Matriptase-2 mutations in iron-refractory iron deficiency anemia patients provide new insights into protease activation mechanisms
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Title
Matriptase-2 mutations in iron-refractory iron deficiency anemia patients provide new insights into protease activation mechanisms
Authors
Keywords
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Journal
HUMAN MOLECULAR GENETICS
Volume 18, Issue 19, Pages 3673-3683
Publisher
Oxford University Press (OUP)
Online
2009-07-11
DOI
10.1093/hmg/ddp315
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Note: Only part of the references are listed.- Molecular mechanisms of the defective hepcidin inhibition in TMPRSS6 mutations associated with iron-refractory iron deficiency anemia
- (2009) L. Silvestri et al. BLOOD
- Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis
- (2009) A. J. Ramsay et al. HAEMATOLOGICA
- Lack of the bone morphogenetic protein BMP6 induces massive iron overload
- (2009) Delphine Meynard et al. NATURE GENETICS
- BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
- (2009) Billy Andriopoulos Jr et al. NATURE GENETICS
- Prostatic trypsin-like kallikrein-related peptidases (KLKs) and other prostate-expressed tryptic proteinases as regulators of signalling via proteinase-activated receptors (PARs)
- (2008) Andrew J. Ramsay et al. BIOLOGICAL CHEMISTRY
- Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis
- (2008) A. R. Folgueras et al. BLOOD
- Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin
- (2008) Y. Xia et al. BLOOD
- Two nonsense mutations in the TMPRSS6 gene in a patient with microcytic anemia and iron deficiency
- (2008) F. Guillem et al. BLOOD
- The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin
- (2008) Laura Silvestri et al. Cell Metabolism
- A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron
- (2008) M. A. Melis et al. HAEMATOLOGICA
- Kallikrein-related Peptidase 4 (KLK4) Initiates Intracellular Signaling via Protease-activated Receptors (PARs)
- (2008) Andrew J. Ramsay et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)
- (2008) Karin E Finberg et al. NATURE GENETICS
- The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency
- (2008) X. Du et al. SCIENCE
- The type II transmembrane serine protease Matriptase-2 - identification, structural features, enzymology, expression pattern and potential roles
- (2007) Andrew et al. Frontiers in Bioscience-Landmark
- Type II transmembrane serine proteases in development and disease
- (2007) R SZABO et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
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