Article
Microbiology
Patricia A. Darrah, Joseph J. Zeppa, Chuangqi Wang, Edward B. Irvine, Allison N. Bucsan, Mark A. Rodgers, Supriya Pokkali, Joshua A. Hackney, Megha Kamath, Alexander G. White, H. Jacob Borish, L. James Frye, Jaime Tomko, Kara Kracinovsky, Philana Ling Lin, Edwin Klein, Charles A. Scanga, Galit Alter, Sarah M. Fortune, Douglas A. Lauffenburger, JoAnne L. Flynn, Robert A. Seder, Pauline Maiello, Mario Roederer
Summary: Recent research shows that intravenous administration of BCG vaccine provides better protection against tuberculosis. A dose-ranging study in macaques reveals that CD4 T cell immunity and NK cells in the bronchoalveolar lavage (BAL) correlate with protection.
CELL HOST & MICROBE
(2023)
Editorial Material
Multidisciplinary Sciences
Masanori Matsuzaki, Teppei Ebina
Summary: In June 2021, two papers utilized two-photon or one-photon microscopes to study the motor cortex in macaque monkeys over several months, successfully decoding the direction of natural arm reaching from population activity.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Annette B. Vogel, Isis Kanevsky, Ye Che, Kena A. Swanson, Alexander Muik, Mathias Vormehr, Lena M. Kranz, Kerstin C. Walzer, Stephanie Hein, Alptekin Gueler, Jakob Loschko, Mohan S. Maddur, Ayuko Ota-Setlik, Kristin Tompkins, Journey Cole, Bonny G. Lui, Thomas Ziegenhals, Arianne Plaschke, David Eisel, Sarah C. Dany, Stephanie Fesser, Stephanie Erbar, Ferdia Bates, Diana Schneider, Bernadette Jesionek, Bianca Saenger, Ann-Kathrin Wallisch, Yvonne Feuchter, Hanna Junginger, Stefanie A. Krumm, Andre P. Heinen, Petra Adams-Quack, Julia Schlereth, Stefan Schille, Christoph Kroener, Ramon de la Caridad Guimil Garcia, Thomas Hiller, Leyla Fischer, Rani S. Sellers, Shambhunath Choudhary, Olga Gonzalez, Fulvia Vascotto, Matthew R. Gutman, Jane A. Fontenot, Shannan Hall-Ursone, Kathleen Brasky, Matthew C. Griffor, Seungil Han, Andreas A. H. Su, Joshua A. Lees, Nicole L. Nedoma, Ellene H. Mashalidis, Parag Sahasrabudhe, Charles Y. Tan, Danka Pavliakova, Guy Singh, Camila Fontes-Garfias, Michael Pride, Ingrid L. Scully, Tara Ciolino, Jennifer Obregon, Michal Gazi, Ricardo Carrion, Kendra J. Alfson, Warren Kalina, Deepak Kaushal, Pei-Yong Shi, Thorsten Klamp, Corinna Rosenbaum, Andreas N. Kuhn, Ozlem Tureci, Philip R. Dormitzer, Kathrin U. Jansen, Ugur Sahin
Summary: The two vaccine candidates, BNT162b1 and BNT162b2, developed contain modified messenger RNA encoding immunogens derived from the spike glycoprotein of SARS-CoV-2. They have shown promising immune responses in mice and rhesus macaques, with ongoing phase I trials in Germany and the USA and a global phase II/III trial for BNT162b2.
Article
Biochemistry & Molecular Biology
Malika Aid, Michaela Sciacca, Katherine McMahan, David Hope, Jinyan Liu, Catherine Jacob-Dolan, Olivia Powers, Julia Barrett, Cindy Wu, Audrey Mutoni, Tetyana Murdza, Hannah Richter, Jason Velasco, Elyse Teow, Mona Boursiquot, Anthony Cook, Tatyana Orekov, Melissa Hamilton, Laurent Pessaint, Alaina Ryan, Tammy Hayes, Amanda J. Martinot, Michael S. Seaman, Mark G. Lewis, Hanne Andersen, Dan H. Barouch
Summary: The study investigates the immune responses and skin lesions caused by mpox virus in rhesus macaques infected through different routes. Transcriptomic analysis reveals insights into the pathogenesis and immunity of mpox. The macaque model shows potential for evaluating mpox vaccines and therapeutics.
