Review
Cell Biology
Mohammad Samare-Najaf, Asma Neisy, Ali Samareh, Delaram Moghadam, Navid Jamali, Reza Zarei, Fatemeh Zal
Summary: Reproduction involves significant molecular, cellular, and tissue changes, and recent studies have highlighted the importance of basic molecular pathways, such as autophagy, in reproductive processes. This comprehensive review provides an up-to-date overview of the role of autophagy in male reproduction, including spermatogenesis, sperm motility and viability, and male sex hormones, as well as female reproduction, including germ cells and oocyte viability, ovulation, implantation, fertilization, and female sex hormones. The review also discusses the impact of disrupted autophagic flux on reproductive disorders, including infertility-related conditions such as oligospermia, azoospermia, asthenozoospermia, teratozoospermia, globozoospermia, premature ovarian insufficiency, polycystic ovarian syndrome, endometriosis, and others.
Article
Cell Biology
Liu Yang, Siqi Wang, Zengxiang Pan, Xing Du, Qifa Li
Summary: The deubiquitinase USP9X positively regulates the expression of TGFBR2, a key component of the TGF-beta signaling pathway, in granulosa cells. This activation of the TGF-beta pathway by USP9X leads to the suppression of granulosa cell apoptosis and plays a crucial role in female fertility.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Beatriz Moreira-Pinto, Lia Costa, Eduarda Felgueira, Bruno M. Fonseca, Irene Rebelo
Summary: Resveratrol's effects on ovarian granulosa cells depend on its concentration, with low concentrations having a protective role and high concentrations affecting cell viability and steroidogenic function.
Article
Biochemistry & Molecular Biology
Jingjie Xu, Huaxia Wang, Ailing Wang, Jia Xu, Chenxi Fu, Zhekun Jia, Ke Yao, Xiangjun Chen
Summary: Congenital cataract is a major cause of blindness in children globally. A novel beta B2 mutation W151R was found to be prone to aggregation due to low solubility and poor structural stability, but the negative effect of the mutation was reversed by administration of lanosterol.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Medicine, Research & Experimental
Xu Li, Gaoqing Xu, Zhiqiang Li, Hongyu Liu, Xin Ma, Lianyu Yang, Pengju Zhang, Jing Zhao, Jun Wang, Wenfa Lu
Summary: Research indicates that GnIH inhibits the proliferation and promotes apoptosis of bovine granulosa cells through the p38 signaling pathway, and the use of a p38 activator can alleviate these effects.
Article
Biochemistry & Molecular Biology
Chao Chen, Muhammad Jamil Ahmad, Tingzhu Ye, Chao Du, Xinxin Zhang, Aixin Liang, Liguo Yang
Summary: The study demonstrated that CTSB serves as a proapoptotic agent and plays a critical role in folliculogenesis in female mice by mediating apoptosis, autophagy, proliferation, and steroidogenesis. Therefore, CTSB could be a potential prognostic agent for female infertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Audrey J. Gaskins, Robert B. Hood, Jennifer B. Ford, Russ Hauser, Anna K. Knight, Alicia K. Smith, Todd M. Everson
Summary: This study investigated the relationship between traffic-related air pollution (TRAP) exposure and supplemental folic acid intake with epigenetic aging and CpG-specific DNA methylation in granulosa cells (GC). The results showed associations between TRAP exposure and folic acid intake with DNA methylation sites, but no significant effects on epigenetic aging of GC. These findings suggest that differential DNA methylation may be a potential mechanism underlying the effects of TRAP and folic acid on ovarian function.
CLINICAL EPIGENETICS
(2023)
Article
Veterinary Sciences
Fang Chen, Xiaoqing Zhu
Summary: This study investigated the effects of activin A (ACT-A) on porcine ovarian granulosa cells (GCs) apoptosis and the underlying molecular mechanism. The results showed that ACT-A could attenuate apoptosis and enhance estrogen synthesis in GCs. ACT-A also enhanced the expression of estrogen receptor-beta (ER beta) induced by FSH, inhibiting ROS accumulation and apoptosis. These findings suggest a protective role of ACT-A in apoptosis by reducing ROS through ER beta, which can improve follicular function and animal reproductive performance.
