Article
Biochemistry & Molecular Biology
Chunyan Wu, Shu Fang, Huijian Zhang, Xiaoqiang Li, Yuejun Du, Yudan Zhang, Xiaochun Lin, Ling Wang, Xiaoqin Ma, Yaoming Xue, Meiping Guan
Summary: The study demonstrates the crucial role of long non-coding RNA XIST in brown preadipocytes differentiation and metabolic regulation, suggesting its potential therapeutic implications for combating obesity.
MOLECULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Vanessa M. Lima, Jianming Liu, Bruna B. Brandao, Caroline A. Lino, Camila S. Balbino Silva, Marcio A. C. Ribeiro, Tiago E. Oliveira, Caroline C. Real, Daniele de Paula Faria, Carly Cederquist, Zhan-Peng Huang, Xiaoyun Hu, Maria Luiza Barreto-Chaves, Julio C. B. Ferreira, William T. Festuccia, Marcelo A. Mori, C. Ronald Kahn, Da-Zhi Wang, Gabriela P. Diniz
Summary: miR-22 plays a role in white, beige, and brown adipocyte differentiation. Deletion of miR-22 reduces white adipocyte differentiation, increases BAT activity, and enhances resistance in HFD-fed mice.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Nutrition & Dietetics
So-Won Heo, Kyung-Sook Chung, Young-Seo Yoon, Soo-Yeon Kim, Hye-Shin Ahn, Yu-Kyong Shin, Sun-Hee Lee, Kyung-Tae Lee
Summary: Obesity is a global threat to public health, leading to diseases such as type 2 diabetes and non-alcoholic fatty liver disease. In this study, we found that a herbal extract called EECM has anti-obesity effects by inhibiting adipogenesis and lipogenesis and regulating adipogenic hormones. EECM was also effective in reducing body weight gain, body fat accumulation, and adipocyte and lipid accumulation in mice. It induced thermogenic factors in brown adipose tissue and restored gut microbiome composition. EECM may serve as a promising therapeutic agent for preventing obesity.
Article
Medicine, Research & Experimental
Saeed Daneshyar, Gholamreza Tavoosidana, Mahdi Bahmani, Saeed Shokati Basir, Maryam Delfan, Ismail Laher, Ayoub Saeidi, Urs Granacher, Hassane Zouhal
Summary: This study aims to investigate the combined effects of high-fat diets and exercise training on autophagy in mouse white adipose tissue. The results show that both the high-fat diet and exercise training groups had increased levels of autophagy-related genes and proteins. The combination of high-fat diet and exercise enhances autophagosome formation and modulates lysosomal degradation in white adipose tissue.
Article
Endocrinology & Metabolism
Megan Stefkovich, Sarah Traynor, Lan Cheng, David Merrick, Patrick Seale
Summary: The study demonstrates that Dpp4+ interstitial progenitor cells play a crucial role in adipogenesis, especially in the expansion of visceral adipose tissue under HFD stimulation.
MOLECULAR METABOLISM
(2021)
Article
Medicine, Research & Experimental
Seyyed Mohammad Reza Hashemnia, Reza Meshkani, Fahimeh Zamani-Garmsiri, Maryam Shabani, Maryam Tajabadi-Ebrahimi, Iraj Ragerdi Kashani, Seyed Davar Siadat, Samaneh Mohassel Azadi, Solaleh Emamgholipour
Summary: New evidence suggests that B. coagulans can be a promising alternative for treating metabolic disorders. However, its effects on obesity-induced adipose tissue inflammation are still unknown.
Article
Biochemistry & Molecular Biology
Yugo Kato, Yoshinori Aoki, Chikako Kiyose, Koji Fukui
Summary: T3s attenuate obesity by inhibiting body fat and serum cholesterol increase, and also improve cognitive function.
Article
Biophysics
Pooja Anantha, Zhenhui Liu, Piyush Raj, Ishan Barman
Summary: In this study, we used optical diffraction tomography (ODT) and Raman spectroscopy to investigate the early stages of differentiation of human white preadipocytes (HWPs) and human brown preadipocytes (HBPs). We found that HBPs accumulate lipids more rapidly and have a higher lipid mass than HWPs. Additionally, HBPs have higher lipid unsaturation levels than HWPs.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Medicine, Research & Experimental
Cho-Rong Bae, Young-Guen Kwon
Summary: The endothelial dysfunction blocker CU06-1004 was found to reduce lipid accumulation and improve insulin resistance and hepatic steatosis. This may make it a potential therapeutic agent for the prevention of obesity and obesity-related disorders.