Article
Biochemistry & Molecular Biology
Ala Moshiri, Fang Fang, Pei Zhuang, Haoliang Huang, Xue Feng, Liang Li, Roopa Dalal, Yang Hu
Summary: Researchers attempted to replicate the mouse glaucoma model in rhesus macaque monkeys and found that it successfully recapitulated the severe degeneration seen in acute human glaucoma. However, the monkeys showed dynamic changes in intraocular pressure, indicating the need for further optimization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Katherine McMahan, Jingyou Yu, Noe B. Mercado, Carolin Loos, Lisa H. Tostanoski, Abishek Chandrashekar, Jinyan Liu, Lauren Peter, Caroline Atyeo, Alex Zhu, Esther A. Bondzie, Gabriel Dagotto, Makda S. Gebre, Catherine Jacob-Dolan, Zhenfeng Li, Felix Nampanya, Shivani Patel, Laurent Pessaint, Alex Van Ry, Kelvin Blade, Jake Yalley-Ogunro, Mehtap Cabus, Renita Brown, Anthony Cook, Elyse Teow, Hanne Andersen, Mark G. Lewis, Douglas A. Lauffenburger, Galit Alter, Dan H. Barouch
Summary: Adoptive transfer of purified IgG from convalescent macaques protects naive macaques against SARS-CoV-2 infection, and cellular immune responses contribute to protection against rechallenge with SARS-CoV-2. The findings suggest that relatively low antibody titres are sufficient for protection against SARS-CoV-2 in macaques, while higher antibody titres are required for treatment of SARS-CoV-2 infection.
Article
Behavioral Sciences
Greg Jensen, Vincent P. Ferrera, Herbert S. Terrace
Summary: The research found that monkeys show preferences for novel test pairs when learning sequence relationships, but perform below chance when the pairs are incongruent with training. The joint contributions of transitive inference and positional inference explain this behavior.
Article
Virology
Yishu Gong, Matilda Mostrom, Claire Otero, Sarah Valencia, Alice F. Tarantal, Amitinder Kaur, Sallie R. Permar, Cliburn Chan
Summary: Approximately 0.7% of infants are born with congenital cytomegalovirus (CMV), with potential long-term consequences. The rhesus CMV (RhCMV) infection of rhesus monkey fetuses is an important animal model for studying CMV infection. A mathematical model was developed to study the risk of placental transmission of CMV, considering factors such as timing of inoculation, maternal immune suppression, and hyper-immune globulin infusion.
Article
Immunology
Andrew D. White, Laura Sibley, Charlotte Sarfas, Alexandra Morrison, Jennie Gullick, Simon Clark, Fergus Gleeson, Anthony McIntyre, Cecilia Lindestam Arlehamn, Alessandro Sette, Francisco J. Salguero, Emma Rayner, Esteban Rodriguez, Eugenia Puentes, Dominick Laddy, Ann Williams, Mike Dennis, Carlos Martin, Sally Sharpe
Summary: The study found that intradermal vaccination with MTBVAC in adult rhesus macaques induced immune responses that led to improved outcomes after M. tuberculosis challenge, supporting the potential of MTBVAC as an effective prophylactic vaccine for tuberculosis vaccination campaigns.
Article
Biochemistry & Molecular Biology
Camille Testard, Sam M. Larson, Marina M. Watowich, Cassandre H. Kaplinsky, Antonia Bernau, Matthew Faulder, Harry H. Marshall, Julia Lehmann, Angelina Ruiz-Lambides, James P. Higham, Michael J. Montague, Noah Snyder-Mackler, Michael L. Platt, Lauren J. N. Brent
Summary: Climate change is exacerbating weather-related disasters, impacting resilience and vulnerability. Following Hurricane Maria, a study on rhesus macaques found that monkeys invested in building new social connections, showing a preference for adaptation through new relationships rather than reinforcing existing ones.
