Article
Chemistry, Physical
Jeroni Morey, Pere Llinas, Alberto Bueno-Costa, Alberto J. Leon, M. Nieves Pina
Summary: Two different raltitrexed gold and silver nanoparticles were synthesized and evaluated for their delivery of antitumoral drug. The silver nanoparticles strongly inhibited cancer cell viability, while the gold nanoparticles showed no cytotoxic effects. This suggests that silver raltitrexed nanoparticles could be a potential delivery system for certain cancer cells.
Article
Chemistry, Multidisciplinary
Kishwor Poudel, Asmita Banstola, Milan Gautam, Zar Chi Soe, Le Minh Pham, Jee-Heon Jeong, Han-Gon Choi, Sae Kwang Ku, Chul Soon Yong, Tuan Hiep Tran, Jong Oh Kim
Summary: The study successfully constructed redox- and laser-responsive nanourchins capable of releasing MTX and ICG upon GSH induction and laser irradiation, leading to tumor growth inhibition. The combination of Bi2S3 and ICG generated heat and reactive oxygen species, further enhancing the anticancer activity of MTX against cancer cells. This targeted nanocarrier system showed promising results in in vitro and in vivo studies, with tumor-selective attributes and effective tumor ablation without affecting vital organs.
Article
Chemistry, Multidisciplinary
M. J. Hernandez-Esparza, Ilaria Fratoddi, Sara Cerra, K. Juarez-Moreno, R. Huirache-Acuna
Summary: This research presents an evaluation of a hybrid material based on gold nanoparticles stabilized with 3-mercapto-propanesulfonate and loaded with methotrexate drug. The study demonstrates the effectiveness of the nanosystem in treating cervical cancer and melanoma, as well as its toxicity towards tumor cells.
NANOSCALE ADVANCES
(2023)
Article
Chemistry, Physical
Tommaso A. Salamone, Lavinia Rutigliano, Beatrice Pennacchi, Sara Cerra, Roberto Matassa, Stefania Nottola, Fabio Sciubba, Chiara Battocchio, Martina Marsotto, Alessandra Del Giudice, Andrei Chumakov, Anton Davydok, Souren Grigorian, Gianluca Canettieri, Enzo Agostinelli, Ilaria Fratoddi
Summary: This study demonstrates that hydrophilic thiol-functionalized colloidal gold nanoparticles (AuNPs) can be used as drug delivery probes due to their small size and hydrophilic nature. AuNPs possess unique properties for their applications in nanomedicine, especially in cancer treatment as diagnostics and therapeutic tools. The experiments conducted included spectroscopic and morphostructural characterizations, as well as solid state and dispersed phase experiments, aiming to understand the structure-properties correlations. In vitro studies showed that the MTX-loaded AuNPs had a more potent effect compared to free MTX, and the active role of AuNPs in drug penetration was evidenced.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Carla Daruich de Souza, Angelica Bueno Barbezan, Wilmmer Alexander Arcos Rosero, Sofia Nascimento dos Santos, Diego Vergacas de Sousa Carvalho, Carlos Alberto Zeituni, Emerson Soares Bernardes, Daniel Perez Vieira, Patrick Jack Spencer, Martha Simoes Ribeiro, Maria Elisa Chuery Martins Rostelato
Summary: This study describes a method for synthesizing radioactive Gold-198 nanoparticles without the use of surfactants. The results demonstrate the effectiveness of these nanoparticles in both in vitro and in vivo experiments.
Article
Biotechnology & Applied Microbiology
Jeaneen Venkatas, Moganavelli Singh
Summary: The aim of this study is to synthesize curcumin-reduced gold nanoparticles (AuNPs) for efficient delivery and expression of the IL-12 gene in cervical cancer (HeLa) cells in vitro. Stable, spherical AuNPs effectively compacted and protected the IL-12 DNA and tolerated well in vitro. Real-time quantitative PCR and ELISA confirmed the successful delivery and expression of the IL-12 gene in HeLa cells. The favorable attributes of this AuNP-delivery system and the significant IL-12 expression obtained suggest potential for cytokine-based therapy or immunotherapy in cervical cancer.
Review
Nanoscience & Nanotechnology
Yan Yang, Xi Zheng, Lu Chen, Xuefeng Gong, Hao Yang, Xingmei Duan, Yuxuan Zhu
Summary: Cancer is the second leading cause of death in the world and poses a serious threat to human health. Nanomedicine, particularly gold nanoparticles (AuNPs), has emerged as a promising technology for overcoming the limitations of conventional cancer therapies. This review discusses the current achievements and clinical trials of AuNPs in anticancer applications, as well as the challenges in translating basic findings into the clinic, providing a reference for future research.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Chaitali Surve, Ananya Banerjee, S. Anupriya, Rajasree Chakraborty, Dhiraj Kumar, Ramesh Butti, Mahadeo Gorain, Sabyasachi Parida, Gopal C. Kundu, Supriya Shidhaye, Srinivas Patnaik
Summary: The efficacy of novel methotrexate-loaded nanoparticles (MTX-NPs) in the treatment of breast cancer was evaluated in vitro and in vivo. The results showed that MTX-NPs have improved cellular uptake and in vivo efficacy, making them a promising candidate for breast cancer treatment.
Review
Pharmacology & Pharmacy
Meena Bhandari, Seema Raj, Ashwani Kumar, Dilraj Preet Kaur
Summary: Multifunctional nanoparticles show promising characteristics for overcoming side effects in cancer treatment. Despite numerous studies supporting the advantages of eco-friendly nanoparticles, they have yet to find their way into clinical translation.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Prashant Kesharwani, Ruiyang Ma, Liang Sang, Mahak Fatima, Afsana Sheikh, Mohammed A. S. Abourehab, Neelima Gupta, Zhe-Sheng Chen, Yun Zhou
Summary: Cancer is a devastating disease, and more efficient, non-invasive therapies with minimal side effects are needed. Gold nanoparticles with impressive optical properties have been at the forefront of bioengineered cancer therapy. This review discusses the optical features of gold nanoparticles and highlights the recent research on their application, especially gold nanorods, in combating various cancers such as breast, lung, colon, oral, prostate, and pancreatic cancer.
Review
Biochemistry & Molecular Biology
Nandan Gupta, Rishabha Malviya
Summary: The use of gold nanoparticles in photothermal therapy for cancer treatment is highlighted in this communication, showing their potential in warning cancer cells to other therapies, modulating cellular permeability and delivery, and achieving effective therapy management.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Chemistry, Multidisciplinary
Subin Son, Jungryun Kim, Jaewon Kim, Byungkook Kim, Jieun Lee, Yuri Kim, Mingle Li, Heemin Kang, Jong Seung Kim
Summary: Light-based phototherapy has limitations in cancer treatment due to its limited penetration depth. To overcome these limitations, various energy sources such as ultrasound, chemiluminescence, radiation, microwave, electricity, and magnetic field have been developed. Combining these energy sources with other strategies or therapies can improve the effectiveness of cancer treatment.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Engineering, Biomedical
Hamed Nosrati, Farzad Seidi, Ali Hosseinmirzaei, Navid Mousazadeh, Ali Mohammadi, Mohammadreza Ghaffarlou, Hossein Danafar, Joao Conde, Ali Sharafi
Summary: Utilizing all-in-one nanoparticles for synchronous chemoradiotherapy significantly enhances cancer therapy efficacy, as demonstrated by studies on cell viability, proliferation, and ROS production. In vivo anticancer experiments show that the mPEG-CUR@Au system improves radiation sensitivity in 4T1 mammary carcinoma and completely eradicates breast cancer.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Guozhen Deng, He Zha, Hongzhi Luo, Yi Zhou
Summary: The burden of cancer is increasing rapidly, and developing precise intervention measures for cancer detection and treatment is crucial. This review summarizes the latest progress in the application of aptamer-modified gold nanoparticles in cancer targeted diagnosis and delivery of therapeutic agents to cancer cells, highlighting the prospects and challenges of translating these studies into clinical applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dnyaneshwar Kalyane, Suryanarayana Polaka, Nupur Vasdev, Rakesh Kumar Tekade
Summary: This study presents a quality-by-design approach to develop targeted photothermal nanoseeds for the treatment of TNBC. These nanoseeds have nanometric size, show reversible photothermal effect upon laser activation, and exhibit significant anticancer activity.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yiran Qu, Innocent Bekard, Ben Hunt, Jamie Black, Louis Fabri, Sally L. Gras, Sandra. E. Kentish
Summary: This study compares the performance of a nanofiber device and a resin column for antibody capture. The nanofiber device has a larger housing volume and lower binding capacity, but comparable eluate purity to the resin column. It shows high stability, can be used for multiple cycles, and maintains consistent eluate quality when scaled up. The use of a single nanofiber device can significantly reduce costs compared to a resin column, especially when the number of batches is limited.
