Article
Cell Biology
Faye L. Styles, Moza M. Al-Owais, Jason L. Scragg, Eulashini Chuntharpursat-Bon, Nishani T. Hettiarachchi, Jonathan D. Lippiat, Aisling Minard, Robin S. Bon, Karen Porter, Piruthivi Sukumar, Chris Peers, Lee D. Roberts
Summary: The Kv1.3 voltage-gated potassium channel drives cellular proliferation by increasing oxidative phosphorylation and generating reactive oxygen species independently of redox balance, mitochondrial membrane potential, or calcium signaling. Reduction of reactive oxygen concentrations inhibits Kv1.3-induced proliferation.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Supriya Ramesha, Sruti Rayaprolu, Christine A. Bowen, Cynthia R. Giver, Sara Bitarafan, Hai M. Nguyen, Tianwen Gao, Michael J. Chen, Ngozi Nwabueze, Eric B. Dammer, Amanda K. Engstrom, Hailian Xiao, Andrea Pennati, Nicholas T. Seyfried, David J. Katz, Jacques Galipeau, Heike Wulff, Edmund K. Waller, Levi B. Wood, Allan Levey, Srikant Rangaraju
Summary: By studying Kv1.3-expressing CNS-MPs in AD mouse models, researchers have identified unique molecular features of these cells and confirmed their microglial origin. Blocking Kv1.3 channels in vivo resulted in reduced Aβ burden, increased anti-inflammatory CNS-MPs, and a prophagocytic phenotype in AD mouse models.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Xin Zhang, Xiulin Lin, Hui Luo, Yuanxing Zhi, Xin Yi, Xiaoyan Wu, Wendi Duan, Ying Cao, Jianxin Pang, Shuwen Liu, Pingzheng Zhou
Summary: Potassium efflux mediated by the Kv1.3 channel plays a critical role in TLR3/4 activation, and pharmacological inhibition of Kv1.3 may be beneficial for treating autoimmune diseases and bacterial infections.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Melania Melis, Iole Tomassini Barbarossa, Roberto Crnjar, Giorgia Sollai
Summary: Smell strongly influences food choice and hedonistic evaluation. The Kv1.3 gene's polymorphism has significant effects on olfactory function and BMI. The sex-related differences in olfactory function may be partially attributed to the Kv1.3 gene's polymorphism.
Article
Multidisciplinary Sciences
Albert Vallejo-Gracia, Daniel Sastre, Magali Colomer-Molera, Laura Sole, Maria Navarro-Perez, Jesusa Capera, Sara R. Roig, Oriol Pedros-Gamez, Irene Estadella, Orsolya Szilagyi, Gyorgy Panyi, Peter Hajdu, Antonio Felipe
Summary: KCNE4 serves as a crucial regulator in modulating immune system physiology by controlling Kv1.3-associated leukocyte functions.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
K. George Chandy, Karoline Sanches, Raymond S. Norton
Summary: The voltage-gated potassium channel K(V)1.3 is an important therapeutic target for autoimmune and neuroinflammatory diseases. Recent structural studies have provided insights into the conformational changes of the channel and the mechanism of ion permeation. These findings contribute to a better understanding of the slow inactivation mechanism of K(V) channels and can guide the development of future immunotherapeutics targeting K(V)1.3.
Article
Biology
Jesusa Capera, Mireia Perez-Verdaguer, Roberta Peruzzo, Maria Navarro-Perez, Juan Martinez-Pinna, Armando Alberola-Die, Andres Morales, Luigi Leanza, Ildiko Szabo, Antonio Felipe
Summary: The voltage-gated potassium channel Kv1.3 plays a dual role in immune cells and cancer cells, with its different cellular locations leading to involvement in distinct physiological processes.
Article
Medicine, General & Internal
Christian Malte Bosselmann, Ulrike B. S. Hedrich, Peter Mueller, Lukas Sonnenberg, Shridhar Parthasarathy, Ingo Helbig, Holger Lerche, Nico Pfeifer
Summary: This study focuses on the impact of variants in genes encoding voltage-gated potassium channels on neurological diseases. A taxonomy-based multi-task learning support vector machine model is developed to predict functional variants of voltage-gated potassium channels, which may assist in precision therapies.
