Review
Cell Biology
Andrea Reszegi, Peter Tatrai, Eszter Regos, Ilona Kovalszky, Kornelia Baghy
Summary: Syndecan-1 is a protein that regulates cell activities and plays a crucial role in liver diseases and hepatocellular carcinoma. It is involved in various physiological and pathological processes, including cell proliferation, inflammation, and matrix remodeling.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Lokender Kumar, Monish Bisen, Azhar Khan, Pradeep Kumar, Sanjay Kumar Singh Patel
Summary: This review discusses the role of MMPs in skeletal muscle function, muscle injury and repair, as well as the potential applications of MMPs in the treatment of musculoskeletal disorders.
Article
Biochemistry & Molecular Biology
Bohee Jang, Ayoung Kim, Yejin Lee, Jisun Hwang, Jee-Young Sung, Eun-Ju Jang, Yong-Nyun Kim, Ji-Hye Yun, Jeongmin Han, Ji-Joon Song, Weontae Lee, Eok-Soo Oh
Summary: A synthetic peptide (S2-P) that binds to the pro-domain of matrix metalloproteinase-7 (MMP-7) to inhibit colon cancer activities has been modified to improve its anticancer potential. The modified peptide (S2-FE) showed improved interaction affinities for MMP-7 and effectively inhibited cancer activities in vitro and in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yang Liu, Fei Wang, Zhe Li, Yanling Mu, Voon Wee Yong, Mengzhou Xue
Summary: This study found that chlorogenic acid (CGA) can provide neuroprotection in intracerebral hemorrhage (ICH) by inhibiting the expression of EMMPRIN and MMP-2/9, alleviating neuroinflammation, blood-brain barrier disruption, cell death, and brain injury.
Article
Medicine, Research & Experimental
Preety Choudhary, Tapasi Roy, Abhishek Chatterjee, Vineet Kumar Mishra, Suyash Pant, Snehasikta Swarnakar
Summary: Forced swim stress induces gastric ulceration by promoting ROS overproduction, while melatonin provides gastroprotection by reducing inflammation burden, inhibiting MMP-3 activity, and other mechanisms.
Review
Chemistry, Medicinal
Usman Sabir, Hong-mei Gu, Da-Wei Zhang
Summary: MMPs have a complex role in liver fibrosis, with high expression in the early stage causing tissue damage and promoting fibrosis progression, and downregulation in the later stage facilitating ECM accumulation and disease progression. Phytochemicals can modulate MMP activity and ECM turnover, alleviating disease progression, but their effects depend on disease models, stages, and the dosage, timing, and duration of phytochemicals used.
PHYTOTHERAPY RESEARCH
(2023)
Review
Medicine, Research & Experimental
Liang Shan, Fengling Wang, Dandan Zhai, Xiangyun Meng, Jianjun Liu, Xiongwen Lv
Summary: Liver fibrosis is a consequence of chronic liver injuries, characterized by the imbalance of extracellular matrix production and degradation. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are crucial in collagen synthesis and lysis. This article reviews experimental studies on liver fibrosis based on MMPs/TIMPs and highlights the potential of targeting this interaction as a therapeutic strategy for hepatic fibrosis. The article also summarizes drugs, including natural products, that have been found to reduce liver fibrosis by altering the ratio of MMPs/TIMPs.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Oncology
Aniko Keller-Pinter, Szuzina Gyulai-Nagy, Daniel Becsky, Laszlo Dux, Laszlo Rovo
Summary: Cell migration is essential for the formation of metastasis and is a key feature of malignancy. Syndecan-4 (SDC4) plays a crucial role in cell migration by regulating various signaling pathways and biological processes. Its involvement in tumor progression has been demonstrated, highlighting its significance in cell movement and metastasis.
Review
Biochemistry & Molecular Biology
Min-Seob Kim, Se-Eun Ha, Moxin Wu, Hannah Zogg, Charles F. Ronkon, Moon-Young Lee, Seungil Ro
Summary: The composition and changes of the cellular microenvironment play a crucial role in cancer development, with alterations in the ECM significantly impacting the tumor microenvironment. ECM components are important in colorectal cancer and have potential roles as biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Medicinal
Sanjib Das, Sk Abdul Amin, Tarun Jha
Summary: Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) play significant roles in solid tumor invasion, metastasis, and angiogenesis, while their role in hematological malignancies is less understood. Recent studies have shown correlations between gelatinases and hematological malignancies, leading to the development of potential inhibitors for these conditions.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Environmental Sciences
Carlos Ramos, Rebeca Canedo-Mondragon, Carina Becerril, Georgina Gonzalez-Avila, Ana Laura Esquivel, Ana Lilia Torres-Machorro, Martha Montano
Summary: Exposure to short-term wood smoke was found to significantly increase total cells, macrophages, neutrophils, and collagen in the respiratory system of guinea pigs, leading to overexpression of pro-inflammatory cytokines, MMPs, and TIMPs in lung tissue.