VETERINARY SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xuan Zhang, Dingding Zhang, Hongmin Li, Zhaojun Liu, Yatong Yang, Jiameng Li, Lishiyuan Tang, Jingli Tao, Honglin Liu, Ming Shen
Summary: This study reveals an innovative protective mechanism of melatonin against hypoxia-induced granulosa cell (GC) apoptosis by selectively inhibiting mitochondrial ROS (mtROS) generation. Melatonin activates MTNR1B to promote SOD2 expression, effectively suppressing mtROS-JNK-FOXO1-mediated apoptosis.
Article
Cell Biology
Xing Du, Qiqi Li, Liu Yang, Qiang Zeng, Siqi Wang, Qifa Li
Summary: The study revealed that NORFA plays a crucial role in controlling the transcriptome of porcine granulosa cells, affecting cell functions and survival status, involving multiple signaling pathways. Its deficiency may lead to abnormal apoptosis and impaired function of porcine granulosa cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Yuan Xiao, Jia-Wen Xiang, Qian Gao, Yue-Yue Bai, Zhao-Xia Huang, Xiao-Hui Hu, Ling Wang, David Wan-Cheng Li
Summary: Research has shown that Mab21L1 promotes survival of lens epithelial cells by regulating the expression of αB-crystallin and suppressing the ATR/CHK1/p53 pathway. This finding contributes to a better understanding of the functional mechanism of Mab21L1.
Article
Agriculture, Dairy & Animal Science
Yuqi Li, Zhuofan Zhang, Siqi Wang, Xing Du, Qifa Li
Summary: MiR-423 inhibits the initiation of follicular atresia and early apoptosis of granulosa cells, potentially improving female fertility. It interacts with the SMAD7 gene to suppress its expression and apoptosis-inducing function in granulosa cells.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Toxicology
Jaustin Dufour, Reem Sabry, Jibran Y. Khokhar, Laura A. Favetta
Summary: Maternal stress can impact offspring's stress-related behaviors through changes in the HPA axis. THC, a component of cannabis, has contradictory effects on fertility and stress relief. In this study, the effects of THC on bovine granulosa cells were evaluated, showing no effects on cell viability or apoptosis. High cortisol concentrations increased expression of 11β-HSD1, while combined with high THC, it decreased expression. GR expression was unaffected by cortisol treatments, and low THC treatment maintained increased expression.
TOXICOLOGY IN VITRO
(2023)
Article
Cell Biology
Yufang Liu, Siwu Guo, Xiaoyun He, Yanting Jiang, Qionghua Hong, Rong Lan, Mingxing Chu
Summary: The G>C mutation in the RBP4 gene was found to be closely associated with reproductive traits in goats, and this mutation can enhance the transcriptional activity and expression of RBP4, thereby improving the fertility of goats.
Article
Agriculture, Dairy & Animal Science
Xiaoge Zhou, Zhaoyi Mo, Yankun Li, Liang Huang, Sihai Yu, Lan Ge, Yamei Hu, Shengjie Shi, Lutong Zhang, Liguang Wang, Lei Gao, Gongshe Yang, Guiyan Chu
Summary: Oleic acid induces lipid accumulation and reduces steroidogenesis in livestock in a negative energy-balance state. This study provides important insights into the fertility decline in such animals.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Oncology
Qian Gao, Hanxiao Ren, Mingkun Chen, Ziguang Niu, Haibo Tao, Yin Jia, Jianrong Zhang, Wenjie Li
MOLECULAR MEDICINE REPORTS
(2016)
Review
Pharmacology & Pharmacy
Hong Lei, Qian Gao, Shan-Rong Liu, Jian Xu
FRONTIERS IN PHARMACOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Hanxiao Ren, Haibo Tao, Qian Gao, Wei Shen, Ziguang Niu, Junjie Zhang, Haiting Mao, Aiying Du, Wenjie Li
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Medicine, Research & Experimental
Fenfen Xiang, Bei Cui, Qian Gao, Jianrong Zhang, Junjie Zhang, Wenjie Li
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2012)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)