Article
Multidisciplinary Sciences
Alessandro Ianni, Poonam Kumari, Shahriar Tarighi, Nicolas G. Simonet, Daniela Popescu, Stefan Guenther, Soraya Holper, Andreas Schmidt, Christian Smolka, Shijing Yue, Marcus Kruger, Claudia Fiorillo, Alejandro Vaquero, Eva Bober, Thomas Braun
Summary: Adaptation to different forms of environmental stress is crucial for maintaining cellular functions and survival, with nucleolus playing a decisive role as a signaling hub; SIRT7 is an essential component for regulating p53 stability during stress responses induced by UV irradiation; Through ATR-mediated phosphorylation, SIRT7 promotes deacetylation of NPM, affecting ubiquitination and stabilization of p53 in response to genotoxic stress.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Francisco Alejandro Lagunas-Rangel
Summary: SIRT7, a member of the sirtuin family, has emerged as a key player in various cellular processes and is involved in the development and progression of diseases, especially cancer. This review aims to provide an in-depth understanding of the role of SIRT7 in cancer carcinogenesis and progression by elucidating the underlying molecular mechanisms, and also discusses the feasibility and challenges associated with the development of drugs that can modulate SIRT7 activity.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Mengfei Cao, Qianru Zhao, Xia Sun, Han Qian, Shumei Lyu, Rui Chen, Hao Xia, Wei Yuan
Summary: Acetylation is an important protein modification method, and SIRT3 protects mitochondria from damage by regulating acetylation, thereby maintaining normal heart function. SIRT3 depletion and defects lead to mitochondrial dysfunction, resulting in the development of cardiovascular diseases. Therefore, a comprehensive understanding of the role of SIRT3 in cardiovascular diseases is crucial for the development of new therapeutic strategies.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Neurosciences
Jennifer N. Pearson-Smith, Ruth Fulton, Christopher Q. Huynh, Anna G. Figueroa, Gia B. Huynh, Li -Ping Liang, Lindsey B. Gano, Cole R. Michel, Nichole Reisdorph, Richard Reisdorph, Kristofer S. Fritz, Eric Verdin, Manisha Patel
Summary: Mitochondrial dysfunction is a key factor in the development of neurologic disorders and aging. SIRT3 plays a role in regulating mitochondrial function through deacetylation of proteins involved in metabolism and antioxidant activity. Deletion of SIRT3 from neurons leads to mitochondrial hyperacetylation and impaired neuronal excitability and metabolism.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Fatema Akter, Tomonori Tsuyama, Tatsuya Yoshizawa, Shihab U. Sobuz, Kazuya Yamagata
Summary: SIRT7 interacts with and deacetylates PPAR gamma 2 at the K382 residue, leading to decreased lipid accumulation and dysregulation of lipogenesis-related genes. The findings suggest that SIRT7-dependent deacetylation of PPAR gamma 2 at K382 controls lipogenesis in adipocytes.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
Yuichi Kimura, Yasuhiro Izumiya, Satoshi Araki, Satoru Yamamura, Shinsuke Hanatani, Yoshiro Onoue, Toshifumi Ishida, Yuichiro Arima, Taishi Nakamura, Eiichiro Yamamoto, Takafumi Senokuchi, Tatsuya Yoshizawa, Masataka Sata, Shokei Kim-Mitsuyama, Naomi Nakagata, Eva Bober, Thomas Braun, Koichi Kaikita, Kazuya Yamagata, Kenichi Tsujita
Summary: Sirt7 plays a crucial role in neointimal formation after vascular injury, and its deficiency attenuates the formation of neointima. The study revealed that Sirt7(-/-) mice exhibited a significant reduction in neointima and modulation of cyclins and CDK2 in VSMCs when compared to WT mice. These findings suggest that Sirt7 could be a potential target for the treatment of vascular diseases.