BIOCHEMICAL ENGINEERING JOURNAL
(2024)
Article
Biotechnology & Applied Microbiology
Brandon Moore, Christos Georgakis, Chris Antoniou, Sarwat Khattak
Summary: Fed-batch cell culture processes are commonly used in biomanufacturing due to their simplicity and applicability in cGMP environments. However, the challenge lies in the changing physiochemical conditions within the bioreactor as the cell density changes. Traditional response surface models (RSMs) are commonly used for optimization but are limited by their use of time-invariant factors. Dynamic RSM (DRSM) models can predict the time-dependent impact of process inputs, allowing for optimization of process operations that change over time.
BIOCHEMICAL ENGINEERING JOURNAL
(2024)
Article
Biotechnology & Applied Microbiology
Lin Li, Yunfan Bai, Chuhua Qi, Yile Du, Xiaoxiao Ma, Yutong Li, Pingping Wu, Shuangli Chen, Sijing Zhang
Summary: A succinic anhydride-modified apple pomace (SAMAP) was synthesized to address environmental issues caused by the accumulation of apple pomace and effectively treat heavy metal ions. SAMAP exhibited high adsorption capacity for Cu(II) and Pb(II), suggesting its potential application in wastewater treatment.
BIOCHEMICAL ENGINEERING JOURNAL
(2024)
Article
Biotechnology & Applied Microbiology
Peter Satzer
Summary: Water for injection (WFI) production in the biopharmaceutical industry consumes excessive amounts of water and energy. Recycling buffers can potentially save up to 90% of resources, but achieving the full theoretical potential is impossible when a risk-aware design is used. Universal risk-based assessment is important for regulatory authorities to consider the implementation of such a strategy.
BIOCHEMICAL ENGINEERING JOURNAL
(2024)
Article
Biotechnology & Applied Microbiology
Gaoya Sun, Lingkai Jin, Guangxue Wang, Xiaoge Wang, Jin Huang
Summary: In this study, heterologous expression and homologous overexpression of ABC transporter proteins AatA and MdlB were found to improve butyric acid production in C. tyrobutyricum. The overexpression of these proteins upregulated the expression levels of key enzymes in the acetate synthesis pathway and promoted the synthesis and secretion of acetic acid. Additionally, the increase in ATPase activity facilitated sugar utilization, induced extracellular secretion of acetate, and shortened fermentation periods.
BIOCHEMICAL ENGINEERING JOURNAL
(2024)
Article
Biotechnology & Applied Microbiology
Taiki Okamura, Rina Aritomi, Takuya Matsumoto, Ryosuke Yamada, Hidehiko Hirakawa, Hiroyasu Ogino
Summary: In this study, proline was introduced to improve the stability of putidaredoxin reductase (PdR) in the Pseudomonas putida cytochrome P450 system. It was found that PdR_T221P had a longer half-life at high temperatures compared to wild-type PdR, but a shorter half-life in the presence of methanol. Molecular dynamics simulations supported these findings.
BIOCHEMICAL ENGINEERING JOURNAL
(2024)
Article
Biotechnology & Applied Microbiology
Yuying Hu, Xiaofan Wang, Shihao Zhang, Zimu Liu, Tengfang Hu, Xin Wang, Xiaoming Peng, Hongling Dai, Jing Wu, Fengping Hu
Summary: This study investigates the effect of iron-carbon micro-electrolysis (ICME) materials on high-solid anaerobic digestion (HSAD). The results show that ICME materials promote methane production in HSAD by increasing the attachment area of microorganisms and facilitating symbiotic metabolism of certain bacterial species. This study provides new insights into microbial mechanisms and enhances our understanding of ICME material enhancement in HSAD.
BIOCHEMICAL ENGINEERING JOURNAL
(2024)
Article
Biotechnology & Applied Microbiology
Jibao Liu, Yufeng Xu, Yuansong Wei
Summary: This study investigated the role of sludge rheology in anaerobic digestion (AD) and found that rheological properties increased with the increase of solid content, resulting in a negative effect on methane production. An extended ADM1 model revealed that enhanced sludge rheological properties increased mass diffusion resistance and reduced uptake rate of acetate.
