A Role for the Tyrosine Kinase Pyk2 in Depolarization-induced Contraction of Vascular Smooth Muscle

Synthesis of novel diarylamino-1,3,5-triazine derivatives as FAK inhibitors with anti-angiogenic activity

(2013) Pascal Dao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Myosin Regulatory Light Chain Diphosphorylation Slows Relaxation of Arterial Smooth Muscle

(2012) Cindy Sutherland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging Targets in Osteoporosis Disease Modification

(2010) John G. Allen et al.   JOURNAL OF MEDICINAL CHEMISTRY

PYK2/PDZ-RhoGEF Links Ca 2+ Signaling to RhoA

(2009) Zhekang Ying et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Salicylates dilate blood vessels through inhibiting PYK2-mediated RhoA/Rho-kinase activation

(2009) Zhekang Ying et al.   CARDIOVASCULAR RESEARCH

Targeting Pyk2 for therapeutic intervention

(2009) Christopher A Lipinski et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Structural Characterization of Proline-rich Tyrosine Kinase 2 (PYK2) Reveals a Unique (DFG-out) Conformation and Enables Inhibitor Design

(2009) Seungil Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein-tyrosine kinase CAKβ/PYK2 is activated by binding Ca2+/calmodulin to FERM F2 α2 helix and thus forming its dimer

(2008) Takayuki Kohno et al.   BIOCHEMICAL JOURNAL

Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): Structure–activity relationships and strategies for the elimination of reactive metabolite formation

(2008) Daniel P. Walker et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Small Molecule Inhibitor, 1,2,4,5-Benzenetetraamine Tetrahydrochloride, Targeting the Y397 Site of Focal Adhesion Kinase Decreases Tumor Growth

(2008) Vita M. Golubovskaya et al.   JOURNAL OF MEDICINAL CHEMISTRY