CIRCULATION JOURNAL
(2021)
Article
Biotechnology & Applied Microbiology
Tatsuya Kato, Junya Azegami, Mai Kano, Hesham A. El Enshasy, Enoch Y. Park
Summary: This study found that Nicotinamide and disruption of AgHST1 or AgHST3 genes enhanced riboflavin production in Ashbya gossypii. Acetylation of H3K56 also led to an increase in riboflavin production.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Physiology
Elena Sidorova-Darmos, Merrick S. S. Fallah, Richard Logan, Cheng Yu Lin, James H. H. Eubanks
Summary: Post-translational modification of mitochondrial proteins can regulate the functional activity of mitochondria and influence neural circuit function in the brain. Sirt3, a protein deacetylase enzyme in mitochondria, was found to regulate mitochondrial proteome acetylation levels in the brain. The absence of Sirt3 increased the sensitivity of neural systems to the stimulant amphetamine.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Xinyi Wang, Xiao Jiang, Boran Li, Jiahua Zheng, Jiansheng Guo, Lei Gao, Mengjie Du, Xialian Weng, Lin Li, She Chen, Jingzi Zhang, Lei Fang, Ting Liu, Liang Wang, Wei Liu, Dante Neculai, Qiming Sun
Summary: The study reveals that the ER-phagy receptor FAM134B is acetylated by CBP acetyltransferase and phosphorylated by CAMKII, leading to the degradation of the endoplasmic reticulum (ER). On the other hand, SIRT7 deacetylates FAM134B to reduce its activity in ER degradation. This work provides mechanistic insights into how ER-phagy is regulated and controlled.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
David Siegel, Peter S. Harris, Cole R. Michel, Rafael de Cabo, Kristofer S. Fritz, David Ross
Summary: The stress induced protein NQO1 undergoes redox-dependent acetylation, with specific lysine residues in the C-terminal and helix seven regions being acetylated. This acetylation can be regulated by sirtuin-mediated deacetylation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Hai-Bo Yu, Sheng-Tao Cheng, Fang Ren, Yong Chen, Xiao-Feng Shi, Vincent Kam Wai Wong, Betty Yuen Kwan Law, Ji-Hua Ren, Shan Zhong, Wei-Xian Chen, Hong-Mei Xu, Zhen-Zhen Zhang, Jie-Li Hu, Xue-Fei Cai, Yuan Hu, Wen-Lu Zhang, Quan-Xin Long, Lin He, Zhong-Wen Hu, Hui Jiang, Hong-Zhong Zhou, Ai-Long Huang, Juan Chen
Summary: Histone modifications, especially histone acetylation and methylation, play critical roles in the epigenetic regulation of cccDNA transcription. SIRT7 interacts with HBV core protein to catalyze histone 3 lysine 122 desuccinylation and cooperates with histone methyltransferase to induce silencing of HBV transcription through modulation of chromatin structure. Transcriptional silencing of cccDNA may represent a novel antiviral strategy for the prevention or treatment of HBV infection.
Article
Medicine, Research & Experimental
Jianghua Zheng, Qiang Tan, Hang Chen, Kai Chen, Haifei Wang, Zhilong Chen, Yong Xi, Hongshun Yin, Kun Lai, Yujuan Liu
Summary: This study revealed that SNHG7-003 may inhibit the proliferation, migration and invasion of VSMCs through the miR-1306-5p/SIRT7 signaling pathway, providing a novel basis for the development of treatment strategies for AS.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Immunology
Marisa Conte, Daniela Eletto, Martina Pannetta, Anna M. Petrone, Maria C. Monti, Chiara Cassiano, Giorgio Giurato, Francesca Rizzo, Peter Tessarz, Antonello Petrella, Alessandra Tosco, Amalia Porta
Summary: This study investigates the role of Hst3p in H3K56 acetylation regulation in Candida albicans and its potential as a target for antifungal drugs. Through genomic and transcriptomic analyses, H3K56 acetylation is found to be associated with Candida spp. pathogenicity, and inhibition of Hst3p leads to transcriptional changes in multiple genes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Microbiology
Cora N. Betsinger, Joshua L. Justice, Matthew D. Tyl, Julia E. Edgar, Hanna G. Budayeva, Yaa F. Abu, Ileana M. Cristea
Summary: This study expands the understanding of the mechanisms underlying HCMV-induced cell cycle dysregulation and highlights the potential regulatory feedback between SIRT2 and CDK2, which may have implications in other viral infections and human diseases.