Article
Virology
Suqin Duan, Fengmei Yang, Yanyan Li, Yuan Zhao, Li Shi, Meng Qin, Quan Liu, Weihua Jin, Junbin Wang, Lixiong Chen, Wei Zhang, Yongjie Li, Ying Zhang, Jingjing Zhang, Shaohui Ma, Zhanlong He, Qihan Li
Summary: This study used rhesus macaques to mimic hand, foot and mouth disease (HFMD) in humans and found that during acute infection, the macaques showed viremia and clinical symptoms similar to those in humans, as well as significant inflammatory pathological damages in multiple organs. During the recovery period, some animals developed severe hyperglycemia due to inflammatory factors. The findings suggest that rhesus macaques can serve as a non-human primate animal model for studying the pathophysiology of CV-A10 and evaluating potential human therapies.
Article
Microbiology
Stella G. G. Hoft, Keith D. D. Kauffman, Shunsuke Sakai, Cecilia S. Lindestam S. Arlehamn, Alessandro Sette, Daniel F. F. Hoft, Richard Herbert, Daniel L. L. Barber
Summary: Alternative delivery routes of BCG vaccine for tuberculosis, such as intradermal injection, may provide better protection. In this study, rhesus macaques were used to compare the airway immune response induced by intradermal versus intragastric delivery of BCG. The results showed that intragastric delivery induced lower T cell response in the airways, possibly due to the imprinting of gut-homing receptors on T cells.
Article
Immunology
Denise C. Hsu, Kesara Chumpolkulwong, Michael J. Corley, Taweewun Hunsawong, Dutsadee Inthawong, Alexandra Schuetz, Rawiwan Imerbsin, Decha Silsorn, Panupat Nadee, Jumpol Sopanaporn, Yuwadee Phuang-Ngern, Chonticha Klungthong, Matthew Reed, Stefan Fernandez, Lishomwa C. Ndhlovu, Robert Paul, Luis Lugo-Roman, Nelson L. Michael, Kayvon Modjarrad, Sandhya Vasan
Summary: This study aimed to assess the neurocognitive impact of Zika virus (ZIKV) infection in adult rhesus macaques. Neurocognitive assessments and measurements of immune activation markers were performed, revealing that ZIKV infection caused neuroinflammation and neurocognitive impairment. This model proves to be useful in studying the effects of neuroinflammation on neurobehavior.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Keith D. Kauffman, Shunsuke Sakai, Nickiana E. Lora, Sivaranjani Namasivayam, Paul J. Baker, Olena Kamenyeva, Taylor W. Foreman, Christine E. Nelson, Deivide Oliveira-de-Souza, Caian L. Vinhaes, Ziv Yaniv, Cecilia S. Lindestam Arleham, Alessandro Sette, Gordon J. Freeman, Rashida Moore, Alan Sher, Katrin D. Mayer-Barber, Bruno B. Andrade, Juraj Kabat, Laura E. Via, Daniel L. Barber
Summary: Blocking PD-1 increases the number and functionality of Mtb-specific CD8 T cells in granulomas of rhesus macaques, but has a lesser impact on CD4 T cells with more of an inhibitory effect.
SCIENCE IMMUNOLOGY
(2021)
Article
Immunology
Justin Pollara, Matthew Zirui Tay, R. Whitney Edwards, Derrick Goodman, Andrew R. Crowley, Robert J. Edwards, David Easterhoff, Haleigh E. Conley, Taylor Hoxie, Thaddeus Gurley, Caroline Jones, Emily Machiele, Marina Tuyishime, Elizabeth Donahue, Shalini Jha, Rachel L. Spreng, Thomas J. Hope, Kevin Wiehe, Max M. He, M. Anthony Moody, Kevin O. Saunders, Margaret E. Ackerman, Guido Ferrari, Georgia D. Tomaras
Summary: The study found differences in ADP activity between humans and macaques, but certain engineered antibodies can effectively enhance ADP activity in both species. These results contribute to a better translation of human and macaque antibody and FcR biology, and may help to improve testing accuracy and evaluations of future prevention strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Anatomy & Morphology
Yuki Hattori
Summary: Microglia, the resident immune cells of the central nervous system, are generated from progenitors in the yolk sac during early embryonic stages and colonize brain structures through migration and proliferation. Despite being a minor population in the developing cortex, microglia interact with neural lineage cells through filopodia extension and migration. Their distribution in the developing brain changes in a stage-dependent manner, playing roles in regulating neurogenesis and neuronal circuit formation.
