Article
Genetics & Heredity
Liping Wang, Hairui Fan, Yinggang Zou, Qiuyue Yuan, Xuming Hu, Xujing Chen, Chunhui Zhu, Xiaomei Zhang, Hengmi Cui
Summary: This study conducted high-throughput lncRNA sequencing of follicular fluid exosomes in PCOS and non-PCOS patients, identifying significant upregulation of hormones like estrogen, testosterone, and luteinizing hormone in PCOS patients. Functional analysis indicated potential involvement of lncRNAs in the pathogenesis of PCOS.
FRONTIERS IN GENETICS
(2021)
Review
Oncology
Mohammad Roshani, Ghazaleh Baniebrahimi, Mahboubeh Mousavi, Noushid Zare, Reza Sadeghi, Reza Salarinia, Amirhossein Sheida, Danial Molavizadeh, Sara Sadeghi, Farzaneh Moammer, Mohammad Reza Zolfaghari, Hamed Mirzaei
Summary: Exosomal lncRNAs play a crucial role in the biology of gastrointestinal cancer and can be utilized as biomarkers for diagnosis, prognosis, and potential treatment targets.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daniele Lettieri-Barbato, Katia Aquilano, Carolina Punziano, Giuseppina Minopoli, Raffaella Faraonio
Summary: Cell senescence plays critical roles in various aspects of organism life, including tissue development, homeostasis, tumor suppression, and aging-related diseases. Oxidative stress, caused by inadequate detoxification of reactive oxygen/nitrogen species, is a major driver of senescence. Non-coding RNAs, such as microRNAs, long non-coding RNAs, and circular RNAs, are important regulators of cellular processes, including oxidative stress responses and senescence.
Review
Cell Biology
Lina Ma, Zhang Zhang
Summary: This comment provides an overview of the types and features of lncRNA databases worldwide, and discusses their contribution to lncRNA research.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2023)
Review
Medicine, Research & Experimental
Amirhosein Maharati, Meysam Moghbeli
Summary: Breast cancer is a major global health challenge, and investigating the molecular mechanisms involved in its progression can lead to improved therapeutic and diagnostic strategies. Long non-coding RNAs (lncRNAs) play important roles in regulating cytokine and growth factor-dependent signaling pathways in breast tumor cells. This review discusses the oncogenic role of lncRNAs in promoting PI3K/AKT, MAPK, and TGF-β signaling pathways in breast cancer and suggests lncRNA inhibition as a potential therapeutic strategy to reduce tumor growth and as reliable diagnostic markers in breast cancer patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Medicine, General & Internal
Yachen Shi, Qingyun Wang, Ruize Song, Yan Kong, Zhijun Zhang
Summary: Non-coding RNAs, such as microRNAs, circular RNAs, and long non-coding RNAs, play important roles in regulating normal biological processes and may be implicated in the pathogenesis of human diseases like depression. Clinical studies have shown that abnormal expression of ncRNAs in depressed patients compared to healthy individuals, with potential for ncRNAs to serve as biomarkers for diagnosis and treatment. Despite uncertainties regarding their precise roles, ncRNAs demonstrate promising clinical value in the management of depression.
Review
Biochemistry & Molecular Biology
Ania Canseco-Rodriguez, Valeria Masola, Vincenza Aliperti, Maria Meseguer-Beltran, Aldo Donizetti, Ana Maria Sanchez-Perez
Summary: Neuroinflammation plays a major role in the onset of Alzheimer's Disease (AD), and it exerts its toxic effect through regulation of non-coding RNAs such as miRNAs. Although the association between miRNAs and inflammation in AD has been studied, the role of long non-coding RNAs (lncRNAs) in neurodegenerative diseases is less explored. Recent studies have shown that specific lncRNAs in plasma-isolated extracellular vesicles (EVs) may serve as reliable biomarkers for AD, which holds promise for improving risk prediction and patient stratification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Plant Sciences
K. Bharathan Sruthi, Athira Menon, P. Akash, Eppurath Soniya
Summary: Long non-coding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides without coding potential. Recent research shows that lncRNAs can code for micropeptides, which are generated from small open reading frames (smORFs) and found in short mRNAs and non-coding RNAs. Although micropeptides play critical roles in plant development and stress, only a few functions have been verified so far.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Junaid Zafar, Junlin Huang, Xiaoxia Xu, Fengliang Jin
Summary: Over the last decade, there has been a growing interest in long non-coding RNAs (lncRNAs) among scientists. LncRNAs play important roles in various biological processes, and have greatly expanded our understanding of RNA's regulatory potential. However, our knowledge of lncRNAs in insects is limited compared to mammals. This article reviews experimentally validated lncRNAs in insects, as well as lncRNAs identified through bioinformatic tools, and discusses the challenges and future prospects of studying lncRNAs in insects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biology
Massimiliano Agostini, Mara Mancini, Eleonora Candi
Summary: Metabolic reprogramming is a hallmark of cancers and long non-coding RNAs play a role in regulating cancer-specific metabolic alterations. This overview focuses on breast cancer metabolic reprogramming and the involvement of long non-coding RNAs in driving these alterations.