Review
Biochemistry & Molecular Biology
Francisco Alejandro Lagunas-Rangel
Summary: Aging is caused by the accumulation of molecular and cellular damage over time. SIRT7, an enzyme with important functions in aging and life extension, has been found to be closely related to age-related processes and may be associated with certain age-related diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell Biology
Hitomi Kaneko, Taku Kaitsuka, Kazuhito Tomizawa
Article
Biochemistry & Molecular Biology
Yuichi Kariba, Tatsuya Yoshizawa, Yoshifumi Sato, Tomonori Tsuyama, Eiichi Araki, Kazuya Yamagata
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Cardiac & Cardiovascular Systems
Yuichi Kimura, Yasuhiro Izumiya, Satoshi Araki, Satoru Yamamura, Shinsuke Hanatani, Yoshiro Onoue, Toshifumi Ishida, Yuichiro Arima, Taishi Nakamura, Eiichiro Yamamoto, Takafumi Senokuchi, Tatsuya Yoshizawa, Masataka Sata, Shokei Kim-Mitsuyama, Naomi Nakagata, Eva Bober, Thomas Braun, Koichi Kaikita, Kazuya Yamagata, Kenichi Tsujita
Summary: Sirt7 plays a crucial role in neointimal formation after vascular injury, and its deficiency attenuates the formation of neointima. The study revealed that Sirt7(-/-) mice exhibited a significant reduction in neointima and modulation of cyclins and CDK2 in VSMCs when compared to WT mice. These findings suggest that Sirt7 could be a potential target for the treatment of vascular diseases.
CIRCULATION JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Takeshi Chujo, Kazuhito Tomizawa
Summary: tRNA molecules play crucial roles in protein synthesis, and aberrations in tRNA modifications can lead to tRNA modopathies, which manifest as dysfunctions of the brain and/or kidney, mitochondrial diseases, and cancer. However, the molecular mechanisms linking aberrant tRNA modifications to diseases remain largely unknown.
Article
Endocrinology & Metabolism
Fatema Akter, Tomonori Tsuyama, Tatsuya Yoshizawa, Shihab U. Sobuz, Kazuya Yamagata
Summary: SIRT7 interacts with and deacetylates PPAR gamma 2 at the K382 residue, leading to decreased lipid accumulation and dysregulation of lipogenesis-related genes. The findings suggest that SIRT7-dependent deacetylation of PPAR gamma 2 at K382 controls lipogenesis in adipocytes.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Infectious Diseases
Nihad Adnan, Shahad Saif Khandker, Ahsanul Haq, Mousumi Akter Chaity, Abdul Khalek, Anawarul Quader Nazim, Taku Kaitsuka, Kazuhito Tomizawa, Masayasu Mie, Eiry Kobatake, Sohel Ahmed, Nor Azlina A. Ali, Mohib Ullah Khondoker, Mainul Haque, Mohd Raeed Jamiruddin
Summary: This study investigated the correlation of Ct value, storage temperature, and conditions with SARS-CoV-2 diagnosis using a newly developed ELISA system. Results showed that the ELISA system had highest sensitivity for samples with Ct <= 30 and stored at -80 degrees C, with specificity ranging between 98.3% and 100%. Early infection phase diagnosis and lower temperature preservation of samples are crucial for rapid antigen ELISA tests.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Hiroyuki Fukuda, Takeshi Chujo, Fan-Yan Wei, Sheng-Lan Shi, Mayumi Hirayama, Taku Kaitsuka, Takahiro Yamamoto, Hiroyuki Oshiumi, Kazuhito Tomizawa
Summary: The study demonstrated the essential role of tRNA m(1) A58 modification in both early and late steps of HIV-1 replication, as well as the necessity of TRMT6 for efficient 5-methylation of U54 in tRNA(3)(Lys). This highlights the fundamental importance of tRNA modifications in the cellular network and underscored its significance in retroviral infection.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yoshihiro Yoshikawa, Atsushi Tamura, Susumu Tsuda, Eisuke Domae, Shunyao Zhang, Nobuhiko Yui, Takashi Ikeo, Tatsuya Yoshizawa
Summary: In this study, the potential of carboxymethyl carbamate-modified AdPRX (CMC-AdPRX) for treating bone diseases was investigated. The results suggest that CMC-AdPRX can adsorb to calcium phosphate and suppress the functional expression of differentiated osteoclasts.