Article
Oncology
Daeun You, Yisun Jeong, Sun Young Yoon, Sung A. Kim, Seok Won Kim, Seok Jin Nam, Jeong Eon Lee, Sangmin Kim
Summary: In triple-negative breast cancer cells, the expression of IL-1β is decreased by celastrol, leading to reduced proliferation and invasiveness of cancer cells, as well as a decrease in the expression of IL-8 and matrix metalloproteinases.
Article
Neurosciences
Yang Liu, Zhe Li, Suliman Khan, Ruiyi Zhang, Ruixue Wei, Yan Zhang, Mengzhou Xue, V. Wee Yong
Summary: The study demonstrates that minocycline plays a protective role in ICH by reducing EMMPRIN and MMP-9 expression, alleviating BBB disruption, inhibiting neuroinflammation, and decreasing neuronal degeneration and death.
NEUROSCIENCE LETTERS
(2021)
Article
Fisheries
Heng Chi, Jing Xing, Xiuzhen Sheng, Wenbin Zhan
Summary: MMP-9 is a protein belonging to the Matrix Metalloprotease family and plays crucial roles in various biological processes. This study investigated the characteristics and functions of the MMP-9 gene (PoMMP-9) in flounder, revealing its involvement in immune responses and tissue healing. The results suggest that PoMMP-9 is inducible and can recruit inflammatory cells through extracellular traps (ETs) for pathogen elimination and wound healing at inflammatory sites.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiao-dan Xia, Govind Gill, Haiming Lin, Daniela M. Roth, Xiang-jiang Wang, Feng-yi Su, Adekunle Alabi, Maria Alexiou, Ziyang Zhang, Gui-qing Wang, Daniel Graf, Da-wei Zhang
Summary: Membrane-type I metalloproteinase (MT1-MMP/MMP14) plays a key role in various pathophysiological processes, including severe inflammatory arthritis. The deficiency of MT1-MMP leads to noticeable joint swelling and severe arthritis in adult mice. Targeting specific cell types for MT1-MMP inhibition may be crucial for potential therapeutic use in arthritis.
Article
Oncology
Yaerim Kim, Su-Kil Park, Won Yong Cho, Kwon Wook Joo, Sug Kyun Shin, Dae Joong Kim, Yong-Lim Kim, Sung Hyun Son, Wookyung Chung, Kwang Young Lee, Sung Kwang Park, Joong Kyung Kim, Soo Wan Kim, Duk-Hee Kang, Jin Kuk Kim, Jin Seok Jeon, Kang Wook Lee, Chang Hwa Lee, Dong-Jin Oh, Won Suk An, Jong Soo Lee, Gun Woo Kang, Jun-young Do, Jung Pyo Lee, Kyubok Jin
Article
Endocrinology & Metabolism
Yu-Ji Lee, Yusuke Okuda, John Sy, Yoshitsugu Obi, Duk-Hee Kang, Steven Nguyen, Jui Ting Hsiung, Christina Park, Connie M. Rhee, Csaba P. Kovesdy, Elani Streja, Kamyar Kalantar-Zadeh
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Article
Transplantation
Duk-Hee Kang, Yuji Lee, Carola Ellen Kleine, Yong Kyu Lee, Christina Park, Jui-Ting Hsiung, Connie M. Rhee, Csaba P. Kovesdy, Kamyar Kalantar-Zadeh, Elani Streja
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2020)
Letter
Urology & Nephrology
Yuka Sato, Daniel I. Feig, Austin G. Stack, Duk-Hee Kang, Miguel A. Lanaspa, A. Ahsan Ejaz, L. Gabriela Sanchez-Lozada, Masanari Kuwabara, Claudio Borghi, Richard J. Johnson
NATURE REVIEWS NEPHROLOGY
(2020)
Article
Environmental Sciences
Soo Jeong Choi, Min Sung Lee, Duk-Hee Kang, Gang Jee Ko, Hee-Sook Lim, Byung Chul Yu, Moo Yong Park, Jin Kuk Kim, Chul-Hee Kim, Seung Duk Hwang, Jun Chul Kim, Chang Won Won, Won Suk An
Summary: In the elderly, higher serum myostatin levels may be associated with higher muscle mass and better physical performances. Serum myostatin/appendicular skeletal muscle mass ratio may predict physical performance instead of myostatin level alone.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Urology & Nephrology
Eunjung Cho, Soo Jeong Choi, Duk-Hee Kang, Kamyar Kalantar-Zadeh, Gang-Jee Ko
Summary: This review explores the impact of high-protein diets (HPDs) on kidney health, finding that HPDs are associated with a rapid decline in kidney function. The mechanism involves increased renal blood flow, glomerular hyperfiltration, and potential inflammation and glomerulosclerosis. Athletes and bodybuilders who follow HPDs long-term may be at a higher risk of developing HPD nephropathy.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2022)
Article
Urology & Nephrology
Kyun Young Kim, Jung-Hwa Ryu, Duk-Hee Kang, Seung-Jung Kim, Kyu Bok Choi, Shina Lee
Summary: This study investigated the association between fluid balance and short-term mortality outcomes in end-stage kidney disease patients undergoing chronic hemodialysis and requiring continuous renal replacement therapy. The results showed that increased cumulative output was significantly associated with reduced short-term mortality risk in these patients.