Article
Biochemical Research Methods
Yuqiu Wang, Junmin Li, Dayun Lu, Qian Meng, Nixue Song, Hu Zhou, Xiao Xiao, Liming Sun, Hongwen Zhu
Summary: This study investigated the molecular and cellular mechanisms of diet-induced thermogenesis (DIT) in response to high fat diet (HFD) by proteome and phosphoproteome analysis. The findings indicated that Uncoupling protein 1 (UCP1) and its phosphorylation were increased in brown adipose tissue (BAT) after HFD, along with upregulated proteins related to fatty acid oxidation and mitochondrial functions. In contrast, most metabolic-related proteins were downregulated in subcutaneous white adipose tissue (sWAT), accompanied by decreased mitochondrial proteins and inactivated kinases. These findings provide valuable insights into the differential regulatory networks of HFD in BAT and sWAT.
JOURNAL OF PROTEOMICS
(2022)
Article
Biochemistry & Molecular Biology
Alexandra Paul, Belen Chanclon, Cecilia Brannmark, Pernilla Wittung-Stafshede, Charlotta S. Olofsson, Ingrid Wernstedt Asterholm, Sapun H. Parekh
Summary: Brown adipose tissue (BAT) is highly metabolically active and can catabolize nutrients to produce heat. Studies have shown that dietary fatty acids can regulate lipid deposition in BAT, similar to white adipose tissue (WAT). This study aimed to compare the effects of sustained dietary intervention on lipid metabolism and deposition in WAT and interscapular BAT.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Review
Endocrinology & Metabolism
Irem Altun, Xiaocheng Yan, Siegfried Ussar
Summary: Adipose tissue is important for energy storage and regulating metabolism. Obesity can lead to dysfunction in adipose tissue, affecting the composition and function of stromal cells. Immune cells in adipose tissue play essential roles in regulating adipocyte function. Macrophages, mast cells, innate lymphoid cells, and T cells all have a significant impact on adipocyte progenitor proliferation, differentiation, and lineage commitment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aline Almeida da Silva, Elisangela Martins da Silva Perez, Ingrid Samantha Tavares de Figueiredo, Nylane Maria Nunes de Alencar, Ana Paula Negreiros Nunes Alves, Fabiano Andre Narciso Fernandes, Renata Prado Vasconcelos, Ariclecio Cunha de Oliveira, Socorro Vanesca Frota Gaban
Summary: This study investigated the effects of virgin coconut oil (VCO) on body weight, white fat depots, and biochemical and morphological parameters in male Swiss mice fed standard (SD) or high-fat (HFD) diets. The results showed that low-dose VCO supplementation did not improve obesity, had no effects on hepatic or renal function, and had beneficial effects on the lipid profile only in animals fed HFD.
Article
Biochemistry & Molecular Biology
Seita Osawa, Hisashi Kato, Yuki Maeda, Hisashi Takakura, Junetsu Ogasawara, Tetsuya Izawa
Summary: This study investigated the impact of exercise training and high-fat diet on the differentiation potential of adipose-derived stem cells (ADSCs) and found variations in amino acid accumulation under different conditions. The findings also revealed the influence of exercise training on amino acid metabolism pathways in ADSCs-derived adipocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Heegu Jin, Hyun-Ji Oh, Sehaeng Cho, Ok-Hwan Lee, Boo-Yong Lee
Summary: The study demonstrates that okra complex has beneficial effects on lipid metabolism through multiple pathways, reducing body weight and adipose tissue mass in mice and improving blood glucose, cholesterol, and triglycerides in obese mice. It may be useful for the therapy and prevention of obesity and related metabolic diseases.
