Organizing the genome with H2A histone variants

Ascending the nucleosome face: Recognition and function of structured domains in the histone H2A–H2B dimer

(2012) John J. Wyrick et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Comparative Epigenomic Annotation of Regulatory DNA

(2012) Shu Xiao et al.   CELL

Genome-wide Nucleosome Specificity and Directionality of Chromatin Remodelers

(2012) Kuangyu Yen et al.   CELL

Analysis of active chromatin modifications in early mammalian embryos reveals uncoupling of H2A.Z acetylation and H3K36 trimethylation from embryonic genome activation

(2012) Ana Bošković et al.   Epigenetics

The nonhistone, N-terminal tail of an essential, chimeric H2A variant regulates mitotic H3-S10 dephosphorylation

(2012) X. Song et al.   GENES & DEVELOPMENT

 Np63  represses anti-proliferative genes via H2A.Z deposition

(2012) C. L. Gallant-Behm et al.   GENES & DEVELOPMENT

ATRX-mediated chromatin association of histone variant macroH2A1 regulates  -globin expression

(2012) K. Ratnakumar et al.   GENES & DEVELOPMENT

A Conserved Function for the H2A.Z C Terminus

(2012) Daniel Wratting et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency

(2012) V. Pasque et al.   JOURNAL OF CELL SCIENCE

MacroH2A1 Regulates the Balance between Self-Renewal and Differentiation Commitment in Embryonic and Adult Stem Cells

(2012) C. Creppe et al.   MOLECULAR AND CELLULAR BIOLOGY

Histone Variant H2A.Bbd Is Associated with Active Transcription and mRNA Processing in Human Cells

(2012) Michael Y. Tolstorukov et al.   MOLECULAR CELL

New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?

(2012) Karolin Luger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Histone H2A.Z inheritance during the cell cycle and its impact on promoter organization and dynamics

(2012) Maxim Nekrasov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genome-wide profiles of H2AX and γ-H2AX differentiate endogenous and exogenous DNA damage hotspots in human cells

(2012) Jungmin Seo et al.   NUCLEIC ACIDS RESEARCH

The basic linker of macroH2A stabilizes DNA at the entry/exit site of the nucleosome

(2012) Srinivas Chakravarthy et al.   NUCLEIC ACIDS RESEARCH

H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization

(2012) Clemens Bönisch et al.   NUCLEIC ACIDS RESEARCH

Histone H2A variants in nucleosomes and chromatin: more or less stable?

(2012) C. Bonisch et al.   NUCLEIC ACIDS RESEARCH

A unified phylogeny-based nomenclature for histone variants

(2012) Paul B Talbert et al.   Epigenetics & Chromatin

SWI/SNF-Like Chromatin Remodeling Factor Fun30 Supports Point Centromere Function in S. cerevisiae

(2012) Mickaël Durand-Dubief et al.   PLoS Genetics

H2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions

(2012) Manching Ku et al.   GENOME BIOLOGY

Diversity of operation in ATP-dependent chromatin remodelers

(2011) Swetansu K. Hota et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Histone chaperones link histone nuclear import and chromatin assembly

(2011) Kristin M. Keck et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Towards a mechanism for histone chaperones

(2011) Simon J. Elsässer et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Proteome analysis of protein partners to nucleosomes containing canonical H2A or the variant histones H2A.Z or H2A.X

(2011) Satoru Fujimoto et al.   BIOLOGICAL CHEMISTRY

Histone variant innovation in a rapidly evolving chordate lineage

(2011) Alexandra Moosmann et al.   BMC EVOLUTIONARY BIOLOGY

Histone H2A.Z prepares the prostate specific antigen (PSA) gene for androgen receptor-mediated transcription and is upregulated in a model of prostate cancer progression

(2011) Deanna Dryhurst et al.   CANCER LETTERS

Global Regulation of H2A.Z Localization by the INO80 Chromatin-Remodeling Enzyme Is Essential for Genome Integrity

(2011) Manolis Papamichos-Chronakis et al.   CELL

γH2A is a component of yeast heterochromatin required for telomere elongation

(2011) Tasuku Kitada et al.   CELL CYCLE

The chaperone–histone partnership: for the greater good of histone traffic and chromatin plasticity

(2011) Maria Hondele et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Acetylation of H2A.Z is a key epigenetic modification associated with gene deregulation and epigenetic remodeling in cancer

(2011) F. Valdes-Mora et al.   GENOME RESEARCH

Targeting of the SUN protein Mps3 to the inner nuclear membrane by the histone variant H2A.Z

(2011) Jennifer M. Gardner et al.   JOURNAL OF CELL BIOLOGY

QKI-Mediated Alternative Splicing of the Histone Variant MacroH2A1 Regulates Cancer Cell Proliferation

