Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase

TRPV4: New therapeutic target for inflammatory bowel diseases

(2014) Nathalie Vergnolle   BIOCHEMICAL PHARMACOLOGY

Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease

(2013) M D Hollenberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

The puzzle of TRPV4 channelopathies

(2013) Bernd Nilius et al.   EMBO REPORTS

Protease-activated Receptor 2 (PAR2) Protein and Transient Receptor Potential Vanilloid 4 (TRPV4) Protein Coupling Is Required for Sustained Inflammatory Signaling

(2013) Daniel P. Poole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Temporomandibular joint pain: A critical role for Trpv4 in the trigeminal ganglion

(2013) Yong Chen et al.   PAIN

UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling

(2013) Carlene Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient receptor potential vanilloid 1 (TRPV1), TRPV4, and the kidney

(2012) M. Kaßmann et al.   Acta Physiologica

TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis

(2012) Li Ye et al.   CELL

Plasmin and chymotrypsin have distinct preferences for channel activating cleavage sites in the γ subunit of the human epithelial sodium channel

(2012) Silke Haerteis et al.   JOURNAL OF GENERAL PHYSIOLOGY

Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S

(2012) Silke Haerteis et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception

(2011) Manish Raisinghani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Electrophysiological properties of heteromeric TRPV4–C1 channels

(2011) Xin Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110)

(2011) JY Suen et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRPV4-Mediated Calcium Influx into Human Bronchial Epithelia upon Exposure to Diesel Exhaust Particles

(2011) Jinju Li et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Neutrophil Elastase Acts as a Biased Agonist for Proteinase-activated Receptor-2 (PAR2)

(2011) Rithwik Ramachandran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in TRPV4 cause an inherited arthropathy of hands and feet

(2011) Shireen R Lamandé et al.   NATURE GENETICS

Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain

(2011) Y. Chen et al.   NEUROSCIENCE

Determinants of TRPV4 Activity following Selective Activation by Small Molecule Agonist GSK1016790A

(2011) Min Jin et al.   PLoS One

Forward Genetic Analysis Reveals Multiple Gating Mechanisms of TRPV4

(2010) Stephen Loukin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A mutation of the epithelial sodium channel associated with atypical cystic fibrosis increases channel open probability and reduces Na+self inhibition

(2010) Robert Rauh et al.   JOURNAL OF PHYSIOLOGY-LONDON

Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis

(2010) W. Everaerts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes

(2009) Mimi N. Phan et al.   ARTHRITIS AND RHEUMATISM

Identification and characterization of novel TRPV4 modulators

(2009) Fabien Vincent et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cholesterol Depletion of the Plasma Membrane Prevents Activation of the Epithelial Sodium Channel (ENaC) by SGK1

(2009) Bettina Krueger et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Agonist-Biased Signaling via Proteinase Activated Receptor-2: Differential Activation of Calcium and Mitogen-Activated Protein Kinase Pathways

(2009) R. Ramachandran et al.   MOLECULAR PHARMACOLOGY

Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4

(2009) Han-Xiang Deng et al.   NATURE GENETICS

Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C

(2009) Guida Landouré et al.   NATURE GENETICS

The vanilloid transient receptor potential channel TRPV4: From structure to disease

(2009) Wouter Everaerts et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia

(2008) Walter E. B. Sipe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Prostatic trypsin-like kallikrein-related peptidases (KLKs) and other prostate-expressed tryptic proteinases as regulators of signalling via proteinase-activated receptors (PARs)

(2008) Andrew J. Ramsay et al.   BIOLOGICAL CHEMISTRY

Transient Receptor Potential Vanilloid-4 Has a Major Role in Visceral Hypersensitivity Symptoms

(2008) Nicolas Cenac et al.   GASTROENTEROLOGY

Selective Role for TRPV4 Ion Channels in Visceral Sensory Pathways

(2008) Stuart M. Brierley et al.   GASTROENTEROLOGY

Kallikrein-related Peptidase 4 (KLK4) Initiates Intracellular Signaling via Protease-activated Receptors (PARs)

(2008) Andrew J. Ramsay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-((1S)-1- -3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Part I

(2008) K. S. Thorneloe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cleavage in the γ-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels

(2008) Alexei Diakov et al.   JOURNAL OF PHYSIOLOGY-LONDON

Prostate-Specific Kallikreins-2 and -4 Enhance the Proliferation of DU-145 Prostate Cancer Cells through Protease-Activated Receptors-1 and -2

(2008) G. J. Mize et al.   MOLECULAR CANCER RESEARCH

Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia

(2008) Matthew J Rock et al.   NATURE GENETICS