Review
Biochemistry & Molecular Biology
Han-Bi Kim, Ji-Young Um, Bo-Young Chung, Jin-Cheol Kim, Seok-Young Kang, Chun-Wook Park, Hye-One Kim
Summary: The aryl hydrocarbon receptor (AhR) is crucial for the metabolism of xenobiotics and has been found to be associated with various diseases in different organs. Recent studies have shed light on its functions in chronic inflammatory skin diseases such as atopic dermatitis (AD) and psoriasis (PS), as well as its impact on the immune system of the skin. The therapeutic effects of AhR ligands have been demonstrated, but further research is needed to fully understand the roles of AhR in chronic inflammatory skin diseases.
Review
Pharmacology & Pharmacy
Aeshah Alluli, Willem Rijnbout St James, David H. Eidelman, Carolyn J. Baglole
Summary: The aryl hydrocarbon receptor (AhR) is activated by endogenous ligands and xenobiotic chemicals, and its activation has both physiological and toxicological effects. It has been found that the activation of AhR can influence the expression and function of long non-coding RNA (lncRNA), which plays important roles in various physiological processes and diseases. The interplay between AhR and lncRNA needs further investigation to better understand their relationship and implications.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Geriatrics & Gerontology
Sara Abudahab, E. T. Price, M. G. Dozmorov, L. S. Deshpande, J. L. McClay
Summary: This article mainly discusses the role of aryl hydrocarbon receptor (AhR) in aging and longevity, as well as several AhR ligands with potential anti-aging properties. The article suggests that AhR-driven expression of xenobiotic metabolism genes into old age may be a key mechanism through which moderate induction of AhR elicits positive benefits on longevity and healthspan. Additionally, the article shows that liver-specific AhR target genes are enriched among genes subject to epigenetic aging through integration of publicly available datasets. Hence, the interplay between AhR and epigenetic aging should be the subject of future research, and a broad range of non-toxic AhR ligands should be investigated for their potential to promote healthspan and longevity.
JOURNAL OF NUTRITION HEALTH & AGING
(2023)
Article
Biochemistry & Molecular Biology
Ji-Young Um, Bo-Young Chung, Han-Bi Kim, Jin-Cheol Kim, Chun-Wook Park, Hye-One Kim
Summary: This study confirms the hypomethylation and overexpression of AhRR in psoriatic skin lesions, regulating pro-inflammatory responses in TCDD-treated HaCaT cells through the NF-κB signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Sarah Y. Y. Kado, Keith Bein, Alejandro R. R. Castaneda, Arshia A. A. Pouraryan, Nicole Garrity, Yasuhiro Ishihara, Andrea Rossi, Thomas Haarmann-Stemmann, Colleen A. A. Sweeney, Christoph F. A. Vogel
Summary: IDO2 is a tryptophan-catabolizing enzyme with a distinct expression pattern compared to IDO1. Recent studies indicate that IDO2 exerts both non-enzymatic and pro-inflammatory activity, which may play a role in diseases such as autoimmunity and cancer. This study found that IDO2 expression can be induced by activation of the aryl hydrocarbon receptor (AhR) through endogenous compounds and environmental pollutants.
Article
Immunology
Christoph F. A. Vogel, Gwendal Lazennec, Sarah Y. Kado, Carla Dahlem, Yi He, Alejandro Castaneda, Yasuhiro Ishihara, Christian Vogeley, Andrea Rossi, Thomas Haarmann-Stemmann, Juliann Jugan, Hidetoshi Mori, Alexander D. Borowsky, Michele A. La Merrill, Colleen Sweeney
Summary: AhRR is a potential tumor suppressor that can inhibit the development of mammary tumors, suggesting therapeutic potential for the restoration and expression of AhRR.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Charlotte Esser
Summary: Identifying historical trajectories is helpful in research to clarify important shifts in science. This review discusses the role of AHR in linking environmental pollution toxicity with healthy adaptive immune and skin responses, revealing opportunities for targeting AHR in treating various diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Toxicology
Anitha Vijay, Nina R. Boyle, Supriya M. Kumar, Gary H. Perdew, Shanthi Srinivasan, Andrew D. Patterson
Summary: This study investigates the effects of a persistent organic pollutant on the enteric nervous system, finding that it leads to delayed intestinal motility and neuronal damage, thereby affecting gastrointestinal function.
TOXICOLOGICAL SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Ziyue Kou, Wei Dai
Summary: Aryl hydrocarbon receptor (AHR) is a cellular protein involved in detoxification of xenobiotic compounds. Research has shown that AHR plays important roles in normal development and homeostasis, and its deficiency can lead to various developmental abnormalities.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Environmental Sciences
Khursheed Iqbal, Stephen H. Pierce, Keisuke Kozai, Pramod Dhakal, Regan L. Scott, Katherine F. Roby, Carrie A. Vyhlidal, Michael J. Soares
Summary: TCDD exposure affects placental adaptations, with higher doses leading to pregnancy termination. These adaptations depend on maternal AHR signaling, rather than placental or fetal AHR signaling or the presence of CYP1A1 as a prominent AHR target.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Article
Oncology
Michelle M. Steidemann, Jian Liu, Kalin Bayes, Lizbeth P. Castro, Shelagh Ferguson-Miller, John J. Lapres
Summary: Cellular homeostasis requires the use of multiple environmental sensors to respond to different compounds. The aryl hydrocarbon receptor (AHR) and the translocator protein (TSPO) are two proteins involved in cellular homeostasis, and their interaction affects mitochondrial-related genes. Knockouts for AHR and TSPO were created in a mouse lung epithelial cell line, and the cells' response to ligands for AHR and TSPO was analyzed through RNA-seq. The results suggest that AHR and TSPO participate in similar pathways that contribute to mitochondrial homeostasis.