(2011) L. Novikov et al.   MOLECULAR AND CELLULAR BIOLOGY

Histone H2A.Z acid patch residues required for deposition and function

(2011) Kurt Jensen et al.   MOLECULAR GENETICS AND GENOMICS

A unique H2A histone variant occupies the transcriptional start site of active genes

(2011) Tatiana A Soboleva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of u-PAR gene expression by H2A.Z is modulated by the MEK–ERK/AP-1 pathway

(2011) Santosh Chauhan et al.   NUCLEIC ACIDS RESEARCH

Genomic Organization of H2Av Containing Nucleosomes in Drosophila Heterochromatin

(2011) Zhenhai Zhang et al.   PLoS One

X Chromosome Inactivation and Differentiation Occur Readily in ES Cells Doubly-Deficient for MacroH2A1 and MacroH2A2

(2011) Borko Tanasijevic et al.   PLoS One

The FUN30 Chromatin Remodeler, Fft3, Protects Centromeric and Subtelomeric Domains from Euchromatin Formation

(2011) Annelie Strålfors et al.   PLoS Genetics

Stepwise Histone Replacement by SWR1 Requires Dual Activation with Histone H2A.Z and Canonical Nucleosome

(2010) Ed Luk et al.   CELL

Multiple facets of the unique histone variant macroH2A: From genomics to cell biology

(2010) Matthew J. Gamble et al.   CELL CYCLE

Epigenetic Modifications in Double-Strand Break DNA Damage Signaling and Repair

(2010) D. Rossetto et al.   CLINICAL CANCER RESEARCH

Changes in the nuclear deposition of histone H2A variants during pre-implantation development in mice

(2010) B. Nashun et al.   DEVELOPMENT

Histone Variants in Metazoan Development

(2010) Laura A. Banaszynski et al.   DEVELOPMENTAL CELL

Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation

(2010) Ana Cuadrado et al.   EMBO JOURNAL

Random deposition of histone variants: A cellular mistake or a novel regulatory mechanism?

(2010) Sara Hardy et al.   Epigenetics

Approaching the molecular and physiological function of macroH2A variants

(2010) Marcus Buschbeck et al.   Epigenetics

Nucleoplasmin Binds Histone H2A-H2B Dimers through Its Distal Face

(2010) Isbaal Ramos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NuA4-dependent Acetylation of Nucleosomal Histones H4 and H2A Directly Stimulates Incorporation of H2A.Z by the SWR1 Complex

(2010) Mohammed Altaf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-Wide Distribution of MacroH2A1 Histone Variants in Mouse Liver Chromatin

(2010) L. N. Changolkar et al.   MOLECULAR AND CELLULAR BIOLOGY

The histone variant macroH2A suppresses melanoma progression through regulation of CDK8

(2010) Avnish Kapoor et al.   NATURE

Histone variants — ancient wrap artists of the epigenome

(2010) Paul B. Talbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Systematic identification of fragile sites via genome-wide location analysis of γ-H2AX

(2010) Rachel K Szilard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae

(2010) Alexandra B Lantermann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

H2A.Z nucleosomes enriched over active genes are homotypic

(2010) Christopher M Weber et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification and characterization of the two isoforms of the vertebrate H2A.Z histone variant

(2010) Ryo Matsuda et al.   NUCLEIC ACIDS RESEARCH

Genome-Wide Evolutionary Analysis of Eukaryotic DNA Methylation

(2010) A. Zemach et al.   SCIENCE

Histone variant macroH2A1 deletion in mice causes female-specific steatosis

(2010) Mathieu Boulard et al.   Epigenetics & Chromatin

Roles for H2A.Z and Its Acetylation in GAL1 Transcription and Gene Induction, but Not GAL1-Transcriptional Memory

(2010) Jeffrey E. Halley et al.   PLOS BIOLOGY

Rad3ATR Decorates Critical Chromosomal Domains with γH2A to Protect Genome Integrity during S-Phase in Fission Yeast

(2010) Sophie Rozenzhak et al.   PLoS Genetics

Genome-Wide Views of Chromatin Structure

(2009) Oliver J. Rando et al.   Annual Review of Biochemistry

The Biology of Chromatin Remodeling Complexes

(2009) Cedric R. Clapier et al.   Annual Review of Biochemistry

Acetylation of Vertebrate H2A.Z and Its Effect on the Structure of the Nucleosome

(2009) Toyotaka Ishibashi et al.   BIOCHEMISTRY

NuA4 and SWR1-C: two chromatin-modifying complexes with overlapping functions and componentsThis paper is one of a selection of papers published in this Special Issue, entitled 30th Annual International Asilomar Chromatin and Chromosomes Conference, and has undergone the Journal's usual peer review process.