Article
Agronomy
Xiaoyi Huo, Haihao Ma, Hang Zhu, Jia Liu, Yong Zhou, Xiaomao Zhou, Zheming Liu
Summary: This study examined the expression profile and pharmacological properties of the Kv2 channel in Plutella xylostella. It identified several high potency inhibitors and provided insights into further research and designing novel insecticides.
PEST MANAGEMENT SCIENCE
(2023)
Review
Oncology
Lulan Chen, Yue He, Xiangdong Wang, Junbo Ge, Hua Li
Summary: Cardiac voltage-gated ion channels are crucial for maintaining normal heart excitability and contraction. Studying VGICs can help identify new targets for heart disease and drug evaluation.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Alexey I. Kuzmenkov, Andrei M. Gigolaev, Ernesto L. Pinheiro-Junior, Steve Peigneur, Jan Tytgat, Alexander A. Vassilevski
Summary: Previous studies have identified key amino acid residues in scorpion toxins that block potassium channels, particularly in the α-KTx family affecting voltage-gated potassium channels (KV). A conserved K-C-X-N motif is found in the C-terminal half of their sequence, with the X position usually occupied by methionine or isoleucine. Comparing the activity of peptides differing only by this residue on a panel of KV1 channels, it was found that toxins with methionine specifically affect KV1.1 and 1.6 isoforms. The refined K-C-M/I-N motif is the principal structural element of α-KTx that contributes to high affinity and selectivity to KV channels.
Article
Agronomy
Linlin Yuan, Kun Zhang, Zhenglei Wang, Limin Xian, Kaiyang Liu, Shaoying Wu
Summary: The sodium channel of Drosophila suzukii was cloned and found to have diverse gating properties and RNA editing.
PEST MANAGEMENT SCIENCE
(2023)
Article
Neurosciences
Hui Liu, Hong-Gang Wang, Geoffrey Pitt, Zhe Liu
Summary: This study investigates the subcellular localization and dynamics of voltage-gated sodium channels Na(v)1.2 and Na(v)1.6 using genome editing, super-resolution, and live-cell single-molecule imaging. The researchers discovered a previously uncharacterized trafficking pathway for Na(v)1.2 and revealed the developmental regulation of Na(v)1.2 and Na(v)1.6 in different subcellular compartments.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
Joy R. Wright, Sarah Jones, Sasikumar Parvathy, Leonard K. Kaczmarek, Ian Forsythe, Richard W. Farndale, Jonathan M. Gibbins, Martyn P. Mahaut-Smith
Summary: Kv1.3 deficiency in platelets leads to enhanced ADP-induced platelet aggregation and secretion, as well as increased surface expression of platelet integrin alpha(IIb); however, in vivo thrombus formation experiments show no significant difference compared to wild type mice, suggesting compensatory pro-thrombotic pathways may be at play. Kv1.3 plays a role in modulating integrin-dependent platelet adhesion, with implications for understanding its contribution to normal physiological platelet function and disease models.
Review
Biochemistry & Molecular Biology
Alla F. Fomina, Hai M. Nguyen, Heike Wulff
Summary: In the past 5 years, inhibitors of the potassium channel K(V)1.3 have been shown to reduce neuroinflammation in various disease models by reducing microglia activation and suppressing pro-inflammatory cytokines and nitric oxide production. Recent studies have revealed that K(V)1.3 channels not only regulate membrane potential, but also play a crucial role in regulating calcium influx in microglia, similar to their role in T cells.