DENTAL MATERIALS JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Hironori Mizutani, Yoshifumi Sato, Masaya Yamazaki, Tatsuya Yoshizawa, Yukio Ando, Mitsuharu Ueda, Kazuya Yamagata
Summary: This study found that the expression of SIRT7 is increased in the brain of Alzheimer's disease patients. Treatment with A beta(42) increased the expression of NOX4, leading to the production of reactive oxygen species (ROS) and apoptosis. Knockdown of SIRT7 inhibited A beta(42)-induced ROS production and apoptosis by suppressing the upregulation of NOX4. These findings suggest that inhibiting SIRT7 may be beneficial in the pathogenesis of AD by regulating ROS production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Masaji Sakaguchi, Shota Okagawa, Yuma Okubo, Yuri Otsuka, Kazuki Fukuda, Motoyuki Igata, Tatsuya Kondo, Yoshifumi Sato, Tatsuya Yoshizawa, Takaichi Fukuda, Kazuya Yamagata, Weikang Cai, Yu-Hua Tseng, Nobuo Sakaguchi, C. Ronald Kahn, Eiichi Araki
Summary: The study reveals that Alpha4 regulates insulin receptor tyrosine phosphorylation via the YBX-1/PTP1B pathway, contributing to the maintenance of adipose tissue homeostasis and systemic metabolism. Impairment of alpha4 leads to decreased insulin-induced Akt-mediated phosphorylation and increased expression of tyrosine phosphatase PTP1B through decreased association with Y-box protein 1.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Tatsuya Yoshizawa, Yoshifumi Sato, Shihab U. Sobuz, Tomoya Mizumoto, Tomonori Tsuyama, Md Fazlul Karim, Keishi Miyata, Masayoshi Tasaki, Masaya Yamazaki, Yuichi Kariba, Norie Araki, Eiichi Araki, Shingo Kajimura, Yuichi Oike, Thomas Braun, Eva Bober, Johan Auwerx, Kazuya Yamagata
Summary: This study reveals that SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions. SIRT7 deficiency in mice leads to higher body temperature and energy expenditure, as well as increased UCP1 protein level. Mechanistically, SIRT7 deacetylates an RNA-binding protein to enhance its inhibition on UCP1 translation, and attenuates the expression of batokine genes.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Tomoya Mizumoto, Tatsuya Yoshizawa, Yoshifumi Sato, Takaaki Ito, Tomonori Tsuyama, Akiko Satoh, Satoshi Araki, Kenichi Tsujita, Masaru Tamura, Yuichi Oike, Kazuya Yamagata
Summary: This study reveals that the loss of SIRT7 extends lifespan and improves glucose metabolism in male mice. Furthermore, the serum FGF21 levels of Sirt7 KO mice are significantly higher than that of WT mice, which may be involved in the beneficial effects.
Article
Biochemistry & Molecular Biology
Tomonori Tsuyama, Yoshifumi Sato, Tatsuya Yoshizawa, Takaaki Matsuoka, Kazuya Yamagata
Summary: Hypoxia-induced transcriptional repressor BHLHE40 suppresses insulin secretion by inhibiting the expression of MAFA in beta-cells.
Article
Biochemistry & Molecular Biology
Toru Miwa, Tatsuya Katsuno, Fan-Yan Wei, Kazuhito Tomizawa
Summary: Previous studies have shown that age-related hearing loss (AHL) in Cdk5rap1-knockout mice is associated with cochlear pathology. This study aimed to identify mitochondrial alterations in the cochlea of Cdk5rap1-knockout mice with AHL. The results indicate that dysfunctional mitochondria in the lateral wall, rather than the loss of hair cells and spiral ganglion neurons, contribute to the onset of AHL. The study provides valuable insights into the underlying mechanisms of AHL and the relationship between aberrant tRNA modification-induced hearing loss and mitochondrial dysfunction.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