BIOCHEMICAL ENGINEERING JOURNAL
(2024)
Article
Biotechnology & Applied Microbiology
Xiaoyan Liu, Zongze Chen, Dewen Kong, Xinying Zhang, Chuanhua Wang, Yongqi Wang
Summary: This study explored the role of intracellular and extracellular enzymes of Acinetobacter baumannii and Talaromyces sp. in the degradation of crude oil. The extracellular enzymes of Talaromyces sp. were more effective in degrading n-alkanes, while those of Acinetobacter baumannii had a better effect on aromatic hydrocarbons. The degradation enzyme systems of both bacteria and fungi complemented each other, improving the overall degradation ability.
BIOCHEMICAL ENGINEERING JOURNAL
(2024)
Article
Biotechnology & Applied Microbiology
Jing Dong, Lingli Xu, Yuxiang Liu, Li Ren, Ke Yuan
Summary: The utilization of biochar-immobilized microorganisms is an effective method for eliminating phenol from water. The high susceptibility of bacteria to environmental factors is a challenge for practical implementation. In this study, biochar was used to reduce microbial susceptibility and enhance phenol removal. The addition of biochar altered the dominant species of phenol-degrading bacteria and response surface analysis indicated the significant influence of biochar pyrolysis temperature and experimental temperature on phenol removal rate.
BIOCHEMICAL ENGINEERING JOURNAL
(2024)
Article
Biotechnology & Applied Microbiology
Zibin Pan, Mengying Liu, Zuliang Chen
Summary: This study successfully removed metalloids and heavy metals from acid mine drainage (AMD) using bio-synthesized Fe/Cu nanoparticles (Fe/Cu NPs). The Fe/Cu NPs showed high removal capacities and the presence of organic substances contributed to their stability.
BIOCHEMICAL ENGINEERING JOURNAL
(2024)
Article
Biotechnology & Applied Microbiology
Guangbing Liu, Han Zhang, Jincan Huang, Lu Zhang, Teng Zhang, Xuemin Yu, Weijing Liu, Chunkai Huang
Summary: This study investigated the effect of Fenton pre-treatment on the treatment efficiency of printing and dyeing wastewater (PDW) using two anaerobic/aerobic-membrane bioreactors (A/O-MBRs). The results showed that Fenton pre-treatment significantly improved the removal efficiency of COD and AOX in PDW, and reduced membrane fouling. The Shannon indices and metagenomics analysis indicated that the microbial diversity in anaerobic flocs was higher than that in aerobic flocs, and EC3.1.1.45 and pcaI were identified as key functional genes.
BIOCHEMICAL ENGINEERING JOURNAL
(2024)
Article
Biotechnology & Applied Microbiology
Lidia Borgosz, Duygu Dikicioglu
Summary: The Industrial Internet of Things (IIoT) is a system that connects devices and provides real-time insight into industrial processes. However, the complexity and regulatory requirements of the biomanufacturing sector make it challenging to implement IIoT. There is a need for universal solutions to overcome this challenge and advance the field of biomanufacturing.
BIOCHEMICAL ENGINEERING JOURNAL
(2024)
Article
Biotechnology & Applied Microbiology
Yajie Li, Weikang Kong, Yuyao Zhang, Huarui Zhou, Hongbo Liu, Salma Tabassum
Summary: In this study, the iron-carbon multi-micro electric field coupling anaerobic co-digestion technique was used to treat coal gasification wastewater (CGW). The experimental results showed that under optimal operating conditions, this technique can significantly reduce the toxicity of the wastewater and achieve high removal efficiencies. Additionally, the analysis of microbial communities revealed that the coupling system promotes direct interspecies electron transfer.
BIOCHEMICAL ENGINEERING JOURNAL
(2024)
Article
Biotechnology & Applied Microbiology
Aparecido Nivaldo Modenes, Debora Gozzi Fernandes, Daniela Estelita Goes Trigueros, Matheus Guilherme Amador, Fernando Rodolfo Espinoza-Quinones, Taysa de Souza Braniz, Adilson Ricken Schuelter, Glacy Jaqueline da Silva, Lucimar Pereira Bonett
Summary: This study aimed to systematically remove organic pollutants from raw dairy wastewater with high concentrations of COD, TOC, and TN using Poterioochromonas malhamensis algae strains. The results showed that the biomass yield rate using FP-PBRs was 10% higher than tubular PBRs, and the organic pollution in wastewater was significantly reduced with a decrease of about 98% in COD, 95% in TN, and 92% in TOC.
BIOCHEMICAL ENGINEERING JOURNAL
(2024)