ANATOMICAL SCIENCE INTERNATIONAL
(2022)
Article
Neurosciences
Yuki Hattori, Haruka Itoh, Yoji Tsugawa, Yusuke Nishida, Kaori Kurata, Akiyoshi Uemura, Takaki Miyata
Summary: This study reveals the important role of pericytes in the distribution and function of microglia in the developing brain. Pericytes promote microglial proliferation and the production of soluble factors, indirectly affecting microglial effects on neural progenitors.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Mariko Komuro, Masaki Nagane, Rikito Endo, Takashi Nakamura, Takayoshi Miyamoto, Chiaki Niwa, Tomoki Fukuyama, Hideyoshi Harashima, Naoyuki Aihara, Junichi Kamiie, Rimina Suzuki, Tadashi Yamashita
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease characterized by excessive activation of T cells. This study investigated the involvement of glycosphingolipids (GSLs) in IBD. The results showed that decreased expression of UDPglucose ceramide glucosyltransferase (UGCG), a GSLs synthase, was associated with IBD. Decreased UGCG led to worsened colitis and lower levels of regulatory T cells (Treg). Additionally, treatment with glucosylceramide (GlcCer) nanoparticles showed potential efficacy in preventing DSS-induced colitis, suggesting GlcCer in T cells as a therapeutic target for IBD patients.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Nako Maishi, Yu Sakurai, Hiroto Hatakeyama, Yui Umeyama, Takashi Nakamura, Rikito Endo, Mohammad Towfik Alam, Cong Li, Dorcas Akuba-Muhyia Annan, Hiroshi Kikuchi, Hirofumi Morimoto, Masahiro Morimoto, Kosuke Akiyama, Noritaka Ohga, Yasuhiro Hida, Hideyoshi Harashima, Kyoko Hida
Summary: This study explored the therapeutic effect of biglycan inhibition in renal cell carcinoma by using a specific nanodevice to deliver siRNA against biglycan into tumor endothelial cells (TECs). The results showed that biglycan silencing by the nanodevice inhibited tumor growth and normalized tumor microenvironmental factors.
Review
Chemistry, Multidisciplinary
Takashi Nakamura, Norikazu Isoda, Yoshihiro Sakoda, Hideyoshi Harashima
Summary: This review discusses drug delivery strategies, especially the use of lipid-based nanocarriers, for combating respiratory virus infections. To overcome respiratory viruses, it is necessary to acquire knowledge about international surveillance systems, virology, and ecology, and to determine the effectiveness of immune responses.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Takashi Nakamura, Sion Elisabeth Elfainatur Haloha, Hideyoshi Harashima
Summary: The combination of polyinosinic-polycytidylic acid (poly I:C) and antigen loaded liposome has been shown to improve cancer immunotherapy and has the potential for effective antitumor immunity. The study investigated the effects of using poly I:C and an antigen loaded liposome for cancer immunotherapy and found that it significantly inhibited systemic cytokine production and improved the immune status in tumors. The findings provide implications for the development of intravenous liposomal vaccines.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Takashi Nakamura, Kyoko Kawakami, Momoka Nomura, Yusuke Sato, Mamoru Hyodo, Hiroto Hatakeyama, Yoshihiro Hayakawa, Hideyoshi Harashima
Summary: This study identified a parameter of immune status in the tumor microenvironment (TME) and demonstrated the effectiveness of cancer immunotherapy using an adjuvant loaded lipid nanoparticle (LNP) based on this parameter. Analysis of gene expression revealed a panel of 10 genes associated with effective antitumor effects. The findings suggest the potential of immune status analysis in the TME for developing cancer immunotherapies using a delivery system.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Multidisciplinary Sciences
Koyo Tsujikawa, Kohei Hamanaka, Yuichi Riku, Yuki Hattori, Norikazu Hara, Yohei Iguchi, Shinsuke Ishigaki, Atsushi Hashizume, Satoko Miyatake, Satomi Mitsuhashi, Yu Miyazaki, Mayumi Kataoka, Li Jiayi, Keizo Yasui, Satoshi Kuru, Haruki Koike, Kenta Kobayashi, Naruhiko Sahara, Norio Ozaki, Mari Yoshida, Akiyoshi Kakita, Yuko Saito, Yasushi Iwasaki, Akinori Miyashita, Takeshi Iwatsubo, Takeshi Ikeuchi, Takaki Miyata, Gen Sobue, Naomichi Matsumoto, Kentaro Sahashi, Masahisa Katsuno
Summary: This study identified the role of Filamin-A in promoting tau aggregation in progressive supranuclear palsy (PSP) patients without tau mutations. It found that nonmutated tau interacts with actin filaments through increased levels of Filamin-A, resulting in enhanced phosphorylation and insolubility of tau. The study also showed that reducing Filamin-A levels corrected aberrant tau levels in PSP cell cultures.