Article
Biochemistry & Molecular Biology
Christopher G. Fenton, Mithlesh Kumar Ray, Wei Meng, Ruth H. Paulssen
Summary: Long non-coding RNAs (lncRNAs) have been found to be involved in the development of ulcerative colitis (UC), and their interplay with DNA methylation and the role of environmental factors in disease development remain to be fully explored. This study analyzed mucosal biopsies from UC patients and normal controls to identify UC-associated lncRNAs regulated by differentially methylated regions (DMRs). The study also identified genes involved in inflammatory immune responses downstream of DMR-regulated lncRNAs. Understanding the interplay between lncRNA expression and DNA methylation in UC could enhance our knowledge of its pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Xin Yu, Xueqing Zhu, Hongjun Xu, Linfeng Li
Summary: Keloids are pathological wound healing conditions that significantly impact patients by causing psychosocial and functional distress. The main pathophysiology of keloid is the deposition of extracellular matrix (ECM) and proliferation of human fibroblasts. Recent research has shown that deregulated long non-coding RNAs (LncRNAs) contribute to the formation of keloids. Exploring lncRNA-based methods holds promise as new effective therapies against keloids.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Mirjana T. Macvanin, Zoran Gluvic, Jelena Radovanovic, Magbubah Essack, Xin Gao, Esma R. Isenovic
Summary: Diabetic cardiomyopathy (DCMP) is a leading cause of morbidity and mortality in diabetic patients, and non-coding RNAs such as miRNAs and lncRNAs have been found to play a protective role in regulating processes related to DCMP. This paper reviews the literature on the roles of miRNAs and lncRNAs in DCMP in diabetes and demonstrates their potential for future DCMP treatment in diabetic patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Cinzia Aurilia, Simone Donati, Gaia Palmini, Francesca Miglietta, Irene Falsetti, Teresa Iantomasi, Maria Luisa Brandi
Summary: Tumors of the parathyroid glands are common endocrine diseases characterized by parathyroid hormone hypersecretion, with a wide range of clinical presentations and typically treated through surgical removal. Recent studies have suggested that alterations to the epigenetic mechanisms could play a pivotal role in tumorigenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Fatemeh Salabi, Hedieh Jafari, Shahrokh Navidpour, Ayeh Sadat Sadr
Summary: The study identified specific lncRNAs in Androctonus crassicauda and analyzed their characteristics using a stringent filtering pipeline and machine learning tools. The majority of these lncRNAs were found to be novel with no identifiable orthologs in closely related species. The analysis revealed unique features of A. crassicauda lncRNAs, including lower protein-coding potential, lower GC content, shorter transcript length, and less number of isoform per gene.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Hong Lei, Qian Gao, Shan-Rong Liu, Jian Xu
FRONTIERS IN PHARMACOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Qian Gao, Li-Li Sun, Fen-Fen Xiang, Li Gao, Yin Jia, Jian-Rong Zhang, Hai-Bo Tao, Jun-Jie Zhang, Wen-Jie Li
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2014)
Article
Biochemistry & Molecular Biology
Hanxiao Ren, Haibo Tao, Qian Gao, Wei Shen, Ziguang Niu, Junjie Zhang, Haiting Mao, Aiying Du, Wenjie Li
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Medicine, Research & Experimental
Fenfen Xiang, Bei Cui, Qian Gao, Jianrong Zhang, Junjie Zhang, Wenjie Li
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2012)