Article
Environmental Sciences
Jongmin Oh, Shinhee Ye, Duk-Hee Kang, Eunhee Ha
Summary: The study found that long-term exposure to PM2.5, PM10, NO2, and CO air pollutants is associated with decreased kidney function and increased risk of CKD.
ENVIRONMENTAL RESEARCH
(2022)
Review
Peripheral Vascular Disease
Takahiko Nakagawa, Ana Andres-Hernando, Tomoki G. Kosugi, Laura Sanchez-Lozada, Peter Stenvinkel, Karolina Kublickiene, S. Ananth Karumanchi, Duk-Hee Kang, Hideto Kojima, Bernardo R. Rodriguez-Iturbe, Dean A. Tolan, Miguel J. Lanaspa, Richard Johnson
Summary: Preeclampsia is a hypertensive disorder of pregnancy caused by abnormal placentation. Fructose, which plays a critical role in fetal growth, is produced in the placenta during early pregnancy to assist fetal survival in a hypoxic environment. Impaired placentation leads to excessive fructose production, which drives various pathological features of preeclampsia. In addition, dietary fructose intake has been identified as an independent risk factor for preeclampsia.
HYPERTENSION RESEARCH
(2023)
Editorial Material
Peripheral Vascular Disease
Takahiko Nakagawa, Duk-Hee Kang, Richard J. J. Johnson
HYPERTENSION RESEARCH
(2023)
Review
Urology & Nephrology
Takahiko Nakagawa, Duk-Hee Kang
Summary: The Warburg effect, typically seen in cancer cells, has also been found to play a role in non-cancer disorders such as kidney disease. In the kidney, fructose appears to mediate the Warburg effect by promoting glycolysis over mitochondrial respiration, potentially leading to chronic kidney disease.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Medicine, General & Internal
Youn Kyung Kee, Sang Youb Han, Duk-Hee Kang, Jung Woo Noh, Kyung Hwan Jeong, Gheun-Ho Kim, Yang Wook Kim, Beom Seok Kim
Summary: The study found that patients preferred DW-7202 over AST-120 as an oral adsorbent, with improved adherence after switching. Changes in kidney function markers and uremic toxin levels were not significantly different between the two types of adsorbents; the treatment efficacy and safety of DW-7202 were comparable to AST-120.
YONSEI MEDICAL JOURNAL
(2021)
Review
Urology & Nephrology
A. Ahsan Ejaz, Takahiko Nakagawa, Mehmet Kanbay, Masanari Kuwabara, Ada Kumar, Fernando E. Garcia Arroyo, Carlos Roncal-Jimenez, Fumihiko Sasai, Duk-Hee Kang, Thomas Jensen, Ana Andres Hernando, Bernardo Rodriguez-Iturbe, Gabriela Garcia, Dean R. Tolan, Laura G. Sanchez-Lozada, Miguel A. Lanaspa, Richard J. Johnson
SEMINARS IN NEPHROLOGY
(2020)
Letter
Medicine, General & Internal
Duk-Hee Kang, Laura G. Sanchez-Lozada, Richard J. Johnson
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Review
Urology & Nephrology
Duk-Hee Kang
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2020)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
