Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies

Nanobodies: Natural Single-Domain Antibodies

(2013) Serge Muyldermans   Annual Review of Biochemistry

Understanding, recognizing, and managing toxicities of targeted anticancer therapies

(2013) Grace K. Dy et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains

(2013) Karl R. Schmitz et al.   STRUCTURE

Novel Antiplatelet Agents: ALX-0081, a Nanobody Directed towards von Willebrand Factor

(2013) Jozef Bartunek et al.   Journal of Cardiovascular Translational Research

Exploiting structure similarity in refinement: automated NCS and target-structure restraints inBUSTER

(2012) Oliver S. Smart et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Nanobody-Based Targeting of the Macrophage Mannose Receptor for EffectiveIn VivoImaging of Tumor-Associated Macrophages

(2012) Kiavash Movahedi et al.   CANCER RESEARCH

Targeting breast carcinoma with radioiodinated anti-HER2 Nanobody

(2012) Marek Pruszynski et al.   NUCLEAR MEDICINE AND BIOLOGY

Nanobody®-based chromatin immunoprecipitation/micro-array analysis for genome-wide identification of transcription factor DNA binding sites

(2012) Trong Nguyen-Duc et al.   NUCLEIC ACIDS RESEARCH

Structural and functional analysis of phosphorylation-specific binders of the kinase ERK from designed ankyrin repeat protein libraries

(2012) L. Kummer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanobody stabilization of G protein-coupled receptor conformational states

(2011) Jan Steyaert et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Constraining Enzyme Conformational Change by an Antibody Leads to Hyperbolic Inhibition

(2011) David Oyen et al.   JOURNAL OF MOLECULAR BIOLOGY

A Conserved Glu–Arg Salt Bridge Connects Coevolved Motifs That Define the Eukaryotic Protein Kinase Fold

(2011) Jie Yang et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody

(2011) Young-Jun Park et al.   NUCLEIC ACIDS RESEARCH

Neonatal Lethality in Knockout Mice Expressing the Kinase-Dead Form of the Gefitinib Target GAK Is Caused by Pulmonary Dysfunction

(2011) Hiroe Tabara et al.   PLoS One

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Protein kinases: evolution of dynamic regulatory proteins

(2010) Susan S. Taylor et al.   TRENDS IN BIOCHEMICAL SCIENCES

GAK, a regulator of clathrin-mediated membrane traffic, also controls centrosome integrity and chromosome congression

(2009) H. Shimizu et al.   JOURNAL OF CELL SCIENCE

Structure of wild-type Plk-1 kinase domain in complex with a selective DARPin

(2008) Tiago M. Bandeiras et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites

(2008) Ashley C W Pike et al.   EMBO JOURNAL

Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus

(2008) Anita Y. Lam et al.   JOURNAL OF STRUCTURAL BIOLOGY

Essential Role of Cyclin-G–associated Kinase (Auxilin-2) in Developing and Mature Mice

(2008) Dong-won Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Structure of the Human Protein Kinase MPSK1 Reveals an Atypical Activation Loop Architecture

(2008) Jeyanthy Eswaran et al.   STRUCTURE