Article
Biochemistry & Molecular Biology
Takafumi Fukui, Hironao Tateno, Takashi Nakamura, Yuma Yamada, Yusuke Sato, Norimasa Iwasaki, Hideyoshi Harashima, Ken Kadoya
Summary: This study investigated the potential of liposomes as an efficient drug-delivery system for treating disorders of the central nervous system. By optimizing the liposomes and conducting experiments in a rat model, the study confirmed successful retrograde transport to the spinal cord and dorsal root ganglia. Modifying the liposomes with different substances improved their transport efficiency, providing valuable insights for the future development of novel DDS targeting the CNS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Alaa M. Khalifa, Takashi Nakamura, Yusuke Sato, Takanori Sato, Mamoru Hyodo, Yoshihiro Hayakawa, Hideyoshi Harashima
Summary: The interval and number of doses of STING-LNP, combined with PD-1 antibody, played a crucial role in inducing optimal combined antitumor activity against melanoma lung metastasis.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Minori Asa, Daisuke Morita, Jin Kuroha, Tatsuaki Mizutani, Naoki Mori, Bunzo Mikami, Masahiko Sugita
Summary: The study shows that human HLA-A*24:02 and HLA-C*14:02 proteins have the ability to bind N-myristoylated short lipopeptides, contrary to their known function of binding conventional long peptides. It was found that the structural flexibility of the large B pocket of these proteins primarily contributes to their capacity to bind chemically distinct ligands.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yuma Yamada, Yusuke Sato, Takashi Nakamura, Hideyoshi Harashima
Summary: The recent progress in drug delivery systems has led to a new era in understanding the molecular mechanisms of cancer survival. This review summarizes new cancer strategies based on these delivery systems, including improving cancer immunotherapy, utilizing genome editing for therapeutic cargoes, and targeting cancer cell mitochondria through membrane fusion.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Pharmacology & Pharmacy
Takashi Nakamura, Yusuke Sato, Yuma Yamada, Mahmoud M. Abd Elwakil, Seigo Kimura, Mahmoud A. Younis, Hideyoshi Harashima
Summary: This review summarizes the new era of nanomedicines in nucleic acids/gene therapy and discusses the possibilities and expectations of extrahepatic delivery. Passive targeting, active targeting, and controlled intracellular trafficking are important factors for successful therapeutic results. Additionally, mitochondrial delivery is introduced as a novel strategy to expand the therapeutic dimension of nucleic acids/gene therapy.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Takashi Nakamura, Taisei Nakade, Yusuke Sato, Hideyoshi Harashima
Summary: This study reports the use of CL1H6-LNP, a lipid nanoparticle, for delivering mRNA to NK-92 cells. Compared to the benchmark DLin-MC3-DMA based LNP, the CL1H6-LNP showed higher mRNA expression intensity and 100% cell transfection efficiency. The efficient mRNA delivery by CL1H6-LNP is attributed to its high affinity for NK-92 cells and rapid fusion with the endosomal membrane, highlighting its potential as a non-viral vector for modifying NK-92 cell functions.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Immunology
Daisuke Morita, Minori Asa, Masahiko Sugita
Summary: Complementarity-determining regions (CDRs) of alpha beta T-cell receptors (TCRs) sense peptide-bound MHC (pMHC) complexes via chemical interactions, contributing to antigen specificity and MHC restriction. Conformational changes in peptide ligands occur upon TCR docking, affecting the exposure of T-cell epitopes. Ligand recognition by specific TCRs involves not only epitopic residues, but also non-epitopic residues affecting ligand plasticity and antigenicity (NR-PA).
INTERNATIONAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)