EXPERIMENTAL CELL RESEARCH
(2023)
Review
Cell Biology
Claudia Rejano-Gordillo, Ana Ordiales-Talavero, Ana Nacarino-Palma, Jaime M. Merino, Francisco J. Gonzalez-Rico, Pedro M. Fernandez-Salguero
Summary: The transcription factor aryl hydrocarbon receptor (AHR) is a key regulator involved in cell functions and tumor progression. It can act as either an oncogene or a tumor suppressor, depending on the specific organ, tissue and cell type. In addition to its role in cell adhesion and migration, AHR has potential as a therapeutic tool, diagnosis and prognosis marker.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Engineering, Environmental
Yongyi Wei, Hainan Sun, Songyan Zhang, Heidi Qunhui Xie, Cong Li, Bin Zhao, Bing Yan
Summary: This study found that different environmental nanoparticles have varying effects on the cellular detoxification process. Multi-walled carbon nanotubes can impact the potential detoxification of dioxin-induced toxicity through modulating the AhR signaling pathway.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Lucia Sladekova, Sridhar Mani, Zdenek Dvorak
Summary: The aryl hydrocarbon receptor (AhR) is a crucial member of the helix-loop-helix transcription factors family, playing a central role in host physiology and various pathophysiologies. Activation of AhR is ligand-driven and the pharmacology of activation is dependent on the type and quantity of ligand. Therefore, understanding AhR ligands is essential for further advancements in the field. This minireview clarifies misconceptions and explores the true nature of AhR activation by discussing selected chemical classes and their qualification as true receptor ligands.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Cell Biology
Tiziana Guarnieri
Summary: This review discusses the significant role of Aryl hydrocarbon Receptor (AhR) in the inflammatory framework of COVID-19, including its regulation of ACE-2 and B(0)AT1 expression, as well as its induction of IDO-1 and production of IL-6.
Article
Anatomy & Morphology
Eiki Kimura, Chiharu Tohyama
FRONTIERS IN NEUROANATOMY
(2017)
Article
Toxicology
Eiki Kimura, Chiharu Tohyama
ARCHIVES OF TOXICOLOGY
(2018)
Article
Multidisciplinary Sciences
Eiki Kimura, Ken-ichiro Kubo, Toshihiro Endo, Wenting Ling, Kazunori Nakajima, Masaki Kakeyama, Chiharu Tohyama
Meeting Abstract
Toxicology
E. Kimura, F. Maekawa, C. Tohyama
TOXICOLOGY LETTERS
(2018)
Article
Multidisciplinary Sciences
Hesbon Z. Amenya, Chiharu Tohyama, Seiichiroh Ohsako
SCIENTIFIC REPORTS
(2016)
Article
Environmental Sciences
Yoshinori Ikenaka, Yuichi Miyabara, Takahiro Ichise, Shouta Nakayama, Collins Nimako, Mayumi Ishizuka, Chiharu Tohyama
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2019)
Article
Pharmacology & Pharmacy
Keiko Aida-Yasuoka, Noriko Nishimura, Nozomi Fujisawa, Nozomi Endo, Shuh Narumiya, Chiharu Tohyama
Article
Toxicology
Nozomi Fujisawa, Wataru Yoshioka, Hiroyuki Yanagisawa, Chiharu Tohyama
ARCHIVES OF TOXICOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Wataru Yoshioka, Chiharu Tohyama
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Toxicology
Nozomi Fujisawa, Chiharu Tohyama, Wataru Yoshioka
JOURNAL OF TOXICOLOGICAL SCIENCES
(2019)
Article
Biology
Nozomi Endo, Waka Ujita, Masaya Fujiwara, Hideaki Miyauchi, Hiroyuki Mishima, Yusuke Makino, Lisa Hashimoto, Hiroshi Oyama, Manabu Makinodan, Mayumi Nishi, Chiharu Tohyama, Masaki Kakeyama
COMMUNICATIONS BIOLOGY
(2018)
Article
Toxicology
Nozomi Fujisawa, Wataru Yoshioka, Hiroyuki Yanagisawa, Chiharu Tohyama
ARCHIVES OF TOXICOLOGY
(2018)
Article
Medicine, Research & Experimental
Ken-Ichiro Kubo, Kimiko Deguchi, Taku Nagai, Yukiko Ito, Keitaro Yoshida, Toshihiro Endo, Seico Benner, Wei Shan, Ayako Kitazawa, Michihiko Aramaki, Kazuhiro Ishii, Minkyung Shin, Yuki Matsunaga, Kanehiro Hayashi, Masaki Kakeyama, Chiharu Tohyama, Kenji F. Tanaka, Kohichi Tanaka, Sachio Takashima, Masahiro Nakayama, Masayuki Itoh, Yukio Hirata, Barbara Antalffy, Dawna D. Armstrong, Kiyofumi Yamada, Ken Inoue, Kazunori Nakajima
Article
Biochemistry & Molecular Biology
Toshiki Aiba, Toshiyuki Saito, Akiko Hayashi, Shinji Sato, Harunobu Yunokawa, Toru Maruyama, Wataru Fujibuchi, Hisaka Kurita, Chiharu Tohyama, Seiichiroh Ohsako
BMC MOLECULAR BIOLOGY
(2017)
Article
Toxicology
Eiki Kimura, Ken-ichiro Kubo, Toshihiro Endo, Kazunori Nakajima, Masaki Kakeyama, Chiharu Tohyama
JOURNAL OF TOXICOLOGICAL SCIENCES
(2017)
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)