(2009) Phoebe Y.T. Lu et al.   Biochemistry and Cell Biology

New developments in post-translational modifications and functions of histone H2A variantsThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB’s 51st Annual Meeting – Epigenetics and Chromatin Dynamics, and has undergone the Journal’s usual peer review process.

(2009) Anita A. Thambirajah et al.   Biochemistry and Cell Biology

Characterization of the histone H2A.Z-1 and H2A.Z-2 isoforms in vertebrates

(2009) Deanna Dryhurst et al.   BMC BIOLOGY

Mechanisms that Specify Promoter Nucleosome Location and Identity

(2009) Paul D. Hartley et al.   CELL

Histone H2A.Z is essential for estrogen receptor signaling

(2009) N. Gevry et al.   GENES & DEVELOPMENT

The histone variant macroH2A1 marks repressed autosomal chromatin, but protects a subset of its target genes from silencing

(2009) M. J. Gamble et al.   GENES & DEVELOPMENT

A canonical promoter organization of the transcription machinery and its regulators in the Saccharomyces genome

(2009) B. J. Venters et al.   GENOME RESEARCH

Histone Variant H2A.Z Regulates Centromere Silencing and Chromosome Segregation in Fission Yeast

(2009) Haitong Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chromosome-wide Rad51 Spreading and SUMO-H2A.Z-Dependent Chromosome Fixation in Response to a Persistent DNA Double-Strand Break

(2009) Marian Kalocsay et al.   MOLECULAR CELL

Histone H2A.Z cooperates with RNAi and heterochromatin factors to suppress antisense RNAs

(2009) Martin Zofall et al.   NATURE

H3.3/H2A.Z double variant–containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions

(2009) Chunyuan Jin et al.   NATURE GENETICS

An acetylated form of histone H2A.Z regulates chromosome architecture in Schizosaccharomyces pombe

(2009) Hyun-Soo Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation

(2009) Gyula Timinszky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The histone variant macroH2A is an epigenetic regulator of key developmental genes

(2009) Marcus Buschbeck et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesis

(2009) Toyotaka Ishibashi et al.   NUCLEIC ACIDS RESEARCH

Cooperative action of TIP48 and TIP49 in H2A.Z exchange catalyzed by acetylation of nucleosomal H2A

(2009) Jongkyu Choi et al.   NUCLEIC ACIDS RESEARCH

Histone macroH2A isoforms predict the risk of lung cancer recurrence

(2009) J C Sporn et al.   ONCOGENE

The Euchromatic and Heterochromatic Landscapes Are Shaped by Antagonizing Effects of Transcription on H2A.Z Deposition

(2009) Sara Hardy et al.   PLoS Genetics

The Schizosaccharomyces pombe JmjC-Protein, Msc1, Prevents H2A.Z Localization in Centromeric and Subtelomeric Chromatin Domains

(2009) Luke Buchanan et al.   PLoS Genetics

MacroH2A Allows ATP-Dependent Chromatin Remodeling by SWI/SNF and ACF Complexes but Specifically Reduces Recruitment of SWI/SNF†

(2008) Evelyn Y. Chang et al.   BIOCHEMISTRY

H2AZ Is Enriched at Polycomb Complex Target Genes in ES Cells and Is Necessary for Lineage Commitment

(2008) Menno P. Creyghton et al.   CELL

Histone chaperones in nucleosome eviction and histone exchange

(2008) Young-Jun Park et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A–H2B acidic pocket

(2008) Lucie Roussel et al.   EMBO REPORTS

Weak but Uniform Enrichment of the Histone Variant macroH2A1 along the Inactive X Chromosome

(2008) F. Mietton et al.   MOLECULAR AND CELLULAR BIOLOGY

Nucleosome organization in the Drosophila genome

(2008) Travis N. Mavrich et al.   NATURE

Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks

(2008) Daniel Zilberman et al.   NATURE

Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail

(2008) William F. Marzluff et al.   NATURE REVIEWS GENETICS

NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B

(2008) Zheng Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A phosphorylated subpopulation of the histone variant macroH2A1 is excluded from the inactive X chromosome and enriched during mitosis

(2008) E. Bernstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Genomic Distribution and Function of Histone Variant HTZ-1 during C. elegans Embryogenesis

(2008) Christina M. Whittle et al.   PLoS Genetics

H2A.Bbd: a quickly evolving hypervariable mammalian histone that destabilizes nucleosomes in an acetylation-independent way

(2007) José María Eirín-López et al.   FASEB JOURNAL