SIRT7 restricts HBV transcription and replication through catalyzing desuccinylation of histone H3 associated with cccDNA minichromosome

SIRT3 restricts HBV transcription and replication via epigenetic regulation of cccDNA involving SUV39H1 and SETD1A histone methyltransferases

(2018) Ji-Hua Ren et al.   HEPATOLOGY

Chronic Hepatitis B Infection

(2018) Lydia S. Y. Tang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

SIRT7 suppresses the epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis by promoting SMAD4 deacetylation

(2018) Wenlu Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix

(2018) Masatoshi Fukuda et al.   Nature Communications

Hepatitis B virus: The challenge of an ancient virus with multiple faces and a remarkable replication strategy

(2018) Andrea Caballero et al.   ANTIVIRAL RESEARCH

Epigenetic regulation of hepatitis B virus covalently closed circular DNA: Implications for epigenetic therapy against chronic hepatitis B

(2017) Xupeng Hong et al.   HEPATOLOGY

PRMT5 restricts hepatitis B virus replication through epigenetic repression of covalently closed circular DNA transcription and interference with pregenomic RNA encapsidation

(2017) Wen Zhang et al.   HEPATOLOGY

The Role of cccDNA in HBV Maintenance

(2017) Lena Allweiss et al.   Viruses-Basel

Sirtuins and DNA damage repair: SIRT7 comes to play

(2017) Berta N. Vazquez et al.   Nucleus

Sirtuins and DNA damage repair: SIRT7 comes to play

(2017) Berta N. Vazquez et al.   Nucleus

The role of sirtuins in aging and age-related diseases

(2016) Mateusz Wątroba et al.   Advances in Medical Sciences

Attacking hepatitis B virus cccDNA – The holy grail to hepatitis B cure

(2016) Julie Lucifora et al.   JOURNAL OF HEPATOLOGY

SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing

(2016) Sifan Chen et al.   Nature Communications

SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability

(2016) Lei Li et al.   Nature Communications

Sirtuin 7 in cell proliferation, stress and disease: Rise of the Seventh Sirtuin!

(2015) Shashi Kiran et al.   CELLULAR SIGNALLING

HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B

(2015) Michael Nassal   GUT

HBx relieves chromatin-mediated transcriptional repression of hepatitis B viral cccDNA involving SETDB1 histone methyltransferase

(2015) Lise Rivière et al.   JOURNAL OF HEPATOLOGY

Mapping of histone modifications in episomal HBV cccDNA uncovers an unusual chromatin organization amenable to epigenetic manipulation

(2015) Philipp Tropberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stabilization of SIRT7 deacetylase by viral oncoprotein HBx leads to inhibition of growth restrictive RPS7 gene and facilitates cellular transformation

(2015) Vijaya Pandey et al.   Scientific Reports

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

(2014) Dongryeol Ryu et al.   Cell Metabolism

Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5

(2014) Minjia Tan et al.   Cell Metabolism

Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA

(2014) J. Lucifora et al.   SCIENCE

Intracellular distribution of human SIRT7 and mapping of the nuclear/nucleolar localization signal

(2013) Shashi Kiran et al.   FEBS Journal

Sirtuin 1 Regulates Hepatitis B Virus Transcription and Replication by Targeting Transcription Factor AP-1

(2013) J.-H. Ren et al.   JOURNAL OF VIROLOGY

Repression of RNA Polymerase I upon Stress Is Caused by Inhibition of RNA-Dependent Deacetylation of PAF53 by SIRT7

(2013) Sifan Chen et al.   MOLECULAR CELL

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

(2013) Jeongsoon Park et al.   MOLECULAR CELL

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

(2013) Hong Jiang et al.   NATURE

Sirtuins: NAD+-dependent deacetylase mechanism and regulation

(2012) Anthony A Sauve et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome

(2012) Laura Belloni et al.   JOURNAL OF CLINICAL INVESTIGATION

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation

(2012) Matthew F. Barber et al.   NATURE

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Interplay between SIRT proteins and tumour suppressor transcription factors in chemotherapeutic resistance of cancer

(2010) Yolanda Olmos et al.   DRUG RESISTANCE UPDATES

Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis

(2009) A. Grob et al.   JOURNAL OF CELL SCIENCE

Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function

(2009) L. Belloni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA