015) Mahzad Akbarpour et al.   Science Translational Medicine

Long-Term Safety and Efficacy of Factor IX Gene Therapy in Hemophilia B

(2014) Amit C. Nathwani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treatment of Diabetes and Long-Term Survival After Insulin and Glucokinase Gene Therapy

(2013) D. Callejas et al.   DIABETES

Protection of Islet Grafts Through Transforming Growth Factor-β–Induced Tolerogenic Dendritic Cells

(2013) David C. Thomas et al.   DIABETES

Correction of Diabetic Hyperglycemia and Amelioration of Metabolic Anomalies by Minicircle DNA Mediated Glucose-Dependent Hepatic Insulin Production

(2013) Tausif Alam et al.   PLoS One

Immune mechanisms in type 1 diabetes

(2013) Maja Wållberg et al.   TRENDS IN IMMUNOLOGY

DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

(2012) Brian J Ferguson et al.   eLife

Successful attenuation of humoral immunity to viral capsid and transgenic protein following AAV-mediated gene transfer with a non-depleting CD4 antibody and cyclosporine

(2011) J H McIntosh et al.   GENE THERAPY

Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B

(2011) Amit C. Nathwani et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Liver as a Lymphoid Organ

(2009) Ian Nicholas Crispe   Annual Review of Immunology

Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients

(2009) B. Keymeulen et al.   BLOOD

Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver

(2009) Ekaterina Breous et al.   HEPATOLOGY

Functional inhibition related to structure of a highly potent insulin-specific CD8 T cell clone using altered peptide ligands

(2007) Liliana G. Petrich de Marquesini et al.   EUROPEAN JOURNAL OF IMMUNOLOGY