Article
Biochemistry & Molecular Biology
Changyou Jiang, Xueying Wang, Qiumin Le, Peipei Liu, Cao Liu, Zhilin Wang, Guanhong He, Ping Zheng, Feifei Wang, Lan Ma
Summary: The study reveals that morphine coordinates the function of SST- and PV-INs in the PrL via different opioid receptors to disinhibit pyramidal neurons and enhance reward.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Zhilin Wang, Tao Jin, Qiumin Le, Cao Liu, Xueying Wang, Feifei Wang, Lan Ma
BIOLOGICAL PSYCHIATRY
(2020)
Article
Medicine, Research & Experimental
Xi Shen, Hongyuan Gao, Qiuju Chen, Renfei Cai, Qifeng Lyu, Yun Wang, Li Wang, Yanping Kuang
MEDICAL SCIENCE MONITOR
(2020)
Article
Obstetrics & Gynecology
Xi Shen, Hui Long, Wenya Guo, Yating Xie, Hongyuan Gao, Jie Zhang, Yun Wang, Qifeng Lyu, Yanping Kuang, Li Wang
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2020)
Article
Cell Biology
Yu Gao, Minjie Shen, Jose Carlos Gonzalez, Qiping Dong, Sudharsan Kannan, Johnson T. Hoang, Brian E. Eisinger, Jyotsna Pandey, Sahar Javadi, Qiang Chang, Daifeng Wang, Linda Overstreet-Wadiche, Xinyu Zhao
Article
Biology
Li Wang, Wenya Guo, Xi Shen, Shel Yeo, Hui Long, Zhexuan Wang, Qifeng Lyu, Allan E. Herbison, Yanping Kuang
Article
Physiology
Xi Shen, Hui Long, Hongyuan Gao, Wenya Guo, Yating Xie, Di Chen, Yanyan Cong, Yun Wang, Dongying Li, Jiqiang Si, Leiwen Zhao, Qifeng Lyu, Yanping Kuang, Li Wang
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Multidisciplinary Sciences
Hui Long, Weina Yu, Sha Yu, Mingru Yin, Ling Wu, Qiuju Chen, Renfei Cai, Lun Suo, Li Wang, Qifeng Lyu, Yanping Kuang
Summary: The study investigated the impact of progesterone on clinical oocyte outcomes and the coordination between progesterone and follicle stimulating hormone (FSH) in regulating follicle growth and oocyte yields. Findings revealed that progesterone inhibited granular cell proliferation and follicle growth through the PI3K/AKT and MAPK signaling pathways, ultimately affecting oocyte outcomes in clinical settings.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Minjie Shen, Yu Guo, Qiping Dong, Yu Gao, Michael E. Stockton, Meng Li, Sudharsan Kannan, Tomer Korabelnikov, Keegan A. Schoeller, Carissa L. Sirois, Chen Zhou, Jonathan Le, Daifeng Wang, Qiang Chang, Qian-Quan Sun, Xinyu Zhao
Summary: Parvalbumin interneurons (PVIs) are influenced by the regulation of the FXR1 gene, impacting behaviors and oscillations related to schizophrenia. This reveals a potential mechanism of action for FXR1 in schizophrenia.
MOLECULAR PSYCHIATRY
(2021)
Article
Endocrinology & Metabolism
Xi Shen, Yating Xie, Di Chen, Wenya Guo, Gang Feng, Weiming Jiang, Hui Long, Qifeng Lyu, Wei Jin, Yanping Kuang, Li Wang
Summary: This study found that parental body mass index (BMI) has an impact on cumulative live birth rate (CLBR) with a freeze-all strategy, with female overweight/obesity having a more significant negative effect on CLBR compared to male BMI.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Changyou Jiang, Xiao Yang, Guanhong He, Fan Wang, Zhilin Wang, Wendong Xu, Ying Mao, Lan Ma, Feifei Wang
Summary: Neuronal plasticity in the ventral tegmental area (VTA) is crucial for drug dependence, with morphine exposure leading to preferential projection of neurons to the nucleus accumbens (NAc) and dopamine-dependent positive reinforcement. Chronic morphine exposure enhances connections between corticotrophin-releasing hormone (CRH) neurons of the central amygdala and VTA neurons, mediating negative effects during opiate withdrawal. Pharmacological intervention or CRISPR-mediated repression of CRH receptors weakens inhibitory inputs and alleviates negative effects during opiate withdrawal.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Ming-Shuo Shao, Xiao Yang, Chen-Chun Zhang, Chang-You Jiang, Ying Mao, Wen-Dong Xu, Lan Ma, Fei-Fei Wang
Summary: This study found that protein O-GlcNAcylation in DAergic neurons in the VTA plays an important role in regulating the response to natural reward and motor learning in mice.
NEUROSCIENCE BULLETIN
(2022)
Article
Biochemistry & Molecular Biology
Guanhong He, Ziqing Huai, Changyou Jiang, Bing Huang, Zhen Tian, Qiumin Le, Guangyuan Fan, Haibo Li, Feifei Wang, Lan Ma, Xing Liu
Summary: The incubation phenomenon, where cue-induced drug craving progressively increases over prolonged withdrawal, is a major factor in persistent relapse for cocaine addiction. This study found that neuronal ensembles in the nucleus accumbens shell (NAcSh) show increasing activation induced by cue-induced drug-seeking after a 30-day withdrawal. Inhibition or activation of NAcSh cocaine-ensembles suppressed or promoted craving for cocaine, indicating the critical role of NAcSh cocaine-ensembles in incubation for cocaine craving.
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Xiaocen Fan, Jiachen Song, Chaonan Ma, Yanbo Lv, Feifei Wang, Lan Ma, Xing Liu
Summary: This study found that increased norepinephrine release from the locus coeruleus to the medial prefrontal cortex during contextual fear conditioning is crucial for memory tagging and remote memory storage. It is regulated by the ventrolateral periaqueductal grey and can be promoted by activating beta1-adrenergic receptor signaling in juvenile mice.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