Article
Physiology
Yiming Shen, Jin Bong Park, So Yeong Lee, Seong Kyu Han, Pan Dong Ryu
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Hee Kyoung Joo, Yu Ran Lee, Eun-Ok Lee, Myoung Soo Park, Sunga Choi, Cuk-Seong Kim, Jin-Bong Park, Byeong Hwa Jeon
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Article
Biotechnology & Applied Microbiology
Bo-Hyung Lee, Dominique Garmyn, Laurent Gal, Cyprien Guerin, Laurent Guillier, Alain Rico, Bjoern Rotter, Pierre Nicolas, Pascal Piveteau
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2019)
Article
Microbiology
Amber L. Dorey, Bo-Hyung Lee, Bjorn Rotter, Conor P. O'Byrne
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Microbiology
Bo-Hyung Lee, Sophie Cole, Stephanie Badel-Berchoux, Laurent Guillier, Benjamin Felix, Nicolas Krezdorn, Michel Hebraud, Thierry Bernardi, Ibrahim Sultan, Pascal Piveteau
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Neurosciences
Sudip Pandit, Chiranjivi Neupane, Junsung Woo, Ramesh Sharma, Min-Ho Nam, Gyu-Seung Lee, Min-Hee Yi, Nara Shin, Dong Woon Kim, Hyunsill Cho, Byeong Hwa Jeon, Hyun-Woo Kim, C. Justin Lee, Jin Bong Park
Article
Pharmacology & Pharmacy
Ramesh Sharma, Michiko Nakamura, Chiranjivi Neupane, Byeong Hwa Jeon, Hyewon Shin, Susan M. Melnick, Kelli J. Glenn, Il-Sung Jang, Jin Bong Park
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Article
Microbiology
Miguel Villoria Recio, Bo-Hyung Lee, Eva Maria Sternkopf Lillebaek, Birgitte H. Kallipolitis, Cormac G. M. Gahan, Hanne Ingmer, Marianne Halberg Larsen
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Parasitology
Kwon Moo Park, Sun-Don Kim, Jin Bong Park, Sung-Jong Hong, Pan Dong Ryu
Summary: In this study, 2 types of cation channels and 1 type of anion channel were identified in Ascaris suum tissues. The gating of these channels did not vary significantly with voltage and their ionic selectivity is relatively low. Further research is needed to explore their molecular nature, functions, and potential as targets for anthelmintic drugs.
KOREAN JOURNAL OF PARASITOLOGY
(2021)
Biographical-Item
Integrative & Complementary Medicine
Ku Youn Baik, Hak Soo Shin, Pan-Dong Ryu
JOURNAL OF ACUPUNCTURE AND MERIDIAN STUDIES
(2022)
Article
Integrative & Complementary Medicine
Yiming Shen, Yu Jeong Kim, Pan Dong Ryu
Summary: This study demonstrates that adrenergic signaling mediates hyperplastic morphological changes in the organ surface primo vascular system (PVS) in rats. These findings help to explain the morphological dynamics of the PVS tissues and further understand the pathophysiological roles of the PVS.
JOURNAL OF ACUPUNCTURE AND MERIDIAN STUDIES
(2022)
Article
Veterinary Sciences
Jun-Sik Lim, Eutteum Kim, Pan-Dong Ryu, Son-Il Pak
Summary: This study estimated the basic reproduction number (R-0) of African swine fever (ASF) in wild boars in South Korea and found 22 local transmission clusters showing seasonal patterns. The R-0 estimates showed a temporal increasing trend and positive association with habitat suitability of wild boar.
JOURNAL OF VETERINARY SCIENCE
(2021)
Article
Ecology
Cyprien Guerin, Bo-Hyung Lee, Benjamin Fradet, Erwin van Dijk, Bogdan Mirauta, Claude Thermes, Jean-Francois Bernardet, Francis Repoila, Eric Duchaud, Pierre Nicolas, Tatiana Rochat
Summary: This study conducted extensive transcriptome analysis of Flavobacterium psychrophilum, identifying genome maps, transcription start sites, and gene expression profiles across various conditions. It highlighted the connection between genes, environmental conditions, and phenotypic traits, providing insights into gene regulation and revealing characteristics linked to the phylogenetic position and ecological niche of the bacterium. The results also suggested potential directions for future research on protein and regulatory elements involved in host-pathogen interactions, metabolic pathways, and molecular machineries.
ISME COMMUNICATIONS
(2021)
Article
Veterinary Sciences
Seung Yub Shin, Tae Hee Han, Hyuk Joon Kwon, Sun Joong Kim, Pan Dong Ryu
Summary: The study showed that dexamethasone can reduce mortality in chickens infected with vvIBDV, while treatment with aspirin or vitamin E plus selenium did not affect mortality. The bursa of Fabricius appeared to have shrunk in chickens following infection.
JOURNAL OF VETERINARY SCIENCE
(2021)
Article
Integrative & Complementary Medicine
Chae Jeong Lim, Yiming Shen, Min Cheol Choi, Pan Dong Ryu
JOURNAL OF ACUPUNCTURE AND MERIDIAN STUDIES
(2020)