Targeting Pyk2 for therapeutic intervention

Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2

(2009) James Lulo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural Characterization of Proline-rich Tyrosine Kinase 2 (PYK2) Reveals a Unique (DFG-out) Conformation and Enables Inhibitor Design

(2009) Seungil Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Pyk2 FERM domain as a target to inhibit glioma migration

(2009) J. C. Loftus et al.   MOLECULAR CANCER THERAPEUTICS

Focal Adhesion Kinase-Related Proline-Rich Tyrosine Kinase 2 and Focal Adhesion Kinase Are Co-Overexpressed in Early-Stage and Invasive ErbB-2-Positive Breast Cancer and Cooperate for Breast Cancer Cell Tumorigenesis and Invasiveness

(2008) Emy Behmoaram et al.   AMERICAN JOURNAL OF PATHOLOGY

Protein-tyrosine kinase CAKβ/PYK2 is activated by binding Ca2+/calmodulin to FERM F2 α2 helix and thus forming its dimer

(2008) Takayuki Kohno et al.   BIOCHEMICAL JOURNAL

Merlin Is a Potent Inhibitor of Glioma Growth

(2008) Y.-K. I. Lau et al.   CANCER RESEARCH

Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271

(2008) W. G. Roberts et al.   CANCER RESEARCH

Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation

(2008) C. K. Sun et al.   CARCINOGENESIS

Focal Adhesion Kinase: Targeting Adhesion Signaling Pathways for Therapeutic Intervention

(2008) J. T. Parsons et al.   CLINICAL CANCER RESEARCH

Allosteric modulation of kinases and GPCRs: design principles and structural diversity

(2008) Jana A Lewis et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Small molecular weight protein–protein interaction antagonists—an insurmountable challenge?

(2008) Alexander Dömling   CURRENT OPINION IN CHEMICAL BIOLOGY

Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK

(2008) Sara M. Weis et al.   JOURNAL OF CELL BIOLOGY

PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility

(2008) Yangmi Lim et al.   JOURNAL OF CELL BIOLOGY

Extended survival of Pyk2 or FAK deficient orthotopic glioma xenografts

(2008) Christopher A. Lipinski et al.   JOURNAL OF NEURO-ONCOLOGY

Up-regulation of proline-rich tyrosine kinase 2 in non-small cell lung cancer

(2008) Siyang Zhang et al.   LUNG CANCER

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity

(2007) Zhijian Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Focal adhesion kinase as a regulator of cell tension in the progression of cancer

(2007) Robert W. Tilghman et al.   SEMINARS IN CANCER BIOLOGY